当前位置： SCI文献检索 > CELLULAR SIGNALLING期刊下所有文献 > Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.

Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.

Abstract：

:Understanding receptor activation is important for disease intervention. Activation of the receptor tyrosine kinase c-KIT is involved in numerous diseases including melanoma, mastocytosis, multiple myeloma and gastrointestinal stromal tumors. To better understand the regulation of activation, we studied the two c-KIT isoforms, c-KIT(-) and c-KIT(+), which differ by a tetrapeptide insert GNNK, located in the extracellular juxtamembrane domain of the c-KIT(+) isoform. This region is important for regulating receptor activation. Here we show that the consecutive elimination of one amino acid at a time from the GNNK tetrapeptide insert gradually increases receptor tyrosine phosphorylation, ubiquitination, internalization and downstream MAP kinase-ERK activation. Successively decreasing the insert length progressively improves cell survival during drug treatment. Our results indicate that the length of the tetrapeptide fine-tunes receptor activity, thus providing deeper insight into c-KIT activation.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Phung B,Steingrímsson E,Rönnstrand L

doi

10.1016/j.cellsig.2013.07.011

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

2231-8

issue

11

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(13)00209-X

journal_volume

25

pub_type

杂志文章

相关文献

CELLULAR SIGNALLING文献大全
  • HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation.

    abstract：:The HMG-box protein 1 (HBP1) is a transcriptional regulator and a potential tumor suppressor that controls cell proliferation, differentiation and oncogene-mediated senescence. In a previous study, we showed that AKT activation through the PI3K/AKT/FOXO pathway represses HBP1 expression at the transcriptional level in...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2018.01.014

    authors： Bollaert E,Johanns M,Herinckx G,de Rocca Serra A,Vandewalle VA,Havelange V,Rider MH,Vertommen D,Demoulin JB

    更新日期：2018-04-01 00:00:00

  • Gax inhibits perivascular preadipocyte biofunction mediated by IGF-1 induced FAK/Pyk2 and ERK2 cooperative pathways.

    abstract：:Perivascular adipocyte (PVAC) biofunctions were closely related to cardiovascular diseases; its specific biological mechanisms remained unclear. How to adjust PVAC functions of vascular cells is an important topic. The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways partic...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.09.017

    authors： Liu P,Feng J,Kong F,Lu Q,Xu H,Meng J,Jiang Y

    更新日期：2014-12-01 00:00:00

  • Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells.

    abstract：:SCF induces autophosphorylation of Kit and activates a variety of signaling components including Jnks, Erks, PI 3 Kinase, the JAK-Stat pathway and members of the Src family. Previously we showed that Lyn is activated at multiple points during SCF-induced cell cycle progression and contributes to SCF-mediated growth, c...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2004.06.004

    authors： Shivakrupa R,Linnekin D

    更新日期：2005-01-01 00:00:00

  • Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brain.

    abstract：:NO-sensitive guanylyl cyclase (GC) acts as the effector molecule for NO and therefore plays a key role in the NO/cGMP signalling cascade. Besides the long known GC isoform (alpha(1)beta(1)), another heterodimer (alpha(2)beta(1)) has recently been identified to be associated with PSD-95 in brain.Here, we report on the ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(02)00078-5

    authors： Mergia E,Russwurm M,Zoidl G,Koesling D

    更新日期：2003-02-01 00:00:00

  • Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway.

    abstract：:It has been widely reported that exosomes derived from mesenchymal stem cells (MSCs) have a protective effect on myocardial infarction (MI). However, the specific molecules which play a damaging role in MSCs shuttled miRNAs are much less explored. MiRNA-153-3p (miR-153-3p) is a vital miRNA which has been proved to mod...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109812

    authors： Ning W,Li S,Yang W,Yang B,Xin C,Ping X,Huang C,Gu Y,Guo L

    更新日期：2021-01-01 00:00:00

  • CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation.

