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Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response.

Abstract：

:Immune responses to pathogens are regulated by immune receptors containing either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibitory motif (ITIM). The important diarrheal pathogen enteropathogenic Escherichia coli (EPEC) require delivery and insertion of the bacterial translocated intimin receptor (Tir) into the host plasma membrane for pedestal formation. The C-terminal region of Tir, encompassing Y483 and Y511, shares sequence similarity with cellular ITIMs. Here, we show that EPEC Tir suppresses the production of inflammatory cytokines by recruitment of SHP-2 and subsequent deubiquitination of TRAF6 in an ITIM dependent manner. Our findings revealed a novel mechanism by which the EPEC utilize its ITIM motifs to suppress and evade the host innate immune response, which could lead to the development of novel therapeutics to prevent bacterial infection.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Yan D,Quan H,Wang L,Liu F,Liu H,Chen J,Cao X,Ge B

doi

10.1016/j.cellsig.2013.05.020

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1887-94

issue

9

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(13)00145-9

journal_volume

25

pub_type

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