Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates.

abstract：:The type II epithelial-mesenchymal transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system effects of EMT on sig...

journal_title：Cellular signalling

authors： Desai P,Yang J,Tian B,Sun H,Kalita M,Ju H,Paulucci-Holthauzen A,Zhao Y,Brasier AR,Sadygov RG

更新日期：2015-07-01 00:00:00

abstract：:PI3K signalling pathways link cell surface receptors to the control of several intracellular functions including cell growth, survival and movement. Filamins are important regulators of cortical actin structure and function. LL5beta is a filamin binding protein that is an effector of the PI3K signalling pathway. We de...

journal_title：Cellular signalling

authors： Paranavitane V,Stephens LR,Hawkins PT

更新日期：2007-04-01 00:00:00

abstract：:The N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-OMe (1) analogues for-Thp-Leu-Ain-OMe (2), for-Thp-Leu-Phe-OMe (3), for-Met-Leu-Ain-OMe (4), for-Met-Delta(z)Leu-Phe-OMe (5), for-Met-Lys-Phe-For-Met-Lys-Phe (6), for-Met-Leu-Pheol-COMe (7), and for-Nle-Leu-Phe-OMe (8) have been studied. Some of these have been ...

journal_title：Cellular signalling

authors： Ferretti ME,Nalli M,Biondi C,Colamussi ML,Pavan B,Traniello S,Spisani S

更新日期：2001-04-01 00:00:00

abstract：:Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T cells. Its role in T-cell development has been established by the severe combined immune deficiency syndrome in ZAP-70 deficient human...

journal_title：Cellular signalling

authors： Kaur M,Singh M,Silakari O

更新日期：2014-11-01 00:00:00

abstract：:Recent studies have shown DAPk as a molecular modulator induced by the second messenger, responsible for controlling cell destiny decisions, but the detailed mechanism mediating the role of DAPk1 during cell death is still not fully understood. In this present report, we attempted to characterize the effects of TNF-α ...

journal_title：Cellular signalling

authors： Yoo HJ,Byun HJ,Kim BR,Lee KH,Park SY,Rho SB

更新日期：2012-07-01 00:00:00

abstract：:Calmodulin (CaM) antagonists, trifluoperazine (TFP) or calmidazolium (R24571), dose-dependently inhibited cAMP and folic acid (FA) chemotaxis in Dictyostelium. Developing, starved, and refed cells were compared to determine if certain CaM-binding proteins (CaMBPs) and CaM-dependent phosphorylation events could be iden...

journal_title：Cellular signalling

authors： Gauthier ML,O'Day DH

更新日期：2001-08-01 00:00:00

abstract：:Protein kinase CK2 is a critical factor for the survival of cells. It is overexpressed in many cancer cells and provides protection against apoptosis in these cells. Inhibition of CK2 kinase activity in various cancer cells leads to apoptosis, which makes CK2 an attractive target for cancer therapy. Little is, however...

journal_title：Cellular signalling

authors： Intemann J,Saidu NE,Schwind L,Montenarh M

更新日期：2014-07-01 00:00:00

abstract：:High affinity Ins(1,4,5)P3-binding sites of permeabilized hepatocytes are probably the ligand recognition sites of the receptors that mediate the effects of Ins(1,4,5)P3 on intracellular Ca2+ mobilization. We have now solubilized these sites from rat liver membranes in the zwitterionic detergent, CHAPS, and shown that...

journal_title：Cellular signalling

authors： Bond JM,Taylor CW

更新日期：1991-01-01 00:00:00

abstract：:Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thu...

journal_title：Cellular signalling

authors： Pei F,Liu J,Zhang L,Pan X,Huang W,Cen X,Huang S,Jin Y,Zhao Z

更新日期：2021-02-01 00:00:00

abstract：:The adaptor protein Gab-2 coordinates the assembly of the IL-3 signalsome comprising Gab-2, Grb2, Shc, SHP-2 and PI3K. To investigate the role of the pleckstrin homology domain of Gab-2 in this process, epitope-tagged wild type Gab-2 (WTGab-2), Gab-2 lacking its PH domain (DeltaPHGab-2) and the Gab-2 PH domain alone (...

journal_title：Cellular signalling

authors： Edmead CE,Fox BC,Stace C,Ktistakis N,Welham MJ

更新日期：2006-08-01 00:00:00

abstract：:We have studied the effects of cholinergic agonists on the rates of insulin release and the concentrations of diacylglycerol (DAG) and intracellular free Ca2+ ([Ca2+]i) in the beta-cell line MIN6. Insulin secretion was stimulated by glucose, by glibenclamide and by bombesin. In the presence of glucose, both acetylchol...

