当前位置： SCI文献检索 > CELLULAR SIGNALLING期刊下所有文献 > FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway.

FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway.

Abstract：

:Calcineurin inhibitors such as cyclosporin A (CsA) and FK506 have been used in solid organ and hematopoietic stem cell transplantations to suppress immune function. However, these immunosuppresants are associated with severe endothelial dysfunction. We investigated whether CsA and FK506 induce endothelial dysfunction using a three-dimensional culture blood vessel model, in which human umbilical vein endothelial cells form and maintain capillary-like tube and lumen structures. We found that FK506, but not CsA, induced breakdown of the tube structures and endothelial cell death. FK506 inhibited calcineurin activity, but FK506-induced tube breakdown and cell death was not suppressed by RNA interference targeting calcineurin Aα. FK506 also induced caspase activation, but caspase inhibition by zVAD(OMe)-fmk failed to suppress FK506-induced tube breakdown and cell death. FK506 induced attenuation of Akt and extracellular-regulated kinase 1/2 (ERK1/2). Furthermore, Akt inhibition by LY294002 or ERK1/2 inhibition by PD98059 induced tube breakdown and cell death. Present results suggest that FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Eguchi R,Kubo S,Ohta T,Kunimasa K,Okada M,Tamaki H,Kaji K,Wakabayashi I,Fujimori Y,Ogawa H

doi

10.1016/j.cellsig.2013.05.008

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1731-8

issue

9

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(13)00133-2

journal_volume

25

pub_type

杂志文章

相关文献

CELLULAR SIGNALLING文献大全
  • Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells.

    abstract：:Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). This study aimed to investigate the roles of LPA2 and LPA3 in the modulation of chemoresistance to anticancer drug in lung cancer A549 cells. In cell survival assay...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109551

    authors： Ueda N,Minami K,Ishimoto K,Tsujiuchi T

    更新日期：2020-05-01 00:00:00

  • Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.

    abstract：:The activation of corticotrophin-releasing hormone receptor (CRHR) 1 is implicated in neuronal injury in experimental stroke. However, little is known about the relationship between CRHR1 activation and brain endothelial barrier impairment after ischemia and reperfusion (I/R). Recently we have demonstrated that the ac...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2019.109467

    authors： Cao C,Zhou J,Wu X,Qian Y,Hong Y,Mu J,Jin L,Zhu C,Li S

    更新日期：2020-02-01 00:00:00

  • Identification of distinct signalling pathways for somatostatin receptors SSTR1 and SSTR2 as revealed by microphysiometry.

    abstract：:Somatostatin receptors (SSTRs) are known to mediate diverse cellular responses. Most target cell express more than one SSTR isoform, making it difficult to define the signalling pathway used by individual receptor subtypes. Thus, we have expressed SSTR1 or SSTR2 in rat pituitary F4C1 cells which lack endogenous SSTRs....

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(99)00019-4

    authors： Chen L,Tashjian AH Jr

    更新日期：1999-07-01 00:00:00

  • Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.

    abstract：:Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development. In this study, we demonstrated for the first time that CMPK was overexpressed in human ovarian epithelial borderline and...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2017.04.009

    authors： Zhou D,Zhang L,Sun W,Guan W,Lin Q,Ren W,Zhang J,Xu G

    更新日期：2017-07-01 00:00:00

  • Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells.

    abstract：:Extracellular adenine dinucleotides are modulators of blood vessel tone. We have previously demonstrated that Ap(2)A and Ap(4)A induce the synthesis of nitric oxide (NO) from bovine aortic endothelial cells (BAEC) while Ap(3)A and Ap(5)A do not [FEBS Lett. 427 (1998) 320; Arch. Biochem. Biophys. 364 (1999) 280.]. In t...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(00)00147-9

    authors： Haghiac M,Pojoga LH,Hilderman RH

    更新日期：2001-02-01 00:00:00

  • The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice.

