Abstract:
:We describe a 3-year-old male patient with an unusual congenital lesion on the plantar surface of the left foot that had been asymptomatic until shortly before presentation. Histologic examination of the plaque revealed a thinner keratin layer, increased pigmentation, and a pilosebaceous unit with a visible vellus hair. We tentatively hypothesize from this single case that a disruption in the normal sequence of events of morphogenesis, and particularly in dorsal-to-ventral orientation, may have occurred in this patient.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Dragan L,Lorincz AL,Medenica MM,Phillips SBdoi
10.1016/s0190-9622(99)70163-5subject
Has Abstractpub_date
1999-05-01 00:00:00pages
769-71issue
5 Pt 1eissn
0190-9622issn
1097-6787pii
S0190-9622(99)70163-5journal_volume
40pub_type
杂志文章abstract:BACKGROUND:Knowledge is limited regarding unknown primary Merkel cell carcinoma (UPMCC). OBJECTIVE:We sought to document the characteristics and behavior of UPMCC, and determine the most appropriate treatment. METHODS:A multicenter, retrospective, consecutive study reviewing patients given a diagnosis of UPMCC betwee...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,多中心研究,评审
doi:10.1016/j.jaad.2012.07.035
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Malignant melanomas occur with increased frequency and at an early age in patients with xeroderma pigmentosum (XP). OBJECTIVE:The purpose of this study was to describe the histologic features of malignant melanomas in patients with XP and to search for a possible precursor lesion. METHODS:Clinical records ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(93)70079-9
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma. OBJECTIVE:We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma. METHODS:We conducted a retros...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2015.06.052
更新日期:2015-09-01 00:00:00
abstract::Carcinoma of the cervix is a common neoplasm, which annually affects 50,000 women in the United States. When cervical carcinoma metastasizes, it most often involves the lung, bone, and liver; only rarely does it metastasize to the skin. We describe a patient with previously diagnosed carcinoma of the cervix who presen...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2001.112389
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Lentigo maligna (LM) often displays extensive subclinical spread. Mohs micrographic surgery (MMS) has been proposed to help delineate the true histologic margin; however, visualizing atypical melanocytes on frozen section is challenging and often requires confirmatory permanent paraffin sections. OBJECTIVE:...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2002.119197
更新日期:2002-01-01 00:00:00
abstract::The etiology of mycosis fungoides (MF) is uncertain, although infectious agents and other environmental exposures have been implicated. We describe what appears to be the first case in which both a husband and his wife were diagnosed with large-cell transformation of MF. After 10 years of having stage I MF, the wife d...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2005.09.013
更新日期:2006-05-01 00:00:00
abstract::Sunscreen preparations can reduce the erythemogenic ( sunburning ) effects of solar ultraviolet radiation (UVR). Less is known about the ability of sunscreens to protect against other forms of UVR-induced damage. This study was designed to yield data on epidermal cell damage at UVR doses sufficient to provoke vascular...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(84)70088-0
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Facial erythema is a clinical hallmark of rosacea and often causes social and psychological distress. Although facial erythema assessments are a common endpoint in rosacea clinical trials, their reliability has not been evaluated. OBJECTIVE:The objective of this study was to evaluate the inter- and intrarat...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2014.05.044
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Seborrheic dermatitis is commonly treated with anti-inflammatory products, including topical corticosteroids. Pimecrolimus cream 1% also exerts anti-inflammatory activity by inhibiting T-cell cytokine production. OBJECTIVE:We sought to compare the efficacy and safety of twice-daily pimecrolimus for treatmen...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jaad.2006.11.007
更新日期:2007-08-01 00:00:00
abstract::A cutaneous and soft tissue reaction that resulted from a broken thermometer inside the mouth of a 10-year-old boy is described. Metallic mercury globules and glass pieces were identified in the excised tissue. On histologic examination, a zone of necrosis, polymorphonuclear leukocytes, macrophages, and multinucleated...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/0190-9622(91)70283-8
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Epidemiology and patterns of antibiotic resistance for Staphylococcus aureus are changing in the United States. OBJECTIVE:We sought to determine the epidemiology and antibiotic susceptibility profiles in S aureus cutaneous infections in a pediatric dermatology tertiary health care facility in North Carolina...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2009.07.030
更新日期:2010-05-01 00:00:00
abstract::George Cheyne Shattuck's 1808 dissertation on structure and function of the skin is one of the earliest American writings on the topic of skin diseases. Although this essay contributed no important new observations, it does provide insight into the attitudes of American physicians in the post-Revolutionary War period ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 传,历史文章,杂志文章
doi:10.1067/mjd.2002.119644
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Necrolytic migratory erythema (NME) is an uncommon inflammatory dermatosis with a distinct clinical and histologic appearance. NME is usually associated with glucagonoma. Only a few cases of NME in the absence of glucagonoma have been previously reported. OBJECTIVE:We sought to understand further the pathog...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(95)90345-3
