Abstract：
:The Reelin-Disabled 1 (Dab1) signaling pathway plays an important role in neuronal cell migration during brain development. Dab1, an intracellular adapter protein which is tyrosine phosphorylated upon Reelin stimulation, has been directly implicated in the transmission and termination of Reelin-mediated signaling. Two main forms of Dab1 have been identified in the developing chick retina, an early isoform (Dab1-E) expressed in progenitor cells and a late isoform (Dab1-L, a.k.a. Dab1) expressed in differentiated cells. Dab1-E is missing two Src family kinase (SFK) phosphorylation sites that are critical for Reelin-Dab1 signaling and is not tyrosine phosphorylated. We have recently demonstrated a role for Dab1-E in the maintenance of retinal progenitor cells. Here, we report that Dab1-E is phosphorylated at serine/threonine residues independent of Reelin. Cdk2, highly expressed in retinal progenitor cells, mediates Dab1-E phosphorylation at serine 475 which in turn promotes ubiquitination-triggered proteasome degradation of Dab1-E. Inhibition of protein phosphatase 1 and/or protein phosphatase 2A leads to increased Dab1-E instability. We propose that Dab1 turnover is regulated by both Reelin-independent serine/threonine phosphorylation and Reelin-dependent tyrosine phosphorylation.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Gao Z,Godbout Rdoi
10.1016/j.cellsig.2010.11.007subject
Has Abstractpub_date
2011-03-01 00:00:00pages
555-65issue
3eissn
0898-6568issn
1873-3913pii
S0898-6568(10)00319-0journal_volume
23pub_type
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journal_title：Cellular signalling
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journal_title：Cellular signalling
pub_type： 杂志文章
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journal_title：Cellular signalling
pub_type： 杂志文章
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abstract：:This article has been withdrawn at the request of the Editors. The Publisher apologises for any inconvenience that this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Cellular signalling
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doi：10.1016/j.cellsig.2008.05.011
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journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2012.05.011
更新日期：2012-09-01 00:00:00
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更新日期：2017-04-01 00:00:00
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.cellsig.2007.02.009
更新日期：2007-07-01 00:00:00
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journal_title：Cellular signalling
pub_type： 杂志文章,评审
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journal_title：Cellular signalling
pub_type： 杂志文章,评审
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更新日期：1996-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Cellular signalling
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Cellular signalling
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journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2009.07.018
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journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2005.09.009
更新日期：2006-07-01 00:00:00
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journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2011.03.008
更新日期：2011-07-01 00:00:00
abstract：:Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins, and that the Ser 824 residue of TRPV4 is phosphorylated by SGK1. In this study, ...
journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2011.11.002
更新日期：2012-03-01 00:00:00
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journal_title：Cellular signalling
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更新日期：2008-10-01 00:00:00