    abstract：:It is well established that the IFN-gamma/STAT1 pathway plays an important role in the pancreatic beta-cell apoptosis that is observed in STZ-induced type 1 diabetes; however, the upstream regulatory proteins involved have not been understood. Here, we investigated whether activating transcription factor 3 (ATF3) affe...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2010.06.007

    authors： Kim JY,Song EH,Lee S,Lim JH,Choi JS,Koh IU,Song J,Kim WH

    更新日期：2010-11-01 00:00:00

  • Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

    abstract：:Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and psoriatic arthritis. However, little is known on the expression patter...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2016.01.007

    authors： Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

    更新日期：2016-07-01 00:00:00

  • Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling.

    abstract：:Cancer cells are able to survive under conditions that cause endoplasmic reticulum stress (ER-stress), and can adapt to this stress by upregulating cell-survival signalling pathways and down-regulating apoptotic pathways. The cellular response to ER-stress is controlled by the unfolded protein response (UPR). Small Rh...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2018.01.004

    authors： Bright MD,Clarke PA,Workman P,Davies FE

    更新日期：2018-04-01 00:00:00

  • HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

    abstract：:We found that CKD712, an S enantiomer of YS49, strongly inhibited inducible nitric oxide synthase (iNOS) and NO induction but showed a weak inhibitory effect on cyclooxygenase-2 (COX-2) and PGE(2) induction in LPS-stimulated RAW 264.7 cells. We, therefore, investigated the molecular mechanism(s) responsible for this b...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.06.012

    authors： Tsoyi K,Kim HJ,Shin JS,Kim DH,Cho HJ,Lee SS,Ahn SK,Yun-Choi HS,Lee JH,Seo HG,Chang KC

    更新日期：2008-10-01 00:00:00

  • Inhibition of protein kinase C zeta blocks the attachment of stable microtubules to kinetochores leading to abnormal chromosome alignment.

    abstract：:The attachment of spindle microtubules to kinetochores is crucial for accurate segregation of chromosomes to daughter cells during mitosis. While a growing number of proteins involving this step are being identified, its molecular mechanisms are still not clear. Here we show that protein kinase C zeta (PKCzeta) is loc...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2006.05.017

    authors： Liu XF,Xie X,Miki T

    更新日期：2006-12-01 00:00:00

  • Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.

    abstract：:Janus kinase 2 (Jak2) has a pivotal role in erythropoietin (Epo) signaling pathway, including erythrocyte differentiation and Stat5 activation. In the course of screening for critical phosphorylation of tyrosine residues in Jak2, we identified tyrosine 913 (Y(913)) as a novel and functional phosphorylation site, which...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.07.008

    authors： Funakoshi-Tago M,Tago K,Kasahara T,Parganas E,Ihle JN

    更新日期：2008-11-01 00:00:00

  • The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line.

    abstract：:Monoamine oxidase-A (MAO-A) dysfunction has been historically associated with depression. Recently, depression as well as altered MAO-A expression have both been associated with a poor prognosis in cancers, although the mechanism involved remains ambiguous. For example, MAO-A mRNA is repressed across cancers, yet MAO-...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.08.005

    authors： Satram-Maharaj T,Nyarko JN,Kuski K,Fehr K,Pennington PR,Truitt L,Freywald A,Lukong KE,Anderson DH,Mousseau DD

    更新日期：2014-12-01 00:00:00

  • Ephedrine induced thioredoxin-1 expression through β-adrenergic receptor/cyclic AMP/protein kinase A/dopamine- and cyclic AMP-regulated phosphoprotein signaling pathway.

    abstract：:Ephedrine (Eph) is one of alkaloids that has been isolated from the ancient herb ephedra (ma huang) and is used as the treatment of asthma, hypotension and fatigue. However, its molecular mechanism remains unknown. Thioredoxin-1 (Trx-1) is a redox regulating protein, which has various biological activities, including ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.02.007

    authors： Jia JJ,Zeng XS,Li Y,Ma S,Bai J

    更新日期：2013-05-01 00:00:00

  • The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer.

