Overexpression of p75(NTR) increases survival of breast cancer cells through p21(waf1).

abstract：:In humans injured myocardium cannot avert the onset and progression of ventricular dysfunction because of limited regenerative ability of myocytes. Although limited renaissance of cardiomyocytes has been reported in human infarcted hearts, it is generally accredited that non-functional fibrous tissue replaces the dead...

journal_title：Cellular signalling

authors： Verma V,Purnamawati K,Manasi,Shim W

更新日期：2013-05-01 00:00:00

abstract：:Follistatin-like 1 (FSTL1) functions as a pivotal modulator of inflammation and is implicated in many inflammatory diseases such as rheumatoid arthritis. Here, we report that FSTL1 is strongly upregulated and secreted during osteoclast differentiation of bone marrow-derived macrophages (BMMs) and that FSTL1 positively...

journal_title：Cellular signalling

authors： Kim HJ,Kang WY,Seong SJ,Kim SY,Lim MS,Yoon YR

更新日期：2016-09-01 00:00:00

abstract：:Dysfunctional regulation of signaling pathways downstream of the insulin receptor plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. In this study we report both in vitro and in vivo experimental evidence for a role of Cullin-RING E3 ubiquitin ligase 7 (CRL7) in the regulation of insul...

journal_title：Cellular signalling

authors： Scheufele F,Wolf B,Kruse M,Hartmann T,Lempart J,Mühlich S,Pfeiffer AFH,Field LJ,Charron MJ,Pan ZQ,Engelhardt S,Sarikas A

更新日期：2014-02-01 00:00:00

abstract：:PGE2 and prostacyclin each enhance cAMP synthesis in the osteoblast-like cell line UMR-106. The amount of cAMP induced by PGE2 was 5-7-fold greater than the amount induced by cicaprost or iloprost, stable prostacyclin analogues. Both PGE2 and the two prostacyclin analogues enhanced cAMP synthesis with similar time dep...

journal_title：Cellular signalling

authors： Khanin M,Liel Y,Rimon G

更新日期：1999-03-01 00:00:00

abstract：:The strong inhibition of thrombin-induced platelet functions induced by okadaic acid is not correlated with the partial modification of pleckstrin phosphorylation, which remains still phosphorylated two min after stimulation, indicating that protein kinase C is not affected by okadaic acid. We then investigated the ef...

journal_title：Cellular signalling

authors： Mauco G,Artçanuthurry V,Pidard D,Grelac F,Maclouf J,Lévy-Tolédano S

更新日期：1997-01-01 00:00:00

abstract：:We have previously demonstrated that inhibition of calmodulin (CaM) and the concomitant reduction of PI3K interfere with H-Ras-mediated activation of Raf-1 [1]. In the present study, we show that CaM has completely opposite effects on K-Ras-mediated Raf-1 activation. The differential contribution of CaM in the regulat...

journal_title：Cellular signalling

authors： Moretó J,Vidal-Quadras M,Pol A,Santos E,Grewal T,Enrich C,Tebar F

更新日期：2009-12-01 00:00:00

abstract：:Proliferation of vascular smooth muscle cells (VSMCs) plays key roles in the progression of intimal hyperplasia, but the molecular mechanisms that trigger VSMC proliferation after vascular injury remain unclear. c-Ski, a co-repressor of transforming growth factor β (TGF-β)/Smad signaling, was detected to express in VS...

journal_title：Cellular signalling

authors： Li J,Li P,Zhang Y,Li GB,Zhou YG,Yang K,Dai SS

更新日期：2013-01-01 00:00:00

abstract：:The Wnt signalling pathway is conserved in various species from worms to mammals, and plays important roles in development, cellular proliferation, and differentiation. The molecular mechanisms by which the Wnt signal regulates cellular functions are becoming increasingly well understood. Wnt stabilizes cytoplasmic be...

journal_title：Cellular signalling

authors： Kikuchi A

更新日期：1999-11-01 00:00:00

abstract：:The ADP-ribosylation factor (Arf) Arf GTPase-activating proteins (GAPs) are a family of proteins that induce hydrolysis of GTP bound to Arf. A conserved domain containing a zinc finger motif mediates catalysis. The substrate, Arf.GTP, affects membrane trafficking and actin remodelling. Consistent with activity as an A...

journal_title：Cellular signalling

authors： Randazzo PA,Hirsch DS

更新日期：2004-04-01 00:00:00

abstract：:High affinity Ins(1,4,5)P3-binding sites of permeabilized hepatocytes are probably the ligand recognition sites of the receptors that mediate the effects of Ins(1,4,5)P3 on intracellular Ca2+ mobilization. We have now solubilized these sites from rat liver membranes in the zwitterionic detergent, CHAPS, and shown that...

