当前位置： SCI文献检索 > CELLULAR SIGNALLING期刊下所有文献 > Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival.

Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival.

Abstract：

:About 40,000 American women die from metastatic breast cancer each year despite advancements in treatment. Approximately, 15% of breast cancers are triple-negative for estrogen receptor, progesterone receptor, and HER2. Triple-negative cancer is characterized by more aggressive, harder to treat with conventional approaches and having a greater possibility of recurrence. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid signaling mediator has emerged as a key regulatory molecule in breast cancer progression. Therefore, we investigated whether cytosolic sphingosine kinase type 1 (SphK1) and nuclear sphingosine kinase type 2 (SphK2), the enzymes that make S1P are critical for growth and PI3K/AKT, ERK-MAP kinase mediated survival signaling of lung metastatic variant LM2-4 breast cancer cells, generated from the parental triple-negative MDA-MB-231 human breast cancer cell line. Similar with previous report, SphKs/S1P signaling is critical for the growth and survival of estrogen receptor positive MCF-7 human breast cancer cells, was used as our study control. MDA-MB-231 did not show a significant effect of SphKs/S1P signaling on AKT, ERK, and p38 pathways. In contrast, LM2-4 cells that gained lung metastatic phenotype from primary MDA-MB-231 cells show a significant effect of SphKs/S1P signaling requirement on cell growth, survival, and cell motility. PF-543, a selective potent inhibitor of SphK1, attenuated epidermal growth factor (EGF)-mediated cell growth and survival signaling through inhibition of AKT, ERK, and p38 MAP kinase pathways mainly in LM2-4 cells but not in parental MDA-MB-231 human breast cancer cells. Moreover, K-145, a selective inhibitor of SphK2, markedly attenuated EGF-mediated cell growth and survival of LM2-4 cells. We believe this study highlights the importance of SphKs/S1P signaling in metastatic triple-negative breast cancers and targeted therapies.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Maiti A,Takabe K,Hait NC

doi

10.1016/j.cellsig.2017.01.021

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

85-92

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(17)30025-6

journal_volume

32

pub_type

杂志文章

相关文献

CELLULAR SIGNALLING文献大全
  • TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD.

    abstract：:Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological ranges. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. The initia...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.12.009

    authors： Stokes A,Wakano C,Koblan-Huberson M,Adra CN,Fleig A,Turner H

    更新日期：2006-10-01 00:00:00

  • The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex.

    abstract：:The interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) has been shown to activate NF-kappaB independently of its kinase function after interaction with the IKK complex. In order to investigate the mechanism of NF-kappaB activation by PKR, we identified the domain of PKR responsible for stimu...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2006.02.010

    authors： Bonnet MC,Daurat C,Ottone C,Meurs EF

    更新日期：2006-11-01 00:00:00

  • Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1.

    abstract：:In this report, we examined the role of activin in the regulation of cell growth inhibition of human hepatocarcinoma cells. Using RNase protection assay for various cell cycle regulators and Western blotting experiments, we show that activin treatment of HepG2 cells leads to increased gene expression of the cyclin-dep...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2003.11.002

    authors： Ho J,de Guise C,Kim C,Lemay S,Wang XF,Lebrun JJ

    更新日期：2004-06-01 00:00:00

  • Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.

    abstract：:Understanding receptor activation is important for disease intervention. Activation of the receptor tyrosine kinase c-KIT is involved in numerous diseases including melanoma, mastocytosis, multiple myeloma and gastrointestinal stromal tumors. To better understand the regulation of activation, we studied the two c-KIT ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.07.011

    authors： Phung B,Steingrímsson E,Rönnstrand L

    更新日期：2013-11-01 00:00:00

  • The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis.

    abstract：:Nitric oxide (NO) is known to regulate redox-sensitive signalling pathways in physiology and pathophysiology. Depending on its concentration, the NO-releasing compound S-nitrosoglutathione (GSNO) causes negative and positive regulation of thymocyte apoptosis. At levels below 0.6 mM, GSNO produces deoxyribonucleic acid...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(95)02051-9

    authors： Sandau K,Brüne B

    更新日期：1996-03-01 00:00:00

  • Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.

