Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

abstract：:Calcineurin (CnA) is an important signalling molecule in skeletal muscle, in the promotion of differentiation, slow-fibre phenotype and possibly fibre hypertrophy. We found that stable expression of constitutively active CnA in muscle C2C12 cells strongly activated NF-kappaB, a key mediator of muscle wasting. NF-kappa...

journal_title：Cellular signalling

authors： Alzuherri H,Chang KC

更新日期：2003-05-01 00:00:00

abstract：:We investigate the mechanisms underlying the intracellular calcium pulse that occurs in response to extracellular adenosine triphosphate (ATP) in osteoclasts. We find that pre-loading of GDP-beta-S abolishes the response in Ca(2+)-free medium, demonstrating an internal release of Ca2+ via a pathway that involves a G p...

journal_title：Cellular signalling

authors： Yu H,Ferrier J

更新日期：1994-11-01 00:00:00

abstract：:The β-catenin signaling axis is critical for normal embryonic development and tissue homeostasis in adults. We have previously shown that extracellular enzyme transglutaminase 2 (TG2) activates β-catenin signaling in vascular smooth muscle cells (VSMCs). In this study, we provide several lines of evidence that TG2 fun...

journal_title：Cellular signalling

authors： Deasey S,Nurminsky D,Shanmugasundaram S,Lima F,Nurminskaya M

更新日期：2013-12-01 00:00:00

abstract：:Human neutrophils pre-incubated with granulocyte-macrophage-colony-stimulating factor (GM-CSF) exhibit an enhanced mobilization of calcium in response to secondary stimuli such as chemotactic factors. The mechanisms underlying this priming effect of GM-CSF were examined. It was first demonstrated that the additional c...

journal_title：Cellular signalling

authors： Naccache PH,Hamelin B,Gaudry M,Bourgoin S

更新日期：1991-01-01 00:00:00

abstract：:Endothelial cell apoptosis induced by hypoxia is implicated in the pathogenesis of vascular diseases. However, the underlying mechanism is not clearly elucidated. In this study, we found that hypoxia increased Mxi1-0 expression, and the Mxi1-0 siRNA could inhibit caspase-8 activation and apoptosis in HUVECs induced by...

journal_title：Cellular signalling

authors： Hu Z,Wang F,Wu Z,Gu H,Dong N,Jiang X,Xu J,Wu Z,Wechsler DS,Zheng D

更新日期：2018-11-01 00:00:00

abstract：:Macrophages take up oxidized low density lipoprotein (oxLDL) after being exposed to it in the blood vessels. oxLDL transforms macrophages into foam cells, which are a hallmark of atherosclerosis. The effects that oxLDL have on the inflammatory responses of foam cells are not clear. Here, we investigated how oxLDL modu...

journal_title：Cellular signalling

authors： Min KJ,Cho KH,Kwon TK

更新日期：2012-06-01 00:00:00

abstract：:The constitutively activated mutation (V617F) of tyrosine kinase Janus kinase 2 (JAK2) is found in the majority of patients with myeloproliferative neoplasms (MPNs). The development of a novel chemical compound to suppress JAK2 V617F mutant-induced onset of MPNs and clarification of the signaling cascade downstream of...

journal_title：Cellular signalling

authors： Funakoshi-Tago M,Nagata T,Tago K,Tsukada M,Tanaka K,Nakamura S,Mashino T,Kasahara T

更新日期：2012-11-01 00:00:00

abstract：:Transforming growth factor β (TGF-β), a cytokine, and its receptors play a vital role during normal embryogenesis, cell proliferation, differentiation, apoptosis and migration. Ran-binding protein in the microtubule-organizing center (RanBPM) serves as a scaffold protein that has been shown to interact with many other...

journal_title：Cellular signalling

authors： Zhang J,Ma W,Tian S,Fan Z,Ma X,Yang X,Zhao Q,Tan K,Chen H,Chen D,Huang BR

更新日期：2014-01-01 00:00:00

abstract：:Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T cells. Its role in T-cell development has been established by the severe combined immune deficiency syndrome in ZAP-70 deficient human...

journal_title：Cellular signalling

authors： Kaur M,Singh M,Silakari O

更新日期：2014-11-01 00:00:00

abstract：:Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activati...

