Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product.

abstract：:Fas-ligand/CD178 belongs to the TNF family proteins and is the well-characterized inducer of cell death. We showed previously that the interaction of Fas-ligand and caveolin-1 is necessary for Fas-ligand translocation to rafts, and the subsequent induction of Fas-ligand-dependent cell death. Both molecules can undergo...

journal_title：Cellular signalling

authors： Glukhova XA,Trizna JA,Proussakova OV,Gogvadze VG,Beletsky IP

更新日期：2020-06-01 00:00:00

abstract：:The TAK1 plays a pivotal role in the innate immune response of Drosophila by controlling the activation of JNK and NF-kappaB. Activation of TAK1 in mammals is mediated by two TAK1-binding proteins, TAB1 and TAB2, but the role of the TAB proteins in the immune response of Drosophila has not yet been established. Here, ...

journal_title：Cellular signalling

authors： Zhuang ZH,Sun L,Kong L,Hu JH,Yu MC,Reinach P,Zang JW,Ge BX

更新日期：2006-07-01 00:00:00

abstract：:NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that downregulate the functions of CD4+ T, CD8+ T, natural killer (NK) cells, and macrophages through TGF-β1 production. Early growth response genes 2 (Egr2) and 3 (Egr3) maintain immune homeostasis by modulating T lymphocyte development, inhibiting ...

journal_title：Cellular signalling

authors： Han S,Zhu T,Ding S,Wen J,Lin Z,Lu G,Zhang Y,Xiao W,Ding Y,Jia X,Chen H,Gong W

更新日期：2020-12-01 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)) mediates induction of cytotoxicity in various cell types. GSK-3beta has been found to participate in a number of signaling pathways, including cell proliferation and cell death. In the present study, we show that GSK-3beta is rapidly dephosphorylated and activated in response to H(2)O(2) t...

journal_title：Cellular signalling

authors： Shin SY,Chin BR,Lee YH,Kim JH

更新日期：2006-05-01 00:00:00

abstract：:Calcineurin inhibitors such as cyclosporin A (CsA) and FK506 have been used in solid organ and hematopoietic stem cell transplantations to suppress immune function. However, these immunosuppresants are associated with severe endothelial dysfunction. We investigated whether CsA and FK506 induce endothelial dysfunction ...

journal_title：Cellular signalling

authors： Eguchi R,Kubo S,Ohta T,Kunimasa K,Okada M,Tamaki H,Kaji K,Wakabayashi I,Fujimori Y,Ogawa H

更新日期：2013-09-01 00:00:00

abstract：:Proliferation of mammalian cells both in vivo and in vitro is dependent upon physiological concentrations of extracellular Ca2+. Growth factor stimulation of quiescent cells at the G0/G1 border usually results in a rapid mobilization of Ca2+ from both intra- and extracellular pools. However, Ca2+ influx is also requir...

journal_title：Cellular signalling

authors： Takuwa N,Zhou W,Takuwa Y

更新日期：1995-02-01 00:00:00

abstract：:Clinical studies have elucidated the negative correlation between microtubules-associated protein 1 light chain 3-B (LC3B) protein expression and overall survival of breast cancer patients. Our previous data demonstrated corticortropin-releasing hormone family (CRHs) suppressed migration of breast cancer cells via CRH...

journal_title：Cellular signalling

authors： Jin L,Qian Y,Zhou J,Dai L,Cao C,Zhu C,Li S

更新日期：2019-06-01 00:00:00

abstract：:Heterotrimeric G proteins typically transduce signals from G protein-coupled receptors (GPCRs) to effector proteins. In the conventional G protein signaling paradigm, the G protein is located at the cytoplasmic surface of the plasma membrane, where, after activation by an agonist-bound GPCR, the GTP-bound Gα and free ...

journal_title：Cellular signalling

authors： Hewavitharana T,Wedegaertner PB

更新日期：2012-01-01 00:00:00

abstract：:The implication of protein kinase C in the phenomenon of pancreatic acinar cell desensitization to carbamylcholine, caerulein and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated using a potent PKC inhibitor, staurosporine. At a concentration of 1 microM, staurosporine caused a maximum 64%...

journal_title：Cellular signalling

authors： Morisset J,Paquette B,Benrezzak O

更新日期：1991-01-01 00:00:00

abstract：:Induction of nitrosative stress has been observed in various cancer types and in tumor environment. However, it is still unclear how cancer cells combat the effect of nitrosative stress. The main targets of nitrosative stress in cells are cellular lipids, proteins and DNA. Autophagy or self-cleaning generates energy f...

