听力与言语-语言病理学

行为科学

医学伦理学

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  • Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid.

    abstract::Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylat...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109875

    authors: Velazquez FN,Hernandez-Corbacho M,Trayssac M,Stith JL,Bonica J,Jean B,Pulkoski-Gross MJ,Carroll BL,Salama MF,Hannun YA,Snider AJ

    更新日期:2021-03-01 00:00:00

  • Wnt signalling pathway in bladder cancer.

    abstract::Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targete...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109886

    authors: Wu G,Weng W,Xia P,Yan S,Zhong C,Xie L,Xie Y,Fan G

    更新日期:2021-03-01 00:00:00

  • Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis.

    abstract::Renal fibrosis is characterized by chronic inflammation and excessive accumulation of extracellular matrix and progressively leads to functional insufficiency and even total loss of kidney function. In this study we investigated the anti-fibrotic potential of two highly selective and potent SK2 inhibitors, SLM6031434 ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109881

    authors: Schwalm S,Beyer S,Hafizi R,Trautmann S,Geisslinger G,Adams DR,Pyne S,Pyne N,Schaefer L,Huwiler A,Pfeilschifter J

    更新日期:2021-03-01 00:00:00

  • Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT (SLC7A11).

    abstract::The cystine/glutamate antiporter xCT (SLC7A11) is frequently overexpressed in many cancers, including glioblastoma. Cystine taken up by the cells via xCT is reduced to cysteine, which is used to synthesize glutathione for antioxidant cellular defense. However, overexpression of xCT causes cell death under glucose-limi...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109874

    authors: Yamamoto M,Teramoto K,Katoh H

    更新日期:2021-02-01 00:00:00

  • Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.

    abstract::The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinas...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109842

    authors: Kaur H,Moreau R

    更新日期:2021-02-01 00:00:00

  • Review: ER stress-induced cell death in osteoarthritic cartilage.

    abstract::In cartilage, chondrocytes are responsible for the biogenesis and maintenance of the extracellular matrix (ECM) composed of proteins, glycoproteins and proteoglycans. Various cellular stresses, such as hypoxia, nutrient deprivation, oxidative stress or the accumulation of advanced glycation end products (AGEs) during ...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109880

    authors: Rellmann Y,Eidhof E,Dreier R

    更新日期:2021-02-01 00:00:00

  • The functions of mechanosensitive ion channels in tooth and bone tissues.

    abstract::Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thu...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109877

    authors: Pei F,Liu J,Zhang L,Pan X,Huang W,Cen X,Huang S,Jin Y,Zhao Z

    更新日期:2021-02-01 00:00:00

  • Neutrophil signaling during myocardial infarction wound repair.

    abstract::Neutrophils are key effector cells of the innate immune system, serving as a first line of defense in the response to injury and playing essential roles in the wound healing process. Following myocardial infarction (MI), neutrophils infiltrate into the infarct region to propagate inflammation and begin the initial pha...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109816

    authors: Daseke MJ 2nd,Chalise U,Becirovic-Agic M,Salomon JD,Cook LM,Case AJ,Lindsey ML

    更新日期:2021-01-01 00:00:00

  • Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer.

    abstract::Proteoglycans (PGs) represent a large proportion of the components that constitute the extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a covalent link to a specific glycosaminoglycan type. As part of the ECM, heparan sulfate (HS)PGs participate in both physiological and pathologi...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109822

    authors: Hassan N,Greve B,Espinoza-Sánchez NA,Götte M

    更新日期:2021-01-01 00:00:00

  • Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway.

    abstract::It has been widely reported that exosomes derived from mesenchymal stem cells (MSCs) have a protective effect on myocardial infarction (MI). However, the specific molecules which play a damaging role in MSCs shuttled miRNAs are much less explored. MiRNA-153-3p (miR-153-3p) is a vital miRNA which has been proved to mod...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109812

    authors: Ning W,Li S,Yang W,Yang B,Xin C,Ping X,Huang C,Gu Y,Guo L

    更新日期:2021-01-01 00:00:00

  • Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.

    abstract::The endogenous circadian clock functions to maintain optimal physiological health through the tissue specific coordination of gene expression and synchronization between tissues of metabolic processes throughout the 24 hour day. Individuals face numerous challenges to circadian function on a daily basis resulting in s...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109904

    authors: Parnell AA,De Nobrega AK,Lyons LC

    更新日期:2020-12-25 00:00:00

  • Imatinib exhibit synergistic pleiotropy in the prevention of colorectal cancer by suppressing proinflammatory, cell survival and angiogenic signaling.

