Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB.


:The TAK1 plays a pivotal role in the innate immune response of Drosophila by controlling the activation of JNK and NF-kappaB. Activation of TAK1 in mammals is mediated by two TAK1-binding proteins, TAB1 and TAB2, but the role of the TAB proteins in the immune response of Drosophila has not yet been established. Here, we report the identification of a TAB2-like protein in Drosophila called dTAB2. dTAB2 can interact with dTAK1, and stimulate the activation of the JNK and NF-kB signaling pathway. Furthermore, we have found that silencing of dTAB2 expression by dsRNAi inhibits JNK activation by peptidoglycans (PGN), but not by NaCl or sorbitol. In addition, suppression of dTAB2 blocked PGN-induced expression of antibacterial peptide genes, a function normally mediated by the activation of NF-kappaB signaling pathway. No significant effect on p38 activation by dTAB2 was found. These results suggest that dTAB2 is specifically required for PGN-induced activation of JNK and NF-kappaB signaling pathways.


Cell Signal


Cellular signalling


Zhuang ZH,Sun L,Kong L,Hu JH,Yu MC,Reinach P,Zang JW,Ge BX




Has Abstract


2006-07-01 00:00:00














  • Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation.

    abstract::Neuroprotective effects of alpha(2)-adrenergic receptor (AR) agonists are mediated via the alpha(2A)AR subtype, but the molecular mechanisms underlying these actions are still not elucidated. A two-hybrid screen was performed to identify new proteins that may control alpha(2)AR receptor function and trafficking. This ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Weber B,Schaper C,Wang Y,Scholz J,Bein B

    更新日期:2009-10-01 00:00:00

  • Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

    abstract::Microglia play a prominent role in the brain's inflammatory response to injury or infection by migrating to affected locations, secreting inflammatory molecules, and phagocytosing damaged tissue. However, because severe or chronic neuroinflammation exacerbates many neurological conditions, controlling microglia action...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Yuskaitis CJ,Jope RS

    更新日期:2009-02-01 00:00:00

  • Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells.

    abstract::In Galpha(z)-deficient mice, survival of sympathetic neurons is significantly attenuated in the presence of pertussis toxin (PTX). This suggests that G(i/o) proteins may have distinct roles in neuronal survival. Here, we investigated the possible involvement of G(i/o) proteins in nerve growth factor (NGF)-induced pro-...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Wu EH,Wong YH

    更新日期:2005-07-01 00:00:00

  • Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.

    abstract::The endogenous circadian clock functions to maintain optimal physiological health through the tissue specific coordination of gene expression and synchronization between tissues of metabolic processes throughout the 24 hour day. Individuals face numerous challenges to circadian function on a daily basis resulting in s...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Parnell AA,De Nobrega AK,Lyons LC

    更新日期:2020-12-25 00:00:00

  • Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

    abstract::Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and psoriatic arthritis. However, little is known on the expression patter...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

    更新日期:2016-07-01 00:00:00

  • Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells.

    abstract::Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin. Here, we have foc...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Karger A,Fitzner B,Brock P,Sparmann G,Emmrich J,Liebe S,Jaster R

    更新日期:2008-10-01 00:00:00

  • Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding.

    abstract::Members of the phosducin gene family were initially proposed to act as down-regulators of G protein signaling by binding G protein betagamma dimers (Gbetagamma) and inhibiting their ability to interact with G protein alpha subunits (Galpha) and effectors. However, recent findings have over-turned this hypothesis by sh...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Willardson BM,Howlett AC

    更新日期:2007-12-01 00:00:00

  • Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus.

    abstract::Agonist stimulation of G-protein coupled receptors (GPCRs) results in the redistribution of the receptor from the cell surface into intracellular compartments through the process of endocytosis. Monitoring ligand-mediated internalization of GPCRs in living cells has become experimentally accessible by applying fluores...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Böhme I,Stichel J,Walther C,Mörl K,Beck-Sickinger AG

    更新日期:2008-10-01 00:00:00

  • Cyclic AMP modulates interleukin-1 action in a cytotoxic T-cell hybridoma.

    abstract::The induction of cytolytic activity in PC60, a murine T-cell hybridoma, is paralleled by a rise in the level of BLT-esterase (N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl esterase), a serine esterase specific for activated T-cells. Both interleukin-1 (IL-1) and dibutyryl cAMP were albe to increase the esterase activi...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Schlegel-Haueter SE,Aebischer F

    更新日期:1990-01-01 00:00:00

  • Calcium, calmodulin and cell cycle progression.

