当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis.

A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis.

Abstract：

BACKGROUND:Safe and efficacious topical treatments are needed for atopic dermatitis (AD). OBJECTIVE:We assessed the safety and efficacy of tapinarof cream (2 concentrations and 2 application frequencies) in patients with AD. METHODS:A double-blind, vehicle-controlled, randomized, 6-arm trial (1:1:1:1:1:1) in patients age 12 to 65 years, with body surface area involvement of at least 5% to 35% and an Investigator's Global Assessment score of 3 or higher (moderate to severe) at baseline. Primary end points included an Investigator's Global Assessment score of clear or almost clear (0 or 1) and a minimum 2-grade improvement (treatment success) at week 12. Secondary analyses included a 75% or greater improvement in Eczema Area and Severity Index score, reduction of numeric rating scale (NRS) score for itch from baseline, and other prespecified end points. RESULTS:The rates of treatment success with tapinarof cream at week 12 were 53% (a concentration of 1% twice daily), 46% (a concentration of 1% once daily), 37% (a concentration of 0.5% twice daily), 34% (0.5% once daily), 24% (vehicle twice daily), and 28% (vehicle once daily). The rate with a concentration of 1% twice daily (53%) was statistically significantly higher than the rate with vehicle twice daily (24%). Treatment success was maintained for 4 weeks after the end of tapinarof treatment. The rate of treatment-emergent adverse events was higher with tapinarof (93 of 165 [56%]) than with vehicle (34 of 82 [41%]), and the events were mild to moderate in intensity. LIMITATIONS:Large confirmation trials are needed. CONCLUSIONS:Tapinarof cream is efficacious and well tolerated in adolescent and adult patients with AD.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Peppers J,Paller AS,Maeda-Chubachi T,Wu S,Robbins K,Gallagher K,Kraus JE

doi

10.1016/j.jaad.2018.06.047

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

89-98.e3

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(18)32203-5

journal_volume

80

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY文献大全
  • Cutaneous botryomycosis in a patient with acquired immunodeficiency syndrome.

    abstract：:A patient with acquired immunodeficiency syndrome presented with multiple pruritic papules and nodules over the trunk and extremities. Biopsy specimens from two of these lesions contained granules within abscesses of the papillary dermis. There were numerous gram-positive cocci within the granules. Culture of one lesi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(87)80072-5

    authors： Patterson JW,Kitces EN,Neafie RC

    更新日期：1987-01-01 00:00:00

  • Follicular accentuation of leukocytoclastic vasculitis in an HIV-seropositive man. Report of a case and review of the literature.

    abstract：:Palpable purpura in a follicular localization developed in association with acute epididymitis in a white man who was seropositive for the human immunodeficiency virus (HIV). Biopsy specimens revealed a leukocytoclastic vasculitis with follicular accentuation. With antibiotic therapy the vasculitis resolved, but it re...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/0190-9622(91)70143-p

    authors： Weimer CE Jr,Sahn EE

    更新日期：1991-05-01 00:00:00

  • Olmsted syndrome--congenital palmoplantar and periorificial keratoderma.

    abstract：:We are reporting the third case of the Olmsted syndrome, an entity that has received little attention in the medical literature. The syndrome consists of congenital diffuse, sharply marginated keratoderma of the palms and soles, onychodystrophy , constrictions of digits, and periorificial keratoses. Our patient, in ad...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(84)80264-9

    authors： Poulin Y,Perry HO,Muller SA

    更新日期：1984-04-01 00:00:00

  • Unilateral dermatomal superficial telangiectasia. Nine new cases and a review of unilateral dermatomal superficial telangiectasia.

    abstract：:Unilateral dermatomal superficial telangiectasia (UDST) may be congenital or acquired. Acquired UDST may occur coincident with physiologic states of estrogen increase, including puberty and pregnancy in women and adrenarche in men. Acquired UDST may also occur in estrogenized pathologic states such as chronic hepatic ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(83)70051-4

    authors： Wilkin JK,Smith JG Jr,Cullison DA,Peters GE,Rodriquez-Rigau LJ,Feucht CL

    更新日期：1983-04-01 00:00:00

  • Cutaneous reactions to chemotherapeutic drugs and targeted therapies for cancer: part I. Conventional chemotherapeutic drugs.

