Solubilization of rat liver inositol 1,4,5-trisphosphate receptor.

abstract：:The adaptor protein Gab-2 coordinates the assembly of the IL-3 signalsome comprising Gab-2, Grb2, Shc, SHP-2 and PI3K. To investigate the role of the pleckstrin homology domain of Gab-2 in this process, epitope-tagged wild type Gab-2 (WTGab-2), Gab-2 lacking its PH domain (DeltaPHGab-2) and the Gab-2 PH domain alone (...

journal_title：Cellular signalling

authors： Edmead CE,Fox BC,Stace C,Ktistakis N,Welham MJ

更新日期：2006-08-01 00:00:00

abstract：:Wnt5a, a non-transforming Wnt family member, plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in gastric cancer progression remains poorly defined. In this study, we found that Wnt5a dose-dependently stimulated the migration of human gastric cancer cells (SGC-7901), with the maxim...

journal_title：Cellular signalling

authors： Liu J,Zhang Y,Xu R,Du J,Hu Z,Yang L,Chen Y,Zhu Y,Gu L

更新日期：2013-02-01 00:00:00

abstract：:PI3K signalling pathways link cell surface receptors to the control of several intracellular functions including cell growth, survival and movement. Filamins are important regulators of cortical actin structure and function. LL5beta is a filamin binding protein that is an effector of the PI3K signalling pathway. We de...

journal_title：Cellular signalling

authors： Paranavitane V,Stephens LR,Hawkins PT

更新日期：2007-04-01 00:00:00

abstract：:Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease. Activation of CaMKIIδ is also known to regulate cardiovascular inflammation and is reported to be required for pro-inflammatory NF-κB signalling. In this...

journal_title：Cellular signalling

authors： Martin TP,McCluskey C,Cunningham MR,Beattie J,Paul A,Currie S

更新日期：2018-11-01 00:00:00

abstract：:Although increasing evidence demonstrated that deregulation of mircoRNA-503 (miRNA-503) contributes to tumorigenesis, little is known about the biological role and intrinsic regulatory mechanisms of miR-503 in prostate cancer (PCa). In present study, we found that miR-503 was significantly downregulated in advanced PC...

journal_title：Cellular signalling

authors： Jiang X,Chen Y,Du E,Yang K,Zhang Z,Qi S,Xu Y

更新日期：2016-09-01 00:00:00

abstract：:Prostatic stromal proliferation may be commonly associated with the development of benign prostatic hyperplasia. In this study, we investigate the role of testosterone and protein kinase C in stimulating cultured stromal cell proliferation. Testosterone increased the uptake of [(3)H]-thymidine into the human cultured ...

journal_title：Cellular signalling

authors： Haynes JM,Frydenberg M,Majewski H

更新日期：2001-10-01 00:00:00

abstract：:Modulation of immune responses is an important strategy employed by pathogens to enable their survival in host organisms. Secreted immunomodulatory molecules are key weapons in the pathogen's battle with the host immune system. In this review, we will discuss the immunomodulatory effects of the phosphorylcholine-conta...

journal_title：Cellular signalling

authors： Goodridge HS,Deehan MR,Harnett W,Harnett MM

更新日期：2005-01-01 00:00:00

abstract：:The protective effect of Regulator of G protein Signaling 2 (RGS2) in cardiac hypertrophy is thought to occur through its ability to inhibit the chronic GPCR signaling that promotes pathogenic growth both in vivo and in cultured cardiomyocytes. However, RGS2 is known to have additional functions beyond its activity as...

journal_title：Cellular signalling

authors： Chidiac P,Sobiesiak AJ,Lee KN,Gros R,Nguyen CH

更新日期：2014-06-01 00:00:00

abstract：:Insulin/IGF-1 action is driven by a complex and highly integrated signalling network. Loss-of-function studies indicate that the major insulin/IGF-1 receptor substrate (IRS) proteins, IRS-1 and IRS-2, mediate different biological functions in vitro and in vivo, suggesting specific signalling properties despite their h...

journal_title：Cellular signalling

authors： Rabiee A,Krüger M,Ardenkjær-Larsen J,Kahn CR,Emanuelli B

更新日期：2018-07-01 00:00:00

abstract：:p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function. The Cas family of ...

