Abstract：
BACKGROUND/AIM:To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation. PATIENTS AND METHODS:Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation. RESULTS:Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da. CONCLUSION:Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Mordhorst LB,Sorbe B,Ahlin Csubject
Has Abstractpub_date
2012-11-01 00:00:00pages
4913-22issue
11eissn
0250-7005issn
1791-7530pii
32/11/4913journal_volume
32pub_type
杂志文章abstract：:In spite of endoscopic surveillance programs, 90% of patients initially presenting with Barrett's carcinoma have locally advanced disease. In these patients, preoperative chemotherapy increases the chance of a curative resection in responding patients. Unfortunately, response occurs in only 50% of patients after chemo...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：1998-05-01 00:00:00
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journal_title：Anticancer research
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doi：
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Anticancer research
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更新日期：2016-04-01 00:00:00
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journal_title：Anticancer research
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更新日期：1997-09-01 00:00:00
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更新日期：2004-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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