Abstract:
:Nitric oxide (NO) is known to regulate redox-sensitive signalling pathways in physiology and pathophysiology. Depending on its concentration, the NO-releasing compound S-nitrosoglutathione (GSNO) causes negative and positive regulation of thymocyte apoptosis. At levels below 0.6 mM, GSNO produces deoxyribonucleic acid (DNA) laddering, which is inhibited by activation of protein kinase C (PKC), cycloheximide treatment, and calcium chelation. Higher concentrations of the NO donor (1-2 mM) suppress thymocyte apoptosis initiated by the classical agonist dexamethasone. Inhibition of apoptosis by NO is analogous to the action of the thiol-blocking compound N-ethylmaleimide (NEM) and the glutathione-S-transferase substrate 1-chloro-2,4-dinitrobenzene (CDNB). Inhibition of apoptosis results from thiol modification of critical proteins in response to NO treatment. Depending on the concentration, GSNO can be involved either in toxic or in protective signalling in thymocyte biology.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Sandau K,Brüne Bdoi
10.1016/0898-6568(95)02051-9subject
Has Abstractpub_date
1996-03-01 00:00:00pages
173-7issue
3eissn
0898-6568issn
1873-3913pii
0898-6568(95)02051-9journal_volume
8pub_type
杂志文章abstract::In diverse neuronal processes ranging from neuronal survival to synaptic plasticity cyclic adenosine monophosphate (cAMP)-dependent signaling is tightly connected with the protein kinase B (PKB)/Akt pathway but the precise nature of this connection remains unknown. In the current study we investigated the effect of tw...
journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2018.03.003
更新日期:2018-07-01 00:00:00
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journal_title:Cellular signalling
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journal_title:Cellular signalling
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更新日期:1997-02-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2014.11.035
更新日期:2015-03-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2011.11.005
更新日期:2012-03-01 00:00:00
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journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2014.02.017
更新日期:2014-07-01 00:00:00
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journal_title:Cellular signalling
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doi:10.1016/j.cellsig.2003.09.012
更新日期:2004-04-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2011.12.001
更新日期:2012-04-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/0898-6568(95)02009-8
更新日期:1995-11-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2014.09.017
更新日期:2014-12-01 00:00:00
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journal_title:Cellular signalling
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doi:10.1016/j.cellsig.2005.08.019
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journal_title:Cellular signalling
pub_type: 杂志文章
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2004.12.003
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2016.02.011
更新日期:2016-05-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/0898-6568(95)00039-r
更新日期:1995-09-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2010.06.007
更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0898-6568(92)90051-9
更新日期:1992-11-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/0898-6568(92)90049-e
更新日期:1992-11-01 00:00:00
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journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章,评审
doi:10.1016/j.cellsig.2016.12.010
更新日期:2017-02-01 00:00:00
abstract::Mice lacking the gene for suppressor of cytokine signaling 1 (SOCS1) show defective homeostasis of T lymphocytes due to accumulation of CD8(+) T cells, resulting at least partly from dysregulated IL-15 signaling. IL-15 alone does not stimulate proliferation of naïve CD8 T cells, but can synergize with IL-21 to induce ...
journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/j.cellsig.2006.10.003
更新日期:2007-04-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
doi:10.1016/0898-6568(93)90026-i
更新日期:1993-05-01 00:00:00