journal_title：Cellular signalling

authors： Chakraborty S,Datta S,Ghosh S

更新日期：2019-12-01 00:00:00

abstract：:13-(S)-Hydroxyoctadecadienoic acid (13-HODE), the lipoxygenase metabolite of linoleic acid, has been shown to reverse the epidermal hyperproliferation induced by topical application of docosahexaenoic acid (DNA, 22:6 n-3) on guinea pig skin. Our initial studies demonstrated that 13-HODE exerts a selective inhibition o...

journal_title：Cellular signalling

authors： Mani I,Iversen L,Ziboh VA

更新日期：1998-02-01 00:00:00

abstract：:Somatostatin receptors (SSTRs) are known to mediate diverse cellular responses. Most target cell express more than one SSTR isoform, making it difficult to define the signalling pathway used by individual receptor subtypes. Thus, we have expressed SSTR1 or SSTR2 in rat pituitary F4C1 cells which lack endogenous SSTRs....

journal_title：Cellular signalling

authors： Chen L,Tashjian AH Jr

更新日期：1999-07-01 00:00:00

abstract：:Angiotensin I and II have been shown to directly induce protein degradation in skeletal muscle through an increased activity and expression of the ubiquitin-proteasome proteolytic pathway. This investigation determines the role of the nuclear transcription factor nuclear factor-kappaB (NF-kappaB) in this process. Usin...

journal_title：Cellular signalling

authors： Russell ST,Wyke SM,Tisdale MJ

更新日期：2006-07-01 00:00:00

abstract：:Macrophages play many different roles in tissue inflammation and immunity, and the plasticity of macrophage polarization is closely associated with acute inflammatory responses. O-GlcNAcylation is an important type of post-translational modification, which subtly modulates inflammation responses. Transforming growth f...

journal_title：Cellular signalling

authors： Zhang D,Xu Z,Tao T,Liu X,Sun X,Ji Y,Han L,Qiu H,Zhu G,Shen Y,Zhu L,Shen A

更新日期：2016-11-01 00:00:00

abstract：:Oxidative stress is an increase in the reduction potential or a large decrease in the reducing capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is the production of reactive oxygen species (ROS), which include free radicals and peroxides. Some of the less reactive of these ...

journal_title：Cellular signalling

authors： Genestra M

更新日期：2007-09-01 00:00:00

abstract：:Metformin, the most used drug for the treatment of diabetes type 2 patients, has been shown to have anti-cancer properties. In this study, we found that metformin induced apoptosis in Primary Effusion Lymphoma (PEL) cells, an aggressive B cell lymphoma associated with KSHV against which the conventional therapies usua...

journal_title：Cellular signalling

authors： Granato M,Gilardini Montani MS,Romeo MA,Santarelli R,Gonnella R,D'Orazi G,Faggioni A,Cirone M

更新日期：2017-12-01 00:00:00

abstract：:The N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-OMe (1) analogues for-Thp-Leu-Ain-OMe (2), for-Thp-Leu-Phe-OMe (3), for-Met-Leu-Ain-OMe (4), for-Met-Delta(z)Leu-Phe-OMe (5), for-Met-Lys-Phe-For-Met-Lys-Phe (6), for-Met-Leu-Pheol-COMe (7), and for-Nle-Leu-Phe-OMe (8) have been studied. Some of these have been ...

journal_title：Cellular signalling

authors： Ferretti ME,Nalli M,Biondi C,Colamussi ML,Pavan B,Traniello S,Spisani S

更新日期：2001-04-01 00:00:00

abstract：:The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is not yet completely understood. In this study, we obse...

journal_title：Cellular signalling

authors： Kim J,Kim SY,Kang S,Yoon HR,Sun BK,Kang D,Kim JH,Song JJ

更新日期：2012-07-01 00:00:00

abstract：:In order to elucidate the molecular events in signal transduction, examination of the interaction between Ras and Raf-1 seems crucial. Many Raf-1 mutants have been investigated in terms of their binding activities to Ras, where only a few Ras mutants have been examined thus far. We have investigated the Raf-1-binding ...

journal_title：Cellular signalling

authors： Hiwasa T,Kasama M,Nakadai T,Sawada T,Sakiyama S

更新日期：1996-08-01 00:00:00

abstract：:The pro-apoptotic protein BIM(EL) is phosphorylated by ERK1/2 and this targets the protein for poly-ubiquitination and degradation by the proteasome as a survival mechanism. To define in greater detail the sequence determinants required for BIM(EL) turnover we have compared various BIM splice variants and truncation m...

