当前位置： SCI文献检索 > CELLULAR SIGNALLING期刊下所有文献 > Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway.

Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway.

Abstract：

:Embryonic stem cells (ESC) are pluripotent and could be maintained in vitro in a self-renewing state indefinitely, at the same time preserving their potential to differentiate towards more specific lineages. Despite the progress in the field, the complex network of signalling cascades involved in the maintenance of the self-renewing and pluripotent state remains not fully understood. In the present study, we have investigated the role of lysophosphatidic acid (LPA), a potent mitogen present in serum, in Ca(2+) signalling and early gene activation in mouse ESC (mESC). In these cells, we detected the expression of the G-protein coupled LPA receptor subtypes LPA(1), LPA(2) and LPA(3). Using fluorescence Ca(2+) imaging techniques, we showed that LPA induced an increase in intracellular Ca(2+) concentration. This increase was also observed in the absence of extracellular Ca(2+), suggesting the involvement of internal stores. Pre-treatment with BAPTA-AM, thapsigargin or U-73122 efficiently blocked this Ca(2+) release, indicating that LPA was evoking Ca(2+) mobilization from the endoplasmic reticulum via the phospholipase C (PLC) pathway. Interestingly, this signalling cascade initiated by LPA was involved in inducing the expression of the Ca(2+)-dependent early response gene c-myc, a key gene implicated in ESC self-renewal and pluripotency. Additionally, LPA increased the proliferation rate of mESC. Our findings therefore outline the physiological role of LPA in mESC.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Todorova MG,Fuentes E,Soria B,Nadal A,Quesada I

doi

10.1016/j.cellsig.2008.12.005

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

523-8

issue

4

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(08)00372-0

journal_volume

21

pub_type

杂志文章

相关文献

CELLULAR SIGNALLING文献大全
  • Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.

    abstract：:Janus kinase 2 (Jak2) has a pivotal role in erythropoietin (Epo) signaling pathway, including erythrocyte differentiation and Stat5 activation. In the course of screening for critical phosphorylation of tyrosine residues in Jak2, we identified tyrosine 913 (Y(913)) as a novel and functional phosphorylation site, which...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.07.008

    authors： Funakoshi-Tago M,Tago K,Kasahara T,Parganas E,Ihle JN

    更新日期：2008-11-01 00:00:00

  • FOXO3a-dependent up-regulation of Mxi1-0 promotes hypoxia-induced apoptosis in endothelial cells.

    abstract：:Endothelial cell apoptosis induced by hypoxia is implicated in the pathogenesis of vascular diseases. However, the underlying mechanism is not clearly elucidated. In this study, we found that hypoxia increased Mxi1-0 expression, and the Mxi1-0 siRNA could inhibit caspase-8 activation and apoptosis in HUVECs induced by...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2018.08.009

    authors： Hu Z,Wang F,Wu Z,Gu H,Dong N,Jiang X,Xu J,Wu Z,Wechsler DS,Zheng D

    更新日期：2018-11-01 00:00:00

  • Regulation of alternative splicing of CD44 in cancer.

    abstract：:CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility, cell survival and proliferation as well as the formation of tumor microenvironment. CD44 contains two variable regions encoded by variable exons. Alternative splicing, which is often deregulated in cancer, can produce vario...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2014.07.011

    authors： Prochazka L,Tesarik R,Turanek J

    更新日期：2014-10-01 00:00:00

  • Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes.

    abstract：:Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important roles in adipogenesis and inflammation. The aim of this study is to investigate the impact of GATA-3 s...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109735

    authors： Al-Mansoori L,Al-Jaber H,Madani AY,Mazloum NA,Agouni A,Ramanjaneya M,Abou-Samra AB,Elrayess MA

    更新日期：2020-11-01 00:00:00

  • β-Hydroxybutyrate: A signaling metabolite in starvation response?

    abstract：:Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BH...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2016.04.005

    authors： Rojas-Morales P,Tapia E,Pedraza-Chaverri J

    更新日期：2016-08-01 00:00:00

  • Lovastatin inhibits receptor-stimulated Ca(2+)-influx in retinoic acid differentiated U937 and HL-60 cells.

