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The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation.

Abstract：

:Wnt3a activates proliferation of fibroblasts cells via activation of both extracellular signal-regulated kinase (ERK) and Wnt/beta-catenin signaling pathways. In this study, we show that the phosphatidyl inositol 3 kinases (PI3K)-Akt pathway is also involved in the Wnt3a-induced proliferation. Akt was activated within 30 min by Wnt3a in NIH3T3 cells. By Wnt3a treatment, activated Akt was transiently accumulated in nucleus although beta-catenin was accumulated in the nucleus of cells in a prolonged manner. The Wnt3a-induced Akt activation was not affected by siRNA-mediated reduction of beta-catenin, indicating that Wnt3a-induced Akt activation may occur independently of beta-catenin. The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K. The growth and proliferation induced by Wnt3a were blocked by treatments of the PI3K inhibitors. Furthermore, Wnt3a-induced proliferation was blocked by Akt siRNA. These results reveal that the PI3K-Akt pathway mediates the Wnt3a-induced growth and proliferation of NIH3T3 cells.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Kim SE,Lee WJ,Choi KY

doi

10.1016/j.cellsig.2006.08.008

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

511-8

issue

3

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(06)00194-X

journal_volume

19

pub_type

杂志文章

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