Abstract:
:Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate. In this paper, we examined the sequences and structures of the MutT/Nudix superfamily. And two recent developed methods were employed for data analyses of the superfamily. One is QH method evaluating the similarities among structures for structural phylogeny. The other method is clustering analysis by using the CLANS program that could analysis thousands of sequences of the full dataset rather than the representative sequences of the superfamily. Finally, we proposed a more objective classification of the MutT/Nudix superfamily members based on detailed sequence and structure analyses.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Lin J,Tian B,Hua Ydoi
10.2174/092986608783330350subject
Has Abstractpub_date
2008-01-01 00:00:00pages
108-12issue
1eissn
0929-8665issn
1875-5305journal_volume
15pub_type
杂志文章abstract::The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, s...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180917163142
更新日期:2019-01-01 00:00:00
abstract::Marine species are comprising about a half of the whole global biodiversity; the sea offers an enormous resource for novel bioactive compounds. Several of the marine origin species show multifunctional bioactivities and characteristics that are useful for a discovery and/or reinvention of biologically active compounds...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666160802160222
更新日期:2017-01-01 00:00:00
abstract::Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cycli...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200212123542
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Nanosheets of SnO2 which an n-type semiconductor with a rutile-type crystalline structure are predominantly used as gas sensors. SnO2 nanosheets have a tetragonal crystal structure where growth along the c-axis is suppressed to form a sheet. The major exposed facets of SnO2 nanosheets have {110}, {101} and {...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666171206114429
更新日期:2018-01-01 00:00:00
abstract::A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones identify any otherwise abnormal conformat...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191026111951
更新日期:2020-01-01 00:00:00
abstract::Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies. The enzyme-loaded red blood cells function as bioreactors to deplete bloodstream substrate. This delivery system provides improved pharmacodynamics with protection from circulating proteoly...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:
更新日期:2013-04-01 00:00:00
abstract::In the last few decades, novel drug delivery strategies have been a big priority to the formulation scientists. Peptides and proteins have drawn a special attention for their wide scope in the area. Serum albumin, transferrin, recom- binant proteins, virus capsids etc. are used as carrier for drug and biomolecules. Co...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866521666140804160907
更新日期:2014-01-01 00:00:00
abstract::After several studies on prediction of mutation, we examine the effect of three sampling strategies, the sampling based on years, the sampling based on number of mutations, and the sampling based on the unpredictable portion of amino-acid pairs, on the prediction performance in H5N1 hemagglutinins. The results show th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785133735
更新日期:2008-01-01 00:00:00
abstract::The reaction between Arg-Gly-Asp (RGD) and Lys-Gly-Asp (KGD) derivatives with 3,4',5-trihydroxy-trans-stilbene (resveratrol) was investigated. Knowing that resveratrol, RGD as well as KGD analogues inhibit human platelet aggregation in vitro, it was tempting for us to examine whether their coupling products present en...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607782541141
更新日期:2007-01-01 00:00:00
abstract::Eukaryotic translation initiation factor 5A (eIF-5A) is universally found in all eukaryotic cells. It is the only protein in nature known to contain the unusual amino acid hypusine, a post-translationally modified lysine. Recombinant human eIF-5A was crystallized by the hanging-drop vapor diffusion method. Crystals we...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866054696091
更新日期:2005-10-01 00:00:00
abstract::Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cyc...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666160816152755
更新日期:2017-01-01 00:00:00
abstract::Tumor vasculatures express high levels of α(V)β(3)/α(V)β(5) and α(5)β(1) integrins. Peptide containing the RGD (Arg-Gly-Asp) sequence, which is present in ligands of integrins, is effective in targeting therapeutic reagents to tumor vascular endothelium. In this study, we investigated whether the biological activity o...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:
更新日期:2011-06-15 00:00:00