journal_title：Cellular signalling

authors： Barrett A,Pellet-Many C,Zachary IC,Evans IM,Frankel P

更新日期：2013-04-01 00:00:00

abstract：:Major diseases such as cardiovascular diseases, rheumatoid arthritis, diabetes, obesity and tumor growth are known to involve inflammation. Inflammatory molecules such as MCP-1, TNF-α, IL-1β and IL-8 are known to promote angiogenesis. MCP-induced protein (MCPIP), originally discovered as a novel zinc finger protein in...

journal_title：Cellular signalling

authors： Roy A,Kolattukudy PE

更新日期：2012-11-01 00:00:00

abstract：:We previously showed that an increase of cellular Bcl-xL mediates acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and knockdown of Bcl-xL expression greatly sensitized TRAIL-induced cytotoxicity. Here, we show that Daxx downregulation increases the anti-tumorigenic activity throu...

journal_title：Cellular signalling

authors： Kang S,Kang D,Bakhtiar Ul Islam SM,Je S,Kim JH,Song JJ

更新日期：2015-06-01 00:00:00

abstract：:The role of microtubules (MTs) in steroid hormone-dependent human glucocorticoid receptor (hGR) activation/translocation is controversial. It was demonstrated recently that colchicine (COL) down-regulates hGR-driven genes in primary human hepatocytes by a mechanism involving inhibition of hGR translocation to the nucl...

journal_title：Cellular signalling

authors： Dvorák Z,Modrianský M,Ulrichová J,Maurel P,Vilarem MJ,Pascussi JM

更新日期：2005-02-01 00:00:00

abstract：:Forkhead-associated domain (FHA) is a phosphopeptide recognition domain embedded in some regulatory proteins. With similar fold type to important eukaryotic signaling molecules such as Smad2 and IRF3, the role of bacterial FHA domain is intensively pursued. Reported bacterial FHA domain roles include: regulation of gl...

journal_title：Cellular signalling

authors： Weiling H,Xiaowen Y,Chunmei L,Jianping X

更新日期：2013-03-01 00:00:00

abstract：:We have demonstrated previously that chronic exposure to endothlin-1 enhances glucose transport in 3T3-L1 adipocytes via augmented GLUT1 mRNA and protein accumulation. In the present study, we further examined the combined effect of endothelin-1 (ET-1) and cAMP on glucose transport. In cells pretreated with ET-1 and 8...

journal_title：Cellular signalling

authors： Fong JC,Kao YS,Tsai HY,Chiou YY,Chiou GY

更新日期：2004-07-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitors (CKI) interact with cyclin-cdk complexes to arrest mitogen-stimulated transit through the cell cycle, but we and others have recently shown that these molecules can exert permissive effects on cell cycle transit as well. The p53 protein induces transcription of the p21(Waf1/Cip1)...

journal_title：Cellular signalling

authors： Weiss RH,Randour CJ

更新日期：2000-06-01 00:00:00

abstract：:In this study, we demonstrate that EGF inhibits the TGF-β1-induced apoptosis of Huh7 cells. TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway. TGF-β1 also inhibits the activation of S6 kinase 1 which phosphorylates the serine 67 res...

journal_title：Cellular signalling

authors： Matsuhashi S,Hamajima H,Xia J,Zhang H,Mizuta T,Anzai K,Ozaki I

更新日期：2014-03-01 00:00:00

abstract：:15-lipoxygenase (15-LO) is known to play an important role in chronic pulmonary hypertension. Accumulating evidence for its down-stream participants in the vasoconstriction and remodeling processes of pulmonary arteries, while how hypoxia regulates 15-LO/15-hydroxyeicosatetraenoic acid (15-HETE) to mediate hypoxic pul...

journal_title：Cellular signalling

authors： Zhang L,Ma J,Shen T,Wang S,Ma C,Liu Y,Ran Y,Wang L,Liu L,Zhu D

更新日期：2012-10-01 00:00:00

abstract：:RAW macrophages, which express the PDE4D3 and PDE4D5 cAMP phosphodiesterase isoforms, exhibited increased PDE4 activity when challenged with H2O2 in a fashion that was negated by treatment with the cell permeant antioxidant, N-acetyl cysteine and by diphenyleneiodonium chloride, an inhibitor of NADPH oxidase. In Cos1 ...

journal_title：Cellular signalling

authors： Hill EV,Sheppard CL,Cheung YF,Gall I,Krause E,Houslay MD

更新日期：2006-11-01 00:00:00

abstract：:Desensitization of the micro-opioid receptor (MOR) has been implicated as an important regulatory process in the development of tolerance to opiates. Monitoring the release of intracellular Ca(2+) ([Ca(2+)](i)), we reported that [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO)-induced receptor desensitization req...

