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The miR-29b-Sirt1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species.

Abstract：

:Endogenous reactive oxygen species (ROS) control is important for the maintenance of self-renewal of embryonic stem (ES) cells. Although miRNAs have been found to be critically involved in the regulation of the self-renewal, whether miRNAs can regulate the signaling axis to control ROS in ES cells is unclear. Here we show that miR-29b specifically regulates the self-renewal of mouse ES cells in response to ROS generated by antioxidant-free culture. Sirt1 is the direct target of miR-29b and can also make mES cells sensitive to ROS and regulate the self-renewal of mES cells during the response of ROS. We further found that Sirt1 could attenuate the miR-29b function in regulating mES cells' self-renewal in response to ROS. Our results determined that miR-29b-Sirt1 axis regulates self-renewal of mES cells in response to ROS.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Xu Z,Zhang L,Fei X,Yi X,Li W,Wang Q

doi

10.1016/j.cellsig.2014.03.010

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1500-5

issue

7

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(14)00103-X

journal_volume

26

pub_type

杂志文章

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