    abstract：:MAP Kinase Phosphatase-2 (MKP-2) is a dual specific nuclear phosphatase which is selective for both ERK and JNK, MAP kinases implicated in the regulation of apoptosis in response to genotoxic stress. Here we report the conditional expression of MKP-2 in human embryonic kidney cells 293. We demonstrate that Flag-WT-MKP...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.01.003

    authors： Cadalbert L,Sloss CM,Cameron P,Plevin R

    更新日期：2005-10-01 00:00:00

  • Loss of Raf-1-binding activity of v-Ha-Ras by the deletion of amino acid residues 64-72 and 143-151.

    abstract：:In order to elucidate the molecular events in signal transduction, examination of the interaction between Ras and Raf-1 seems crucial. Many Raf-1 mutants have been investigated in terms of their binding activities to Ras, where only a few Ras mutants have been examined thus far. We have investigated the Raf-1-binding ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(96)00078-2

    authors： Hiwasa T,Kasama M,Nakadai T,Sawada T,Sakiyama S

    更新日期：1996-08-01 00:00:00

  • Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival.

    abstract：:T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway. The JAK/STAT pathway has recently been shown to be downstream targets of trichothecenes. However, whether there is any crosstalk between JNK and JAK/STAT pathway...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.09.013

    authors： Wu Q,Wang X,Wan D,Li J,Yuan Z

    更新日期：2014-12-01 00:00:00

  • Nore1B regulates TCR signaling via Ras and Carma1.

    abstract：:Nore1A was originally identified as a potential Ras effector, and Nore1B is an alternatively spliced isoform. Both share a Ras/Rap association domain (RA domain) but only Nore1A contains sequence motifs that predict SH3 domain binding and diacylglycerol/phorbol ester binding in the amino-terminal region. Here we repor...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2006.01.015

    authors： Ishiguro K,Avruch J,Landry A,Qin S,Ando T,Goto H,Xavier R

    更新日期：2006-10-01 00:00:00

  • CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2.

    abstract：:CD40 is critically involved in Fas-mediated cholangiocyte apoptosis during liver inflammation, but the underlying signalling events are poorly understood. Our recent work implicated AP-1 in CD40-induced cholangiocyte apoptosis, but suggested involvement of other signalling pathways. Because STAT3 has been implicated i...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.05.015

    authors： Ahmed-Choudhury J,Williams KT,Young LS,Adams DH,Afford SC

    更新日期：2006-04-01 00:00:00

  • The miR-29b-Sirt1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species.

    abstract：:Endogenous reactive oxygen species (ROS) control is important for the maintenance of self-renewal of embryonic stem (ES) cells. Although miRNAs have been found to be critically involved in the regulation of the self-renewal, whether miRNAs can regulate the signaling axis to control ROS in ES cells is unclear. Here we ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.03.010

    authors： Xu Z,Zhang L,Fei X,Yi X,Li W,Wang Q

    更新日期：2014-07-01 00:00:00

  • TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells.

    abstract：:Transmembrane prostate androgen-induced protein (TMEPAI) is a type I transmembrane protein induced by several intracellular signaling pathways such as androgen, TGF-β, EGF, and Wnt signaling. It has been reported that TMEPAI functions to suppress TGF-β and androgen signaling but here, we report a novel function of TME...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2019.03.016

    authors： Amalia R,Abdelaziz M,Puteri MU,Hwang J,Anwar F,Watanabe Y,Kato M

    更新日期：2019-07-01 00:00:00

  • Differential mechanisms involved in RG-7388 and Nutlin-3 induced cell death in SJSA-1 osteosarcoma cells.

    abstract：:Targeted therapy is becoming the mainstay of cancer treatment due to reduced side effects and enhanced tumor attack. In the last few decades, Murine Double Minute 2 (MDM2) protein has become one of the targets for developing cancer therapies. Blocking MDM2-p53 interaction has long been considered to offer a broad rang...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109742

    authors： Natarajan U,Venkatesan T,Dhandayuthapani S,Dondapatti P,Rathinavelu A

    更新日期：2020-11-01 00:00:00

  • GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.

