Abstract：
:Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thus, mechanotransduction is a key process in many developmental, physiological and pathological processes in tooth and bone. Mechanosensitive ion channels such as Piezo1 and Piezo2 are important participants in mechanotransduction, but their functions in tooth and bone are poorly understood. This review summarizes our current understanding of mechanosensitive ion channels and their roles in tooth and bone tissues. Research in these areas may shed new light on the regulation of tooth and bone tissues and potential treatments for diseases affecting these tissues.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Pei F,Liu J,Zhang L,Pan X,Huang W,Cen X,Huang S,Jin Y,Zhao Zdoi
10.1016/j.cellsig.2020.109877subject
Has Abstractpub_date
2021-02-01 00:00:00pages
109877eissn
0898-6568issn
1873-3913pii
S0898-6568(20)30354-5journal_volume
78pub_type
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