Calcium may preferentially deposit in areas of elastic tissue damage.

abstract：BACKGROUND:Atopic dermatitis (AD), a chronic, highly pruritic skin disorder, impairs quality of life (QoL). Janus kinase inhibitors suppress inflammatory and pruritus-associated cytokine signaling in AD. OBJECTIVE:To report the effects of ruxolitinib (RUX) cream on itch and QoL in AD. METHODS:A total of 307 adult pat...

journal_title：Journal of the American Academy of Dermatology

authors： Kim BS,Sun K,Papp K,Venturanza M,Nasir A,Kuligowski ME

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) have poorer outcomes if treated when large. OBJECTIVE:We sought to estimate the growth rate of BCCs and SCCs and examine the relationship of personal, pathway, and cancer factors with cancer size (diameter). METHODS:We surveyed pati...

journal_title：Journal of the American Academy of Dermatology

authors： Kricker A,Armstrong B,Hansen V,Watson A,Singh-Khaira G,Lecathelinais C,Goumas C,Girgis A

更新日期：2014-03-01 00:00:00

abstract：:The psychosocial impact of infection with human immunodeficiency virus (HIV) can be viewed from three perspectives: (1) the issues focused by acquired immunodeficiency syndrome (AIDS), (2) the persons affected, and (3) the emotions encountered. Among the many issues faced by AIDS patients, their families, and their ca...

journal_title：Journal of the American Academy of Dermatology

authors： Cline DJ

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Increases in the incidence of malignant melanoma have been among the largest of all cancers in the United States. OBJECTIVE:We report updated trends in melanoma rates among the US white population. METHODS:Incidence and mortality rates were calculated for 1973 to 1994. Trends were examined with stratificat...

journal_title：Journal of the American Academy of Dermatology

authors： Hall HI,Miller DR,Rogers JD,Bewerse B

更新日期：1999-01-01 00:00:00

abstract：:The Norwegian-Russian border area is polluted because of emissions from two local Russian nickel refineries. We patch tested the general adult population on both sides of the border. Only 7.2% of the Russian women were sensitized to nickel, compared with 27.5% of the Norwegian women. We suggest that long-term exposure...

journal_title：Journal of the American Academy of Dermatology

authors： Smith-Sivertsen T,Tchachtchine V,Lund E

更新日期：2002-03-01 00:00:00

abstract：:To develop guidelines for the follow-up of patients with primary cutaneous melanoma (clinical Stage I), we studied 295 patients who had presented with a primary melanoma and who subsequently developed evidence of metastatic disease in the course of follow-up. Cox multivariate analysis was used to assess the influence ...

journal_title：Journal of the American Academy of Dermatology

authors： Kelly JW,Blois MS,Sagebiel RW

更新日期：1985-11-01 00:00:00

abstract：:The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They have been shown to inhibit the proliferation of transformed cell lines in vitro and transplanted tumors in vivo. In cultured murine melanoma cells, retinoids inhibit proliferation and induce diffe...

journal_title：Journal of the American Academy of Dermatology

authors： Meyskens FL Jr,Edwards L,Levine NS

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:The histopathological and clinical overlapping features between condyloma acuminata and bowenoid papulosis can present a diagnostic challenge and we sought to determine if immunochemistry can be helpful in this setting. OBJECTIVE:In this study, we evaluate the specificity and sensitivity of p16 immunohistoc...

journal_title：Journal of the American Academy of Dermatology

authors： Kazlouskaya V,Shustef E,Allam SH,Lal K,Elston D

更新日期：2013-09-01 00:00:00

abstract：:A single application (16 to 20 hours) of 1% gamma benzene hexachloride (GBH) lotion, when applied to a total island population of 178 persons in which seventy-four clinically had scabies, resulted in a cure rate of over 98%. Re-examination of the population at 10 and 21 weeks revealed only one remaining individual sti...

journal_title：Journal of the American Academy of Dermatology

authors： Taplin D,Arrue C,Walker JG,Roth WI,Rivera A

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Tissue-destructive and more selective cytotoxic therapies are the main methods used to treat actinic cheilitis. A topical immune stimulant, 5% imiquimod cream, has recently been used for treatment of cutaneous epithelial malignancies including squamous cell carcinoma in situ and basal cell carcinoma. OBJECT...