    abstract::Proliferation of mammalian cells both in vivo and in vitro is dependent upon physiological concentrations of extracellular Ca2+. Growth factor stimulation of quiescent cells at the G0/G1 border usually results in a rapid mobilization of Ca2+ from both intra- and extracellular pools. However, Ca2+ influx is also requir...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Takuwa N,Zhou W,Takuwa Y

    更新日期:1995-02-01 00:00:00

  • Protein kinase A downregulates the phosphorylation of p47 phox in human neutrophils: a possible pathway for inhibition of the respiratory burst.

    abstract::Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A(PKA) is considered to be a physiologic modulator of superoxide generation by stimulated neutrophils. Mechanisms of the inhibitory action of PKA are poorly understood. In this study, we investigated effects of cAMP-elevating agents on the phosphorylation ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Bengis-Garber C,Gruener N

    更新日期:1996-06-01 00:00:00

  • Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.

    abstract::Recent reports show that protein kinase A (PKA), but not exchange protein activated by cAMP (EPAC), acts in a cell autonomous manner to constitutively reduce the angiogenic sprouting capacity of murine and human endothelial cells. Specificity in the cellular actions of individual cAMP-effectors can be achieved when a ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: MacKeil JL,Brzezinska P,Burke-Kleinman J,Theilmann AL,Nicol CJB,Ormiston ML,Maurice DH

    更新日期:2019-10-01 00:00:00

  • Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid induction of the grp78 gene in 9L rat brain tumour cells.

    abstract::The glucose-regulated protein grp78 gene is rapidly transactivated in 9L rat brain tumour (RBT) cells treated with okadaic acid (OA) followed by heat shock (HS) (termed OA-->HS treatment). By Northern blotting analyses and transient transfection assays, we herein show that transactivation of grp78 by OA-->HS is abolis...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Chang WM,Chen KD,Chen LY,Lai MT,Lai YK

    更新日期:2003-01-01 00:00:00

  • Gbetagamma subunit combinations differentially modulate receptor and effector coupling in vivo.

    abstract::In vitro, little specificity is seen for modulation of effectors by different combinations of Gbetagamma subunits from heterotrimeric G proteins. Here, we demonstrate that the coupling of specific combinations of Gbetagamma subunits to different receptors leads to a differential ability to modulate effectors in vivo. ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Robillard L,Ethier N,Lachance M,Hébert TE

    更新日期:2000-10-01 00:00:00

  • Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.

    abstract::In this study, we demonstrate that EGF inhibits the TGF-β1-induced apoptosis of Huh7 cells. TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway. TGF-β1 also inhibits the activation of S6 kinase 1 which phosphorylates the serine 67 res...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Matsuhashi S,Hamajima H,Xia J,Zhang H,Mizuta T,Anzai K,Ozaki I

    更新日期:2014-03-01 00:00:00

  • RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes.

    abstract::Cell surface receptors for high-density lipoprotein (HDL) on hepatocytes are major partners in the regulation of cholesterol homeostasis. We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ectopic F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Malaval C,Laffargue M,Barbaras R,Rolland C,Peres C,Champagne E,Perret B,Tercé F,Collet X,Martinez LO

    更新日期:2009-01-01 00:00:00

  • Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 70 kDa' inhibitors: a review.

    abstract::Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T cells. Its role in T-cell development has been established by the severe combined immune deficiency syndrome in ZAP-70 deficient human...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Kaur M,Singh M,Silakari O

    更新日期:2014-11-01 00:00:00

  • Protein kinase C and annexins: unusual calcium response elements in the cell.

    abstract::Protein kinase C and the annexins appear to share some unusual and potentially important membrane- and calcium-binding properties. While these proteins are calcium response elements, they are not calcium-binding proteins in the formal sense; at intracellular calcium concentrations, they only bind significant amounts o...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Bazzi MD,Nelsestuen GL

    更新日期:1993-07-01 00:00:00

  • Bacillus spore germination: Knowns, unknowns and what we need to learn.

    abstract::How might a microbial cell that is entirely metabolically dormant - and which has the ability to remain so for extended periods of time - irreversibly commit itself to resuming vegetative growth within seconds of being exposed to certain amino acids or sugars? That this process takes place in the absence of any detect...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Christie G,Setlow P

    更新日期:2020-10-01 00:00:00

  • The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice.

    abstract::It is well established that the IFN-gamma/STAT1 pathway plays an important role in the pancreatic beta-cell apoptosis that is observed in STZ-induced type 1 diabetes; however, the upstream regulatory proteins involved have not been understood. Here, we investigated whether activating transcription factor 3 (ATF3) affe...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Kim JY,Song EH,Lee S,Lim JH,Choi JS,Koh IU,Song J,Kim WH