    abstract::Recent global incidences and mortality rates have placed colorectal cancer (CRC) at third and second positions, respectively, among both sexes of all ages. Resistance during chemotherapy is a big problem in the treatment and disease-free survival of CRC patients. Discovery of new anticancer drug(s) is a time taking pr...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109803

    authors: Dhiman DK,Sanyal SN,Vaish V

    更新日期:2020-12-01 00:00:00

  • Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.

    abstract::NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that downregulate the functions of CD4+ T, CD8+ T, natural killer (NK) cells, and macrophages through TGF-β1 production. Early growth response genes 2 (Egr2) and 3 (Egr3) maintain immune homeostasis by modulating T lymphocyte development, inhibiting ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109800

    authors: Han S,Zhu T,Ding S,Wen J,Lin Z,Lu G,Zhang Y,Xiao W,Ding Y,Jia X,Chen H,Gong W

    更新日期:2020-12-01 00:00:00

  • Differential mechanisms involved in RG-7388 and Nutlin-3 induced cell death in SJSA-1 osteosarcoma cells.

    abstract::Targeted therapy is becoming the mainstay of cancer treatment due to reduced side effects and enhanced tumor attack. In the last few decades, Murine Double Minute 2 (MDM2) protein has become one of the targets for developing cancer therapies. Blocking MDM2-p53 interaction has long been considered to offer a broad rang...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109742

    authors: Natarajan U,Venkatesan T,Dhandayuthapani S,Dondapatti P,Rathinavelu A

    更新日期:2020-11-01 00:00:00

  • Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes.

    abstract::Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important roles in adipogenesis and inflammation. The aim of this study is to investigate the impact of GATA-3 s...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109735

    authors: Al-Mansoori L,Al-Jaber H,Madani AY,Mazloum NA,Agouni A,Ramanjaneya M,Abou-Samra AB,Elrayess MA

    更新日期:2020-11-01 00:00:00

  • NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.

    abstract::Signal transducers and activators of transcription 3 (STAT3) is reported to regulate cell proliferation, survival, and differentiation, and thus plays a central role in development and carcinogenesis. Accumulating evidence demonstrated the involvement of cellular Src (c-Src) tyrosine kinase in the activation of STAT3....

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109762

    authors: Wang Y,Liu S,Jiang G,Zhai W,Yang L,Li M,Chang Z,Zhu B

    更新日期:2020-11-01 00:00:00

  • LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-β1 signaling.

    abstract:PURPOSE:Our study aimed to study the role of lncRNA TP73-AS1/miR-539/MMP-8 axis in modulating M2 macrophage polarization in hepatocellular carcinoma (HCC). METHODS:The gene expression levels of TP73-AS1, miR-539 and MMP-8 were modified by transfection with the overexpression or knockdown vectors. The patient survival ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109738

    authors: Chen J,Huang ZB,Liao CJ,Hu XW,Li SL,Qi M,Fan XG,Huang Y

    更新日期:2020-11-01 00:00:00

  • Molecular pathways in peritoneal fibrosis.

    abstract::Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other outcome parameters, yet providing superior quality-of-life measures and cost savings. However, long-term usage of the patient's peritoneal ...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109778

    authors: Balzer MS

    更新日期:2020-11-01 00:00:00

  • CD34 positive cells isolated from traumatized human skeletal muscle require the CD34 protein for multi-potential differentiation.

    abstract::The CD34 protein is regarded as a marker of stem cells from multiple origins. Recently a mesenchymal progenitor CD34 positive cell identified from traumatized human skeletal muscle demonstrates differentiation capability into vascular endothelial cells, osteoblasts and adipocytes. Here they were treated with a small i...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109711

    authors: Wolcott KM,Woodard GE

    更新日期:2020-10-01 00:00:00

  • Bacillus spore germination: Knowns, unknowns and what we need to learn.

    abstract::How might a microbial cell that is entirely metabolically dormant - and which has the ability to remain so for extended periods of time - irreversibly commit itself to resuming vegetative growth within seconds of being exposed to certain amino acids or sugars? That this process takes place in the absence of any detect...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109729

    authors: Christie G,Setlow P

    更新日期:2020-10-01 00:00:00

  • Liver X receptor inhibits the growth of hepatocellular carcinoma cells via regulating HULC/miR-134-5p/FOXM1 axis.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high rate of mortality. Highly upregulated in liver cancer (HULC), the specifically overexpressed long non-coding RNA in human HCC, plays important roles in promoting the growth and metastasis of HCC cells. So downregulating HULC will be bene...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109720

    authors: He J,Yang T,He W,Jiang S,Zhong D,Xu Z,Wei Q,Zhang Y,Shi C

    更新日期:2020-10-01 00:00:00

  • IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.

