Abstract：
:Production of parasite-specific antibodies is an important component of immunity to blood stage malaria infection, as shown by several previous studies in rodent models. However, no study has addressed the induction of humoral immunity by different parasites in a genetically homogeneous host population. Here, levels of parasite-specific immunoglobulin isotypes were measured during primary infections of Plasmodium chabaudi and of Plasmodium yoelii in inbred NIH mice inoculated with cloned lines of either avirulent or virulent erythrocytic parasites. Non-lethal infections were characterized by early and late significant upregulation of IgG2a and IgG1, respectively. In contrast, for lethal infections, a slower, reduced IgG2a response correlated with a rapidly fatal outcome prior to any significant synthesis of IgG1. It is proposed that the sequential upregulated synthesis of parasite-specific IgG2a (cytophilic) and IgG1 (non-cytophilic) is associated with protective immunity to blood stage malaria infections in mice. This may provide an immunological framework for examining humoral immunity to malaria in humans.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Smith EC,Taylor-Robinson AWdoi
10.1007/s00436-002-0687-3subject
Has Abstractpub_date
2003-01-01 00:00:00pages
26-33issue
1eissn
0932-0113issn
1432-1955journal_volume
89pub_type
杂志文章abstract：:The present study aimed to isolate and genotype strains of T. gondii from pigs slaughtered for human consumption in South Brazil. Blood and tissues (heart, diaphragm, liver, tongue, and masseter) from 400 animals were collected at two slaughterhouses. Sera were obtained, and antibodies against T. gondii were detected ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06274-1
更新日期：2019-05-01 00:00:00
abstract：:We studied the effect of host gender and body mass on species richness of flea infracommunities in nine rodent host species from three biomes (temperate zone of central Europe, desert of the Middle East and the tropics of East Africa). Using season- and species-specific generalized linear mixed models and controlling ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3937-2
更新日期：2014-08-01 00:00:00
abstract：:The present study represents the first detailed description of the haptoral sclerites of Macrogyrodactylus clarii Gussev 1961. Light microscopy reveals outgrowths of the hamuli roots; two lateral spine-like extensions of the hood-like accessory sclerites; a ridged, fan-shaped distal end of an accessory sclerite; and t...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06799-w
更新日期：2020-12-01 00:00:00
abstract：:Metazoan parasites of guilds of benthic snails and crustaceans and of four fish families--Gobiidae, Gasterosteidae, Syngnathidae, and Zoarcidae--were investigated off the brackish Salzhaff area (Southwest Baltic) in the semienclosed Salzhaff and the near Rerik Riff in the free Baltic. Comparisons revealed greater simi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050681
更新日期：2000-05-01 00:00:00
abstract：:It was determined that there is a relationship between prevalence and mean densities of Trichodina spp. on Merlangius merlangus and organic pollution, measured as levels of nitrite, nitrate and phosphate in the surrounding environment. Monthly, two left anterior gill arcs of 60 M. merlangus (unless otherwise stated) c...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-1346-2
更新日期：2005-06-01 00:00:00
abstract：:Analyses were made on the adenosine transporter-1 gene in Trypanosoma brucei (TbAT1), encoding a P2-like nucleoside transporter, from T. brucei brucei field stocks to investigate a possible link between the presence of mutations in this gene and isometamidium resistance. We have analysed the gene from 11 isometamidium...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0141-z
更新日期：2006-08-01 00:00:00
abstract：:Allicin is an active ingredient of garlic that has antibacterial, antifungal, antiviral, and antiprotozoal activity. However, the inhibitory effects of allicin on Babesia parasites have not yet been examined. In the present study, allicin was tested as a potent inhibitor against the in vitro growth of bovine and equin...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3654-2
更新日期：2014-01-01 00:00:00
abstract：:cDNA clones for homologues of a molecular chaperone of the endoplasmic reticulum called the immunoglobulin heavy-chain binding protein (BiP) have been isolated from Eimeria maxima and E. tenella sporozoite cDNA libraries. The E. tenella cDNA clone is of full length and has a predicted N-terminal signal sequence of app...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050163