journal_title：Cellular signalling

authors： Rochette-Egly C

更新日期：2003-04-01 00:00:00

abstract：:The functional consequence of cyclic AMP-dependent phosphorylation of rap1B for stimulus-induced platelet activation is not known. Platelets were pretreated with the stable prostacyclin-analogue iloprost and resuspended in plasma without iloprost. Western blot analysis showed that rap1B was completely converted into i...

journal_title：Cellular signalling

authors： Siess W,Grünberg B

更新日期：1993-03-01 00:00:00

abstract：:Staphylococcal alpha-toxin at subcytotoxic concentrations stimulated phosphatidylinositol turnover and arachidonic acid release in undifferentiated cultures of pheochromocytoma PC12 cells. Stimulation of phospholipase A2 but not C was dependent on extracellular calcium. Addition of staphylococcal alpha-toxin to PC12 c...

journal_title：Cellular signalling

authors： Fink D,Contreras ML,Lelkes PI,Lazarovici P

更新日期：1989-01-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP), a master switch of allergic inflammation, plays an important role in the pathogenesis of allergic diseases. Although many compounds upregulate TSLP expression in vivo or in vitro, most of them are pollutants or toxicants. In the previous study, for the first time, we found that a s...

journal_title：Cellular signalling

authors： Weng Y,Wang J,Yang Z,Xi M,Duan J,Guo C,Yin Y,Segawa R,Moriya T,Yonezawa T,Cha BY,Woo JT,Wen A,Hirasawa N

更新日期：2019-05-01 00:00:00

abstract：:The long cyclic AMP (cAMP)-specific phosphodiesterase isoform, PDE4A5 (PDE4A subfamily isoform variant 5), when transiently expressed in COS-7 cells, was shown in subcellular fractionation studies to be associated with both membrane and cytosol fractions, with immunofluorescence analyses identifying PDE4A5 as associat...

journal_title：Cellular signalling

authors： Beard MB,Huston E,Campbell L,Gall I,McPhee I,Yarwood S,Scotland G,Houslay MD

更新日期：2002-05-01 00:00:00

abstract：:Beta-adrenergic, alpha-1-adrenergic and glucagon stimulation of glucose release were compared between hepatocytes which were freshly isolated, incubated for 3 h in suspension or cultivated for 4 or 24 h in plastic culture flasks in the presence and absence of the protein kinase C activator 12-O-tetradecanoylphorbol-13...

journal_title：Cellular signalling

authors： Hermsdorf T,Dettmer D

更新日期：1992-11-01 00:00:00

abstract：:We have compared a new commercially available non-radioactive protein kinase C (PKC) activity assay based on the fluorescent [A9,10K11]glycogen synthase1-11 analogue C1-peptide with a classical radioactive assay based on myelin basic protein4-14 (MBP4-14) and other substrates. The C1-peptide had lower affinity for PKC...

journal_title：Cellular signalling

authors： Erdbrügger W,Strohm P,Michel MC

更新日期：1995-08-01 00:00:00

abstract：:Hepatocyte membranes from both lean and obese Zucker rats exhibited adenylate cyclase activity that could be stimulated by glucagon, forskolin, NaF and elevated concentrations of p[NH]ppG. In membranes from lean animals, functional Gi was detected by the ability of low concentrations of p[NH]ppG to inhibit forskolin-a...

journal_title：Cellular signalling

authors： Houslay MD,Gawler DJ,Milligan G,Wilson A

更新日期：1989-01-01 00:00:00

abstract：:Extracellular-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase (MAPK) regulated by a wide range of mitogens and cellular stresses. Since its cloning in 1995, the lack of biological tools, including antibodies and specific inhibitors, have made it one of the least studied MAPK subfamilies. The di...

journal_title：Cellular signalling

authors： Wang X,Tournier C

更新日期：2006-06-01 00:00:00

abstract：:The effect of phosphatase inhibitors okadaic acid and calyculin-A on cAMP formation and adrenocorticotropic hormone (ACTH) secretion in AtT-20 corticotrophs was investigated. Both okadaic acid and calyculin-A inhibited dose-dependently the accumulation of cAMP in cells stimulated with pituitary adenylate cyclase activ...

