5-Hydroxytryptamine-induced phosphoinositide hydrolysis and Ca2+ mobilisation in canine cultured aorta smooth muscle cells.

abstract：:Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibrotic factor, the role ...

journal_title：Cellular signalling

authors： Overstreet JM,Samarakoon R,Meldrum KK,Higgins PJ

更新日期：2014-07-01 00:00:00

abstract：:Neuro-2a (N2a) cells are derived from spontaneous neuroblastoma of mouse and capable to differentiate into neuronal-like cells. Recently, P2X7 receptor has been shown to sustain growth of human neuroblastoma cells but its role during neuronal differentiation remains unexamined.We characterized the role of P2X7 recepto...

journal_title：Cellular signalling

authors： Wu PY,Lin YC,Chang CL,Lu HT,Chin CH,Hsu TT,Chu D,Sun SH

更新日期：2009-06-01 00:00:00

abstract：:Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1, Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the mechanisms by which Akt isoforms are activated by growth factors and other extracellular stimuli as well as by oncogenic mutations in key upstrea...

journal_title：Cellular signalling

authors： Hers I,Vincent EE,Tavaré JM

更新日期：2011-10-01 00:00:00

abstract：:Heterotrimeric (alphabetagamma) G(s) mediates agonist-induced stimulation of adenylyl cyclase (AC). Cholera toxin (CTx) will ADP-ribosylate the alpha-subunit of G(s) (G(s)alpha). G(s)alpha-deficient cyc(-) membranes were "stripped" of Gbeta. When the stripped cyc(-) were incubated with G(s)alpha and/or Gbetagamma, eac...

journal_title：Cellular signalling

authors： Ganpat MM,Nishimura M,Toyoshige M,Okuya S,Pointer RH,Rebois RV

更新日期：2000-02-01 00:00:00

abstract：:We have compared a new commercially available non-radioactive protein kinase C (PKC) activity assay based on the fluorescent [A9,10K11]glycogen synthase1-11 analogue C1-peptide with a classical radioactive assay based on myelin basic protein4-14 (MBP4-14) and other substrates. The C1-peptide had lower affinity for PKC...

journal_title：Cellular signalling

authors： Erdbrügger W,Strohm P,Michel MC

更新日期：1995-08-01 00:00:00

abstract：:Adrenomedullin is a secreted peptide hormone with multiple functions. Although a number of reports have indicated that adrenomedullin may be involved in tumor progression, its mechanism of action remains obscure. In this study, we have analysed the signal transduction pathway activated by adrenomedullin in human gliom...

journal_title：Cellular signalling

authors： Ouafik L,Berenguer-Daize C,Berthois Y

更新日期：2009-04-01 00:00:00

abstract：:Recent global incidences and mortality rates have placed colorectal cancer (CRC) at third and second positions, respectively, among both sexes of all ages. Resistance during chemotherapy is a big problem in the treatment and disease-free survival of CRC patients. Discovery of new anticancer drug(s) is a time taking pr...

journal_title：Cellular signalling

authors： Dhiman DK,Sanyal SN,Vaish V

更新日期：2020-12-01 00:00:00

abstract：:Protein kinase C and the annexins appear to share some unusual and potentially important membrane- and calcium-binding properties. While these proteins are calcium response elements, they are not calcium-binding proteins in the formal sense; at intracellular calcium concentrations, they only bind significant amounts o...

journal_title：Cellular signalling

authors： Bazzi MD,Nelsestuen GL

更新日期：1993-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is involved in cell survival and proliferation and has been found to be persistently activated in most human cancers mainly through its phosphorylation at Tyr-705. However, the role and regulation of Stat3 Ser-727 phosphorylation...

journal_title：Cellular signalling

authors： Mandal T,Bhowmik A,Chatterjee A,Chatterjee U,Chatterjee S,Ghosh MK

更新日期：2014-08-01 00:00:00

abstract：:Calcineurin inhibitors such as cyclosporin A (CsA) and FK506 have been used in solid organ and hematopoietic stem cell transplantations to suppress immune function. However, these immunosuppresants are associated with severe endothelial dysfunction. We investigated whether CsA and FK506 induce endothelial dysfunction ...

journal_title：Cellular signalling

authors： Eguchi R,Kubo S,Ohta T,Kunimasa K,Okada M,Tamaki H,Kaji K,Wakabayashi I,Fujimori Y,Ogawa H

