Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.

abstract：:Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in ma...

journal_title：Cellular signalling

authors： Okada T,Kajimoto T,Jahangeer S,Nakamura S

更新日期：2009-01-01 00:00:00

abstract：:We demonstrate the expression of S1P(1,3,4,5) the receptors for sphingosine 1-phosphate (S1P), and LPA(1,2,3) the receptors for lysophosphatidic acid (LPA) in T helper 1 (Th1) and T helper 2 (Th2) cells. S1P and LPA induce the chemotaxis of Th1 and Th2 cells, an activity that is resistant to pertussis toxin (PTX) pret...

journal_title：Cellular signalling

authors： Wang L,Knudsen E,Jin Y,Gessani S,Maghazachi AA

更新日期：2004-09-01 00:00:00

abstract：:Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark ...

journal_title：Cellular signalling

authors： Hibbert SA,Watson REB,Griffiths CEM,Gibbs NK,Sherratt MJ

更新日期：2019-02-01 00:00:00

abstract：:The molecular mechanisms that underlie non-genomic induction of the 25-hydroxyvitamin D3 24-hydroxylase (CYP24) gene promoter by the steroid hormone, 1,25-Dihydroxyvitamin D3 (1,25D), are poorly understood. Although we have previously identified a functional inverted GC-box in the early promoter at -113/-105 bp, it is...

journal_title：Cellular signalling

authors： Dwivedi PP,Gao XH,Tan JC,Evdokiou A,Ferrante A,Morris HA,May BK,Hii CS

更新日期：2010-03-01 00:00:00

abstract：:Previous studies from acutely transfected HeLa cells have identified an acidic alpha-helix in the Type IIbeta PtdIns5P 4-kinase (PIPkin IIbeta) as a putative novel nuclear localisation sequence (Ciruela et al. Biochem. J. 364, 587-591 2000). However, some heterogeneity in cellular localisation was always observed, and...

journal_title：Cellular signalling

authors： Richardson JP,Wang M,Clarke JH,Patel KJ,Irvine RF

更新日期：2007-06-01 00:00:00

abstract：:Dynamin, a 100 kD GTPase, is necessary for the normal development and function of mammalian neural tissue. In neurons, it is necessary for the biogenesis of synaptic vesicles, and in other cell types dynamin has a general and important role in clathrin mediated receptor endocytosis. Different isoforms function as mole...

journal_title：Cellular signalling

authors： Scaife RM,Margolis RL

更新日期：1997-09-01 00:00:00

abstract：:Labelling with [3H]glucosamine was used to prepare a transforming growth factor-beta 1 (TGF-beta 1)-sensitive glycosylphosphatidylinositol (GPI) from monolayer cultures of rabbit articular chondrocytes (RAC), which may be involved in control of the cell cycle. The polar headgroup of this glycosylphosphatidylinositol w...

journal_title：Cellular signalling

authors： Vivien D,Bogdanowicz P,Boumediene K,Martiny L,Haye B,Pujol JP

更新日期：1994-02-01 00:00:00

abstract：:Chbl, a 120-kDa proto-oncogene product, whose gene was first identified as part of a transforming gene of a murine retrovirus and whose expression is predominant in haematopoietic cells, consists of an amino-terminal transforming region, a zinc Ring finger, multiple proline-rich stretches, and several potential phosph...

journal_title：Cellular signalling

authors： Liu YC,Altman A

更新日期：1998-06-01 00:00:00

abstract：:We previously showed that activated peroxisome proliferator-activated receptor (PPAR)β/δ can protect pancreatic β cells against lipotoxic apoptosis. However, the molecular mechanism remained unclear. Glucagon-like peptide-1 receptor (GLP-1R) has been reported to exhibit a protective effect against lipotoxic apoptosis ...

journal_title：Cellular signalling

authors： Yang Y,Tong Y,Gong M,Lu Y,Wang C,Zhou M,Yang Q,Mao T,Tong N

更新日期：2014-02-01 00:00:00

abstract：:Perivascular adipocyte (PVAC) biofunctions were closely related to cardiovascular diseases; its specific biological mechanisms remained unclear. How to adjust PVAC functions of vascular cells is an important topic. The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways partic...