journal_title：Cellular signalling

authors： Weng L,Davies M,Ashcroft SJ

更新日期：1993-11-01 00:00:00

abstract：:Mice lacking the gene for suppressor of cytokine signaling 1 (SOCS1) show defective homeostasis of T lymphocytes due to accumulation of CD8(+) T cells, resulting at least partly from dysregulated IL-15 signaling. IL-15 alone does not stimulate proliferation of naïve CD8 T cells, but can synergize with IL-21 to induce ...

journal_title：Cellular signalling

authors： Gagnon J,Ramanathan S,Leblanc C,Ilangumaran S

更新日期：2007-04-01 00:00:00

abstract：:Macrophages play many different roles in tissue inflammation and immunity, and the plasticity of macrophage polarization is closely associated with acute inflammatory responses. O-GlcNAcylation is an important type of post-translational modification, which subtly modulates inflammation responses. Transforming growth f...

journal_title：Cellular signalling

authors： Zhang D,Xu Z,Tao T,Liu X,Sun X,Ji Y,Han L,Qiu H,Zhu G,Shen Y,Zhu L,Shen A

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are key regulators of many cellular pathways. However, the picture for components or regulators involved in the process of miRNA biogenesis and function remains to be further elucidated. Early growth response gene 1 (Egr1) has long been considered as tumor suppressor and transcriptional fa...

journal_title：Cellular signalling

authors： Wei J,Ouyang Y,Li X,Zhu B,Yang J,Cui Y,Chen X,Lin F,Long M,Yang A,Dong K,Zhang H

更新日期：2015-06-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK)-dependent phosphorylation is an important regulator for cytosolic phospholipase A(2) (cPLA(2)). In this study, we found that the protein synthesis inhibitor cycloheximide can potentiate thapsigargin-induced arachidonic acid (AA) release concomitant with ERK phosphorylation f...

journal_title：Cellular signalling

authors： Lin WW,Hsu YW

更新日期：2000-07-01 00:00:00

abstract：:It has been shown lately that activity of G protein-coupled receptors (GPCRs) is regulated by an array of proteins binding to carboxy (C)-terminus of GPCRs. Proteins of 4.1 family are subsets of subcortical cytoskeletal proteins and are known to stabilize cellular structures and proteins at the plasma membrane. One of...

journal_title：Cellular signalling

authors： Goto T,Chiba A,Sukegawa J,Yanagisawa T,Saito M,Nakahata N

更新日期：2013-03-01 00:00:00

abstract：:The long cyclic AMP (cAMP)-specific phosphodiesterase isoform, PDE4A5 (PDE4A subfamily isoform variant 5), when transiently expressed in COS-7 cells, was shown in subcellular fractionation studies to be associated with both membrane and cytosol fractions, with immunofluorescence analyses identifying PDE4A5 as associat...

journal_title：Cellular signalling

authors： Beard MB,Huston E,Campbell L,Gall I,McPhee I,Yarwood S,Scotland G,Houslay MD

更新日期：2002-05-01 00:00:00

abstract：:High levels of VEGF and leptin are strongly linked to worse prognosis of breast cancer. Leptin signalling upregulates VEGF in human and mouse mammary tumor cells (MT), but the specific molecular mechanisms are largely unknown. Pharmacologic and genetic approaches were used to dissect the mechanism of leptin regulation...

journal_title：Cellular signalling

authors： Gonzalez-Perez RR,Xu Y,Guo S,Watters A,Zhou W,Leibovich SJ

更新日期：2010-09-01 00:00:00

abstract：:It is well established that the IFN-gamma/STAT1 pathway plays an important role in the pancreatic beta-cell apoptosis that is observed in STZ-induced type 1 diabetes; however, the upstream regulatory proteins involved have not been understood. Here, we investigated whether activating transcription factor 3 (ATF3) affe...

journal_title：Cellular signalling

authors： Kim JY,Song EH,Lee S,Lim JH,Choi JS,Koh IU,Song J,Kim WH

更新日期：2010-11-01 00:00:00

abstract：:The interactions between kidney and thyroid functions have been known for many years, but how the thyroid affects the kidney function is largely unknown. Here we analyzed the role of T3 on the tubular epithelial-to-mesenchymal transition (EMT), which is recognized to play pivotal roles in the process of renal fibrosis...

