Evidence that generation of inositol 1,4,5-trisphosphate and hydrolysis of phosphatidylinositol 4,5-bisphosphate are rapid responses following addition of fungal elicitor which induces phytoalexin synthesis in lucerne (Medicago sativa) suspension culture

abstract：:Timeless was originally identified in Drosophila as an essential component of circadian cycle regulation, where its function is tightly controlled at the protein level by tyrosine phosphorylation and subsequent degradation. In mammals, Timeless has also been implicated in circadian rhythms as well as cell cycle contro...

journal_title：Cellular signalling

authors： O'Reilly LP,Zhang X,Smithgall TE

更新日期：2013-04-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targete...

journal_title：Cellular signalling

authors： Wu G,Weng W,Xia P,Yan S,Zhong C,Xie L,Xie Y,Fan G

更新日期：2021-03-01 00:00:00

abstract：:Pseudoxanthoma elasticum is an autosomal recessive genodermatosis with variable expression, due to mutations in the ABCC6 or ENPP1 gene. It is characterized by elastic fiber mineralization and fragmentation, resulting in skin, eye and cardiovascular symptoms. Significant advances have been made in the last 20 years wi...

journal_title：Cellular signalling

authors： Van Gils M,Nollet L,Verly E,Deianova N,Vanakker OM

更新日期：2019-03-01 00:00:00

abstract：:alpha-Thrombin activates several G-proteins including members of the Gq, Gi, and G12/13 families, although the physiological importance of these proteins is still not completely understood. We specifically investigated the role of Gq alpha in modulating alpha-thrombin-induced mitogenesis. In Gqa1 cells, a stable cell ...

journal_title：Cellular signalling

authors： Gardner A,Phillips-Mason PJ,Raben DM,Baldassare JJ

更新日期：2002-06-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (Stat6) is critical in Th2 polarization of immune cells and active Stat6 activity has been suggested in anti-tumor immunity in animal models. The present study aims at investigating the impact of natural Stat6 activity on tumor microenvironment in human colorectal can...

journal_title：Cellular signalling

authors： Li BH,Xu SB,Li F,Zou XG,Saimaiti A,Simayi D,Wang YH,Zhang Y,Yuan J,Zhang WJ

更新日期：2012-03-01 00:00:00

abstract：:Na(+)/H(+) exchanger-1 (NHE-1) activity is known to play a critical role in the neuronal injury caused by glutamate. However, the underlying mechanism is not clear. This study shows that NHE-1 activation and its phosphorylation during glutamate exposure were attenuated by the inhibition of protein kinase C (PKC)-βI an...

journal_title：Cellular signalling

authors： Lee BK,Yoon JS,Lee MG,Jung YS

更新日期：2014-04-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitors (CKI) interact with cyclin-cdk complexes to arrest mitogen-stimulated transit through the cell cycle, but we and others have recently shown that these molecules can exert permissive effects on cell cycle transit as well. The p53 protein induces transcription of the p21(Waf1/Cip1)...

journal_title：Cellular signalling

authors： Weiss RH,Randour CJ

更新日期：2000-06-01 00:00:00

abstract：:Differential regulation of PLC-beta 1 and -beta 2 by the G-protein alpha-subunit, G alpha 11, and by G-protein beta gamma-subunits was studied utilizing recombinant PLC-beta 1 and -beta 2. Rat PLC-beta 1 and human PLC-beta 2 were purified after recombinant baculovirus-mediated expression in Sf9 cells. The catalytic pr...

journal_title：Cellular signalling

authors： Paterson A,Boyer JL,Watts VJ,Morris AJ,Price EM,Harden TK

更新日期：1995-09-01 00:00:00

abstract：:In humans, thromboxane (TX) A(2) signals through the TPalpha and TPbeta isoforms of the TXA(2) receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cbeta signaling by TPalpha is directly inhibited by the vasodilators prostacyclin and nitric oxide (NO) whereas that signaling by TPbeta is u...

journal_title：Cellular signalling

authors： Wikström K,Kavanagh DJ,Reid HM,Kinsella BT

更新日期：2008-08-01 00:00:00

abstract：:The ADP-ribosylation factor (Arf) Arf GTPase-activating proteins (GAPs) are a family of proteins that induce hydrolysis of GTP bound to Arf. A conserved domain containing a zinc finger motif mediates catalysis. The substrate, Arf.GTP, affects membrane trafficking and actin remodelling. Consistent with activity as an A...