journal_title：Cellular signalling

authors： Bond JM,Taylor CW

更新日期：1991-01-01 00:00:00

abstract：:Expression of the human alpha 2A-adrenergic receptor gene is induced by cAMP. The present studies were designed to define potential cAMP-responsive enhancer elements (CREs) in the promoter region of this gene. Regions from the 5'-flanking sequences of the gene were placed in a promoterless vector with a chloramphenico...

journal_title：Cellular signalling

authors： Shilo L,Sakaue M,Thomas JM,Philip M,Hoffman BB

更新日期：1994-01-01 00:00:00

abstract：:Receptor for Activated C-Kinase 1 (RACK1) belongs to the WD40 family of proteins, known to act as scaffolding proteins in interaction networks. Accordingly, RACK1 is found to have numerous interacting partners ranging from kinases and signaling proteins to membrane bound receptors and ion channels. Interestingly, RACK...

journal_title：Cellular signalling

authors： Nielsen MH,Flygaard RK,Jenner LB

更新日期：2017-07-01 00:00:00

abstract：:Integrin β6 (ITGB6), an epithelial-specific integrin, is upregulated in oral squamous cell carcinomas (OSCC) and is associated with progression and metastasis of OSCC. Lysophosphatidic acid (LPA), an important bioactive phospholipid present in saliva, has also been related to OSCC cell migration and invasiveness. LPA ...

journal_title：Cellular signalling

authors： Xu M,Yin H,Cai Y,Huang W,Ji Q,Liu F,Shi S,Deng X

更新日期：2019-08-01 00:00:00

abstract：:Type I cGMP-dependent protein kinases (PKGs) translocate to the nucleus to regulate gene expression in some, but not all cell types; we hypothesized that nuclear translocation of PKG may be regulated by extra-nuclear anchoring proteins. The inositol 1,4,5-triphosphate (IP(3)) receptor-associated cGMP kinase substrate ...

journal_title：Cellular signalling

authors： Casteel DE,Zhang T,Zhuang S,Pilz RB

更新日期：2008-07-01 00:00:00

abstract：:We investigated the effects of retinoic acid (RA) on the signalling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with RA significantly inhibited the formation of inositol phosphates induced by 10 microM PGE2 in a dose-dependent manner in the range between 0.1 nM and 0.1 micro...

journal_title：Cellular signalling

authors： Kotoyori J,Tokuda H,Oiso Y,Kozawa O

更新日期：1993-07-01 00:00:00

abstract：:Nephrin, an important structural and signal molecule of podocyte slit-diaphragm (SD), has been suggested to contribute to the angiotensin II (Ang II)-induced podocyte injury. Caveolin-1 has been demonstrated to play a crucial role in signaling transduction. In the present study, we evaluated the role of caveolin-1 in ...

journal_title：Cellular signalling

authors： Ren Z,Liang W,Chen C,Yang H,Singhal PC,Ding G

更新日期：2012-02-01 00:00:00

abstract：:Interferon-α (IFNα) has enormous potential for anti-proliferative and anti-viral treatments. However, clinical success is still hampered due to its limited bioavailability and thus, lack of sustained modulation of disease-relevant protective programs. Consequently, we here examined whether IFNα immobilized on nanoscal...

journal_title：Cellular signalling

authors： Pollok S,Ginter T,Günzel K,Pieper J,Henke A,Stauber RH,Reichardt W,Krämer OH

更新日期：2013-04-01 00:00:00

abstract：:Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the Transforming Growth Factor Beta superfamily. To date over 20 members have been identified in humans with varying functions during processes such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis. Though their functions hav...

journal_title：Cellular signalling

authors： Bragdon B,Moseychuk O,Saldanha S,King D,Julian J,Nohe A

更新日期：2011-04-01 00:00:00

abstract：:Cellular hypoxia can lead to cell death or adaptation and has important effects on development, physiology, and pathology. Here, we investigated the role and regulation of ceramide in hypoxia-induced apoptosis of SH-SY5Y neuroblastoma cells. Hypoxia increased the ceramide concentration; subsequently, we observed bioch...

journal_title：Cellular signalling

authors： Kang MS,Ahn KH,Kim SK,Jeon HJ,Ji JE,Choi JM,Jung KM,Jung SY,Kim DK

更新日期：2010-04-01 00:00:00

abstract：:Our previous oligonucleotide array studies revealed that ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL) express high levels of the disheveled proteins (Dvls), a family of proteins that is integral to the Wnt signaling pathways. In this study, we assessed whether the Dvls are important in the pathogenesis of ...