    abstract：:Quantitative analysis of the proteins which compromise the stimulatory arm of the adenylyl cyclase cascade indicate that the adenylyl cyclase catalytic component is usually the least highly expressed. The effects on both potency of agonist ligands and maximal output resulting from targetted alterations in expression l...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/0898-6568(95)02034-9

    authors： Milligan G

    更新日期：1996-02-01 00:00:00

  • Apelin signalling: a promising pathway from cloning to pharmacology.

    abstract：:The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascul...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2004.09.018

    authors： Masri B,Knibiehler B,Audigier Y

    更新日期：2005-04-01 00:00:00

  • Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation.

    abstract：:Neuroprotective effects of alpha(2)-adrenergic receptor (AR) agonists are mediated via the alpha(2A)AR subtype, but the molecular mechanisms underlying these actions are still not elucidated. A two-hybrid screen was performed to identify new proteins that may control alpha(2)AR receptor function and trafficking. This ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.05.011

    authors： Weber B,Schaper C,Wang Y,Scholz J,Bein B

    更新日期：2009-10-01 00:00:00

  • Unsaturated fatty acids synergistically enhance glucocorticoid-induced gene expression.

    abstract：:Regulation by unsaturated fatty acids of glucocorticoid-sensitive gene transcription was studied in HeLa cells transiently transfected with a mouse mammary tumour virus-luciferase reporter gene. Arachidonic acid and docosahexaenoic acid by themselves had no effect on basal levels of luciferase expression. However, the...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(95)00010-m

    authors： Vallette G,Sumida C,Thobie N,Nunez EA

    更新日期：1995-05-01 00:00:00

  • T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis.

    abstract：:Endoplasmic reticulum (ER) stress activated by perturbations in ER homeostasis induces the unfolded protein response (UPR) with chaperon Grp78 as the key activator of UPR signalling. The aim of UPR is to restore normal ER function; however prolonged or severe ER stress triggers apoptosis of damaged cells to ensure pro...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2010.04.008

    authors： Kyriakakis E,Philippova M,Joshi MB,Pfaff D,Bochkov V,Afonyushkin T,Erne P,Resink TJ

    更新日期：2010-09-01 00:00:00

  • E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.

    abstract：:Tribbles 3 homolog (TRB3) is recently identified as a scaffold-like regulator of various signal transducers and has been implicated in several processes including insulin signaling, NF-kappaB signaling, lipid metabolism and BMP signaling. To further understand cellular mechanisms of TRB3 regulation, we performed a yea...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.01.010

    authors： Zhou Y,Li L,Liu Q,Xing G,Kuai X,Sun J,Yin X,Wang J,Zhang L,He F

    更新日期：2008-05-01 00:00:00

  • Phorbol ester effects on hormonal responses in freshly isolated short-term incubated and cultured hepatocytes.

    abstract：:Beta-adrenergic, alpha-1-adrenergic and glucagon stimulation of glucose release were compared between hepatocytes which were freshly isolated, incubated for 3 h in suspension or cultivated for 4 or 24 h in plastic culture flasks in the presence and absence of the protein kinase C activator 12-O-tetradecanoylphorbol-13...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(92)90051-9

    authors： Hermsdorf T,Dettmer D

    更新日期：1992-11-01 00:00:00

  • Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.

    abstract：:Five G protein-coupled receptors (GPCRs) for the lysophospholipid sphingosine 1-phosphate (S1P) have been cloned and characterized so far. We report here about the identification of gpr3, gpr6 and gpr12 as additional members of the S1P-GPCR family. When expressed transiently in HEK293 cells, gpr3, gpr6 and gpr12 confe...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(02)00041-4

    authors： Uhlenbrock K,Gassenhuber H,Kostenis E

    更新日期：2002-11-01 00:00:00

  • Regulation of stretch-induced JNK activation by stress fiber orientation.

