Abstract:
:Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological ranges. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. The initial report of TRPA1 as a transformation-associated gene product in lung epithelia is at odds with subsequent descriptions of a tissue distribution for TRPA1 that is restricted to sensory neurons. Here, we report that the human TRPA1 protein is widely expressed outside the CNS, and is indeed dys-regulated during oncogenic transformation. We describe that TRPA1 associates with the tumor-suppressor protein CYLD. TRPA1 is a novel substrate for the de-ubiquitinating activity of CYLD, and this de-ubiquitination has the net effect of increasing the cellular pool of TRPA1 proteins. Oncogenic mutations in the CYLD gene may therefore be predicted to alter cellular levels of TRPA1.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Stokes A,Wakano C,Koblan-Huberson M,Adra CN,Fleig A,Turner Hdoi
10.1016/j.cellsig.2005.12.009subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1584-94issue
10eissn
0898-6568issn
1873-3913pii
S0898-6568(06)00002-7journal_volume
18pub_type
杂志文章abstract::The kidney is one of the fastest-aging organs, and renal senescence has become a major disease affecting human health. Renal cellular senescence is regulated by the joint action of multiple signal transduction pathways. The previous study by our research group found that the Janus kinase 2 (JAK2)/signal transducer and...
journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章,评审
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journal_title:Cellular signalling
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更新日期:2012-06-01 00:00:00
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journal_title:Cellular signalling
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doi:10.1016/s0898-6568(96)00119-2
更新日期:1997-01-01 00:00:00
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journal_title:Cellular signalling
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更新日期:2016-01-01 00:00:00
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journal_title:Cellular signalling
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doi:10.1016/j.cellsig.2015.03.013
更新日期:2015-07-01 00:00:00
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journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Cellular signalling
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更新日期:2018-04-01 00:00:00
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doi:10.1016/j.cellsig.2006.12.007
更新日期:2007-06-01 00:00:00
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更新日期:2018-07-01 00:00:00
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更新日期:2019-11-01 00:00:00
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journal_title:Cellular signalling
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更新日期:2014-09-01 00:00:00
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journal_title:Cellular signalling
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doi:10.1016/j.cellsig.2013.11.005
更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.cellsig.2019.109469
更新日期:2020-02-01 00:00:00