journal_title：Cellular signalling

authors： Liu P,Feng J,Kong F,Lu Q,Xu H,Meng J,Jiang Y

更新日期：2014-12-01 00:00:00

abstract：:Glioblastoma, the most lethal form of brain cancer, is characterized by fast growth, migration and invasion of the surrounding parenchyma, with epithelial-to-mesenchymal transition (EMT)-like process being mostly responsible for tumour spreading and dissemination. A number of actors, including cadherins, vimentin, tra...

journal_title：Cellular signalling

authors： Cutone A,Colella B,Pagliaro A,Rosa L,Lepanto MS,Bonaccorsi di Patti MC,Valenti P,Di Bartolomeo S,Musci G

更新日期：2020-01-01 00:00:00

abstract：:The earliest substrates to the transmembrane insulin receptor tyrosine kinase, that would function in insulin signalling, are likely to be associated with the plasma membrane. Rat liver plasma membrane 180,000 M(r) protein (p180) is a substrate to the insulin receptor in vitro [Goren et al. (1990) Cellular Signalling ...

journal_title：Cellular signalling

authors： Goren HJ,Boland D,Fei Q

更新日期：1993-05-01 00:00:00

abstract：:Antidepressants are commonly used in the treatment of anxiety and depression, medical conditions that affect approximately 17-20% of the population. The clinical effects of antidepressants take several weeks to manifest, suggesting that these drugs induce adaptive changes in brain structures affected by anxiety and de...

journal_title：Cellular signalling

authors： Taylor C,Fricker AD,Devi LA,Gomes I

更新日期：2005-05-01 00:00:00

abstract：:Recent studies have shown DAPk as a molecular modulator induced by the second messenger, responsible for controlling cell destiny decisions, but the detailed mechanism mediating the role of DAPk1 during cell death is still not fully understood. In this present report, we attempted to characterize the effects of TNF-α ...

journal_title：Cellular signalling

authors： Yoo HJ,Byun HJ,Kim BR,Lee KH,Park SY,Rho SB

更新日期：2012-07-01 00:00:00

abstract：:Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS) domain of p115 RhoGEF), we investigated the contributions of G(q/11), Gi and G(12/13) proteins to G protein-coupled receptor (GPCR)-mediated activation of the extracellular signal-regulated kinase (ERK) pathway in adult rat ventric...

journal_title：Cellular signalling

authors： Snabaitis AK,Muntendorf A,Wieland T,Avkiran M

更新日期：2005-05-01 00:00:00

abstract：:Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin. Here, we have foc...

journal_title：Cellular signalling

authors： Karger A,Fitzner B,Brock P,Sparmann G,Emmrich J,Liebe S,Jaster R

更新日期：2008-10-01 00:00:00

abstract：:The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascul...

journal_title：Cellular signalling

authors： Masri B,Knibiehler B,Audigier Y

更新日期：2005-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor family and plays key roles in glucose and lipid metabolism. Its transcriptional control of target genes is mediated by ligand-dependent recruitment of coactivators. In this study, we demonstrate that a novel transcriptional modula...

journal_title：Cellular signalling

authors： Choi JS,Choi SS,Kim ES,Seo YK,Seo JK,Kim EK,Suh PG,Choi JH

更新日期：2015-03-01 00:00:00

abstract：:The Reelin-Disabled 1 (Dab1) signaling pathway plays an important role in neuronal cell migration during brain development. Dab1, an intracellular adapter protein which is tyrosine phosphorylated upon Reelin stimulation, has been directly implicated in the transmission and termination of Reelin-mediated signaling. Two...

journal_title：Cellular signalling

authors： Gao Z,Godbout R

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Chemoresistance is one of the main obstacles in the therapy of human cancers, including colorectal cancer (CRC). Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (lncRNA HAND2-AS1) has been demonstrated to be associated with CRC. However, the function of HAND2-AS1 in 5-Fluor...

journal_title：Cellular signalling

authors： Jiang Z,Li L,Hou Z,Liu W,Wang H,Zhou T,Li Y,Chen S

更新日期：2020-02-01 00:00:00

abstract：:Src homology (SH) 3 domains are small modules found in a diverse array of proteins. The presence of an SH3 domain confers upon its resident protein the ability to interact with specific proline-rich sequences in protein binding partners. A major focus of research has highlighted a role for SH3 domain-mediated interact...

