Abstract：
:The kidney is one of the fastest-aging organs, and renal senescence has become a major disease affecting human health. Renal cellular senescence is regulated by the joint action of multiple signal transduction pathways. The previous study by our research group found that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway was involved in angiotensin II (Ang II)-induced senescence of human glomerular mesangial cells. However, the unique role of STAT3 activation in Ang II-induced senescence of human glomerular mesangial cells and the underlying mechanisms remain unclear. The present study revealed that Ang II induced premature senescence, promoted autophagy and activated oxidative stress responses in human glomerular mesangial cells. Autophagy mediates the senescence-inducing effect of Ang II on human glomerular mesangial cells. Inhibition of oxidative stress with N-acetylcysteine (NAC) or interference with STAT3/mechanistic target of rapamycin (mTOR) activity with S3I-201 or STAT3-siRNA suppressed autophagy to a certain extent, which was conducive to delaying the senescence of glomerular mesangial cells. The antioxidant probucol reduced autophagy in human glomerular mesangial cells and alleviated the aging process of these cells by regulating STAT3/mTOR. These findings identify a role of STAT3/mTOR-regulated autophagy in Ang II-induced senescence of human glomerular mesangial cells and may provide a theoretical basis for anti-senescence treatment in clinical practice.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Yang S,Sun D,Wang L,Wang X,Shi M,Jiang X,Gao Xdoi
10.1016/j.cellsig.2018.10.021subject
Has Abstractpub_date
2019-01-01 00:00:00pages
327-338eissn
0898-6568issn
1873-3913pii
S0898-6568(18)30270-5journal_volume
53pub_type
杂志文章abstract：:The Integrin-mediated cell adhesion to the extracellular matrix is implicated in the control of proliferation, survival, migration and differentiation of myoblasts. Focal adhesion kinase (FAK) mediates signals from Integrins and plays an essential role in myotube formation. Cdo forms a multiprotein complex that includ...
journal_title：Cellular signalling
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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doi：10.1016/j.cellsig.2013.08.002
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journal_title：Cellular signalling
pub_type： 杂志文章
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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doi：10.1016/0898-6568(91)90046-w
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journal_title：Cellular signalling
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doi：10.1016/j.cellsig.2006.12.005
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journal_title：Cellular signalling
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journal_title：Cellular signalling
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journal_title：Cellular signalling
pub_type： 杂志文章
doi：10.1016/j.cellsig.2011.04.008
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journal_title：Cellular signalling
pub_type： 杂志文章,评审
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