当前位置： SCI文献检索 > CELLULAR SIGNALLING期刊下所有文献 > Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts.

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts.

Abstract：

:Leptin, the adipocyte-secreted hormone that centrally regulates weight control, is known to function as an immunomodulatory regulator. We investigated the signaling pathway involved in IL-8 production caused by leptin in both rheumatoid arthritis synovial fibroblasts (RASF) and osteoarthritis synovial fibroblasts (OASF). RASF and OASF expressed the long (OBRl) and short (OBRs) isoforms of the leptin receptor. Leptin caused concentration- and time-dependent increases in IL-8 production. Leptin-mediated IL-8 production was attenuated by OBRl receptor antisense oligonucleotide, JAK2 inhibitor or STAT3 small interference RNA (siRNA). Transfection with insulin receptor substrate (IRS)-1 siRNA or dominant-negative mutant of p85 and Akt or pretreatment with phosphatidylinositol 3-kinase inhibitor (Ly294002 and wortmannin), Akt inhibitor, NF-kappaB inhibitor (PDTC) and NF-kappaB inhibitor peptide also inhibited the potentiating action of leptin. Stimulation of RASF with leptin activated IkappaB kinase alpha/beta (IKK alpha/beta), p65 phosphorylation at Ser(276), p65 translocation from the cytosol to the nucleus, and kappaB-luciferase activity. Moreover, pretreatment with p300 inhibitor (curcumin) also blocked IL-8 expression. The binding of p65 to the NF-kappaB elements, as well as the recruitment of p300 and the enhancement of histone H3 acetylation on the IL-8 promoter was enhanced by leptin, which was inhibited by wortmannin, Akt inhibitor or IRS-1 siRNA. These results suggest that leptin increased IL-8 production in synovial fibroblast via the OBRl/JAK2/STAT3 pathway, as well as the activation of IRS1/PI3K/Akt/NF-kappaB-dependent pathway and the subsequent recruitment of p300.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Tong KM,Shieh DC,Chen CP,Tzeng CY,Wang SP,Huang KC,Chiu YC,Fong YC,Tang CH

doi

10.1016/j.cellsig.2008.04.003

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

1478-88

issue

8

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(08)00116-2

journal_volume

20

pub_type

杂志文章

相关文献

CELLULAR SIGNALLING文献大全
  • Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1.

    abstract：:The dual-specificity mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) inactivates MAP kinases by dephosphorylation. Here we show that the proinflammatory cytokine interleukin (IL)-17A induces adult mouse primary cardiac fibroblast (CF) proliferation and migration via IL-17 receptor A//IL-17 receptor C-dep...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.10.010

    authors： Valente AJ,Yoshida T,Gardner JD,Somanna N,Delafontaine P,Chandrasekar B

    更新日期：2012-02-01 00:00:00

  • Transforming growth factor beta 1 potently activates CPP32-like proteases in human hepatoma cells.

    abstract：:Induction of apoptosis in Hep3B hepatoma cells by transforming growth factor beta 1 (TGF-beta 1) was accompanied by the activation of interleukin-1-beta-converting-enzyme-like proteases, which have recently been renamed as caspases. The caspase inhibitor ZVAD-FMK, which has a broader specificity for caspase family pro...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(97)00189-7

    authors： Hung WC,Chang HC,Chuang LY

    更新日期：1998-07-01 00:00:00

  • Nuclear signalling by membrane protein intracellular domains: the AICD enigma.

    abstract：:Alzheimer's disease (AD) is a neurodegenerative illness and the leading cause of dementia in the elderly. The accumulation of amyloid-β peptide (Aβ) is a well-known pathological hallmark associated with the disease. However, Aβ is only one of several metabolites produced by β- and γ-secretase actions on the transmembr...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2011.10.007

    authors： Beckett C,Nalivaeva NN,Belyaev ND,Turner AJ

    更新日期：2012-02-01 00:00:00

  • Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1.

    abstract：:Nephrin, an important structural and signal molecule of podocyte slit-diaphragm (SD), has been suggested to contribute to the angiotensin II (Ang II)-induced podocyte injury. Caveolin-1 has been demonstrated to play a crucial role in signaling transduction. In the present study, we evaluated the role of caveolin-1 in ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.09.022

    authors： Ren Z,Liang W,Chen C,Yang H,Singhal PC,Ding G

    更新日期：2012-02-01 00:00:00

  • The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.

