Regulation of acetylcholine receptor desensitization in mouse myotubes by cytosolic cyclic AMP.

abstract：:Long-term amino acid starvation represents a form of metabolic stress which stimulates gene expression. Here we report that depriving HeLa cells for any one of a series of amino acids activates c-Jun N-terminal kinase-1 (JNK-1). In contrast, the other mitogen-activated protein kinases (MAPKs) ERK-1 and, to a lesser ex...

journal_title：Cellular signalling

authors： Aubel C,Dehez S,Chabanon H,Seva C,Ferrara M,Brachet P

更新日期：2001-06-01 00:00:00

abstract：:Mechanical stretch is an initial factor for cardiac hypertrophy in response to haemodynamic overload (high blood pressure). Stretch of cardiomyocytes activates second messengers such as phosphatidylinositol, protein kinase C, Raf-1 kinase and extracellular signal-regulated protein kinases (ERKs), which are involved in...

journal_title：Cellular signalling

authors： Yamazaki T,Komuro I,Yazaki Y

更新日期：1998-11-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targete...

journal_title：Cellular signalling

authors： Wu G,Weng W,Xia P,Yan S,Zhong C,Xie L,Xie Y,Fan G

更新日期：2021-03-01 00:00:00

abstract：:Leptin, the adipocyte-secreted hormone that centrally regulates weight control, is known to function as an immunomodulatory regulator. We investigated the signaling pathway involved in IL-8 production caused by leptin in both rheumatoid arthritis synovial fibroblasts (RASF) and osteoarthritis synovial fibroblasts (OAS...

journal_title：Cellular signalling

authors： Tong KM,Shieh DC,Chen CP,Tzeng CY,Wang SP,Huang KC,Chiu YC,Fong YC,Tang CH

更新日期：2008-08-01 00:00:00

abstract：:The roles of protein kinase C (PKC) isoenzymes in the differentiation process of THP-1 cells are investigated. Inhibition of PKC by RO 31-8220 reduces the phagocytosis of latex particles and the release of superoxide, prostaglandin E(2) (PGE(2)), and tumour necrosis factor (TNF)-alpha. The proliferation of THP-1 cells...

journal_title：Cellular signalling

authors： Dieter P,Schwende H

更新日期：2000-05-01 00:00:00

abstract：:Reactive Oxygen Species (ROS) are crucial to multiple biological processes involved in the pathophysiology of inflammation, and are also involved in redox signaling responses. Although previous reports have described an association between oxidative events and the modulation of innate immunity, a role for redox signal...

journal_title：Cellular signalling

authors： Secchi C,Carta M,Crescio C,Spano A,Arras M,Caocci G,Galimi F,La Nasa G,Pippia P,Turrini F,Pantaleo A

更新日期：2015-04-01 00:00:00

abstract：:Clathrin-mediated endocytosis is a complex process regulated at many different levels. We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of beta2-adaptin, a subunit of the clat...

journal_title：Cellular signalling

authors： Zimmerman B,Simaan M,Lee MH,Luttrell LM,Laporte SA

更新日期：2009-01-01 00:00:00

abstract：:The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascul...

journal_title：Cellular signalling

authors： Masri B,Knibiehler B,Audigier Y

更新日期：2005-04-01 00:00:00

abstract：:Monoamine oxidase-A (MAO-A) dysfunction has been historically associated with depression. Recently, depression as well as altered MAO-A expression have both been associated with a poor prognosis in cancers, although the mechanism involved remains ambiguous. For example, MAO-A mRNA is repressed across cancers, yet MAO-...

journal_title：Cellular signalling

authors： Satram-Maharaj T,Nyarko JN,Kuski K,Fehr K,Pennington PR,Truitt L,Freywald A,Lukong KE,Anderson DH,Mousseau DD

更新日期：2014-12-01 00:00:00

abstract：:Tyrosine phosphorylation of proteins is a mechanism of signalling for different receptors and is important for cell growth and differentiation. Mast cells and basophils are secretory cells that play a role in inflammatory and immediate allergic reactions. The activation/aggregation of different surface receptors on th...

journal_title：Cellular signalling

authors： Hamawy MM,Mergenhagen SE,Siraganian RP

更新日期：1995-08-01 00:00:00

abstract：:Wnt3a activates proliferation of fibroblasts cells via activation of both extracellular signal-regulated kinase (ERK) and Wnt/beta-catenin signaling pathways. In this study, we show that the phosphatidyl inositol 3 kinases (PI3K)-Akt pathway is also involved in the Wnt3a-induced proliferation. Akt was activated within...

