Abstract：
:To mimic a human malaria infection in the endemic condition, two strains of mice (Balb/c and CBA) were infected and treated several times to generate so-called semi-immune status. As previously reported, neither mice (Balb/c and CBA) strain showed cerebral malaria, even in the susceptible C57BL/6 (B6). The significant difference between the mice strains in our previous study was the rate of destruction of uninfected red blood cells (uRBCs) at infection. After the established repeated cycles of infection and treatment and the final challenge with 10(4) Plasmodium berghei ANKA until minimum Hb, Balb/c and CBA mice were sacrificed. The spleen, liver, brain, kidney, lung, heart, and muscle were removed, stained with hematoxylin-eosin and analyzed with light microscopy. Previous observation suggested that Balb/c destroyed uRBC at much higher rate than the other strains although the parasitemia was very low. Pathological investigation carried out in this study revealed that this destruction was mainly contributed by the uRBCs as no parasite sequestration was observed in any of the organs. However, malaria pigment deposition was observed in spleen and liver of all the semi-immune mice strains. This histopathological study in the severe malaria anemia model, which is difficult to conduct in humans, will be helpful in taking into account different responses to malaria infection when designing therapeutic interventions and vaccine studies.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Helegbe GK,Yanagi T,Senba M,Huy NT,Shuaibu MN,Yamazaki A,Kikuchi M,Yasunami M,Hirayama Kdoi
10.1007/s00436-010-2121-6subject
Has Abstractpub_date
2011-04-01 00:00:00pages
807-14issue
4eissn
0932-0113issn
1432-1955journal_volume
108pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：1989-01-01 00:00:00
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