    abstract：:By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2016.02.012

    authors： Hoa L,Kulaberoglu Y,Gundogdu R,Cook D,Mavis M,Gomez M,Gomez V,Hergovich A

    更新日期：2016-05-01 00:00:00

  • Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells.

    abstract：:Growing evidence shows that chronic inflammation drives the progression of colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes involved in solid tumor metastasis. Epidermal growth factor receptor (EGFR) also plays a key role in cancer cell development. We compared the expr...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.08.017

    authors： Wang JY,Chen BK,Wang YS,Tsai YT,Chen WC,Chang WC,Hou MF,Wu YC,Chang WC

    更新日期：2012-01-01 00:00:00

  • Staphylococcus aureus alpha-toxin activates phospholipases and induces a Ca2+ influx in PC12 cells.

    abstract：:Staphylococcal alpha-toxin at subcytotoxic concentrations stimulated phosphatidylinositol turnover and arachidonic acid release in undifferentiated cultures of pheochromocytoma PC12 cells. Stimulation of phospholipase A2 but not C was dependent on extracellular calcium. Addition of staphylococcal alpha-toxin to PC12 c...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(89)90057-0

    authors： Fink D,Contreras ML,Lelkes PI,Lazarovici P

    更新日期：1989-01-01 00:00:00

  • CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.

    abstract：:CCN1/CYR61 is a matricellular protein of the CCN family, comprising six secreted proteins specifically associated with the extracellular matrix (ECM). CCN1 acts as an enhancer of the cutaneous wound healing process by preventing hypertrophic scar formation through induction of myofibroblast senescence. In liver fibros...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2015.10.013

    authors： Borkham-Kamphorst E,Steffen BT,Van de Leur E,Haas U,Tihaa L,Friedman SL,Weiskirchen R

    更新日期：2016-01-01 00:00:00

  • Signalling via the G protein-activated K+ channels.

    abstract：:The inwardly rectifying K+ channels of the GIRK (Kir3) family, members of the superfamily of inwardly rectifying K+ channels (Kir), are important physiological tools to regulate excitability in heart and brain by neurotransmitters, and the only ion channels conclusively shown to be activated by a direct interaction wi...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/s0898-6568(97)00095-8

    authors： Dascal N

    更新日期：1997-12-01 00:00:00

  • Inter- and intra-cellular mechanism of NF-kB-dependent survival advantage and clonal expansion of radio-resistant cancer cells.

    abstract：:Understanding the underlying mechanism by which cancer cells acquire resistance to radiation and favorably selected for its clonal expansion will provide molecular insight into tumor recurrence at the treatment site. In the present study, we investigated the molecular mechanisms prompted in MCF-7 breast cancer cells i...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2017.01.011

    authors： Yu H,Aravindan N,Xu J,Natarajan M

    更新日期：2017-02-01 00:00:00

  • Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells.

    abstract：:Circulating symmetric dimethylarginine (SDMA) is increased in patients with chronic kidney disease. SDMA is considered an inert metabolite, but because it can transported into cells, we studied the effect of SDMA on glomerular endothelial cells. SDMA suppressed VEGF-induced endothelial nitric oxide synthase (eNOS) pho...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.09.024

    authors： Feliers D,Lee DY,Gorin Y,Kasinath BS

    更新日期：2015-01-01 00:00:00

  • HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-κB pathways in vascular endothelial cells.

    abstract：:Inflammation is characterized by early influx of polymorphonuclear neutrophils (PMNs), followed by a second wave of monocyte recruitment. PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes. However, the pathways for such sig...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2017.12.008

    authors： Chang M,Guo F,Zhou Z,Huang X,Yi L,Dou Y,Huan J

    更新日期：2018-03-01 00:00:00

  • Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection.

    abstract：:Dengue virus (DENV) infection is a disease that is endemic to many parts of the world, and its increasing prevalence ranks it among the diseases considered to be a significant threat to public health. The clinical manifestations of DENV infection range from mild dengue fever (DF) to more severe dengue hemorrhagic feve...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2018.05.002

    authors： Sreekanth GP,Yenchitsomanus PT,Limjindaporn T

    更新日期：2018-08-01 00:00:00

  • Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.