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and type 2 diabetes mellitus (T2DM), and the existing data show conflicting results. OBJECTIVE:To determine the prevalence of T2DM among patients with HS and identify at-risk demographic subgroups. METHODS:Cross-sectional ana...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2018.01.014
更新日期:2018-07-01 00:00:00
abstract::We are reporting seven cases of Mibelli's porokeratosis of the face. Facial involvement of porokeratosis is rare, and in this location the lesions are not clinically recognized. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(80)80333-1
更新日期:1980-10-01 00:00:00
abstract::A patient with fluoroscopy-induced subacute radiation dermatitis is described. Her biopsy specimen showed vacuolar change and necrotic keratinocytes with lymphocytes in direct apposition, or "satellitosis". Lymphocytes in the dermis and infiltrating the epidermis were predominantly CD8+ and a number of the lymphocytes...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(98)70577-8
更新日期:1998-02-01 00:00:00
abstract::The role of estrogens in the development of skin cancer is controversial. Sex steroids have a profound effect on the epidermis and epidermal appendages. Estradiol in pharmacologic doses has been reported to stimulate basal cell carcinoma in an animal model. Sex hormones act by means of a specific protein receptor. In ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70101-2
更新日期:1988-05-01 00:00:00
abstract::A case of Staphylococcus aureus--induced bullous dermatosis limited to the sites of glucocorticosteroid-induced striae atrophicae is described. Skin with compromised mechanical integrity may be more susceptible to disruption by invasion of bacteria and/or by their exotoxin. The pathogenesis of striae atrophicae and th...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(84)70033-8
更新日期:1984-02-01 00:00:00
abstract::Parachlorometaxylenol is used as a germicide in many topical products. To our knowledge, this is the first case of dermatitis from parachlorometaxylenol in electrocardiograph electrodes used with cardiac monitors. The patient also had hand eczema from a germicidal soap containing parachlorometaxylenol. In addition, ou...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(86)70175-8
更新日期:1986-08-01 00:00:00
abstract::We report a case of generalized cutaneous chronic graft-versus-host disease in a 17-month-old infant. Topical treatment with the novel ascomycin substance pimecrolimus once daily for 4 weeks led to a near complete clearance of skin lesions. Importantly, this excellent clinical response was obtained without additional ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2004.02.010
更新日期:2004-06-01 00:00:00
abstract::Pruritus is a common symptom in patients with hepatobiliary disease. Numerous treatments have been attempted. We review published therapeutic trials for hepatobiliary pruritus and utilize statistical analysis to evaluate treatment results. Randomized placebo-controlled studies show cholestyramine, rifampin, naloxone, ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/0190-9622(95)91818-3
更新日期:1995-11-01 00:00:00
abstract::Kapos's varicelliform eruption usually occurs in persons with active skin disease of various types; however, in atopic dermatitis the condition may occur when the underlying disease is inactive. Two cases of widespread herpes simplex infection associated with Darier's disease are reported. In both cases, infection occ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(79)70024-7
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND:Although a variety of ablative, topical, and systemic therapies are used for molluscum contagiosum (MC), none has been well studied or approved by the US Food and Drug Administration. OBJECTIVES:To compare the efficacy and tolerability of topical SB206 (berdazimer sodium gel coadministered with hydrogel) wi...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jaad.2019.09.064
更新日期:2020-04-01 00:00:00
abstract:UNLABELLED:Revolutionary advances in laser research and technology have led to expanded dermatologic laser applications. With the wide range of lasers now available, a large spectrum of skin conditions in the pediatric population can be successfully treated or, in some cases, completely eradicated. Laser treatment of t...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2003.08.004
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD). OBJECTIVE:To assess the risk of lymphoma and the role of topical treatments in patients with AD. METHODS:A systematic literature search and a separate meta-analysis were performed on case control ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jaad.2015.02.1116
更新日期:2015-06-01 00:00:00
abstract::A large variety of underlying conditions and diseases have been associated with zygomycosis. The most common ones include leukemia or lymphoma, burns, renal failure, septicemia, malnutrition, diabetes, cancer, chemotherapy, organ transplantation, and corticosteroid administration. While being ubiquitous in the environ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(83)80023-1
更新日期:1983-06-01 00:00:00
abstract::We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions. He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood. On postnatal day (P...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2008.09.029
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2020.12.023
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:Complications associated with psoriatic arthritis (PsA) may be prevented with early diagnosis and initiation of therapy. Up to one third of psoriasis patients may have PsA. There is a need to screen psoriasis patients early for symptoms of PsA. OBJECTIVE:To develop and validate a patient self-administered t...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2007.04.001
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Patients with epidermal nevi strongly demand cosmetic improvement. Laser treatment appears appealing and is frequently used in clinical practice. Nevertheless, large series with long-term follow-up are missing, preventing definitive conclusions about its real benefit. OBJECTIVE:To evaluate the long-term eff...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.06.013
更新日期:2020-12-01 00:00:00