journal_title：Journal of the American Academy of Dermatology

authors： Smith KJ,Germain M,Yeager J,Skelton H

更新日期：2002-10-01 00:00:00

abstract：:Vulvar melanosis is a condition in which intensely pigmented irregular macules, clinically mimicking malignant melanoma, appear on the vulva. A biopsy specimen shows only marked lower epidermal pigmentation without any melanocytic atypia or nesting. The process is benign, and reassurance is the only treatment. ...

journal_title：Journal of the American Academy of Dermatology

authors： Rudolph RI

更新日期：1990-11-01 00:00:00

abstract：:A 7-week-old male infant with a seizure disorder and an extensive sebaceous nevus of the scalp was examined. Computerized axial tomography (CAT) scan identified an intracerebral mass which proved to be a hamartomatous malofrmation fo the brain. The association of intracranial masses with sebaceous nevi should be recog...

journal_title：Journal of the American Academy of Dermatology

authors： Moskowitz R,Honig PJ

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:A radiofrequency-controlled electrosurgical device (ESD) has been adapted for skin peeling. A high-voltage, low-amperage current converts an irrigant into an ionized vapor, causing molecular dissociation and superficial damage in adjacent tissue. OBJECTIVE:We compared the clinical and histologic effects of ...

journal_title：Journal of the American Academy of Dermatology

authors： Acland KM,Calonje E,Seed PT,Stat C,Barlow RJ

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Patients with pemphigus vulgaris (PV) are genetically linked to two alleles of the HLA subgroup, and circulating antibodies were found in first-degree relatives of these patients, thus showing genetic predisposition. OBJECTIVE:Our purpose was to determine the occurrence of circulating true PV-IgG in patient...

journal_title：Journal of the American Academy of Dermatology

authors： Brandsen R,Frusic-Zlotkin M,Lyubimov H,Yunes F,Michel B,Tamir A,Milner Y,Brenner S

更新日期：1997-01-01 00:00:00

abstract：:A patient with sarcoidosis was treated with thalidomide for disfiguring and painful steroid unresponsive sarcoidal granulomas of the skin. The duration of the therapy was 14 months, during which time, the skin lesions resolved almost completely. The initial dosage was 200 mg a day, which was increased to 400 mg a day ...

journal_title：Journal of the American Academy of Dermatology

authors： Lee JB,Koblenzer PS

更新日期：1998-11-01 00:00:00

abstract：:Four patients with severe psoriasis have been treated with oral cyclosporine for 6 months. Two had generalized erythroderma and two had extensive plaque-type psoriasis; all had either become unresponsive to or were unable to use other accepted treatments. All four patients responded rapidly and were completely clear o...

journal_title：Journal of the American Academy of Dermatology

authors： Picascia DD,Garden JM,Freinkel RK,Roenigk HH Jr

更新日期：1987-09-01 00:00:00

abstract：:The standard definition of itching (as "an unpleasant sensation that provokes the desire to scratch") takes no account of recent advances in knowledge about itch physiology. Always imprecise, this definition is also out-of-date. Its defects are discussed in this article, and some modifications are proposed. ...

journal_title：Journal of the American Academy of Dermatology

authors： Savin JA

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Nonmelanoma skin cancer (NMSC) incidence in patients with vitiligo has not been studied. OBJECTIVE:We sought to quantify the incidence of NMSC in patients with vitiligo. METHODS:A cohort of 477 patients with vitiligo and no history of NMSC seen in an outpatient academic center between January 2001 and Dece...

journal_title：Journal of the American Academy of Dermatology

authors： Hexsel CL,Eide MJ,Johnson CC,Krajenta R,Jacobsen G,Hamzavi I,Lim HW

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Small open studies of patients at high risk for squamous cell carcinoma (SCC) of the skin suggest that oral retinoid use reduces the risk of these tumors. Among patients at lower risk, randomized trials of low doses of retinoids did not demonstrate significant chemopreventive effects. Patients with psoriasis...

journal_title：Journal of the American Academy of Dermatology

authors： Nijsten TE,Stern RS

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and type 2 diabetes mellitus (T2DM), and the existing data show conflicting results. OBJECTIVE:To determine the prevalence of T2DM among patients with HS and identify at-risk demographic subgroups. METHODS:Cross-sectional ana...