更新日期：1996-01-01 00:00:00
abstract：:Extracts were prepared from leaf, bark, and seed of Azadirachta indica, leaf and seed of Prunus persica, bark of Mangifera indica, and leaf of Psidium guajava and were evaluated against Boophilus microplus. Of the eight extracts screened, the extracts prepared from the A. indica seed showed very high level of efficacy...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1173-3
更新日期：2008-12-01 00:00:00
abstract：:Chagas disease, caused by the protozoan Trypanosoma cruzi, is considered to be a multifactorial disease associated with host and parasite genetics, which influence clinical aspects of the disease and other host conditions. In order to understand better the evolution of the disease, this study intended to evaluation of...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5969-5
更新日期：2018-09-01 00:00:00
abstract：:Amebic cysteine protease 2 (EhCP2) was purified from ethyl ether extracts of axenically grown trophozoites of Entamoeba histolytica strain HM1-IMSS. The purification procedure involved molecular filtration and electroelution. Sequence analysis of the purified product revealed EhCP2 and ubiquitin(s). Electrophoretic mi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0763-8
更新日期：2003-06-01 00:00:00
abstract：:The morphology, adult development and genetic characteristics of Echinococcus granulosus isolated from pigs in Poland were examined and compared with those of other recognised strains of E. granulosus. The isolates were characterised by their distinct morphology, rapid maturation and unique DNA hybridisation profiles....
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931216
更新日期：1993-01-01 00:00:00
abstract：:Ixodes holocyclus has a narrow, discontinuous distribution along the east coast of Australia. We studied ticks from 17 localities throughout the geographic range of this tick. The ITS2 of I. holocyclus is 793 bp long. We found nucleotide variation at eight of the 588 nucleotide positions (1.4%) that were compared for ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-001-0533-z
更新日期：2002-03-01 00:00:00
abstract：:Anopheles campestris-like is proven to be a high-potential vector of Plasmodium vivax in Thailand. In this study, A. campestris-like salivary gland proteins were determined and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional gel electrophoresis, and nano-liquid chromat...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3233-y
更新日期：2013-03-01 00:00:00
abstract：:In 1978, the nature of the hypnozoite was discussed in an article that appeared in a relatively obscure journal, which is also where the term was adopted for Plasmodium (a little-known fact). As a result, that commentary on the use of the word "hypnozoite" has been almost completely overlooked. Although the publicatio...
journal_title：Parasitology research
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00436-010-2072-y
更新日期：2011-01-01 00:00:00
abstract：:Systematic, continuous mosquito surveillance is considered the most reliable tool to predict the spread and establishment of alien mosquito species such as the Asian tiger mosquito (Aedes albopictus), Japanese bush mosquito (Aedes japonicus), and the transmission risk of mosquito-borne arboviruses to humans. Only sing...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06287-w
更新日期：2019-05-01 00:00:00
abstract：:Triatoma platensis is occasionally found coexisting with Triatoma infestans in chicken coops in Argentina. Some authors have reported the presence of hybrid specimens of both species in chicken coops and other peridomestic habitats. Given the coexistence of T. infestans with T. platensis and the possibility of generat...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06822-0
更新日期：2020-09-01 00:00:00
abstract：:Galectin plays an important role in host-parasite interactions. In this study, we identified a novel gene encoding galectin-10 (AcGal-10) from the cDNA library of Angiostrongylus cantonensis and characterized its biological role in the parasite. Sequence and phylogeny analysis showed that AcGal-10 is related to other ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3210-5
更新日期：2013-03-01 00:00:00
abstract：:Chicken coccidiosis is a major parasitic disease caused by Eimeria spp. It is controlled and treated using chemical anticoccidial agents. Development of partial or complete resistance toward these anticoccidials is considered a major problem in poultry industry. Allicin is an organosulfur compound produced as a result...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4637-2
更新日期：2015-10-01 00:00:00