journal_title：Cellular signalling

authors： Wiggins CM,Johnson M,Cook SJ

更新日期：2010-05-01 00:00:00

abstract：:Since its discovery in biopsies from breast cancer patients, the effect of corticotropin-releasing hormone (CRH) on carcinoma progression is still unclear. Transforming growth factorβ1 (TGFβ1) promotes Epithelial-Mesenchymal Transition (EMT) and induces Snail1 and Twist1 expressions. Loss of epithelial cadherin (E-cad...

journal_title：Cellular signalling

authors： Jin L,Chen J,Li L,Li C,Chen C,Li S

更新日期：2014-04-01 00:00:00

abstract：:The BRCA1 gene codes for a protein involved in the DNA double strand break (DDSB) repair. Alongside the dominant full-length splicing form of BRCA1, numerous endogenously expressed alternative splicing variants of unknown significance have been described in various tissues. Some of them retain the original BRCA1 readi...

journal_title：Cellular signalling

authors： Sevcik J,Falk M,Kleiblova P,Lhota F,Stefancikova L,Janatova M,Weiterova L,Lukasova E,Kozubek S,Pohlreich P,Kleibl Z

更新日期：2012-05-01 00:00:00

abstract：:Epidermal growth factor (EGF) signaling is critical in normal and aberrant cellular behavior. Extracellular signal-regulated kinase (ERK) mediates important downstream aspects of EGF signaling. Additionally, EGFR undergoes MEK1-dependent ERK consensus site phosphorylation in response to EGF or cytokines such as growth...

journal_title：Cellular signalling

authors： Li X,Huang Y,Jiang J,Frank SJ

更新日期：2008-11-01 00:00:00

abstract：:We previously showed that an increase of cellular Bcl-xL mediates acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and knockdown of Bcl-xL expression greatly sensitized TRAIL-induced cytotoxicity. Here, we show that Daxx downregulation increases the anti-tumorigenic activity throu...

journal_title：Cellular signalling

authors： Kang S,Kang D,Bakhtiar Ul Islam SM,Je S,Kim JH,Song JJ

更新日期：2015-06-01 00:00:00

abstract：:MAPK signalling is a complex process not only requiring the core components Raf, MEK and Erk, but also many proteins like the scaffold protein KSR and several kinases to specifically localize, modulate and fine-tune the outcome of the pathway in a cell context specific manner. In mammals, protein kinase CK2 was shown ...

journal_title：Cellular signalling

authors： Stark F,Pfannstiel J,Klaiber I,Raabe T

更新日期：2011-05-01 00:00:00

abstract：:Skeletal muscle is highly adapted to respond to oxidative imbalances, since it is continuously subjected to an increased production of reactive oxygen species (ROS) during exercise. Oxidative stress, however, has been associated with skeletal muscle atrophy and damage in many diseases. In this study, we examined wheth...

journal_title：Cellular signalling

authors： Kefaloyianni E,Gaitanaki C,Beis I

更新日期：2006-12-01 00:00:00

abstract：:Nephrin, an important structural and signal molecule of podocyte slit-diaphragm (SD), has been suggested to contribute to the angiotensin II (Ang II)-induced podocyte injury. Caveolin-1 has been demonstrated to play a crucial role in signaling transduction. In the present study, we evaluated the role of caveolin-1 in ...

journal_title：Cellular signalling

authors： Ren Z,Liang W,Chen C,Yang H,Singhal PC,Ding G

更新日期：2012-02-01 00:00:00

abstract：:Dissemination of cancer cells to distant organ sites is the leading cause of death due to treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the importance of the development of inappropriate cell survival signaling for various steps in the metastatic process and have noted the particula...

journal_title：Cellular signalling

authors： Agarwal E,Brattain MG,Chowdhury S

更新日期：2013-08-01 00:00:00

abstract：:We demonstrated previously an inhibitory effect of luminal leptin on glucose absorption in differentiated Caco-2 cells. Since this process is dependent on the Na(+) gradient established by the Na(+)/K(+)ATPase this work was undertaken to investigate if the ATPase is one of the hormone's targets. Fully differentiated C...

journal_title：Cellular signalling

authors： El-Zein O,Usta J,El Moussawi L,Kreydiyyeh SI

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:Endovascular interventions performed for atherosclerotic lesions trigger excessive vascular smooth muscle cell (SMC) proliferation leading to intimal hyperplasia. Our previous studies show that following endovascular injury, elevated TGF-β/Smad3 promotes SMC proliferation and intimal hyperplasia. Furthermore ...

journal_title：Cellular signalling

authors： DiRenzo DM,Chaudhary MA,Shi X,Franco SR,Zent J,Wang K,Guo LW,Kent KC

更新日期：2016-05-01 00:00:00