journal_title：Cellular signalling

authors： Kim SE,Lee WJ,Choi KY

更新日期：2007-03-01 00:00:00

abstract：:Disruption of autophagy plays an import role in neurodegenerative disorders, where deficient elimination of abnormal and toxic protein aggregates promotes cellular stress, failure and death. Therefore, induction of autophagy has been proposed as a reasonable strategy to help neurons clear abnormal protein aggregates a...

journal_title：Cellular signalling

authors： Heras-Sandoval D,Pérez-Rojas JM,Hernández-Damián J,Pedraza-Chaverri J

更新日期：2014-12-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibrotic factor, the role ...

journal_title：Cellular signalling

authors： Overstreet JM,Samarakoon R,Meldrum KK,Higgins PJ

更新日期：2014-07-01 00:00:00

abstract：:Growing evidence shows that chronic inflammation drives the progression of colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes involved in solid tumor metastasis. Epidermal growth factor receptor (EGFR) also plays a key role in cancer cell development. We compared the expr...

journal_title：Cellular signalling

authors： Wang JY,Chen BK,Wang YS,Tsai YT,Chen WC,Chang WC,Hou MF,Wu YC,Chang WC

更新日期：2012-01-01 00:00:00

abstract：:The involvement of cytosolic phospholipase A(2) (cPLA(2)) and ceramide in the accumulation of cholesteryl ester induced by the uptake of oxidized low-density lipoproteins (oxLDL) in macrophages was investigated. Uptake of oxLDL by [(3)H]oleic acid-labeled macrophages stimulated the formation of cholesteryl oleate, and...

journal_title：Cellular signalling

authors： Kitatani K,Nemoto M,Akiba S,Sato T

更新日期：2002-08-01 00:00:00

abstract：:Heterotrimeric G proteins typically transduce signals from G protein-coupled receptors (GPCRs) to effector proteins. In the conventional G protein signaling paradigm, the G protein is located at the cytoplasmic surface of the plasma membrane, where, after activation by an agonist-bound GPCR, the GTP-bound Gα and free ...

journal_title：Cellular signalling

authors： Hewavitharana T,Wedegaertner PB

更新日期：2012-01-01 00:00:00

abstract：:CD40 is critically involved in Fas-mediated cholangiocyte apoptosis during liver inflammation, but the underlying signalling events are poorly understood. Our recent work implicated AP-1 in CD40-induced cholangiocyte apoptosis, but suggested involvement of other signalling pathways. Because STAT3 has been implicated i...

journal_title：Cellular signalling

authors： Ahmed-Choudhury J,Williams KT,Young LS,Adams DH,Afford SC

更新日期：2006-04-01 00:00:00

abstract：:We have characterized the role of Drosophila PI3K and AKT in ERK pathway activation involving insulin-induced proliferation using Drosophila Schneider cells. After insulin treatment, dPI3K and dAKT activities were both increased along with activation of the dERK pathway components dMEK and dERK. The insulin-induced ac...

journal_title：Cellular signalling

authors： Kim SE,Cho JY,Kim KS,Lee SJ,Lee KH,Choi KY

更新日期：2004-11-01 00:00:00

abstract：:Nephrin, an important structural and signal molecule of podocyte slit-diaphragm (SD), has been suggested to contribute to the angiotensin II (Ang II)-induced podocyte injury. Caveolin-1 has been demonstrated to play a crucial role in signaling transduction. In the present study, we evaluated the role of caveolin-1 in ...

journal_title：Cellular signalling

authors： Ren Z,Liang W,Chen C,Yang H,Singhal PC,Ding G

更新日期：2012-02-01 00:00:00

abstract：:In more than 90% of cancers including glioma, telomere elongation reverse transcriptase (hTERT) is overexpressed. In the present study, we sought to explore whether matrix metalloproteinase-9 (MMP-9) shRNA could alter hTERT-mediated proliferation in glioma cells. MMP-9 shRNA induced senescence and apoptosis in glioma ...