    abstract::A tight control of the machineries regulating membrane bending and actin dynamics is very important for the generation of membrane protrusions, which are crucial for cell migration and invasion. Protein/protein and protein/phosphoinositides complexes assemble and disassemble to coordinate these mechanisms, the scaffol...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109692

    authors: Antoine M,Vandenbroere I,Ghosh S,Erneux C,Pirson I

    更新日期:2020-09-01 00:00:00

  • Characteristics of circular RNAs generated by human Survival Motor Neuron genes.

    abstract::Circular RNAs (circRNAs) belong to a diverse class of stable RNAs expressed in all cell types. Their proposed functions include sponging of microRNAs (miRNAs), sequestration and trafficking of proteins, assembly of multimeric complexes, production of peptides, and regulation of transcription. Backsplicing due to RNA s...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109696

    authors: Ottesen EW,Singh RN

    更新日期:2020-09-01 00:00:00

  • FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1.

    abstract::Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinic...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109665

    authors: Fan GH,Zhu TY,Huang J

    更新日期:2020-08-01 00:00:00

  • Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma.

    abstract::Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14-15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109638

    authors: Birch JL,Coull BJ,Spender LC,Watt C,Willison A,Syed N,Chalmers AJ,Hossain-Ibrahim MK,Inman GJ

    更新日期:2020-08-01 00:00:00

  • Modulation of polycystic kidney disease by non-coding RNAs.

    abstract:PURPOSE OF REVIEW:microRNAs (miRNAs) are a class of small, evolutionarily conserved, non-coding RNAs (ncRNAs) that function as inhibitors of post-transcriptional mRNA expression. They are implicated in the pathogenesis of numerous diseases, including many common kidney conditions. In this review, we focus on how miRNAs...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109548

    authors: Ramalingam H,Yheskel M,Patel V

    更新日期:2020-07-01 00:00:00

  • Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2.

    abstract:BACKGROUND:Some microRNAs (miRNAs) are involved in osteogenic differentiation. In recent years, increasing evidences have revealed that exosomes contain specific miRNAs. However, the effect and mechanism of miR-23a-5p-containing exosomes in osteoblast remain largely unclear. METHODS:We extracted exosomes from RANKL-in...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109504

    authors: Yang JX,Xie P,Li YS,Wen T,Yang XC

    更新日期:2020-06-01 00:00:00

  • Dephosphorylation of Fas-ligand and caveolin-1 is a prerequisite step in Fas-ligand - caveolin-1 complex formation and cell death stimulation.

    abstract::Fas-ligand/CD178 belongs to the TNF family proteins and is the well-characterized inducer of cell death. We showed previously that the interaction of Fas-ligand and caveolin-1 is necessary for Fas-ligand translocation to rafts, and the subsequent induction of Fas-ligand-dependent cell death. Both molecules can undergo...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109590

    authors: Glukhova XA,Trizna JA,Proussakova OV,Gogvadze VG,Beletsky IP

    更新日期:2020-06-01 00:00:00

  • CRISPR system: Discovery, development and off-target detection.

    abstract::As a revolutionary gene editing tool based on the adaptive immune defense mechanism of bacteria and archaea against exogenous DNA invasion, CRISPR/Cas system shows many remarkable characteristics over ZFNs and TALENs. However, off-target effect remains as one of the major imperfection of CRISPR/Cas system, hindering i...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109577

    authors: Chen S,Yao Y,Zhang Y,Fan G

    更新日期:2020-06-01 00:00:00

  • Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells.

    abstract::Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). This study aimed to investigate the roles of LPA2 and LPA3 in the modulation of chemoresistance to anticancer drug in lung cancer A549 cells. In cell survival assay...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109551

    authors: Ueda N,Minami K,Ishimoto K,Tsujiuchi T

    更新日期:2020-05-01 00:00:00

  • Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

    abstract::Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N morphologically resembles inflammation-inducing pyroptosis - cell destruction triggered by activated caspase-1. The treatment with A + N (or camptothecin) strongly upregulat...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109552

    authors: Krześniak M,Zajkowicz A,Gdowicz-Kłosok A,Głowala-Kosińska M,Łasut-Szyszka B,Rusin M

    更新日期:2020-05-01 00:00:00

  • Human omental adipose-derived mesenchymal stem cells enhance autophagy in ovarian carcinoma cells through the STAT3 signalling pathway.