    abstract：:Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1α, the inducible subunit of HIF-1 is regulated by oxygen as well as by oxygen-independent mechanisms involving phosphorylation. We have previously shown that C...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2015.02.017

    authors： Kourti M,Ikonomou G,Giakoumakis NN,Rapsomaniki MA,Landegren U,Siniossoglou S,Lygerou Z,Simos G,Mylonis I

    更新日期：2015-06-01 00:00:00

  • Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin α(5)β(1)/α(v)β(3)-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells.

    abstract：:The activity of matrix metalloproteinases (MMPs), which selectively degrades the extracellular matrix (ECM), is critical in angiogenesis. Conversely, changes in ECM composition/structure alter the expression and activity of MMPs in various cell types. In the present study, we examined whether changes in ECM compositio...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2010.08.012

    authors： Jin YJ,Park I,Hong IK,Byun HJ,Choi J,Kim YM,Lee H

    更新日期：2011-01-01 00:00:00

  • c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

    abstract：:Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been proposed that the RING fi...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.08.008

    authors： Wiggins CM,Band H,Cook SJ

    更新日期：2007-12-01 00:00:00

  • MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells.

    abstract：:In more than 90% of cancers including glioma, telomere elongation reverse transcriptase (hTERT) is overexpressed. In the present study, we sought to explore whether matrix metalloproteinase-9 (MMP-9) shRNA could alter hTERT-mediated proliferation in glioma cells. MMP-9 shRNA induced senescence and apoptosis in glioma ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.08.001

    authors： Ponnala S,Chetty C,Veeravalli KK,Dinh DH,Klopfenstein JD,Rao JS

    更新日期：2011-12-01 00:00:00

  • Activation of MAP kinases in growth responsive pancreatic cancer cells.

    abstract：:The implication of MAP kinases in the proliferation control of pancreatic cancer cells is still unknown. This study was undertaken to examine the contribution of the p44/p42 and p38 MAP kinases in the mitogenic response to epidermal growth factor (EGF) and bombesin in human pancreatic cancer cells, MIA PaCa-2 and PANC...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(99)00030-3

    authors： Douziech N,Calvo E,Lainé J,Morisset J

    更新日期：1999-08-01 00:00:00

  • Mechanism of induction of muscle protein degradation by angiotensin II.

    abstract：:Angiotensin I and II have been shown to directly induce protein degradation in skeletal muscle through an increased activity and expression of the ubiquitin-proteasome proteolytic pathway. This investigation determines the role of the nuclear transcription factor nuclear factor-kappaB (NF-kappaB) in this process. Usin...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.09.009

    authors： Russell ST,Wyke SM,Tisdale MJ

    更新日期：2006-07-01 00:00:00

  • Cot/Tpl2 and PKCzeta cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain.

    abstract：:Nuclear factor of activated T cells (NFAT) plays a prominent role in gene transcription during the immune response. Growing evidence demonstrates the implication of inducible phosphorylation of the transactivation domain (TAD) of NFAT in transcriptional activation of genes. We have analyzed the regulation of NFATc2 ac...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.02.010

    authors： Gómez-Casero E,San-Antonio B,Iñiguez MA,Fresno M

    更新日期：2007-08-01 00:00:00

  • Protein kinase C-alpha and -beta play antagonistic roles in the differentiation process of THP-1 cells.

    abstract：:The roles of protein kinase C (PKC) isoenzymes in the differentiation process of THP-1 cells are investigated. Inhibition of PKC by RO 31-8220 reduces the phagocytosis of latex particles and the release of superoxide, prostaglandin E(2) (PGE(2)), and tumour necrosis factor (TNF)-alpha. The proliferation of THP-1 cells...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(00)00069-3

    authors： Dieter P,Schwende H

    更新日期：2000-05-01 00:00:00

  • TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration.

    abstract：:Through diametric actions, the transforming growth factor beta (TGFbeta) and Angiotensin II (AngII) play important roles in regulating various biological responses such as cell proliferation and migration. Signaling initiated by TGFbeta and AngII occurs through two structurally and functionally distinct receptor super...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.01.037

    authors： Guo J,Chen H,Ho J,Mancini J,Sontag T,Laporte SA,Richard DE,Lebrun JJ

    更新日期：2009-06-01 00:00:00

  • Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα.

    abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor family and plays key roles in glucose and lipid metabolism. Its transcriptional control of target genes is mediated by ligand-dependent recruitment of coactivators. In this study, we demonstrate that a novel transcriptional modula...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.11.035

    authors： Choi JS,Choi SS,Kim ES,Seo YK,Seo JK,Kim EK,Suh PG,Choi JH

    更新日期：2015-03-01 00:00:00

  • Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling.

    abstract：:The ectodomain of TOLL-like receptors (TLR) is highly glycosylated with several N-linked gylcosylation sites located in the inner concave surface. The precise role of these sugar N-glycans in TLR receptor activation is unknown. Recently, we have shown that Neu1 sialidase and not Neu2, -3 and -4 forms a complex with TL...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.09.038

    authors： Amith SR,Jayanth P,Franchuk S,Finlay T,Seyrantepe V,Beyaert R,Pshezhetsky AV,Szewczuk MR

    更新日期：2010-02-01 00:00:00

  • Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth.

    abstract：:Netrin-1 attracts or repels growing axons during development. The UNC5 receptors mediate the repulsive response, either alone or in complex with DCC receptors. The signaling mechanisms activated by UNC5 are poorly understood. Here, we examined the role of Rho GTPases in UNC5a signaling. We found that UNC5a induced neu...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.09.004

    authors： Picard M,Petrie RJ,Antoine-Bertrand J,Saint-Cyr-Proulx E,Villemure JF,Lamarche-Vane N

    更新日期：2009-12-01 00:00:00

  • Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase.

    abstract：:We examined the involvement of cAMP-dependent protein kinase (A kinase)2 in the inhibition by cilostamide, a specific inhibitor of the low Km cAMP-phosphodiesterase (PDE), on 9,11-epithio-11,12-methanothromboxane A2 (STA2)-induced platelet aggregation. For comparative purposes, the PGE1 analogue, 17S-20-dimethyl-trans...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(92)90039-b

    authors： Nishikawa M,Komada F,Morita K,Deguchi K,Shirakawa S

    更新日期：1992-07-01 00:00:00

  • PTH and PTHrP signaling in osteoblasts.

    abstract：:The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old player...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2009.02.012

    authors： Datta NS,Abou-Samra AB

    更新日期：2009-08-01 00:00:00

  • Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.

    abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinas...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109842

    authors： Kaur H,Moreau R

    更新日期：2021-02-01 00:00:00

  • Lateral mobility of tetramethylrhodamine (TMR) labelled G protein alpha and beta gamma subunits in NG 108-15 cells.

    abstract：:Multi-step signal transducing events, such as those mediated by G proteins, have been difficult to study in intact cells. We prepared fluorescently labelled G protein subunits, tetramethylrhodamine-alpha o (TMR-alpha o) and TMR-beta gamma, in order to study their subcellular distribution and lateral mobility. Heterotr...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(94)90049-3

    authors： Kwon G,Axelrod D,Neubig RR

    更新日期：1994-08-01 00:00:00

  • NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

    abstract：:Ubiquitination controls multiple cellular processes relevant to cancer pathogenesis. Using Gene Set Enrichment Analysis of an mRNA transcriptome dataset, we have identified genes encoding components of the ubiquitin system that are differentially expressed in colorectal cancers as compared to normal colonic mucosa. Am...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2012.08.012

    authors： Eide PW,Cekaite L,Danielsen SA,Eilertsen IA,Kjenseth A,Fykerud TA,Ågesen TH,Bruun J,Rivedal E,Lothe RA,Leithe E

    更新日期：2013-01-01 00:00:00

  • The effect of lentivirus-mediated SIRT1 gene knockdown in the ATDC5 cell line via inhibition of the Wnt signaling pathway.