    abstract：:Recent reports show that protein kinase A (PKA), but not exchange protein activated by cAMP (EPAC), acts in a cell autonomous manner to constitutively reduce the angiogenic sprouting capacity of murine and human endothelial cells. Specificity in the cellular actions of individual cAMP-effectors can be achieved when a ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2019.06.007

    authors： MacKeil JL,Brzezinska P,Burke-Kleinman J,Theilmann AL,Nicol CJB,Ormiston ML,Maurice DH

    更新日期：2019-10-01 00:00:00

  • Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brain.

    abstract：:NO-sensitive guanylyl cyclase (GC) acts as the effector molecule for NO and therefore plays a key role in the NO/cGMP signalling cascade. Besides the long known GC isoform (alpha(1)beta(1)), another heterodimer (alpha(2)beta(1)) has recently been identified to be associated with PSD-95 in brain.Here, we report on the ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(02)00078-5

    authors： Mergia E,Russwurm M,Zoidl G,Koesling D

    更新日期：2003-02-01 00:00:00

  • HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

    abstract：:We found that CKD712, an S enantiomer of YS49, strongly inhibited inducible nitric oxide synthase (iNOS) and NO induction but showed a weak inhibitory effect on cyclooxygenase-2 (COX-2) and PGE(2) induction in LPS-stimulated RAW 264.7 cells. We, therefore, investigated the molecular mechanism(s) responsible for this b...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.06.012

    authors： Tsoyi K,Kim HJ,Shin JS,Kim DH,Cho HJ,Lee SS,Ahn SK,Yun-Choi HS,Lee JH,Seo HG,Chang KC

    更新日期：2008-10-01 00:00:00

  • ZIP kinase, a key regulator of myosin protein phosphatase 1.

    abstract：:Two major physiological roles have been defined for zipper interacting protein kinase (ZIPK), regulation of apoptosis in non-muscle cells and regulation of Ca(2+) sensitization in smooth muscle. Although much attention has focused on the role of ZIPK in the regulation of apoptotic events, its roles in smooth muscle ar...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2005.05.008

    authors： Haystead TA

    更新日期：2005-11-01 00:00:00

  • Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.

    abstract：:Acute myeloid leukemia (AML) cell lines treated by genotoxic agents or by Tumor Necrosis Factor alpha (TNFalpha) acquire potent cytotoxicity towards myeloid cells through activation of granzyme B (GrB)/perforin (PFN) system. Here we first extend this observation to another death receptor activator, Fas Ligand (FasL). ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2006.12.005

    authors： Guilloton F,Jean C,de Thonel A,Laurent G,Quillet-Mary A

    更新日期：2007-06-01 00:00:00

  • Modulation of neutrophil phospholipase C activity and cyclic AMP levels by fMLP-OMe analogues.

    abstract：:The N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-OMe (1) analogues for-Thp-Leu-Ain-OMe (2), for-Thp-Leu-Phe-OMe (3), for-Met-Leu-Ain-OMe (4), for-Met-Delta(z)Leu-Phe-OMe (5), for-Met-Lys-Phe-For-Met-Lys-Phe (6), for-Met-Leu-Pheol-COMe (7), and for-Nle-Leu-Phe-OMe (8) have been studied. Some of these have been ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(01)00140-1

    authors： Ferretti ME,Nalli M,Biondi C,Colamussi ML,Pavan B,Traniello S,Spisani S

    更新日期：2001-04-01 00:00:00

  • The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration.

    abstract：:Disruption of autophagy plays an import role in neurodegenerative disorders, where deficient elimination of abnormal and toxic protein aggregates promotes cellular stress, failure and death. Therefore, induction of autophagy has been proposed as a reasonable strategy to help neurons clear abnormal protein aggregates a...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2014.08.019

    authors： Heras-Sandoval D,Pérez-Rojas JM,Hernández-Damián J,Pedraza-Chaverri J

    更新日期：2014-12-01 00:00:00

  • Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor.

    abstract：:Platelet-activating factor (PAF) is a potent phospholipid mediator involved in several diseases such as allergic asthma, atherosclerosis and psoriasis. The human PAF receptor (PAFR) is a member of the G-protein-coupled receptor family. Following stimulation, PAFR becomes rapidly desensitized; this refractory state is ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.05.015

    authors： Dupré DJ,Thompson C,Chen Z,Rollin S,Larrivée JF,Le Gouill C,Rola-Pleszczynski M,Stanková J