    abstract：:In eukaryotes, proper loading and activation of MCM helicase at chromosomal origins plays a central role in DNA replication. Activation of MCM helicase requires its association with CDC45-GINS complex, but the mechanism of how this complex activates MCM helicase is poorly understood. Here we identified SIK1 (salt-indu...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2016.08.018

    authors： Joshi K,Shah VJ,Maddika S

    更新日期：2016-12-01 00:00:00

  • Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E.

    abstract：:In the canonical model of JAK/STAT signalling STAT transcription factors are activated by JAK mediated tyrosine phosphorylation following pathway stimulation by external cytokines. Activated STAT molecules then homo- or heterodimerise before translocating to the nucleus where they bind to DNA sequences within the prom...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.07.006

    authors： Karsten P,Plischke I,Perrimon N,Zeidler MP

    更新日期：2006-06-01 00:00:00

  • Apoptosis induced by cAMP requires Smac/DIABLO transcriptional upregulation.

    abstract：:Smac/DIABLO is a mitochondrial protein that participates in apoptotic cell death by means of sequestering several members of the inhibitor of apoptosis protein family. This action allows caspase activation, cleavage of key cellular substrates and death. Release from mitochondria is considered the main regulatory step ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.01.001

    authors： Martinez-Velazquez M,Melendez-Zajgla J,Maldonado V

    更新日期：2007-06-01 00:00:00

  • Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells.

    abstract：:In Galpha(z)-deficient mice, survival of sympathetic neurons is significantly attenuated in the presence of pertussis toxin (PTX). This suggests that G(i/o) proteins may have distinct roles in neuronal survival. Here, we investigated the possible involvement of G(i/o) proteins in nerve growth factor (NGF)-induced pro-...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2004.11.008

    authors： Wu EH,Wong YH

    更新日期：2005-07-01 00:00:00

  • Protectin DX prevents H2O2-mediated oxidative stress in vascular endothelial cells via an AMPK-dependent mechanism.

    abstract：:Protectin DX (PDX), which is a novel regulator of 5' adenosine monophosphate-activated protein kinase (AMPK), has recently gained attention for its ability to improve several metabolic diseases. However, the function of PDX in vascular endothelial cells remains unclear. To confirm the protective effects of PDX on endo...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2018.09.011

    authors： Hwang HJ,Jung TW,Kim JW,Kim JA,Lee YB,Hong SH,Roh E,Choi KM,Baik SH,Yoo HJ

    更新日期：2019-01-01 00:00:00

  • Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.

    abstract：:Sustained activation of Akt kinase acts as a focal regulator to increase cell growth and survival, which causes tumorigenesis including breast cancer. Statins, potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, display anticancer activity. The molecular mechanisms by which statins block cancer cell ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.12.010

    authors： Ghosh-Choudhury N,Mandal CC,Ghosh-Choudhury N,Ghosh Choudhury G

    更新日期：2010-05-01 00:00:00

  • The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line.

    abstract：:Monoamine oxidase-A (MAO-A) dysfunction has been historically associated with depression. Recently, depression as well as altered MAO-A expression have both been associated with a poor prognosis in cancers, although the mechanism involved remains ambiguous. For example, MAO-A mRNA is repressed across cancers, yet MAO-...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.08.005

    authors： Satram-Maharaj T,Nyarko JN,Kuski K,Fehr K,Pennington PR,Truitt L,Freywald A,Lukong KE,Anderson DH,Mousseau DD

    更新日期：2014-12-01 00:00:00

  • Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.

    abstract：:Both type I interferons (IFNs) and interferon regulatory factors (IRFs) are well characterized in viral infections, whereas they are far less studied in bacterially activated toll-like receptor (TLR) pathways. Here, we studied the involvement of IRF1 and IRF2 in TLR2-mediated responses. In mouse macrophages, IRF2 was ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.06.017

    authors： Liljeroos M,Vuolteenaho R,Rounioja S,Henriques-Normark B,Hallman M,Ojaniemi M

    更新日期：2008-10-01 00:00:00

  • Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.

