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Effects of ionizing radiation and caffeine treatment on cyclin dependent kinase complexes in V79 hamster cells.

Abstract：

:Exponentially growing V79 Chinese hamster lung fibroblasts irradiated with 7 Gy X-rays undergo cell cycle arrest in the S and G2 phases. These arrests are released, probably on completion of DNA repair. A premature release occurs after treatment of irradiated cells with caffeine. This release is accompanied by increased activity of the p34cdc2 serine/threonine protein kinase complex [Hain et al. (1993) Cancer Res. 53, 1507-1510]. We have investigated in V79 cells whether the association of p34cdc2 with its regulatory subunits cyclin A and B is affected by irradiation and subsequent caffeine treatment and found that this was not the case. The phosphorylation of p34cdc2 as assayed by mobility shift on SDS polyacrylamide gels was increased as early as 0.5 h after irradiation and decreased after subsequent caffeine treatment. A novel protein p40, detected with anti-PSTAIRE antibodies, appeared several fold more abundant than p34cdc2. Its phosphorylation state also changed after irradiation and after subsequent caffeine treatment.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Hain J,Jaussi R,Würgler FE

doi

10.1016/0898-6568(94)90008-6

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

539-50

issue

5

eissn

0898-6568

issn

1873-3913

pii

0898-6568(94)90008-6

journal_volume

6

pub_type

杂志文章

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