    更新日期：2007-10-01 00:00:00

  • Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase.

    abstract：:Cellular hypoxia can lead to cell death or adaptation and has important effects on development, physiology, and pathology. Here, we investigated the role and regulation of ceramide in hypoxia-induced apoptosis of SH-SY5Y neuroblastoma cells. Hypoxia increased the ceramide concentration; subsequently, we observed bioch...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.11.015

    authors： Kang MS,Ahn KH,Kim SK,Jeon HJ,Ji JE,Choi JM,Jung KM,Jung SY,Kim DK

    更新日期：2010-04-01 00:00:00

  • Cyclic AMP modulates interleukin-1 action in a cytotoxic T-cell hybridoma.

    abstract：:The induction of cytolytic activity in PC60, a murine T-cell hybridoma, is paralleled by a rise in the level of BLT-esterase (N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl esterase), a serine esterase specific for activated T-cells. Both interleukin-1 (IL-1) and dibutyryl cAMP were albe to increase the esterase activi...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(90)90045-c

    authors： Schlegel-Haueter SE,Aebischer F

    更新日期：1990-01-01 00:00:00

  • Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.

    abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinas...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109842

    authors： Kaur H,Moreau R

    更新日期：2021-02-01 00:00:00

  • Ephedrine induced thioredoxin-1 expression through β-adrenergic receptor/cyclic AMP/protein kinase A/dopamine- and cyclic AMP-regulated phosphoprotein signaling pathway.

    abstract：:Ephedrine (Eph) is one of alkaloids that has been isolated from the ancient herb ephedra (ma huang) and is used as the treatment of asthma, hypotension and fatigue. However, its molecular mechanism remains unknown. Thioredoxin-1 (Trx-1) is a redox regulating protein, which has various biological activities, including ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.02.007

    authors： Jia JJ,Zeng XS,Li Y,Ma S,Bai J

    更新日期：2013-05-01 00:00:00

  • Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.

    abstract：:Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better understanding of the underlying molecular mechanisms is needed to develop improved drugs. Here, we review the literature to test the hypothesis that a break dow...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2017.11.004

    authors： Kelly MP

    更新日期：2018-01-01 00:00:00

  • Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.

    abstract：:Epac1 is a cAMP-stimulated guanine exchange factor that activates Rap1. The protein product of the T cell leukemia 1 (TCL1) proto-oncogene binds to Akt enhancing its kinase activity. TCL1 and Epac promote cellular proliferation because of their activating effects on Akt. Employing macrophages, we have studied the mech...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.10.008

    authors： Misra UK,Kaczowka SJ,Pizzo SV

    更新日期：2008-01-01 00:00:00

  • Structure and function of phosphatidylinositol-3,4 kinase.

    abstract：:Activation of phosphatidylinositol (PI)-kinase is involved in the regulation of a wide array of cellular activities. The enzyme exists as a dimer, consisting of a catalytic and a regulatory subunit. Five isoforms of the regulatory subunit have been identified and classified into three groups comprising respectively 85...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/s0898-6568(99)00086-8

    authors： Funaki M,Katagiri H,Inukai K,Kikuchi M,Asano T

    更新日期：2000-03-01 00:00:00

  • Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product.

    abstract：:Modulation of immune responses is an important strategy employed by pathogens to enable their survival in host organisms. Secreted immunomodulatory molecules are key weapons in the pathogen's battle with the host immune system. In this review, we will discuss the immunomodulatory effects of the phosphorylcholine-conta...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2004.05.014

    authors： Goodridge HS,Deehan MR,Harnett W,Harnett MM

    更新日期：2005-01-01 00:00:00

  • An extracellular matrix, calmodulin-binding protein from Dictyostelium with EGF-like repeats that enhance cell motility.

    abstract：:CyrA is a novel cysteine-rich protein with four EGFL repeats that was isolated using the calmodulin (CaM) binding overlay technique (CaMBOT), suggesting it is a CaM-binding protein (CaMBP). The full-length 63kDa cyrA is cleaved into two major C-terminal fragments, cyrA-C45 and cyrA-C40. A putative CaM-binding domain w...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.03.008

    authors： Suarez A,Huber RJ,Myre MA,O'Day DH

    更新日期：2011-07-01 00:00:00