    abstract：:We previously showed that activated peroxisome proliferator-activated receptor (PPAR)β/δ can protect pancreatic β cells against lipotoxic apoptosis. However, the molecular mechanism remained unclear. Glucagon-like peptide-1 receptor (GLP-1R) has been reported to exhibit a protective effect against lipotoxic apoptosis ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.11.019

    authors： Yang Y,Tong Y,Gong M,Lu Y,Wang C,Zhou M,Yang Q,Mao T,Tong N

    更新日期：2014-02-01 00:00:00

  • Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.

    abstract：:The function of the 90-kDa heat shock protein (Hsp90) is essential for the regulation of a myriad of signal transduction cascades that control all facets of a cell's physiology. Akt (PKB) is an Hsp90-dependent serine-threonine kinase that plays critical roles in the regulation of muscle cell physiology, including role...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.03.006

    authors： Yun BG,Matts RL

    更新日期：2005-12-01 00:00:00

  • Steering signal transduction pathway towards cardiac lineage from human pluripotent stem cells: a review.

    abstract：:In humans injured myocardium cannot avert the onset and progression of ventricular dysfunction because of limited regenerative ability of myocytes. Although limited renaissance of cardiomyocytes has been reported in human infarcted hearts, it is generally accredited that non-functional fibrous tissue replaces the dead...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2013.01.027

    authors： Verma V,Purnamawati K,Manasi,Shim W

    更新日期：2013-05-01 00:00:00

  • Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process.

    abstract：:Although there is a substantial literature that mitochondria have a crucial role in the aging process, the mechanism has remained elusive. The role of reactive oxygen species, mitochondrial DNA injuries, and a decline in mitochondrial quality control has been proposed. Emerging studies have demonstrated that Krebs cyc...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2014.03.030

    authors： Salminen A,Kaarniranta K,Hiltunen M,Kauppinen A

    更新日期：2014-07-01 00:00:00

  • Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.

    abstract：:Metformin, the most used drug for the treatment of diabetes type 2 patients, has been shown to have anti-cancer properties. In this study, we found that metformin induced apoptosis in Primary Effusion Lymphoma (PEL) cells, an aggressive B cell lymphoma associated with KSHV against which the conventional therapies usua...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2017.09.020

    authors： Granato M,Gilardini Montani MS,Romeo MA,Santarelli R,Gonnella R,D'Orazi G,Faggioni A,Cirone M

    更新日期：2017-12-01 00:00:00

  • Oxyl radicals, redox-sensitive signalling cascades and antioxidants.

    abstract：:Oxidative stress is an increase in the reduction potential or a large decrease in the reducing capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is the production of reactive oxygen species (ROS), which include free radicals and peroxides. Some of the less reactive of these ...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2007.04.009

    authors： Genestra M

    更新日期：2007-09-01 00:00:00

  • Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.

    abstract：:Lithium is an anti-depressant drug that also possesses immunomodulatory functions. The anti-inflammatory effect of lithium is thought to involve activation of the transcription factor CREB, although the underlying mechanism is incompletely understood. We show here that in macrophages lithium stimulates Tpl2, a MAP kin...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.12.010

    authors： Zhang M,Jin W,Zhou X,Yu J,Lee AJ,Sun SC

    更新日期：2009-04-01 00:00:00

  • Tyrosine phosphatase PTP1B modulates store-operated calcium influx.

    abstract：:We have studied modulation of "store-operated calcium influx" by tyrosine phosphatases in the pancreatic acinar cell line AR42J and in HEK 293 cells. We show that inhibition of tyrosine phosphatases by bis-(N,N-dimethyl-hydroxamido) hydrooxovanadate (DMHV) leads to an increase in Ca(2+) release-activated Ca(2+) (CRAC)...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(03)00088-3

    authors： Hsu S,Schmid A,Sternfeld L,Anderie I,Solis G,Hofer HW,Schulz I

    更新日期：2003-12-01 00:00:00

  • ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling.

    abstract：:Epidermal growth factor (EGF) signaling is critical in normal and aberrant cellular behavior. Extracellular signal-regulated kinase (ERK) mediates important downstream aspects of EGF signaling. Additionally, EGFR undergoes MEK1-dependent ERK consensus site phosphorylation in response to EGF or cytokines such as growth...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.08.006

    authors： Li X,Huang Y,Jiang J,Frank SJ

    更新日期：2008-11-01 00:00:00