Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

abstract：:In eukaryotes, proper loading and activation of MCM helicase at chromosomal origins plays a central role in DNA replication. Activation of MCM helicase requires its association with CDC45-GINS complex, but the mechanism of how this complex activates MCM helicase is poorly understood. Here we identified SIK1 (salt-indu...

journal_title：Cellular signalling

authors： Joshi K,Shah VJ,Maddika S

更新日期：2016-12-01 00:00:00

abstract：:Reactive Oxygen Species (ROS) are crucial to multiple biological processes involved in the pathophysiology of inflammation, and are also involved in redox signaling responses. Although previous reports have described an association between oxidative events and the modulation of innate immunity, a role for redox signal...

journal_title：Cellular signalling

authors： Secchi C,Carta M,Crescio C,Spano A,Arras M,Caocci G,Galimi F,La Nasa G,Pippia P,Turrini F,Pantaleo A

更新日期：2015-04-01 00:00:00

abstract：:The effect of 5-hydroxytryptamine (5-HT) on phospholipase C (PLC)-mediated phosphoinositide (PI) hydrolysis and intracellular Ca2+ ([Ca2+]i) changes was investigated in canine cultured aorta smooth muscle cells (ASMCs). 5-HT-stimulated inositol phosphate (IP) accumulation was time and concentration dependent with a ha...

journal_title：Cellular signalling

authors： Chiu CT,Tsao HL,Fan LW,Wang CC,Chien CS,Yang CM

更新日期：1999-05-01 00:00:00

abstract：:alpha-Thrombin activates several G-proteins including members of the Gq, Gi, and G12/13 families, although the physiological importance of these proteins is still not completely understood. We specifically investigated the role of Gq alpha in modulating alpha-thrombin-induced mitogenesis. In Gqa1 cells, a stable cell ...

journal_title：Cellular signalling

authors： Gardner A,Phillips-Mason PJ,Raben DM,Baldassare JJ

更新日期：2002-06-01 00:00:00

abstract：:Transforming growth factory beta (TGF-beta) is a potent growth inhibitor of epithelial cells. One of the strategies used to elucidate the anti-proliferative mode of action of TGF-beta is to find out whether the receptor-generated signals interact with components of the basic machinery of the cell cycle. In this study ...

journal_title：Cellular signalling

authors： Landesman Y,Bringold F,Milne DD,Meek DW

更新日期：1997-05-01 00:00:00

abstract：:Differentiation of preadipocytes into adipocytes and the formation of the subsequent adipose tissue are critical for mammalian growth and development. The molecular mechanism relating to preadipocyte differentiation and adipogenesis from the perspective of miRNAs is not yet completely understood. Here we investigated ...

journal_title：Cellular signalling

authors： Chen C,Xiang H,Peng YL,Peng J,Jiang SW

更新日期：2014-06-01 00:00:00

abstract：:Measurements of prostaglandin E2 (PGE2)-induced adenylyl cyclase activity in membranes isolated from epididymal rat adipocytes revealed inhibition of cAMP production at low concentrations of PGE2 (less than 10 mM) and stimulation at higher concentrations. This biphasic effect of PGE2 was obtained when adenylyl cyclase...

journal_title：Cellular signalling

authors： Cohen-Luria R,Rimon G

更新日期：1992-05-01 00:00:00

abstract：:Mechanical stretch is an initial factor for cardiac hypertrophy in response to haemodynamic overload (high blood pressure). Stretch of cardiomyocytes activates second messengers such as phosphatidylinositol, protein kinase C, Raf-1 kinase and extracellular signal-regulated protein kinases (ERKs), which are involved in...

journal_title：Cellular signalling

authors： Yamazaki T,Komuro I,Yazaki Y

更新日期：1998-11-01 00:00:00

abstract：:Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activati...

journal_title：Cellular signalling

authors： Rochette-Egly C

更新日期：2003-04-01 00:00:00

abstract：:Two major physiological roles have been defined for zipper interacting protein kinase (ZIPK), regulation of apoptosis in non-muscle cells and regulation of Ca(2+) sensitization in smooth muscle. Although much attention has focused on the role of ZIPK in the regulation of apoptotic events, its roles in smooth muscle ar...

journal_title：Cellular signalling

authors： Haystead TA

更新日期：2005-11-01 00:00:00

abstract：:The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor alpha and estrogen receptor beta (ERalpha and ERbeta). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERalpha. Calmodulin contributes to the regulation of ...