    abstract：:Conventional chemotherapy continues to be an important part of cancer management, but may cause various cutaneous reactions because it disturbs specific cell cycle phases. The alkylating agents cyclophosphamide, ifosfamide, and thiotepa can produce hyperpigmentation, while hypersensitivity reactions can be seen with p...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2014.04.014

    authors： Reyes-Habito CM,Roh EK

    更新日期：2014-08-01 00:00:00

  • Improving nonattendance rates among pediatric patients with Medicaid or private insurance.

    abstract：BACKGROUND:Access to dermatologists is low among Medicaid-insured patients. Higher clinic nonattendance among Medicaid-insured patients might affect provider decisions to accept these patients. OBJECTIVE:To determine the effect of different scheduling policies on the attendance among children seen at a pediatric derma...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.02.018

    authors： Chaudhry SB,Siegfried E,Sheikh UA,Simonetta C,Butala N,Armbrecht E

    更新日期：2019-08-01 00:00:00

  • Dermatoscopy versus Tzanck smear test: a comparison of the value of two tests in the diagnosis of pigmented skin lesions.

    abstract：BACKGROUND:Dermatoscopy is the most commonly used noninvasive tool for the diagnosis of pigmented skin lesions, but few studies have investigated the value of cytology in the identification of those lesions. OBJECTIVE:We compared the accuracy of dermatoscopy with that of the Tzanck smear test in the diagnosis of pigme...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jaad.2010.08.019

    authors： Durdu M,Baba M,Seçkin D

    更新日期：2011-11-01 00:00:00

  • A systematic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis siné myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies.

    abstract：OBJECTIVE:Classical dermatomyositis (CDM) patients display the hallmark cutaneous manifestations of dermatomyositis (DM), proximal muscle weakness, and laboratory evidence of myositis. The epidemiology and management of both adult-onset and juvenile-onset CDM has been well characterized. However, the clinical significa...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2005.10.041

    authors： Gerami P,Schope JM,McDonald L,Walling HW,Sontheimer RD

    更新日期：2006-04-01 00:00:00

  • Childhood stye and adult rosacea.

    abstract：BACKGROUND:Little is known about how individuals with a predisposition for rosacea appear in childhood. This retrospective, matched control, longitudinal study examined the relationship between childhood stye and adult rosacea. METHODS:The records of the Rochester Epidemiology Project were examined to identify patient...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2006.03.023

    authors： Bamford JT,Gessert CE,Renier CM,Jackson MM,Laabs SB,Dahl MV,Rogers RS 3rd

    更新日期：2006-12-01 00:00:00

  • Fulminant transfusion-associated graft-versus-host disease in a premature infant.

    abstract：:A fatal case of transfusion-associated graft-versus-host disease developed in a premature infant after receiving several blood products, including nonirradiated white blood cells. Transfusion-associated graft-versus-host disease can be prevented. Irradiation of blood products is the least controversial and most effect...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(89)70116-x

    authors： Berger RS,Dixon SL

    更新日期：1989-05-01 00:00:00

  • Betel: consumption and consequences.

    abstract：:Betel is a compound of natural substances chewed for its psychostimulating effects. Betel is composed of the nut of the areca palm (Areca catechu), the leaf of the betel pepper (Piper betle), and lime (calcium hydroxide). Approximately 200 million persons chew betel regularly throughout the western Pacific basin and s...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(98)70543-2

    authors： Norton SA

    更新日期：1998-01-01 00:00:00

  • Effects of topical clindamycin on intestinal microflora in patients with acne.

    abstract：:Thirty-two patients with acne completed a randomized, double-blind study using topical 1% clindamycin phosphate or its vehicle applied twice daily for 8 weeks for a study of its effects on the intestinal microflora. Two clindamycin patients and one vehicle patient had Clostridium difficile in stools prior to therapy. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0190-9622(86)70153-9

    authors： Siegle RJ,Fekety R,Sarbone PD,Finch RN,Deery HG,Voorhees JJ

    更新日期：1986-08-01 00:00:00

  • Amelanotic acral melanomas: clinicopathological, BRAF mutation, and KIT aberration analyses.

    abstract：BACKGROUND:Amelanotic acral melanoma (AAM) is very rare and difficult to diagnose both clinically and pathologically. Complete-type AAM shows no black to brown pigmentation in the lesion, whereas incomplete-type AAM shows focal or subtle pigmentation. AAM has been the subject of few investigations. OBJECTIVES:We analy...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2013.06.035

    authors： Choi YD,Chun SM,Jin SA,Lee JB,Yun SJ

    更新日期：2013-11-01 00:00:00

  • Topical rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge-Weber syndrome: phase II, randomized, double-blind, intraindividual placebo-controlled clinical trial.

