Abstract：
:Circular RNAs (circRNAs) belong to a diverse class of stable RNAs expressed in all cell types. Their proposed functions include sponging of microRNAs (miRNAs), sequestration and trafficking of proteins, assembly of multimeric complexes, production of peptides, and regulation of transcription. Backsplicing due to RNA structures formed by an exceptionally high number of Alu repeats lead to the production of a vast repertoire of circRNAs by human Survival Motor Neuron genes, SMN1 and SMN2, that code for SMN, an essential multifunctional protein. Low levels of SMN due to deletion or mutation of SMN1 result in spinal muscular atrophy (SMA), a major genetic disease of infants and children. Mild SMA is also recorded in adult population, expanding the spectrum of the disease. Here we review SMN circRNAs with respect to their biogenesis, sequence features, and potential functions. We also discuss how SMN circRNAs could be exploited for diagnostic and therapeutic purposes.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Ottesen EW,Singh RNdoi
10.1016/j.cellsig.2020.109696subject
Has Abstractpub_date
2020-09-01 00:00:00pages
109696eissn
0898-6568issn
1873-3913pii
S0898-6568(20)30173-Xjournal_volume
73pub_type
杂志文章,评审abstract：:Neuro-2a (N2a) cells are derived from spontaneous neuroblastoma of mouse and capable to differentiate into neuronal-like cells. Recently, P2X7 receptor has been shown to sustain growth of human neuroblastoma cells but its role during neuronal differentiation remains unexamined.We characterized the role of P2X7 recepto...
journal_title：Cellular signalling
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journal_title：Cellular signalling
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pub_type： 杂志文章
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journal_title：Cellular signalling
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journal_title：Cellular signalling
pub_type： 杂志文章
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journal_title：Cellular signalling
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doi：10.1016/j.cellsig.2009.01.037
更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Cellular signalling
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journal_title：Cellular signalling
pub_type： 杂志文章,评审
doi：10.1016/j.cellsig.2004.09.013
更新日期：2005-03-01 00:00:00
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journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2005.09.006
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journal_title：Cellular signalling
pub_type： 杂志文章,评审
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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pub_type： 杂志文章,评审
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journal_title：Cellular signalling
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journal_title：Cellular signalling
pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
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journal_title：Cellular signalling
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