Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni.

Abstract:

:The migration of Schistosoma japonicum and S. mansoni through mouse skin epidermis and dermis was compared by immunofluorescence techniques from 4 to 22 h after infection. At all times, the percentage of parasites detected in the dermis was significantly higher for S. japonicum than for S. mansoni. Thus, S. japonicum migrates more rapidly very early after infection. This agrees with the quicker migration observed previously by this species for later times. Both species expressed antigens related to the cercarial glycocalyx on the parasite body and antigenically detectable elastase in the acetabular glands, at least until 22 h after infection. Bot sets of antigens were also left as "traces" in cercarial migration channels in the skin as well as in skin tissue in the absence of detectable worms or migration channels. The data further substantiate differences between schistosome species in the speed of migration, and suggest that glycocalyx-related antigens and cercarial elastase continue to be expressed for at least 1 day after infection.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Wang L,Li YL,Fishelson Z,Kusel JR,Ruppel A

doi

10.1007/s00436-004-1284-4

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

218-23

issue

3

eissn

0932-0113

issn

1432-1955

journal_volume

95

pub_type

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