    abstract：:Cyclic mechanical stretch associated with pulsatile blood pressure can modulate cytoskeletal remodeling and intracellular signaling in vascular endothelial cells. The aim of this study was to evaluate the role of stretch-induced actin stress fiber orientation in intracellular signaling involving the activation of c-ju...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2006.02.008

    authors： Kaunas R,Usami S,Chien S

    更新日期：2006-11-01 00:00:00

  • CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.

    abstract：:CCN1/CYR61 is a matricellular protein of the CCN family, comprising six secreted proteins specifically associated with the extracellular matrix (ECM). CCN1 acts as an enhancer of the cutaneous wound healing process by preventing hypertrophic scar formation through induction of myofibroblast senescence. In liver fibros...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2015.10.013

    authors： Borkham-Kamphorst E,Steffen BT,Van de Leur E,Haas U,Tihaa L,Friedman SL,Weiskirchen R

    更新日期：2016-01-01 00:00:00

  • RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling.

    abstract：:Suppressor of fused (SUFU) is an essential negative regulator of the mammalian Hedgehog (HH) signaling pathway and its loss is associated with cancer development. On a cellular level, endogenous SUFU can mainly be detected in the cytoplasm and the nucleus. However, immunostaining of pancreatic cancer specimen revealed...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.08.037

    authors： Tariki M,Wieczorek SA,Schneider P,Bänfer S,Veitinger S,Jacob R,Fendrich V,Lauth M

    更新日期：2013-12-01 00:00:00

  • Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

    abstract：:The phosphatidylinositol (PI) 3-kinase family of enzymes is now known to be regulated by several different upstream pathways in response to virtually all growth factors and cytokines. In the past few years, the phosphoinositides phosphorylated at the 3-OH position of the inositol ring have been shown to be lipid secon...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/s0898-6568(97)00129-0

    authors： Duronio V,Scheid MP,Ettinger S

    更新日期：1998-04-01 00:00:00

  • Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes.

    abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairments. The classical symptoms of the disease include gradual deterioration of memory and language. Epidemiological studies indicate that around 25-40% of AD patients have sleep-wake cycle disturbances. Importantly, a series of st...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2019.109420

    authors： Havekes R,Heckman PRA,Wams EJ,Stasiukonyte N,Meerlo P,Eisel ULM

    更新日期：2019-12-01 00:00:00

  • IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.

    abstract：:A tight control of the machineries regulating membrane bending and actin dynamics is very important for the generation of membrane protrusions, which are crucial for cell migration and invasion. Protein/protein and protein/phosphoinositides complexes assemble and disassemble to coordinate these mechanisms, the scaffol...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109692

    authors： Antoine M,Vandenbroere I,Ghosh S,Erneux C,Pirson I

    更新日期：2020-09-01 00:00:00

  • Bradykinin-stimulated p42/p44 MAPK activation associated with cell proliferation in corneal keratocytes.

    abstract：:Bradykinin (BK) is released into the tear-film in ocular allergic patients. BK has been shown to exert mitogenic effects on several cell types. However, the mechanisms underlying its action on corneal keratocytes (CKs) were largely unknown. This study was to investigate the mitogenic effect of BK on rabbit CKs linked ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2003.09.005

    authors： Cheng CY,Huang SC,Hsiao LD,Sun CC,Jou MJ,Yang CM

    更新日期：2004-05-01 00:00:00

  • Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.

    abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinas...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109842

    authors： Kaur H,Moreau R

    更新日期：2021-02-01 00:00:00

  • β-Hydroxybutyrate: A signaling metabolite in starvation response?

    abstract：:Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BH...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2016.04.005

    authors： Rojas-Morales P,Tapia E,Pedraza-Chaverri J

    更新日期：2016-08-01 00:00:00