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Insulin-induced cell division is controlled by the adaptor Grb14 in a Chfr-dependent manner.

Abstract：

:Beyond its key role in the control of energy metabolism, insulin is also an important regulator of cell division and neoplasia. However, the molecular events involved in insulin-driven cell proliferation are not fully elucidated. Here, we show that the ubiquitin ligase Chfr, a checkpoint protein involved in G2/M transition, is a new effector involved in the control of insulin-induced cell proliferation. Chfr is identified as a partner of the molecular adapter Grb14, an inhibitor of insulin signalling. Using mammalian cell lines and the Xenopus oocyte as a model of G2/M transition, we demonstrate that Chfr potentiates the inhibitory effect of Grb14 on insulin-induced cell division. Insulin stimulates Chfr binding to the T220 residue of Grb14. Both Chfr binding site and Grb14 C-ter BPS-SH2 domain, mediating IR binding and inhibition, are required to prevent insulin-induced cell division. Targeted mutagenesis revealed that Chfr ligase activity and phosphorylation of its T39 residue, a target of Akt, are required to potentiate Grb14 inhibitory activity. In the presence of insulin, the binding of Chfr to Grb14 activates its ligase activity, leading to Aurora A and Polo-like kinase degradation and blocking cell division. Collectively, our results show that Chfr and Grb14 collaborate in a negative feedback loop controlling insulin-stimulated cell division.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Perdereau D,Cailliau K,Browaeys-Poly E,Lescuyer A,Carré N,Benhamed F,Goenaga D,Burnol AF

doi

10.1016/j.cellsig.2015.01.003

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

798-806

issue

4

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(15)00005-4

journal_volume

27

pub_type

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