journal_title：Cellular signalling

authors： Randazzo PA,Hirsch DS

更新日期：2004-04-01 00:00:00

abstract：:The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anapha...

journal_title：Cellular signalling

authors： Hatano Y,Naoki K,Suzuki A,Ushimaru T

更新日期：2016-10-01 00:00:00

abstract：:Reduced connexin43 (Cx43) expression is frequently detected in different types of human cancer. Cx43 has been shown to regulate cancer cell migration in a cell-type dependent manner. In both primary and recurrent human ovarian cancer, overexpression of TGF-β ligand and its receptors have been detected. TGF-β can regul...

journal_title：Cellular signalling

authors： Qiu X,Cheng JC,Zhao J,Chang HM,Leung PC

更新日期：2015-10-01 00:00:00

abstract：:Protectin DX (PDX), which is a novel regulator of 5' adenosine monophosphate-activated protein kinase (AMPK), has recently gained attention for its ability to improve several metabolic diseases. However, the function of PDX in vascular endothelial cells remains unclear. To confirm the protective effects of PDX on endo...

journal_title：Cellular signalling

authors： Hwang HJ,Jung TW,Kim JW,Kim JA,Lee YB,Hong SH,Roh E,Choi KM,Baik SH,Yoo HJ

更新日期：2019-01-01 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPases) play an essential role in the regulation of reversible tyrosine phosphorylation of cellular proteins that mediate insulin action. In order to explore the potential role of the transmembrane PTPase (LAR) in insulin receptor signal transduction, we overexpressed the full-length LA...

journal_title：Cellular signalling

authors： Li PM,Zhang WR,Goldstein BJ

更新日期：1996-11-01 00:00:00

abstract：:15-lipoxygenase (15-LO) is known to play an important role in chronic pulmonary hypertension. Accumulating evidence for its down-stream participants in the vasoconstriction and remodeling processes of pulmonary arteries, while how hypoxia regulates 15-LO/15-hydroxyeicosatetraenoic acid (15-HETE) to mediate hypoxic pul...

journal_title：Cellular signalling

authors： Zhang L,Ma J,Shen T,Wang S,Ma C,Liu Y,Ran Y,Wang L,Liu L,Zhu D

更新日期：2012-10-01 00:00:00

abstract：:Understanding how cells integrate signals from a variety of chemically diverse information-containing molecules into complex, orchestrated responses such as cell proliferation, differentiation and apoptosis is an overarching goal of cell biology. The ligand molecules that act upon cell surface receptors include those ...

journal_title：Cellular signalling

authors： Malbon CC,Karoor V

更新日期：1998-09-01 00:00:00

abstract：:Inflammation is characterized by early influx of polymorphonuclear neutrophils (PMNs), followed by a second wave of monocyte recruitment. PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes. However, the pathways for such sig...

journal_title：Cellular signalling

authors： Chang M,Guo F,Zhou Z,Huang X,Yi L,Dou Y,Huan J

更新日期：2018-03-01 00:00:00

abstract：:The adaptor protein Gab-2 coordinates the assembly of the IL-3 signalsome comprising Gab-2, Grb2, Shc, SHP-2 and PI3K. To investigate the role of the pleckstrin homology domain of Gab-2 in this process, epitope-tagged wild type Gab-2 (WTGab-2), Gab-2 lacking its PH domain (DeltaPHGab-2) and the Gab-2 PH domain alone (...

journal_title：Cellular signalling

authors： Edmead CE,Fox BC,Stace C,Ktistakis N,Welham MJ

更新日期：2006-08-01 00:00:00

abstract：:Protein Kinase B (PKB/Akt) is a key regulator of cell proliferation, motility and survival. The activation status of PKB is regulated by phosphatidylinositol 3-kinase (PI3K) via the synthesis of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3, PIP3). PTEN antagonises PI3K by degrading PIP3 to phosphatidylinosito...

journal_title：Cellular signalling

authors： Sharrard RM,Maitland NJ

更新日期：2007-01-01 00:00:00

abstract：:Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activati...