journal_title：Cellular signalling

authors： McPherson PS

更新日期：1999-04-01 00:00:00

abstract：:Activation of β2-adrenergic receptor (β2AR) and deorphanized GPR55 has been shown to modulate cancer growth in diverse tumor types in vitro and in xenograft models in vivo. (R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a bivalent compound that agonizes β2AR but inhibits GPR55-mediated pro-oncogenic responses. ...

journal_title：Cellular signalling

authors： Wnorowski A,Such J,Paul RK,Wersto RP,Indig FE,Jozwiak K,Bernier M,Wainer IW

更新日期：2017-08-01 00:00:00

abstract：:It has been widely reported that exosomes derived from mesenchymal stem cells (MSCs) have a protective effect on myocardial infarction (MI). However, the specific molecules which play a damaging role in MSCs shuttled miRNAs are much less explored. MiRNA-153-3p (miR-153-3p) is a vital miRNA which has been proved to mod...

journal_title：Cellular signalling

authors： Ning W,Li S,Yang W,Yang B,Xin C,Ping X,Huang C,Gu Y,Guo L

更新日期：2021-01-01 00:00:00

abstract：:The functional consequence of cyclic AMP-dependent phosphorylation of rap1B for stimulus-induced platelet activation is not known. Platelets were pretreated with the stable prostacyclin-analogue iloprost and resuspended in plasma without iloprost. Western blot analysis showed that rap1B was completely converted into i...

journal_title：Cellular signalling

authors： Siess W,Grünberg B

更新日期：1993-03-01 00:00:00

abstract：:The cystine/glutamate antiporter xCT (SLC7A11) is frequently overexpressed in many cancers, including glioblastoma. Cystine taken up by the cells via xCT is reduced to cysteine, which is used to synthesize glutathione for antioxidant cellular defense. However, overexpression of xCT causes cell death under glucose-limi...

journal_title：Cellular signalling

authors： Yamamoto M,Teramoto K,Katoh H

更新日期：2021-02-01 00:00:00

abstract：:Aurora B kinase forms the enzymatic core of the Chromosomal Passenger Complex (CPC) and is a master regulator of mitosis. Understanding the regulation of Aurora B is critical to illuminate its role in mitosis. INCENP, Survivin and Borealin have all been known to promote Aurora B activation. In this study, we have iden...

journal_title：Cellular signalling

authors： Iyer J,Tsai MY

更新日期：2012-08-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) is reported to regulate cell proliferation, survival, and differentiation, and thus plays a central role in development and carcinogenesis. Accumulating evidence demonstrated the involvement of cellular Src (c-Src) tyrosine kinase in the activation of STAT3....

journal_title：Cellular signalling

authors： Wang Y,Liu S,Jiang G,Zhai W,Yang L,Li M,Chang Z,Zhu B

更新日期：2020-11-01 00:00:00

abstract：:Proliferation of mammalian cells both in vivo and in vitro is dependent upon physiological concentrations of extracellular Ca2+. Growth factor stimulation of quiescent cells at the G0/G1 border usually results in a rapid mobilization of Ca2+ from both intra- and extracellular pools. However, Ca2+ influx is also requir...

journal_title：Cellular signalling

authors： Takuwa N,Zhou W,Takuwa Y

更新日期：1995-02-01 00:00:00

abstract：:MAP Kinase Phosphatase-2 (MKP-2) is a dual specific nuclear phosphatase which is selective for both ERK and JNK, MAP kinases implicated in the regulation of apoptosis in response to genotoxic stress. Here we report the conditional expression of MKP-2 in human embryonic kidney cells 293. We demonstrate that Flag-WT-MKP...

journal_title：Cellular signalling

authors： Cadalbert L,Sloss CM,Cameron P,Plevin R

更新日期：2005-10-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP), a master switch of allergic inflammation, plays an important role in the pathogenesis of allergic diseases. Although many compounds upregulate TSLP expression in vivo or in vitro, most of them are pollutants or toxicants. In the previous study, for the first time, we found that a s...

journal_title：Cellular signalling

authors： Weng Y,Wang J,Yang Z,Xi M,Duan J,Guo C,Yin Y,Segawa R,Moriya T,Yonezawa T,Cha BY,Woo JT,Wen A,Hirasawa N

更新日期：2019-05-01 00:00:00