更新日期：2013-09-01 00:00:00

abstract：:Sustained activation of Akt kinase acts as a focal regulator to increase cell growth and survival, which causes tumorigenesis including breast cancer. Statins, potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, display anticancer activity. The molecular mechanisms by which statins block cancer cell ...

journal_title：Cellular signalling

authors： Ghosh-Choudhury N,Mandal CC,Ghosh-Choudhury N,Ghosh Choudhury G

更新日期：2010-05-01 00:00:00

abstract：:Strong evidence suggests that neutrophils may play an active role in acute and chronic inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. Given the role of pro-inflammatory cytokine TNF-alpha in these inflammatory processes, we planned the present study to investigate the effect of short term in...

journal_title：Cellular signalling

authors： Montecucco F,Steffens S,Burger F,Da Costa A,Bianchi G,Bertolotto M,Mach F,Dallegri F,Ottonello L

更新日期：2008-03-01 00:00:00

abstract：:Adenosine and its analogues inhibited increases in divalent cation influx stimulated by platelet-activating factor (PAF) and formyl-methionyl-leucyl-phenylalanine (FMLP) in a dose-dependent fashion. This effect was antagonized by theophylline, an adenosine receptor antagonist. When extracellular adenosine was removed ...

journal_title：Cellular signalling

authors： Tsuruta S,Ito S,Mikawa H

更新日期：1992-09-01 00:00:00

abstract：:In the canonical model of JAK/STAT signalling STAT transcription factors are activated by JAK mediated tyrosine phosphorylation following pathway stimulation by external cytokines. Activated STAT molecules then homo- or heterodimerise before translocating to the nucleus where they bind to DNA sequences within the prom...

journal_title：Cellular signalling

authors： Karsten P,Plischke I,Perrimon N,Zeidler MP

更新日期：2006-06-01 00:00:00

abstract：:Wnt5a, a non-transforming Wnt family member, plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in gastric cancer progression remains poorly defined. In this study, we found that Wnt5a dose-dependently stimulated the migration of human gastric cancer cells (SGC-7901), with the maxim...

journal_title：Cellular signalling

authors： Liu J,Zhang Y,Xu R,Du J,Hu Z,Yang L,Chen Y,Zhu Y,Gu L

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Our study aimed to study the role of lncRNA TP73-AS1/miR-539/MMP-8 axis in modulating M2 macrophage polarization in hepatocellular carcinoma (HCC). METHODS:The gene expression levels of TP73-AS1, miR-539 and MMP-8 were modified by transfection with the overexpression or knockdown vectors. The patient survival ...

journal_title：Cellular signalling

authors： Chen J,Huang ZB,Liao CJ,Hu XW,Li SL,Qi M,Fan XG,Huang Y

更新日期：2020-11-01 00:00:00

abstract：:The focal adhesion kinase Pyk2 integrates signals from cell adhesion receptors, growth factor receptors, and G-protein-coupled receptors leading to the activation of intracellular signaling pathways that regulate cellular phenotypes. The intrinsic mechanism for the activation of Pyk2 activity remains to be fully defin...

journal_title：Cellular signalling

authors： Riggs D,Yang Z,Kloss J,Loftus JC

更新日期：2011-01-01 00:00:00

abstract：:The upstream stimulatory factors 1 (USF1) and 2 (USF2) are transcription factors which bind to E-box motifs of various promoters regulating a variety of different cellular processes. Only little is known about the regulation of USFs. Here, we identified protein kinase CK2 as an enzyme that phosphorylates USF1 but not ...

journal_title：Cellular signalling

authors： Lupp S,Götz C,Khadouma S,Horbach T,Dimova EY,Bohrer AM,Kietzmann T,Montenarh M

更新日期：2014-12-01 00:00:00

abstract：:The stimulatory G protein (Gs) mediates activation of adenylylcyclase by a ligand-receptor complex. Gs is heterotrimeric (alpha beta gamma) and activation can be accomplished by dissociation of the alpha-subunit (Gs alpha) from the beta gamma-subunit complex (G beta gamma). Gs alpha is also a substrate for choleragen ...

journal_title：Cellular signalling

authors： Warner DR,Okuya S,Rebois RV

更新日期：1996-01-01 00:00:00

abstract：:Two major physiological roles have been defined for zipper interacting protein kinase (ZIPK), regulation of apoptosis in non-muscle cells and regulation of Ca(2+) sensitization in smooth muscle. Although much attention has focused on the role of ZIPK in the regulation of apoptotic events, its roles in smooth muscle ar...