    abstract:BACKGROUND:Our previous study showed that human omental adipose-derived stem cells (ADSCs) promote ovarian cancer growth and metastasis. In this study, the role of autophagy in the ovarian cancer-promoting effects of omental ADSCs was further determined. METHODS:The growth and invasion of ovarian cancer cells were det...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109549

    authors: Chu Y,Wang Y,Li K,Liu M,Zhang Y,Li Y,Hu X,Liu C,Zhou H,Zuo J,Peng W

    更新日期:2020-05-01 00:00:00

  • GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma.

    abstract::High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic cancer. Emerging evidence suggests that tumor-associated macrophages (TAMs) play an immunosuppressive role in the tumor microenvironment and promote tumor growth, angiogenesis, and metastasis in ovarian cancer. Therefore, targeting TAMs in pati...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109539

    authors: El-Arabey AA,Denizli M,Kanlikilicer P,Bayraktar R,Ivan C,Rashed M,Kabil N,Ozpolat B,Calin GA,Salama SA,Abd-Allah AR,Sood AK,Lopez-Berestein G

    更新日期:2020-04-01 00:00:00

  • Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate].

    abstract::The ERBB1/2/4 inhibitor neratinib causes plasma membrane-associated K-RAS to mislocalize into intracellular vesicles; this effect is enhanced by HDAC inhibitors and the combination of [neratinib + sodium valproate] is now a phase I trial (NCT03919292). The present studies were performed to understand resistance mechan...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109525

    authors: Dent P,Booth L,Poklepovic A,Hoff DV,Hancock JF

    更新日期:2020-04-01 00:00:00

  • Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A.

    abstract::Recent studies have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in cancer development and progression. However, the mechanism by which lncRNAs contribute to colorectal cancer remains unclear. In this study, we identified the lncRNA, DANCR, which was upregulated in colorectal cancer. The upregu...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109502

    authors: Lian J,Zhang H,Wei F,Li Q,Lu Y,Yu B,Yu L,Liang X,Wen Y,Jin K,Tang J,Xie W

    更新日期:2020-03-01 00:00:00

  • CDK9 inhibitors reactivate p53 by downregulating iASPP.

    abstract::Loss of p53's tumor-suppressive function, either via TP53 mutation or hyperactive p53 inhibitory proteins, is one of the most frequent events in the development of human cancer. Here, we describe a strategy of pharmacologically inhibiting iASPP, a negative regulator of p53, to restore wild-type p53's tumor-suppressive...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109508

    authors: Wu J,Liang Y,Tan Y,Tang Y,Song H,Wang Z,Li Y,Lu M

    更新日期:2020-03-01 00:00:00

  • Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.

    abstract::The activation of corticotrophin-releasing hormone receptor (CRHR) 1 is implicated in neuronal injury in experimental stroke. However, little is known about the relationship between CRHR1 activation and brain endothelial barrier impairment after ischemia and reperfusion (I/R). Recently we have demonstrated that the ac...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109467

    authors: Cao C,Zhou J,Wu X,Qian Y,Hong Y,Mu J,Jin L,Zhu C,Li S

    更新日期:2020-02-01 00:00:00

  • HOX family transcription factors: Related signaling pathways and post-translational modifications in cancer.

    abstract::HOX family transcription factors belong to a highly conserved subgroup of the homeobox superfamily that determines cellular fates in embryonic morphogenesis and the maintenance of adult tissue architecture. HOX family transcription factors play key roles in numerous cellular processes including cell growth, differenti...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2019.109469

    authors: Yu M,Zhan J,Zhang H

    更新日期:2020-02-01 00:00:00

  • LncRNA HAND2-AS1 inhibits 5-fluorouracil resistance by modulating miR-20a/PDCD4 axis in colorectal cancer.

    abstract:BACKGROUND:Chemoresistance is one of the main obstacles in the therapy of human cancers, including colorectal cancer (CRC). Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (lncRNA HAND2-AS1) has been demonstrated to be associated with CRC. However, the function of HAND2-AS1 in 5-Fluor...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109483

    authors: Jiang Z,Li L,Hou Z,Liu W,Wang H,Zhou T,Li Y,Chen S

    更新日期:2020-02-01 00:00:00

  • Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling.

    abstract::Epithelial ovarian cancer is the fifth common cause of cancer death in women and the most lethal gynecological malignancies. Our previous studies have shown that up-regulation of Connexin43, a gap-junction subunit crucial for cell-cell communication, enhances ovarian cancer cell migration. Betacellulin is a member of ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109439

    authors: Zhao J,Klausen C,Yi Y,Cheng JC,Chang HM,Leung PCK

    更新日期:2020-01-01 00:00:00

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