journal_title：Cellular signalling

authors： Ponnala S,Chetty C,Veeravalli KK,Dinh DH,Klopfenstein JD,Rao JS

更新日期：2011-12-01 00:00:00

abstract：:Lithium salts are important drugs to treat bipolar disorder. Previous work showed that lithium by enforcing the interaction between the transcription factor CREB and its coactivator CRTC1 enhanced cAMP-stimulated CREB-dependent gene transcription. Both CREB and CRTC have been implicated in neuronal adaptation, which m...

journal_title：Cellular signalling

authors： Heinrich A,von der Heyde AS,Böer U,Phu do T,Tzvetkov M,Oetjen E

更新日期：2013-01-01 00:00:00

abstract：:Transforming growth factor β (TGF-β), a cytokine, and its receptors play a vital role during normal embryogenesis, cell proliferation, differentiation, apoptosis and migration. Ran-binding protein in the microtubule-organizing center (RanBPM) serves as a scaffold protein that has been shown to interact with many other...

journal_title：Cellular signalling

authors： Zhang J,Ma W,Tian S,Fan Z,Ma X,Yang X,Zhao Q,Tan K,Chen H,Chen D,Huang BR

更新日期：2014-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults with median survival time of 14.6 months. A small fraction of cancer stem cells (CSC) initiate and maintain tumors thus driving glioma tumorigenesis and being responsible for resistance to classical chemo- and radio-therapies...

journal_title：Cellular signalling

authors： Liu M,Inoue K,Leng T,Guo S,Xiong ZG

更新日期：2014-12-01 00:00:00

abstract：:The nuclear factor kappa B (NF-κB) transcription factor-mediated transcription is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli. Both the proteolytic and non-proteolytic functions of ubiquitination are critically important for the regulation of NF-κB activation. L...

journal_title：Cellular signalling

authors： Fan Y,Yu Y,Mao R,Zhang H,Yang J

更新日期：2011-04-01 00:00:00

abstract：:We found that CKD712, an S enantiomer of YS49, strongly inhibited inducible nitric oxide synthase (iNOS) and NO induction but showed a weak inhibitory effect on cyclooxygenase-2 (COX-2) and PGE(2) induction in LPS-stimulated RAW 264.7 cells. We, therefore, investigated the molecular mechanism(s) responsible for this b...

journal_title：Cellular signalling

authors： Tsoyi K,Kim HJ,Shin JS,Kim DH,Cho HJ,Lee SS,Ahn SK,Yun-Choi HS,Lee JH,Seo HG,Chang KC

更新日期：2008-10-01 00:00:00

abstract：:This article has been withdrawn at the request of the Editors. The Publisher apologises for any inconvenience that this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Cellular signalling

authors： Genestra M

更新日期：2009-03-27 00:00:00

abstract：:In the COS-7 cell signalling network high levels of cAMP produced, for example, by co-stimulation of beta2-adrenergic receptor (beta2-AR) and bradykinin B2 receptor (BKR) may affect epidermal growth factor receptor (EGFR)-mediated activation of extracellular signal-stimulated kinase (ERK). In contrast, co-stimulation ...

journal_title：Cellular signalling

authors： Hanke S,Valkova C,Stirnweiss J,Drube S,Liebmann C

更新日期：2006-07-01 00:00:00

abstract：:The implication of MAP kinases in the proliferation control of pancreatic cancer cells is still unknown. This study was undertaken to examine the contribution of the p44/p42 and p38 MAP kinases in the mitogenic response to epidermal growth factor (EGF) and bombesin in human pancreatic cancer cells, MIA PaCa-2 and PANC...

journal_title：Cellular signalling

authors： Douziech N,Calvo E,Lainé J,Morisset J

更新日期：1999-08-01 00:00:00

abstract：:The maintenance of muscle mass is critical for health and issues associated with the quality of life. Over the last decade, extensive progress has been made with regard to our understanding of the molecules that regulate skeletal muscle mass. Not surprisingly, many of these molecules are intimately involved in the reg...

journal_title：Cellular signalling

authors： Goodman CA,Mayhew DL,Hornberger TA

更新日期：2011-12-01 00:00:00

abstract：:Induction of nitrosative stress has been observed in various cancer types and in tumor environment. However, it is still unclear how cancer cells combat the effect of nitrosative stress. The main targets of nitrosative stress in cells are cellular lipids, proteins and DNA. Autophagy or self-cleaning generates energy f...

journal_title：Cellular signalling

authors： Chakraborty S,Datta S,Ghosh S

更新日期：2019-12-01 00:00:00