journal_title：Journal of the American Academy of Dermatology

authors： Garg A,Birabaharan M,Strunk A

更新日期：2018-07-01 00:00:00

abstract：:Costs for dermatitis can be evaluated against the costs and potential benefits of patch testing on the basis of data available from several sources. Consideration of cost for an individual patient suggests that costs become neutral and benefits become positive if the dermatitis is persistent and multiple physician vis...

journal_title：Journal of the American Academy of Dermatology

authors： Rietschel RL

更新日期：1989-10-01 00:00:00

abstract：:There has been a resurgence of syphilis in the past decade. Uncommonly, diffuse hair loss, termed essential alopecia, is the only sign of syphilitic infection. We describe two patients with syphilis in whom the first sign of disease was alopecia and discuss the clinical and histopathologic findings of essential syphil...

journal_title：Journal of the American Academy of Dermatology

authors： Cuozzo DW,Benson PM,Sperling LC,Skelton HG 3rd

更新日期：1995-05-01 00:00:00

abstract：:A woman with pemphigus vulgaris was treated by plasma exchange. Four separate exchanges of approximately 4,000 ml each were performed over a 2-week period. The patient's pemphigus antibody titer decreased from 1/320 before the first exchange to 1/20 after the final exchange, and no new lesions developed for 3 weeks fo...

journal_title：Journal of the American Academy of Dermatology

authors： Swanson DL,Dahl MV

更新日期：1981-03-01 00:00:00

abstract：:Nonmelanoma skin cancer refers to a broad class of tumors, including actinic keratosis, basal cell carcinoma, and squamous cell carcinoma, and as a group these are the most frequent cancers occurring in light skinned humans. In contrast to the rarity of amelanotic melanoma, nonmelanoma skin cancer commonly lacks pigme...

journal_title：Journal of the American Academy of Dermatology

authors： Zalaudek I,Kreusch J,Giacomel J,Ferrara G,Catricalà C,Argenziano G

更新日期：2010-09-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the occurrence of arterial and/or venous thromboembolic events and obstetric complications in the setting of circulating antiphospholipid antibodies. Dermatologic manifestations are commonly seen in APS with almost half of the patients exhi...

journal_title：Journal of the American Academy of Dermatology

authors： Kriseman YL,Nash JW,Hsu S

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma. OBJECTIVE:We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma. METHODS:We conducted a retros...

journal_title：Journal of the American Academy of Dermatology

authors： Donahue T,Lee CY,Sanghvi A,Obregon R,Sidiropoulos M,Cooper C,Merkel EA,Yélamos O,Ferris L,Gerami P

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Exposure to ultraviolet radiation (from solar and nonsolar sources) is a risk factor for skin cancer. OBJECTIVE:We sought to summarize recent estimates on sunburns, sun-protection behaviors, and indoor tanning available from national and selected statewide behavioral surveys. METHODS:Estimates of the preva...

journal_title：Journal of the American Academy of Dermatology

authors： Buller DB,Cokkinides V,Hall HI,Hartman AM,Saraiya M,Miller E,Paddock L,Glanz K

更新日期：2011-11-01 00:00:00

abstract：:Acrocyanosis is an uncommon condition characterized by symmetric coolness and violaceous discoloration of the hands and feet. The nose, ears, lips, and nipples are also often affected. The disease is temperature dependent and generally worsens with cold exposure. Acrocyanosis is often secondary to a variety of underly...

journal_title：Journal of the American Academy of Dermatology

authors： Nousari HC,Kimyai-Asadi A,Anhalt GJ

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported. OBJECTIVES:To assess the prevalence and incidence of PsA in patients with psoriasis. METHODS:Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of P...

journal_title：Journal of the American Academy of Dermatology

authors： Alinaghi F,Calov M,Kristensen LE,Gladman DD,Coates LC,Jullien D,Gottlieb AB,Gisondi P,Wu JJ,Thyssen JP,Egeberg A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:UVA induces tissue damage via the production of radical oxygen species. Adding antioxidants to UV filters in sunscreens is a novel photoprotective strategy. The topical application of antioxidants in sunscreen can potentially neutralize the UVA-induced free radicals. OBJECTIVES:We sought to assess the degre...

journal_title：Journal of the American Academy of Dermatology

authors： Wang SQ,Osterwalder U,Jung K

更新日期：2011-09-01 00:00:00