journal_title：Cellular signalling

authors： Koch B,Lutz-Bucher B

更新日期：1994-05-01 00:00:00

abstract：:Human ether-à-go-go-related gene (hERG or Kv11.1) encodes the rapidly activated delayed rectifier K(+) current (I(Kr)) in the human heart. Potential regulation of hERG channel by protein tyrosine kinases (PTKs) is not understood. The present study was designed to investigate whether this channel is modulated by PTKs u...

journal_title：Cellular signalling

authors： Zhang DY,Wang Y,Lau CP,Tse HF,Li GR

更新日期：2008-10-01 00:00:00

abstract：:Cardiac hypertrophy is accompanied by excessive collagen deposition in the heart. Despite painstaking research on this fatal disease, the precise role of molecular chaperones in myocardial fibrosis has not yet been elucidated. In this study, we have analyzed the mechanism by which Heat shock protein 90 (Hsp90)/Cell di...

journal_title：Cellular signalling

authors： Datta R,Bansal T,Rana S,Datta K,Chattopadhyay S,Chawla-Sarkar M,Sarkar S

更新日期：2015-12-01 00:00:00

abstract：:We have characterized the role of Drosophila PI3K and AKT in ERK pathway activation involving insulin-induced proliferation using Drosophila Schneider cells. After insulin treatment, dPI3K and dAKT activities were both increased along with activation of the dERK pathway components dMEK and dERK. The insulin-induced ac...

journal_title：Cellular signalling

authors： Kim SE,Cho JY,Kim KS,Lee SJ,Lee KH,Choi KY

更新日期：2004-11-01 00:00:00

abstract：:Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark ...

journal_title：Cellular signalling

authors： Hibbert SA,Watson REB,Griffiths CEM,Gibbs NK,Sherratt MJ

更新日期：2019-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor family and plays key roles in glucose and lipid metabolism. Its transcriptional control of target genes is mediated by ligand-dependent recruitment of coactivators. In this study, we demonstrate that a novel transcriptional modula...

journal_title：Cellular signalling

authors： Choi JS,Choi SS,Kim ES,Seo YK,Seo JK,Kim EK,Suh PG,Choi JH

更新日期：2015-03-01 00:00:00

abstract：:Regulation of nestin gene expression is largely unknown despite that it is widely used as a progenitor cell marker. In this study, we showed that nestin expression is regulated by the thrombin-mediated EGFR transactivation in serum-deprived primary cultures of rat vascular smooth muscle cells (VSMCs). This resulted fr...

journal_title：Cellular signalling

authors： Huang YL,Shi GY,Lee H,Jiang MJ,Huang BM,Wu HL,Yang HY

更新日期：2009-06-01 00:00:00

abstract：:The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anapha...

journal_title：Cellular signalling

authors： Hatano Y,Naoki K,Suzuki A,Ushimaru T

更新日期：2016-10-01 00:00:00

abstract：:Activation of phosphatidylinositol (PI)-kinase is involved in the regulation of a wide array of cellular activities. The enzyme exists as a dimer, consisting of a catalytic and a regulatory subunit. Five isoforms of the regulatory subunit have been identified and classified into three groups comprising respectively 85...

journal_title：Cellular signalling

authors： Funaki M,Katagiri H,Inukai K,Kikuchi M,Asano T

更新日期：2000-03-01 00:00:00

abstract：:T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway. The JAK/STAT pathway has recently been shown to be downstream targets of trichothecenes. However, whether there is any crosstalk between JNK and JAK/STAT pathway...

journal_title：Cellular signalling

authors： Wu Q,Wang X,Wan D,Li J,Yuan Z

更新日期：2014-12-01 00:00:00

abstract：:The strong inhibition of thrombin-induced platelet functions induced by okadaic acid is not correlated with the partial modification of pleckstrin phosphorylation, which remains still phosphorylated two min after stimulation, indicating that protein kinase C is not affected by okadaic acid. We then investigated the ef...

journal_title：Cellular signalling

authors： Mauco G,Artçanuthurry V,Pidard D,Grelac F,Maclouf J,Lévy-Tolédano S

更新日期：1997-01-01 00:00:00

abstract：:Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. In many tissues, orexins activate extracellular signal-regulated kinase (ERK(1/2)) and p38 mitogen-activated protein kinase (MAPK); however, the mechani...

journal_title：Cellular signalling

authors： Tang J,Chen J,Ramanjaneya M,Punn A,Conner AC,Randeva HS

更新日期：2008-09-01 00:00:00