    更新日期:2010-11-01 00:00:00

  • Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor: independent modulation of TPalpha signaling by prostacyclin and nitric oxide.

    abstract::In humans, thromboxane (TX) A(2) signals through the TPalpha and TPbeta isoforms of the TXA(2) receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cbeta signaling by TPalpha is directly inhibited by the vasodilators prostacyclin and nitric oxide (NO) whereas that signaling by TPbeta is u...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Wikström K,Kavanagh DJ,Reid HM,Kinsella BT

    更新日期:2008-08-01 00:00:00

  • IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.

    abstract::A tight control of the machineries regulating membrane bending and actin dynamics is very important for the generation of membrane protrusions, which are crucial for cell migration and invasion. Protein/protein and protein/phosphoinositides complexes assemble and disassemble to coordinate these mechanisms, the scaffol...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Antoine M,Vandenbroere I,Ghosh S,Erneux C,Pirson I

    更新日期:2020-09-01 00:00:00

  • The functions of mechanosensitive ion channels in tooth and bone tissues.

    abstract::Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thu...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Pei F,Liu J,Zhang L,Pan X,Huang W,Cen X,Huang S,Jin Y,Zhao Z

    更新日期:2021-02-01 00:00:00

  • Factors affecting prostacyclin receptor agonist efficacy in different cell types.

    abstract::Octimibate and related nonprostanoid prostacyclin mimetics are partial agonists displaying highly tissue-specific responses. Octimibate demonstrated considerably greater efficacy for stimulation of adenylyl cyclase activity in Chinese hamster ovary cells transiently expressing mouse prostacyclin receptors (mIP-CHO cel...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Kam Y,Chow KB,Wise H

    更新日期:2001-11-01 00:00:00

  • Detection of calmodulin-binding proteins and calmodulin-dependent phosphorylation linked to calmodulin-dependent chemotaxis to folic and cAMP in Dictyostelium.

    abstract::Calmodulin (CaM) antagonists, trifluoperazine (TFP) or calmidazolium (R24571), dose-dependently inhibited cAMP and folic acid (FA) chemotaxis in Dictyostelium. Developing, starved, and refed cells were compared to determine if certain CaM-binding proteins (CaMBPs) and CaM-dependent phosphorylation events could be iden...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Gauthier ML,O'Day DH

    更新日期:2001-08-01 00:00:00

  • Promyogenic function of Integrin/FAK signaling is mediated by Cdo, Cdc42 and MyoD.

    abstract::The Integrin-mediated cell adhesion to the extracellular matrix is implicated in the control of proliferation, survival, migration and differentiation of myoblasts. Focal adhesion kinase (FAK) mediates signals from Integrins and plays an essential role in myotube formation. Cdo forms a multiprotein complex that includ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Han JW,Lee HJ,Bae GU,Kang JS

    更新日期:2011-07-01 00:00:00

  • Thyroid hormone inhibits TGFβ1 induced renal tubular epithelial to mesenchymal transition by increasing miR34a expression.

    abstract::The interactions between kidney and thyroid functions have been known for many years, but how the thyroid affects the kidney function is largely unknown. Here we analyzed the role of T3 on the tubular epithelial-to-mesenchymal transition (EMT), which is recognized to play pivotal roles in the process of renal fibrosis...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Lu X,Chen Z,Liang H,Li Z,Zou X,Luo H,Guo W,Xu L

    更新日期:2013-10-01 00:00:00

  • Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system.

    abstract::Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in ma...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Okada T,Kajimoto T,Jahangeer S,Nakamura S

    更新日期:2009-01-01 00:00:00

  • Function and evolution of ubiquitous bacterial signaling adapter phosphopeptide recognition domain FHA.

    abstract::Forkhead-associated domain (FHA) is a phosphopeptide recognition domain embedded in some regulatory proteins. With similar fold type to important eukaryotic signaling molecules such as Smad2 and IRF3, the role of bacterial FHA domain is intensively pursued. Reported bacterial FHA domain roles include: regulation of gl...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Weiling H,Xiaowen Y,Chunmei L,Jianping X

    更新日期:2013-03-01 00:00:00

  • Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.

    abstract::We previously showed that activated peroxisome proliferator-activated receptor (PPAR)β/δ can protect pancreatic β cells against lipotoxic apoptosis. However, the molecular mechanism remained unclear. Glucagon-like peptide-1 receptor (GLP-1R) has been reported to exhibit a protective effect against lipotoxic apoptosis ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Yang Y,Tong Y,Gong M,Lu Y,Wang C,Zhou M,Yang Q,Mao T,Tong N

    更新日期:2014-02-01 00:00:00