    abstract：:SIRT1 is a highly conserved type III acetyltransferase gene located on chromosome 10 in mammals that belong to the Sirtuins family. In order to explore the effects of the SIRT1 gene in the ATDC5 cell line, an RNAi SIRT1 target sequence was designed and synthesized, aimed to knockdown the expression of SIRT1 in ATDC5 b...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2018.09.016

    authors： Yu F,Yuan Y,Li D,Kou Y,Jiang B,Zhang P

    更新日期：2019-01-01 00:00:00

  • Constitutive and regulated secretion of epidermal growth factor and transforming growth factor-beta1 in MDA-MB-231 breast cancer cell line in 11-day cultures.

    abstract：:Epidermal growth factor (EGF) and transforming growth factor type beta1 (TGF-beta1) exert opposite effects in most cells. A potential regulation between the two factors has been studied at a transcriptional level, but never at a protein level. MDA-MB-231 is a breast carcinoma cell line which possesses large quantities...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(99)00048-0

    authors： Martínez-Carpio PA,Mur C,Rosel P,Navarro MA

    更新日期：1999-10-01 00:00:00

  • The presence of phorbol ester responsive and non-responsive forms of the zeta isozyme of protein kinase C in mouse epidermal cells.

    abstract：:The possible involvement of zeta isozyme of protein kinase C (PKC zeta) in phorbol ester-induced signal transduction was investigated in mouse epidermal cells. Western blot analysis of RESOURCE Q column chromatography eluates obtained from 105,000 g supernatants and particulate fractions of epidermal cells was perform...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(95)00019-l

    authors： Nishikawa K,Yamamoto S,Nagumo H,Maruyama K,Kato R

    更新日期：1995-07-01 00:00:00

  • PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration.

    abstract：:Wnt5a, a non-transforming Wnt family member, plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in gastric cancer progression remains poorly defined. In this study, we found that Wnt5a dose-dependently stimulated the migration of human gastric cancer cells (SGC-7901), with the maxim...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2012.10.012

    authors： Liu J,Zhang Y,Xu R,Du J,Hu Z,Yang L,Chen Y,Zhu Y,Gu L

    更新日期：2013-02-01 00:00:00

  • Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.

    abstract：:Our previous oligonucleotide array studies revealed that ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL) express high levels of the disheveled proteins (Dvls), a family of proteins that is integral to the Wnt signaling pathways. In this study, we assessed whether the Dvls are important in the pathogenesis of ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2012.09.027

    authors： Hegazy SA,Alshareef A,Gelebart P,Anand M,Armanious H,Ingham RJ,Lai R

    更新日期：2013-01-01 00:00:00

  • TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD.

    abstract：:Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological ranges. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. The initia...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.12.009

    authors： Stokes A,Wakano C,Koblan-Huberson M,Adra CN,Fleig A,Turner H

    更新日期：2006-10-01 00:00:00

  • The regulation of cardiac activity by nitric oxide (NO) in the Vietnamese stick insect, Baculum extradentatum.

    abstract：:This study examines the role of the unconventional gaseous signaling molecule nitric oxide (NO) on the regulation of heart rate in the Vietnamese stick insect, Baculum extradentatum. Using nicotinamide dinucleotide hydrogen phosphate (NADPH)-diaphorase histochemistry, as well as immunohistochemistry and Western blotti...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2012.01.010

    authors： da Silva R,da Silva SR,Lange AB

    更新日期：2012-06-01 00:00:00

  • A caffeine/ryanodine-sensitive Ca2+ pool is involved in triggering spontaneous variations of Ca2+ in Jurkat T lymphocytes by a Ca(2+)-induced Ca2+ release (CICR) mechanism.

    abstract：:Caffeine and ryanodine triggered an increase in [Ca2+]i (73 +/- 22 and 61 +/- 18 nM, respectively) in Jurkat cell populations that was independent of external Ca2+. In individual cells, caffeine and ryanodine induced Ca2+ spikes. Jurkat cell populations initially exposed to caffeine did not respond further to ryanodin...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(96)00141-6

    authors： Ricard I,Martel J,Dupuis L,Dupuis G,Payet MD

    更新日期：1997-02-01 00:00:00