    abstract：BACKGROUND:Sturge-Weber syndrome (SWS) is characterized by port-wine stains (PWS) affecting the face, eyes, and central nervous system. Pulsed dye laser (PDL) is the standard treatment for PWS. Unfortunately, recurrence is frequent because of reformation and reperfusion of blood vessels. OBJECTIVE:We sought to assess ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jaad.2014.10.011

    authors： Marqués L,Núñez-Córdoba JM,Aguado L,Pretel M,Boixeda P,Nagore E,Baselga E,Redondo P

    更新日期：2015-01-01 00:00:00

  • Mechanisms of action of topical therapies and the rationale for combination therapy.

    abstract：:The advent of new topical agents such as topical calcineurin inhibitors, as well as the reformulations of older agents in new vehicles, has broadened the treatment approaches to psoriasis and atopic dermatitis. The clinician must now consider additional novel physiologic pathways and mechanisms of action as well as ex...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2005.04.027

    authors： Norris DA

    更新日期：2005-07-01 00:00:00

  • Successful treatment of musk ketone-induced chronic actinic dermatitis with cyclosporine and PUVA.

    abstract：:We describe a patient with chronic actinic dermatitis whose photopatch tests revealed reactions to musk ketone and musk ambrette, both of which were found in his aftershave lotion. Minimal erythema doses of UVA and UVB were decreased. After initial unsuccessful treatment with PUVA therapy the patient was successfully ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(92)70261-d

    authors： Gardeazábal J,Arregui MA,Gil N,Landa N,Ratón JA,Diáz-Pérez JL

    更新日期：1992-11-01 00:00:00

  • Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the beta and gamma subunits of laminin 5.

    abstract：:Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial blistering disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with antiepiligrin cicatricial pemphigoid have been shown to react specifically with the alpha3 chain of laminin 5. We describe the first patient with ant...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(99)70453-6

    authors： Fujimoto W,Toi Y,Okazaki F,Lazarova Z,Yancey KB,Arata J

    更新日期：1999-04-01 00:00:00

  • Lichen planopilaris: a clinicopathologic study.

    abstract：:Three clinicopathologic variants of lichen planopilaris are described. The first is characterized clinically by individual keratotic follicular papules and histologically by a lichenoid inflammatory cell infiltrate confined to the follicular epithelium. The second variant consists of erythematous to violaceous plaques...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(90)70078-v

    authors： Matta M,Kibbi AG,Khattar J,Salman SM,Zaynoun ST

    更新日期：1990-04-01 00:00:00

  • Pili torti in association with citrullinemia.

    abstract：:A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting th...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(85)80018-9

    authors： Patel HP,Unis ME

    更新日期：1985-01-01 00:00:00

  • Cutaneous-type adult T-cell leukemia/lymphoma presenting as a solitary large skin nodule: a review of the literature.

    abstract：:Adult T-cell leukemia/lymphoma (ATLL) often involves the skin. Cases with skin lesions without either leukemic nor lymph node involvement have been categorized into a cutaneous type. While the clinical manifestations of the cutaneous-type ATLL are variable, including multiple papules, nodules, plaques, or erythroderma...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2006.12.031

    authors： Shimizu S,Yasui C,Koizumi K,Ikeda H,Tsuchiya K

    更新日期：2007-11-01 00:00:00

  • Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.

    abstract：:Both mycosis fungoides (MF) and Sézary syndrome (SS) have a chronic, relapsing course, with patients frequently undergoing multiple, consecutive therapies. Treatment is aimed at the clearance of skin disease, the minimization of recurrence, the prevention of disease progression, and the preservation of quality of life...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2013.08.033

    authors： Jawed SI,Myskowski PL,Horwitz S,Moskowitz A,Querfeld C

    更新日期：2014-02-01 00:00:00

  • Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin.

    abstract：:We performed a 22-month trial of topical tretinoin (retinoic acid) in the treatment of photoaging. Thirty patients participated in a 4-month, randomized, blinded, vehicle-controlled study that has been reported previously; 21 patients continued tretinoin therapy on an open-label basis, participating in the study for a...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0190-9622(90)70265-j

    authors： Ellis CN,Weiss JS,Hamilton TA,Headington JT,Zelickson AS,Voorhees JJ

    更新日期：1990-10-01 00:00:00

  • Clinical response and tissue effects of etretinate treatment of patients with solar keratoses and basal cell carcinoma.