journal_title：Cellular signalling

authors： Li L,Sacks DB

更新日期：2007-03-01 00:00:00

abstract：:We report on a novel method to monitor changes in intracellular cAMP concentration ([cAMP]i) within intact living cells using a chimeric fusion of the catalytic subunit of cAMP-dependent protein kinase to green fluorescent protein (PKAcat-GFP). In stably transfected unstimulated fibroblasts, fusion protein fluorescenc...

journal_title：Cellular signalling

authors： Almholt K,Tullin S,Skyggebjerg O,Scudder K,Thastrup O,Terry R

更新日期：2004-08-01 00:00:00

abstract：:Macropinocytosis is an actin-dependent endocytic mechanism mediating internalization of extracellular fluid and associated solutes into cells. The present study was designed to identify the specific protein kinase C (PKC) isoform(s) and downstream effectors regulating actin dynamics during macropinocytosis. We utilize...

journal_title：Cellular signalling

authors： Singla B,Lin HP,Ghoshal P,Cherian-Shaw M,Csányi G

更新日期：2019-01-01 00:00:00

abstract：:Calcineurin inhibitors such as cyclosporin A (CsA) and FK506 have been used in solid organ and hematopoietic stem cell transplantations to suppress immune function. However, these immunosuppresants are associated with severe endothelial dysfunction. We investigated whether CsA and FK506 induce endothelial dysfunction ...

journal_title：Cellular signalling

authors： Eguchi R,Kubo S,Ohta T,Kunimasa K,Okada M,Tamaki H,Kaji K,Wakabayashi I,Fujimori Y,Ogawa H

更新日期：2013-09-01 00:00:00

abstract：:The implication of MAP kinases in the proliferation control of pancreatic cancer cells is still unknown. This study was undertaken to examine the contribution of the p44/p42 and p38 MAP kinases in the mitogenic response to epidermal growth factor (EGF) and bombesin in human pancreatic cancer cells, MIA PaCa-2 and PANC...

journal_title：Cellular signalling

authors： Douziech N,Calvo E,Lainé J,Morisset J

更新日期：1999-08-01 00:00:00

abstract：:We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. While NPRL2 interacts with Rag GTPases, RagD in particular, to interfere with mTORC1 activity in amino acid sc...

journal_title：Cellular signalling

authors： Kwak SS,Kang KH,Kim S,Lee S,Lee JH,Kim JW,Byun B,Meadows GG,Joe CO

更新日期：2016-02-01 00:00:00

abstract：:Treatment of lucerne suspension culture cells with glycoprotein elicitor from the phytopathogenic fungus Verticillium albo-atrum R & B triggers Ca(2+)-mediated induction of antimicrobial secondary metabolites termed phytoalexins. The present study investigated the possible role of polyphosphoinositide signal transduct...

journal_title：Cellular signalling

authors： Walton TJ,Cooke CJ,Newton RP,Smith CJ

更新日期：1993-05-01 00:00:00

abstract：:Both canonical Wnt/beta-catenin and TGFbeta/Smad signaling pathways coordinately regulate pattern formation during embryogenesis as well as tumor progression. Evidence of cross-talk between these two pathways has been reported. Here we demonstrated that the Activin-like kinase 4 (Alk4)/Smad2 pathway facilitates the tr...

journal_title：Cellular signalling

authors： Hirota M,Watanabe K,Hamada S,Sun Y,Strizzi L,Mancino M,Nagaoka T,Gonzales M,Seno M,Bianco C,Salomon DS

更新日期：2008-09-01 00:00:00

abstract：:The mammalian target of rapamycin complex 1(mTORC1) integrates diverse signals to control cell growth, proliferation, survival, and metabolism. Role of reactive oxygen species (ROS) on mTORC1 signaling remains obscure and mechanisms through which ROS modulate mTORC1 are not known.We demonstrate that low doses ROS expo...

journal_title：Cellular signalling

authors： Li M,Zhao L,Liu J,Liu A,Jia C,Ma D,Jiang Y,Bai X

更新日期：2010-10-01 00:00:00

abstract：:A tight control of the machineries regulating membrane bending and actin dynamics is very important for the generation of membrane protrusions, which are crucial for cell migration and invasion. Protein/protein and protein/phosphoinositides complexes assemble and disassemble to coordinate these mechanisms, the scaffol...

journal_title：Cellular signalling

authors： Antoine M,Vandenbroere I,Ghosh S,Erneux C,Pirson I

更新日期：2020-09-01 00:00:00

abstract：:Cross-talk between nuclear receptors involved in the control of drug metabolism is being increasingly recognised as a source of drug side effects. Omeprazole is a well known activator of the aryl hydrocarbon receptor (AhR). We investigated the regulation of AhR by omeprazole-sulphide, a degradation metabolite of omepr...

