RSARF: prediction of residue solvent accessibility from protein sequence using random forest method.

abstract：:A new galactose-specific lectin, named BBL, was purified from seeds of Bauhinia bauhinioides by precipitation with ammonium sulfate, followed by two steps of ion exchange chromatography. BBL haemagglutinated rabbit erythrocytes (native and treated with proteolytic enzymes) showing stability even after exposure to 60 °...

journal_title：Protein and peptide letters

authors： Silva HC,Bari AU,Pereira-Jénior FN,Simões RC,Barroso-Neto IL,Nobre CB,Pereira MG,Nascimento KS,Rocha BA,Delatorre P,Nagano CS,Assreuy AM,Cavada BS

更新日期：2011-04-01 00:00:00

abstract：:Bromelain inhibitor, "bromein", is a proteinase-inhibitor specific to the cysteine proteinase bromelain from pineapple stem. In the stem, eight bromein isoforms are known to exist, and each isoform has a short peptide (light chain) and a long one (heavy chain) with five disulfide bonds. The three-dimensional structure...

journal_title：Protein and peptide letters

authors： Hatano KI,Takahashi K,Tanokura M

更新日期：2018-01-01 00:00:00

abstract：:Porcine β defensin 2(pBD2)is a cationic 37-amino acid antimicrobial peptide with disulfide bonds. Synthetic pBD2 had broad antimicrobial activity against pathogenic bacteria, and thus pBD2 could be a good candidate as a bactericidal agent for pigs. This study reported the successful recombinant expression of pBD2 in E...

journal_title：Protein and peptide letters

authors： Li CL,Zhao YC,Song XY,Huang XX,Zhao WD

更新日期：2013-06-01 00:00:00

abstract：:Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed...

journal_title：Protein and peptide letters

authors： Xu H,Liu WY

更新日期：2003-10-01 00:00:00

abstract：:The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in m...

journal_title：Protein and peptide letters

authors： Fulda S,Linseisen J,Wolfram G,Himmerich S,Gedrich K,Pollmächer T,Himmerich H

更新日期：2010-11-01 00:00:00

abstract：:Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplas...

journal_title：Protein and peptide letters

authors： Ahmad I,Khan TS,Hoessli DC,Walker-Nasir E,Kaleem A,Shakoori AR,Nasir-ud-Din

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Ciprofloxacin (Cip) is the most commonly used quinolone in clinical practice; however large-scale use has favored the increase of multiresistant pathogenic microorganisms. Antimicrobial peptides (AMPs) appear to be a promising alternative in potentiating these conventional drugs. OBJECTIVE:The aim of this s...

journal_title：Protein and peptide letters

authors： Carneiro VA,de Oliveira ST,Silva RL,de Sousa Duarte H,Silva ML,Matos MNC,Cavalcante RMB,Figueira CS,Lorenzón EN,Cilli EM,da Cunha RMS

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides have been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times...

journal_title：Protein and peptide letters

authors： Wu H,Huang J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The heterologous production of antimicrobial peptides in bacterial models can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to increase the expression and solubility of these types of proteins with varying degrees of success. OBJECTIVES:Here, we demonstrate the...

journal_title：Protein and peptide letters

authors： Montfort-Gardeazabal JM,Claudio PCM,Casillas-Vega NG,Zarate X

更新日期：2020-06-10 00:00:00

abstract：:Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in in...

journal_title：Protein and peptide letters

authors： Keskin G,Inal A,Ozışık L

更新日期：2010-10-01 00:00:00

abstract：:Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and r...

journal_title：Protein and peptide letters

authors： Hirano K,Aya K,Matsuoka M,Ueguchi-Tanaka M

更新日期：2012-02-01 00:00:00

abstract：:Apomyoglobin (apoMb) folds through at least two partially folded forms that are detected both as transient intermediates during folding/unfolding kinetics or as stable intermediates at equilibrium. Here, I summarize the results of recent kinetic studies, which combined with detailed characterizations of equilibrium fo...

journal_title：Protein and peptide letters

authors： Jamin M

更新日期：2005-04-01 00:00:00

abstract：:Prediction of thermophilic and mesophilic protein plays a crucial role in both biochemistry and bioengineering. In this study, a different mode of pseudo amino acid composition (PseAAC) was proposed to formulate the protein samples by integrating the amino acid composition, the physic chemical features, as well as the...

journal_title：Protein and peptide letters

authors： Wang D,Yang L,Fu Z,Xia J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Nε-acetyl L-α lysine is an unusual acetylated di-amino acid synthesized and accumulated by certain halophiles under osmotic stress. Osmolytes are generally known to protect proteins and other cellular components under various stress conditions. OBJECTIVE:The structural and functional stability imparted by N...

journal_title：Protein and peptide letters

authors： Joghee NN,Jayaraman G,Selladurai M

更新日期：2020-01-01 00:00:00

abstract：:We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4[29-39]. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, ...

journal_title：Protein and peptide letters

authors： Palladino P,Pedone C,Ragone R,Rossi F,Saviano M,Benedetti E

更新日期：2003-04-01 00:00:00

abstract：:Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate. In this paper, we examined the sequences and structures of the MutT/Nudix...