    abstract：:Patients with basal cell carcinoma and solar keratoses were treated with etretinate. Substantial and prolonged clinical improvement was seen. All patients with solar keratoses showed a decrease in the mean area and number of lesions and eight patients demonstrated complete healing clinically. Two patients experienced ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0190-9622(88)70075-4

    authors： Hughes BR,Marks R,Pearse AD,Gaskell SA

    更新日期：1988-03-01 00:00:00

  • Cutaneous nevi and risk of melanoma death in women and men: A prospective study.

    abstract：BACKGROUND:It was unclear whether an increased number of common nevi (moles) predicts melanoma death. OBJECTIVE:We prospectively examined the association between number of common nevi and risk of melanoma death. METHODS:Our study used data from the Nurses' Health Study (n = 77,288 women) and Health Professionals Foll...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2018.12.058

    authors： Li WQ,Cho E,Weinstock MA,Li S,Stampfer MJ,Qureshi AA

    更新日期：2019-05-01 00:00:00

  • A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad.

    abstract：:We report the case of a congenitally deaf white male with mild palmoplantar keratoderma, ichthyosiform scaling, follicular hyperkeratosis, and mild keratitis, features consistent with keratitis-ichthyosis-deafness syndrome. His major problem was severe, disfiguring, inflammatory dissecting folliculitis of the scalp, h...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2003.12.042

    authors： Montgomery JR,White TW,Martin BL,Turner ML,Holland SM

    更新日期：2004-09-01 00:00:00

  • Response of mononuclear leukocyte cyclic adenosine monophosphate-phosphodiesterase activity to treatment with topical fluorinated steroid ointment in atopic dermatitis.

    abstract：:Our studies of mononuclear leukocyte peripheral blood homogenates demonstrate significantly increased cyclic adenosine monophosphate-specific phosphodiesterase activity in patients with atopic dermatitis who were untreated for 1 week, compared with normal adult nonatopic control subjects. Phosphodiesterase activity is...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(89)70150-x

    authors： Holden CA,Yuen CT

    更新日期：1989-07-01 00:00:00

  • The pharmacology of methotrexate.

    abstract：:Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the imp...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/0190-9622(91)70199-c

    authors： Olsen EA

    更新日期：1991-08-01 00:00:00

  • Regression of Kaposi's sarcoma during therapy with HIV-1 protease inhibitors: a prospective pilot study.

    abstract：BACKGROUND:Early studies using HIV protease inhibitors (PI) showed regression of Kaposi's sarcoma (KS) lesions in some patients. OBJECTIVE:Our purpose was to determine prospectively the influence of PI on HIV-related KS. METHODS:KS lesions of nine patients with progressive cutaneous disease were prospectively evaluat...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(98)70124-0

    authors： Krischer J,Rutschmann O,Hirschel B,Vollenweider-Roten S,Saurat JH,Pechère M

    更新日期：1998-04-01 00:00:00

  • Dermoscopy of black skin: A cross-sectional study of clinical and dermoscopic features of melanocytic lesions in individuals with type V/VI skin compared to those with type I/II skin.

    abstract：BACKGROUND:The identification of "normal" dermoscopic patterns of acquired melanocytic nevi provides better diagnostic accuracy for melanoma in people with black skin. OBJECTIVE:We sought to describe melanocytic lesions (numbers and anatomic distributions) in skin types V and VI compared with skin types I and II, acco...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2015.03.043

    authors： Tuma B,Yamada S,Atallah ÁN,Araujo FM,Hirata SH

    更新日期：2015-07-01 00:00:00

  • Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study.

    abstract：:A panel of antibodies reactive in routinely fixed, paraffin-embedded tissue sections was compared with a panel of antibodies reactive in frozen sections for the immunophenotyping of cutaneous lymphoproliferative disorders. Three T cell-associated markers (UCHL1, MT-1, MT-2, six B cell-associated markers (MB-1, MB-2, L...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(90)70055-m

    authors： Cerroni L,Smolle J,Soyer HP,Martinez Aparicio A,Kerl H

    更新日期：1990-03-01 00:00:00