abstract：:The pathogenicity of 19 hypocrealean entomopathogenic fungi from seven different genera in adult Aedes aegypti was tested. All fungi proved to be pathogenic, and Isaria fumosorosea, Lecanicillium muscarium, Lecanicillium psalliotae, Metarhizium anisopliae, Metarhizium lepidiotae, Metarhizium majus, Metarhizium frigidu...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1991-y
更新日期：2010-10-01 00:00:00
abstract：:The localization and distribution of SALMFamide (S1)-like immunoreactivity (IR), was determined at both the cellular and subcellular level in the central nervous system (CNS) of the nematode roundworm Ascaris suum. The techniques of indirect immunofluorescence in conjunction with confocal scanning laser microscopy and...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050086
更新日期：1996-01-01 00:00:00
abstract：:A new nematode species, Philometra spicarae sp. n. (Philometridae), is described from a gravid female found in the abdominal cavity of spicarel, Spicara smaris (Linnaeus) (Centracanthidae, Perciformes), from the Ionian Sea off Sicily, Italy. The new species differs from most other Philometra spp. parasitic in the abdo...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1877-z
更新日期：2010-07-01 00:00:00
abstract：:Leishmania (L.) tropica is a causative agent of cutaneous and occasionally visceral or viscerotropic leishmaniasis in humans. The dose of parasites influences the course and outcome of disease in some Leishmania species. The effect of parasite dose on L. tropica infection in an experimental model was studied in the cu...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5991-7
更新日期：2018-09-01 00:00:00
abstract：:In vitro leucocyte proliferative responses to parasite antigens and to mitogens as well as lymphocyte sub-types were compared in guinea pigs with genetically determined differences in their ability to express protective immunity against Trichostronylus colubriformis infection. Proliferative responses to parasite antig...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050048
更新日期：2000-04-01 00:00:00
abstract：:The migration of Schistosoma japonicum and S. mansoni through mouse skin epidermis and dermis was compared by immunofluorescence techniques from 4 to 22 h after infection. At all times, the percentage of parasites detected in the dermis was significantly higher for S. japonicum than for S. mansoni. Thus, S. japonicum ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1284-4
更新日期：2005-02-01 00:00:00
abstract：:Tryptophan-N-formylated gramicidin A, a nonhemolytic derivative of the toxic peptide antibiotic gramicidin A, has previously been shown to induce potassium leakage from Plasmodium falciparum-infected erythrocytes in vitro and to inhibit the growth of the parasite. In the present study the antimalarial activities of tw...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932413
更新日期：1995-01-01 00:00:00
abstract：:In the present study the behavior and pathogenicity of second-stage larvae of Toxocara canis were examined in different mouse strains with special emphasis on the major histocompatibility complex (MHC). Mice of the inbred strains BALB, C3H, C57BL, and DBA and the outbred strain NMRI were infected orally with 1000 seco...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932955
更新日期：1994-01-01 00:00:00
abstract：:Cryptosporidium spp. and Giardia duodenalis are protozoan parasites that cause diarrhea in humans and animals. Molecular data on Cryptosporidium spp. and G. duodenalis in calves in the Republic of Korea (ROK) is limited; thus, we investigated the prevalence of Cryptosporidium and Giardia in pre-weaned calves, analyzed...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06482-9
更新日期：2019-12-01 00:00:00
abstract：:Two placebo-controlled pen studies were conducted to assess the efficacy of an imidacloprid 10 %/flumethrin 4.5 % polymer matrix collar (Seresto®, Bayer; Investigational Veterinary Product (IVP)) against the Australian paralysis tick (Ixodes holocyclus). Dogs assigned to the placebo (n = 8) or IVP (n ≥ 8) groups had c...
journal_title：Parasitology research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00436-013-3276-8
更新日期：2013-08-01 00:00:00
abstract：:Naturally occurring bithyniid snails, Bithynia siamensis goniomphalos (Prosobranchia: Bithyniidae), and their intermediate hosts were sampled from Khammouane Province, the Lao People's Democratic Republic, and the prevalence of the carcinogenic human liver fluke, Opisthorchis viverrini, was examined. The presence of O...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2140-3
更新日期：2011-04-01 00:00:00