abstract::Human beta-defensin-2 (hBD2) is A small cationic peptide with A broad range of antimicrobial activity. An E. coli cell-free system was employed to express the hBD2 fusion protein by using the hBD2 gene with 14 rare codons. The results showed that the expression level of trxA-hBD2 fusion protein was 0.35 mg/ml, which i...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775101724
更新日期:2006-01-01 00:00:00
abstract::Adenoregulin is a 33 amino acid antibiotic peptide who belongs to dermaseptin family which is the first vertebrate family to show lethal effects against filamentous fungi, as well as a broad spectrum of pathogenic microorganisms. Synthetic adenoregulin gene was cloned in 2, 4 and 6 tandem repeats and subcloned in pET3...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866053765671
更新日期:2005-05-01 00:00:00
abstract::Quantum mechanical fragment molecular orbital calculations have been performed for receptor binding of the hemagglutinin protein of the recently pandemic influenza 2009 H1N1, A/swine/Iowa/1930, and A/Puerto Rico/8/1934 viruses to α2-6 linked sialyloligosaccharides, as analogs of human receptors. The strongest receptor...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794927893
更新日期:2011-05-01 00:00:00
abstract::A 26-kDa trypsin inhibitor with an N-terminal sequence resembling storage proteins was purified from moth beans (Phaseolus acutifolius). It dose-dependently inhibited trypsin with an IC(50) value of about 0.38 microM. It inhibited [methyl-(3)H] thymidine incorporation by lymphoma MBL2 cells with an IC(50) value of 20 ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791190408
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:In the last years, Antimicrobial Peptides (AMPs) and lipopeptides have received attention as promising candidates to treat infections caused by resistant microorganisms. OBJECTIVE:The main objective of this study was to investigate the effect of repetitive KLFK motifs and the attachment of aliphatic acids t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666181208144629
更新日期:2019-01-01 00:00:00
abstract::Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, a...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787316243
更新日期:2009-01-01 00:00:00
abstract::We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4[29-39]. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033479022
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides have been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180530122835
更新日期:2018-01-01 00:00:00
abstract::Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthe...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160920095131
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200427212940
更新日期:2020-01-01 00:00:00
abstract::An alternative method for expressing the recombinant proteins in Escherichia coli is proposed. Unlike the ordinary induction protocol where the cells in the early- to mid-log phase are induced for the protein production, this alternative protocol utilizes the cells in the stationary phase. By using a glutathione S-tra...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478861
更新日期:2003-08-01 00:00:00
abstract::Nicotinamide adenine dinucleotide (NAD) plays an important role in cellular metabolism and acts as hydrideaccepting and hydride-donating coenzymes in energy production. Identification of NAD protein interacting sites can significantly aid in understanding the NAD dependent metabolism and pathways, and it could further...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612800191017
更新日期:2012-05-01 00:00:00
abstract::A missense mutation of Aspartic to Asparagine acid in 113 position of liver-targeting peptide CSP I-plus modified rEndostatin (rES-CSP) happened unexpectedly results in the changes of protein secondary structure and a reduced bioactivity. With the aim to clarify the structure-function relationships featuring the fuse ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150302125218
更新日期:2015-01-01 00:00:00
abstract::The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607780989985
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Cryptochrome is a flavin-binding blue-light photoreceptor that functions in growth and development in plants, the circadian clock in animals and navigation in birds. However, a lack of purified cryptochrome has hindered studies of the structure and function of this protein. In this study, we obtained a subst...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666181004112308
更新日期:2018-01-01 00:00:00
abstract::Cyclophilin A (CyPA) is a cytosolic receptor of immunosuppressive drug cyclosporin A (CsA) which possesses peptidyl-prodyl cis/trans isomerase (PPIase) activity. The recombinant human CyPA (rhCyPA) gene has been expressed in E. coli M15. Purification was performed using salting-out, as well as Sephacryl S-100 and DEAE...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642670
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass f...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180122100722
更新日期:2018-01-01 00:00:00
abstract::In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866043406643
更新日期:2004-10-01 00:00:00