journal_title：Cellular signalling

authors： Haystead TA

更新日期：2005-11-01 00:00:00

abstract：:Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been proposed that the RING fi...

journal_title：Cellular signalling

authors： Wiggins CM,Band H,Cook SJ

更新日期：2007-12-01 00:00:00

abstract：:In fura-2 loaded isolated mouse pancreatic acinar cells, xanthine oxidase (XOD)-catalyzed reactive oxygen species (ROS) generation caused an increase in the cytosolic Ca(2+) concentration ([Ca(2+)](i)) by release of Ca(2+) from intracellular stores. The ROS-induced Ca(2+) signals showed large variability in shape and ...

journal_title：Cellular signalling

authors： González A,Schmid A,Salido GM,Camello PJ,Pariente JA

更新日期：2002-02-01 00:00:00

abstract：:Dissemination of cancer cells to distant organ sites is the leading cause of death due to treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the importance of the development of inappropriate cell survival signaling for various steps in the metastatic process and have noted the particula...

journal_title：Cellular signalling

authors： Agarwal E,Brattain MG,Chowdhury S

更新日期：2013-08-01 00:00:00

abstract：:Octimibate and related nonprostanoid prostacyclin mimetics are partial agonists displaying highly tissue-specific responses. Octimibate demonstrated considerably greater efficacy for stimulation of adenylyl cyclase activity in Chinese hamster ovary cells transiently expressing mouse prostacyclin receptors (mIP-CHO cel...

journal_title：Cellular signalling

authors： Kam Y,Chow KB,Wise H

更新日期：2001-11-01 00:00:00

abstract：:Beyond its key role in the control of energy metabolism, insulin is also an important regulator of cell division and neoplasia. However, the molecular events involved in insulin-driven cell proliferation are not fully elucidated. Here, we show that the ubiquitin ligase Chfr, a checkpoint protein involved in G2/M trans...

journal_title：Cellular signalling

authors： Perdereau D,Cailliau K,Browaeys-Poly E,Lescuyer A,Carré N,Benhamed F,Goenaga D,Burnol AF

更新日期：2015-04-01 00:00:00

abstract：:Although the antiviral actions of interferons (IFNs) are observed in most types of cells, the antiproliferative effects of IFNalpha/beta are variable as are the mechanisms of growth inhibition that may or may not be due to the induction of apoptosis. To understand more about the mechanisms that are responsible for IFN...

journal_title：Cellular signalling

authors： Gamero AM,Potla R,Sakamoto S,Baker DP,Abraham R,Larner AC

更新日期：2006-08-01 00:00:00

abstract：:Interleukin-1 (IL-1) is the major prototypic proinflammatory cytokine that stimulates degradation of cartilage in arthritis by inducing prominent collagen II-degrading matrix metalloproteinase-13 (MMP-13). Nothing is known about the involvement of adaptor proteins, MyD88, IRAK1 and TRAF6 in MMP-13 regulation. Here we ...

journal_title：Cellular signalling

authors： Ahmad R,Sylvester J,Zafarullah M

更新日期：2007-12-01 00:00:00

abstract：:Synthesis and degradation of lipids in mammalian adipocytes are tightly and coordinatedly regulated by insulin, fatty acids, reactive oxygen species and drugs. Conversely, the lipogenic or lipolytic state of adipocytes is communicated to other tissues by the secretion of soluble adipocytokines. Here we report that ins...

journal_title：Cellular signalling

authors： Müller G,Jung C,Straub J,Wied S,Kramer W

更新日期：2009-02-01 00:00:00

abstract：:Hepatocyte membranes from both lean and obese Zucker rats exhibited adenylate cyclase activity that could be stimulated by glucagon, forskolin, NaF and elevated concentrations of p[NH]ppG. In membranes from lean animals, functional Gi was detected by the ability of low concentrations of p[NH]ppG to inhibit forskolin-a...

journal_title：Cellular signalling

authors： Houslay MD,Gawler DJ,Milligan G,Wilson A

更新日期：1989-01-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) is reported to regulate cell proliferation, survival, and differentiation, and thus plays a central role in development and carcinogenesis. Accumulating evidence demonstrated the involvement of cellular Src (c-Src) tyrosine kinase in the activation of STAT3....

journal_title：Cellular signalling

authors： Wang Y,Liu S,Jiang G,Zhai W,Yang L,Li M,Chang Z,Zhu B

更新日期：2020-11-01 00:00:00