journal_title：Cellular signalling

authors： Gerbal-Chaloin S,Pichard-Garcia L,Fabre JM,Sa-Cunha A,Poellinger L,Maurel P,Daujat-Chavanieu M

更新日期：2006-05-01 00:00:00

abstract：:Beyond its key role in the control of energy metabolism, insulin is also an important regulator of cell division and neoplasia. However, the molecular events involved in insulin-driven cell proliferation are not fully elucidated. Here, we show that the ubiquitin ligase Chfr, a checkpoint protein involved in G2/M trans...

journal_title：Cellular signalling

authors： Perdereau D,Cailliau K,Browaeys-Poly E,Lescuyer A,Carré N,Benhamed F,Goenaga D,Burnol AF

更新日期：2015-04-01 00:00:00

abstract：:Cannabinoids exert a variety of physiological and pharmacological responses in humans through interaction with specific cannabinoid receptors. Cannabinoid receptors described to date belong to the seven-transmembrane-domain receptor superfamily and are coupled through the inhibitory G(i) protein to adenylyl cyclase in...

journal_title：Cellular signalling

authors： Sánchez MG,Ruiz-Llorente L,Sánchez AM,Díaz-Laviada I

更新日期：2003-09-01 00:00:00

abstract：:Mycophenolic acid (MPA), widely used to prevent organ transplant rejection, may induce toxicity and impair function in beta-cells. Mechanisms of MPA-induced cell death have not been fully explored. In this study, we examined gene expression patterns in INS-1E cells and isolated primary rat islets following MPA treatme...

journal_title：Cellular signalling

authors： Park YJ,Ahn HJ,Kim YS,Cho Y,Joo DJ,Ju MK

更新日期：2010-11-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK)-dependent phosphorylation is an important regulator for cytosolic phospholipase A(2) (cPLA(2)). In this study, we found that the protein synthesis inhibitor cycloheximide can potentiate thapsigargin-induced arachidonic acid (AA) release concomitant with ERK phosphorylation f...

journal_title：Cellular signalling

authors： Lin WW,Hsu YW

更新日期：2000-07-01 00:00:00

abstract：:Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin. Here, we have foc...

journal_title：Cellular signalling

authors： Karger A,Fitzner B,Brock P,Sparmann G,Emmrich J,Liebe S,Jaster R

更新日期：2008-10-01 00:00:00

abstract：:We previously showed that protein kinase C (PKC) induces phosphatidylcholine-hydrolysing phospholipase D activation in osteoblast-like MC3T3-E1 cells and that tyrosine kinase is involved in this activation. Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, markedly enhanced the formation of choline indu...

journal_title：Cellular signalling

authors： Kozawa O,Suzuki A,Shinoda J,Oiso Y

更新日期：1995-03-01 00:00:00

abstract：:Cell surface receptors for high-density lipoprotein (HDL) on hepatocytes are major partners in the regulation of cholesterol homeostasis. We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ectopic F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13...

journal_title：Cellular signalling

authors： Malaval C,Laffargue M,Barbaras R,Rolland C,Peres C,Champagne E,Perret B,Tercé F,Collet X,Martinez LO

更新日期：2009-01-01 00:00:00

abstract：:High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic cancer. Emerging evidence suggests that tumor-associated macrophages (TAMs) play an immunosuppressive role in the tumor microenvironment and promote tumor growth, angiogenesis, and metastasis in ovarian cancer. Therefore, targeting TAMs in pati...

journal_title：Cellular signalling

authors： El-Arabey AA,Denizli M,Kanlikilicer P,Bayraktar R,Ivan C,Rashed M,Kabil N,Ozpolat B,Calin GA,Salama SA,Abd-Allah AR,Sood AK,Lopez-Berestein G

更新日期：2020-04-01 00:00:00

abstract：:Cardiac hypertrophy is accompanied by excessive collagen deposition in the heart. Despite painstaking research on this fatal disease, the precise role of molecular chaperones in myocardial fibrosis has not yet been elucidated. In this study, we have analyzed the mechanism by which Heat shock protein 90 (Hsp90)/Cell di...

journal_title：Cellular signalling

authors： Datta R,Bansal T,Rana S,Datta K,Chattopadhyay S,Chawla-Sarkar M,Sarkar S

更新日期：2015-12-01 00:00:00