journal_title：Cellular signalling

authors： Rochette-Egly C

更新日期：2003-04-01 00:00:00

abstract：:We have previously demonstrated that inhibition of calmodulin (CaM) and the concomitant reduction of PI3K interfere with H-Ras-mediated activation of Raf-1 [1]. In the present study, we show that CaM has completely opposite effects on K-Ras-mediated Raf-1 activation. The differential contribution of CaM in the regulat...

journal_title：Cellular signalling

authors： Moretó J,Vidal-Quadras M,Pol A,Santos E,Grewal T,Enrich C,Tebar F

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:microRNAs (miRNAs) are a class of small, evolutionarily conserved, non-coding RNAs (ncRNAs) that function as inhibitors of post-transcriptional mRNA expression. They are implicated in the pathogenesis of numerous diseases, including many common kidney conditions. In this review, we focus on how miRNAs...

journal_title：Cellular signalling

authors： Ramalingam H,Yheskel M,Patel V

更新日期：2020-07-01 00:00:00

abstract：:Arap3 is a phosphoinositide (PI) 3 kinase effector that serves as a GTPase activating protein (GAP) for both Arf and Rho G-proteins. The protein has multiple pleckstrin homology (PH) domains that bind preferentially phosphatidyl-inositol-3,4,5-trisphosphate (PI(3,4,5,)P3) to induce translocation of Arap3 to the plasma...

journal_title：Cellular signalling

authors： Raaijmakers JH,Deneubourg L,Rehmann H,de Koning J,Zhang Z,Krugmann S,Erneux C,Bos JL

更新日期：2007-06-01 00:00:00

abstract：:Eight paralogue members form the family of transmembrane channel-like (TMC) proteins that share considerable sequence homology to anoctamin 1 (Ano1, TMEM16A). Ano1 is a Ca(2+) activated Cl(-) channel that is related to head and neck cancer, often caused by human papilloma virus (HPV) infection. Mutations in TMC 6 and ...

journal_title：Cellular signalling

authors： Sirianant L,Ousingsawat J,Tian Y,Schreiber R,Kunzelmann K

更新日期：2014-12-01 00:00:00

abstract：:In the canonical model of JAK/STAT signalling STAT transcription factors are activated by JAK mediated tyrosine phosphorylation following pathway stimulation by external cytokines. Activated STAT molecules then homo- or heterodimerise before translocating to the nucleus where they bind to DNA sequences within the prom...

journal_title：Cellular signalling

authors： Karsten P,Plischke I,Perrimon N,Zeidler MP

更新日期：2006-06-01 00:00:00

abstract：:Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological ranges. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. The initia...

journal_title：Cellular signalling

authors： Stokes A,Wakano C,Koblan-Huberson M,Adra CN,Fleig A,Turner H

更新日期：2006-10-01 00:00:00

abstract：:Heterotrimeric G proteins typically transduce signals from G protein-coupled receptors (GPCRs) to effector proteins. In the conventional G protein signaling paradigm, the G protein is located at the cytoplasmic surface of the plasma membrane, where, after activation by an agonist-bound GPCR, the GTP-bound Gα and free ...

journal_title：Cellular signalling

authors： Hewavitharana T,Wedegaertner PB

更新日期：2012-01-01 00:00:00

abstract：:Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better understanding of the underlying molecular mechanisms is needed to develop improved drugs. Here, we review the literature to test the hypothesis that a break dow...

journal_title：Cellular signalling

authors： Kelly MP

更新日期：2018-01-01 00:00:00

abstract：:The long cyclic AMP (cAMP)-specific phosphodiesterase isoform, PDE4A5 (PDE4A subfamily isoform variant 5), when transiently expressed in COS-7 cells, was shown in subcellular fractionation studies to be associated with both membrane and cytosol fractions, with immunofluorescence analyses identifying PDE4A5 as associat...

journal_title：Cellular signalling

authors： Beard MB,Huston E,Campbell L,Gall I,McPhee I,Yarwood S,Scotland G,Houslay MD

更新日期：2002-05-01 00:00:00

abstract：:The Wnt signalling pathway is conserved in various species from worms to mammals, and plays important roles in development, cellular proliferation, and differentiation. The molecular mechanisms by which the Wnt signal regulates cellular functions are becoming increasingly well understood. Wnt stabilizes cytoplasmic be...

journal_title：Cellular signalling

authors： Kikuchi A

更新日期：1999-11-01 00:00:00