journal_title：Protein and peptide letters

authors： Lin J,Tian B,Hua Y

更新日期：2008-01-01 00:00:00

abstract：:Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology ...

journal_title：Protein and peptide letters

authors： Kesari P,Neetu,Sharma A,Katiki M,Kumar P,Gurjar BR,Tomar S,Sharma AK,Kumar P

更新日期：2017-01-01 00:00:00

abstract：:The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species...

journal_title：Protein and peptide letters

authors： Joshi RR,Manda C

更新日期：2007-01-01 00:00:00

abstract：:We investigated the in vitro antibiotic activity of the 19-amino acid antimicrobial peptide HP (2-20), derived from the N-terminus of Helicobacter pylori Ribosomal Protein L1 (RPL1), against antibiotic susceptible and resistant pathogens from a patient with gallstones. HP (2-20) was active against antibiotic-susceptib...

journal_title：Protein and peptide letters

authors： Park Y,Hahm JS,Hahm KS

更新日期：2006-01-01 00:00:00

abstract：:Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur. ...

journal_title：Protein and peptide letters

authors： Shiraishi N,Inai Y,Ihara Y

更新日期：2009-01-01 00:00:00

abstract：:The role of interaction between Asn259 (catalytic domain) with Gln821 (C-terminal domain) in PeptidaseN was investigated. The k(cat) of PeptidaseN containing Asn259Asp or Gln821Glu is enhanced whereas it is suppressed in Asn259AspGln821Glu. Structural analysis shows this interaction to change the relative disposition ...

journal_title：Protein and peptide letters

authors： Kumar A,Reddy S,Srinivasan N,Nandi D

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:In this investigation a novel approach based on mucoadhesive superporous hydrogel hybrids (SPHHs) for topi- cal vaginal drug delivery for Metronidazole was tried. METHOD:SPHHs were synthesized by solution polymerization tech- nique. The synthesized SPHHs were characterized for tensile strength, swelling beh...

journal_title：Protein and peptide letters

authors： Chavda H,Chavada G,Patel J,Rangpadiya K,Patel C

更新日期：2014-01-01 00:00:00

abstract：:Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better un...

journal_title：Protein and peptide letters

authors： Nayeem MS,Khan RH

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Protein-carbohydrate interactions play vital roles in several biological processes in living organisms. The comparative analysis of binding site residues along with stabilizing residues in protein-carbohydrate complexes provides ample insights to understand the structure, function and recognition mechanism. ...

journal_title：Protein and peptide letters

authors： Shanmugam NRS,Selvin JFA,Veluraja K,Gromiha MM

更新日期：2018-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) constitute an important alternative in the search for new treatments against pathogens. We analyzed the sequence variability in cytokine and chemokine proteins to investigate whether these molecules contain a sequence useful in the development of new AMPs. Cluster analysis allowed the ide...

journal_title：Protein and peptide letters

authors： Robles-Gomez EE,Flores-Villegas MC,Gonzalez-Manjarrez A,Soriano-Garcia M

更新日期：2013-05-01 00:00:00

abstract：:Coiled coils are important structural modules and domains of protein-protein interactions. Further, they provide the required framework to proteins, like kinesins, myosins and SNAREs, which are either structural or involved in transport of biomolecules. We provide an interactive webserver to measure the strength of in...

journal_title：Protein and peptide letters

authors： Alva V,Syamala Devi DP,Sowdhamini R

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to design and develop stable nanoemulsion formulations containing IFN-γ to probe their use as an immunomodulating agent. The nanoemulsions comprising distilled water, triglycerides of capric acid/caprylic, sobitan-oleate (SP), polysorbate 80 (TW) and propylene glycol (PG) were prepared throug...

journal_title：Protein and peptide letters

authors： Ribeiro EB,Honorio-França AC,França EL,Soler MA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The biocatalytic oxidation of UDP-glucose in the presence of NAD+ is catalyzed by UDP-glucose dehydrogenases. OBJECTIVES:The main objective of this study was the characterization of a UDP-glucose dehydrogenase (AmUGD) from Akkermansia muciniphila, a bacterium originally isolated from human faeces in an anae...

journal_title：Protein and peptide letters

authors： Wei S,Zhang XY,Sun Y,Conway LP,Liu L

更新日期：2017-01-01 00:00:00

abstract：:To identify proteins involved in the molecular mechanisms of pressure overload-induced heart failure, we quantitatively analyzed the left ventricular proteomic profile in a transverse aortic constriction (TAC) mouse model, a well-established model of cardiac hypertrophy and dysfunction. Multidimensional LC-MS/MS in co...

journal_title：Protein and peptide letters

authors： Guan D,Zhao Y,Zhang Y,Tang D,Wu Q

更新日期：2016-01-01 00:00:00

abstract：:Identification on protein folding types is always based on the 27-class folds dataset, which was provided by Ding & Dubchak in 2001. But with the avalanche of protein sequences, fold data is also expanding, so it will be the inevitable trend to improve the existing dataset and expand more folding types. In this paper,...

journal_title：Protein and peptide letters

authors： Liu L,Hu XZ,Liu XX,Wang Y,Li SB

更新日期：2012-04-01 00:00:00