journal_title：Cellular signalling

authors： Chu J,Zheng H,Zhang Y,Loh HH,Law PY

更新日期：2010-04-01 00:00:00

abstract：:Embryonic stem cells (ESC) are pluripotent and could be maintained in vitro in a self-renewing state indefinitely, at the same time preserving their potential to differentiate towards more specific lineages. Despite the progress in the field, the complex network of signalling cascades involved in the maintenance of th...

journal_title：Cellular signalling

authors： Todorova MG,Fuentes E,Soria B,Nadal A,Quesada I

更新日期：2009-04-01 00:00:00

abstract：:Inflammation is characterized by early influx of polymorphonuclear neutrophils (PMNs), followed by a second wave of monocyte recruitment. PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes. However, the pathways for such sig...

journal_title：Cellular signalling

authors： Chang M,Guo F,Zhou Z,Huang X,Yi L,Dou Y,Huan J

更新日期：2018-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) has been shown to up-regulate the expression of vascular cell adhesion molecule (VCAM)-1 which contributes to the occurrence of airway inflammatory diseases. Genetic analysis reveals the existence of activator protein-1 (AP-1) binding site on VCAM-1 promoter region. However, the role of AP-1 i...

journal_title：Cellular signalling

authors： Lin WN,Luo SF,Lin CC,Hsiao LD,Yang CM

更新日期：2009-09-01 00:00:00

abstract：:Non-small cell lung cancer is one of the most aggressive cancers as per as the mortality and occurrence is concerned. Paclitaxel based chemotherapeutic regimes are now used as an important option for the treatment of lung cancer. However, resistance of lung cancer cells to paclitaxel continues to be a major clinical p...

journal_title：Cellular signalling

authors： Chatterjee A,Chattopadhyay D,Chakrabarti G

更新日期：2015-02-01 00:00:00

abstract：:Wnt proteins are secreted glycoproteins that bind to the N-terminal extra-cellular cysteine-rich domain of the Frizzled (Fzd) receptor family. The Fzd receptors can respond to Wnt proteins in the presence of Wnt co-receptors to activate the canonical and non-canonical Wnt pathways. Recent studies indicated that, among...

journal_title：Cellular signalling

authors： King TD,Zhang W,Suto MJ,Li Y

更新日期：2012-04-01 00:00:00

abstract：:Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. In many tissues, orexins activate extracellular signal-regulated kinase (ERK(1/2)) and p38 mitogen-activated protein kinase (MAPK); however, the mechani...

journal_title：Cellular signalling

authors： Tang J,Chen J,Ramanjaneya M,Punn A,Conner AC,Randeva HS

更新日期：2008-09-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) is reported to regulate cell proliferation, survival, and differentiation, and thus plays a central role in development and carcinogenesis. Accumulating evidence demonstrated the involvement of cellular Src (c-Src) tyrosine kinase in the activation of STAT3....

journal_title：Cellular signalling

authors： Wang Y,Liu S,Jiang G,Zhai W,Yang L,Li M,Chang Z,Zhu B

更新日期：2020-11-01 00:00:00

abstract：:DMSO differentiated U937 cells responded to 10(-6) M LTD4, LTB4 and FMLP with an increase in both InsP formation and [Ca2+]i. FMLP caused a greater rise in InsPs than either LTD4 or LTB4, which were equivalent. LTD4, however, caused a greater increase in [Ca2+]i than LTB4 (4-fold) or FMLP. The FMLP [Ca2+]i and InsP re...

journal_title：Cellular signalling

authors： Pollock K,Creba J

更新日期：1990-01-01 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14-15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional...

journal_title：Cellular signalling

authors： Birch JL,Coull BJ,Spender LC,Watt C,Willison A,Syed N,Chalmers AJ,Hossain-Ibrahim MK,Inman GJ

更新日期：2020-08-01 00:00:00

abstract：:The functional consequence of cyclic AMP-dependent phosphorylation of rap1B for stimulus-induced platelet activation is not known. Platelets were pretreated with the stable prostacyclin-analogue iloprost and resuspended in plasma without iloprost. Western blot analysis showed that rap1B was completely converted into i...

journal_title：Cellular signalling

authors： Siess W,Grünberg B

更新日期：1993-03-01 00:00:00