journal_title：Cellular signalling

authors： Hegazy SA,Alshareef A,Gelebart P,Anand M,Armanious H,Ingham RJ,Lai R

更新日期：2013-01-01 00:00:00

abstract：:We have studied the effects of cholinergic agonists on the rates of insulin release and the concentrations of diacylglycerol (DAG) and intracellular free Ca2+ ([Ca2+]i) in the beta-cell line MIN6. Insulin secretion was stimulated by glucose, by glibenclamide and by bombesin. In the presence of glucose, both acetylchol...

journal_title：Cellular signalling

authors： Weng L,Davies M,Ashcroft SJ

更新日期：1993-11-01 00:00:00

abstract：:Src homology (SH) 3 domains are small modules found in a diverse array of proteins. The presence of an SH3 domain confers upon its resident protein the ability to interact with specific proline-rich sequences in protein binding partners. A major focus of research has highlighted a role for SH3 domain-mediated interact...

journal_title：Cellular signalling

authors： McPherson PS

更新日期：1999-04-01 00:00:00

abstract：:Modulation of immune responses is an important strategy employed by pathogens to enable their survival in host organisms. Secreted immunomodulatory molecules are key weapons in the pathogen's battle with the host immune system. In this review, we will discuss the immunomodulatory effects of the phosphorylcholine-conta...

journal_title：Cellular signalling

authors： Goodridge HS,Deehan MR,Harnett W,Harnett MM

更新日期：2005-01-01 00:00:00

abstract：:The induction of cytolytic activity in PC60, a murine T-cell hybridoma, is paralleled by a rise in the level of BLT-esterase (N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl esterase), a serine esterase specific for activated T-cells. Both interleukin-1 (IL-1) and dibutyryl cAMP were albe to increase the esterase activi...

journal_title：Cellular signalling

authors： Schlegel-Haueter SE,Aebischer F

更新日期：1990-01-01 00:00:00

abstract：:Antidepressants are commonly used in the treatment of anxiety and depression, medical conditions that affect approximately 17-20% of the population. The clinical effects of antidepressants take several weeks to manifest, suggesting that these drugs induce adaptive changes in brain structures affected by anxiety and de...

journal_title：Cellular signalling

authors： Taylor C,Fricker AD,Devi LA,Gomes I

更新日期：2005-05-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) can engage multiple pathways to activate ERK1/2 via both G proteins and/or ßarrestin. Receptor recruitment of ßarrestin is also important for GPCR desensitization, internalization and resensitization. Modulation of the receptor/ßarrestin interaction through modification of either co...

journal_title：Cellular signalling

authors： Zimmerman B,Simaan M,Akoume MY,Houri N,Chevallier S,Séguéla P,Laporte SA

更新日期：2011-04-01 00:00:00

abstract：:Ras proteins function as molecular switches that are activated in response to signalling pathways initiated by various extracellular stimuli and subsequently bind to numerous effector proteins leading to the activation of several signalling cascades within the cell. Ras and Ras-related proteins belong to a large super...

journal_title：Cellular signalling

authors： Ferro E,Trabalzini L

更新日期：2010-12-01 00:00:00

abstract：:Dystrophin and the dystrophin-associated protein complex (DAPC) have recently been implicated in cell signalling events. These proteins are ideally placed to transduce signals from the extracellular matrix (ECM) to the cytoskeleton. Here we show that beta-dystroglycan is tyrosine-phosphorylated in C2/C4 mouse myotubes...

journal_title：Cellular signalling

authors： Ilsley JL,Sudol M,Winder SJ

更新日期：2001-09-01 00:00:00

abstract：:mTORC2, the mammalian target of rapamycin complex 2 is activated by upstream growth factors, and performs two major functions, phosphorylation of AKT at the serine of 473 and cell cycle-dependent organization of actin cytoskeleton. However, the mechanisms through which mTORC2 is triggered by these signals remain uncle...

journal_title：Cellular signalling

authors： Xu Y,Lai E,Liu J,Lin J,Yang C,Jia C,Li Y,Bai X,Li M

更新日期：2013-11-01 00:00:00

abstract：:Antiviral responses can be triggered by the cytoplasmic RNA helicase RIG-I that binds to viral RNA. RIG-I-mediated signaling stimulates the transcription factors IRF3 and NF-κB and their activation mechanisms have been intensively studied. Here we examined Sendai virus (SV)-mediated activation of the transcription fac...

journal_title：Cellular signalling

authors： Johnsen IB,Bergstroem B,Stiberg KA,Thommesen L,Anthonsen MW

更新日期：2013-09-01 00:00:00