journal_title：Cellular signalling

authors： Lu X,Chen Z,Liang H,Li Z,Zou X,Luo H,Guo W,Xu L

更新日期：2013-10-01 00:00:00

abstract：:Cyclic mechanical stretch associated with pulsatile blood pressure can modulate cytoskeletal remodeling and intracellular signaling in vascular endothelial cells. The aim of this study was to evaluate the role of stretch-induced actin stress fiber orientation in intracellular signaling involving the activation of c-ju...

journal_title：Cellular signalling

authors： Kaunas R,Usami S,Chien S

更新日期：2006-11-01 00:00:00

abstract：:Targeted therapy is becoming the mainstay of cancer treatment due to reduced side effects and enhanced tumor attack. In the last few decades, Murine Double Minute 2 (MDM2) protein has become one of the targets for developing cancer therapies. Blocking MDM2-p53 interaction has long been considered to offer a broad rang...

journal_title：Cellular signalling

authors： Natarajan U,Venkatesan T,Dhandayuthapani S,Dondapatti P,Rathinavelu A

更新日期：2020-11-01 00:00:00

abstract：:The effect of phosphatase inhibitors okadaic acid and calyculin-A on cAMP formation and adrenocorticotropic hormone (ACTH) secretion in AtT-20 corticotrophs was investigated. Both okadaic acid and calyculin-A inhibited dose-dependently the accumulation of cAMP in cells stimulated with pituitary adenylate cyclase activ...

journal_title：Cellular signalling

authors： Koch B,Lutz-Bucher B

更新日期：1994-05-01 00:00:00

abstract：:Cell surface receptors for high-density lipoprotein (HDL) on hepatocytes are major partners in the regulation of cholesterol homeostasis. We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ectopic F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13...

journal_title：Cellular signalling

authors： Malaval C,Laffargue M,Barbaras R,Rolland C,Peres C,Champagne E,Perret B,Tercé F,Collet X,Martinez LO

更新日期：2009-01-01 00:00:00

abstract：:Staphylococcal alpha-toxin at subcytotoxic concentrations stimulated phosphatidylinositol turnover and arachidonic acid release in undifferentiated cultures of pheochromocytoma PC12 cells. Stimulation of phospholipase A2 but not C was dependent on extracellular calcium. Addition of staphylococcal alpha-toxin to PC12 c...

journal_title：Cellular signalling

authors： Fink D,Contreras ML,Lelkes PI,Lazarovici P

更新日期：1989-01-01 00:00:00

abstract：:We investigated the effects of retinoic acid (RA) on the signalling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with RA significantly inhibited the formation of inositol phosphates induced by 10 microM PGE2 in a dose-dependent manner in the range between 0.1 nM and 0.1 micro...

journal_title：Cellular signalling

authors： Kotoyori J,Tokuda H,Oiso Y,Kozawa O

更新日期：1993-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (Stat6) is critical in Th2 polarization of immune cells and active Stat6 activity has been suggested in anti-tumor immunity in animal models. The present study aims at investigating the impact of natural Stat6 activity on tumor microenvironment in human colorectal can...

journal_title：Cellular signalling

authors： Li BH,Xu SB,Li F,Zou XG,Saimaiti A,Simayi D,Wang YH,Zhang Y,Yuan J,Zhang WJ

更新日期：2012-03-01 00:00:00

abstract：:We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. While NPRL2 interacts with Rag GTPases, RagD in particular, to interfere with mTORC1 activity in amino acid sc...

journal_title：Cellular signalling

authors： Kwak SS,Kang KH,Kim S,Lee S,Lee JH,Kim JW,Byun B,Meadows GG,Joe CO

更新日期：2016-02-01 00:00:00

abstract：:β-Adrenergic receptors (βAR) and D(2)-like dopamine receptors (which include D(2)-, D(3)- and D(4)-dopamine receptors) activate G(s) and G(i), the stimulatory and inhibitory heterotrimeric G proteins, respectively, which in turn regulate the activity of adenylyl cyclase (AC). β(2)-Adrenergic receptors (β(2)AR) and D(4...

journal_title：Cellular signalling

authors： Rebois RV,Maki K,Meeks JA,Fishman PH,Hébert TE,Northup JK

更新日期：2012-11-01 00:00:00

abstract：:Tyrosine phosphorylation of proteins is a mechanism of signalling for different receptors and is important for cell growth and differentiation. Mast cells and basophils are secretory cells that play a role in inflammatory and immediate allergic reactions. The activation/aggregation of different surface receptors on th...

journal_title：Cellular signalling

authors： Hamawy MM,Mergenhagen SE,Siraganian RP

更新日期：1995-08-01 00:00:00