    abstract：:Lovastatin was used to study the role of isoprenylated proteins on stimulus-induced increase of cytosolic Ca2+ in retinoic acid-differentiated U937 and HL-60 cells. Preincubation of the cells with lovastatin for 11-24 h reduced the Ca(2+)-influx induced by PAF of FMLP. The maximal decrease was 60% in U937 cells and 40...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(94)00041-7

    authors： Haag H,Grünberg B,Weber C,Vauti F,Aepfelbacher M,Siess W

    更新日期：1994-09-01 00:00:00

  • A caffeine/ryanodine-sensitive Ca2+ pool is involved in triggering spontaneous variations of Ca2+ in Jurkat T lymphocytes by a Ca(2+)-induced Ca2+ release (CICR) mechanism.

    abstract：:Caffeine and ryanodine triggered an increase in [Ca2+]i (73 +/- 22 and 61 +/- 18 nM, respectively) in Jurkat cell populations that was independent of external Ca2+. In individual cells, caffeine and ryanodine induced Ca2+ spikes. Jurkat cell populations initially exposed to caffeine did not respond further to ryanodin...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(96)00141-6

    authors： Ricard I,Martel J,Dupuis L,Dupuis G,Payet MD

    更新日期：1997-02-01 00:00:00

  • Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.

    abstract：:In this study, we demonstrate that EGF inhibits the TGF-β1-induced apoptosis of Huh7 cells. TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway. TGF-β1 also inhibits the activation of S6 kinase 1 which phosphorylates the serine 67 res...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.11.038

    authors： Matsuhashi S,Hamajima H,Xia J,Zhang H,Mizuta T,Anzai K,Ozaki I

    更新日期：2014-03-01 00:00:00

  • AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells.

    abstract：:AMP-activated protein kinase (AMPK), an important regulator of energy homeostasis, is known to be activated during T cell activation. T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression. ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2012.01.015

    authors： Lee JY,Choi AY,Oh YT,Choe W,Yeo EJ,Ha J,Kang I

    更新日期：2012-06-01 00:00:00

  • The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.

    abstract：:The focal adhesion kinase Pyk2 integrates signals from cell adhesion receptors, growth factor receptors, and G-protein-coupled receptors leading to the activation of intracellular signaling pathways that regulate cellular phenotypes. The intrinsic mechanism for the activation of Pyk2 activity remains to be fully defin...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2010.09.015

    authors： Riggs D,Yang Z,Kloss J,Loftus JC

    更新日期：2011-01-01 00:00:00

  • The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.

    abstract：:PRK1/PKN is a member of the protein kinase C (PKC) superfamily of serine/threonine protein kinases. Despite its important role as a RhoA effector, limited information is available regarding how this kinase is regulated. We show here that the last seven amino acid residues at the C-terminus is dispensable for the catal...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2004.12.003

    authors： Lim WG,Zhu Y,Wang CH,Tan BJ,Armstrong JS,Dokland T,Yang H,Zhu YZ,Teo TS,Duan W

    更新日期：2005-09-01 00:00:00

  • The signalling profile of recombinant human orexin-2 receptor.

    abstract：:Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. In many tissues, orexins activate extracellular signal-regulated kinase (ERK(1/2)) and p38 mitogen-activated protein kinase (MAPK); however, the mechani...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.05.010

    authors： Tang J,Chen J,Ramanjaneya M,Punn A,Conner AC,Randeva HS

    更新日期：2008-09-01 00:00:00

  • CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2.

    abstract：:CD40 is critically involved in Fas-mediated cholangiocyte apoptosis during liver inflammation, but the underlying signalling events are poorly understood. Our recent work implicated AP-1 in CD40-induced cholangiocyte apoptosis, but suggested involvement of other signalling pathways. Because STAT3 has been implicated i...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.05.015

    authors： Ahmed-Choudhury J,Williams KT,Young LS,Adams DH,Afford SC

    更新日期：2006-04-01 00:00:00

  • Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT (SLC7A11).

    abstract：:The cystine/glutamate antiporter xCT (SLC7A11) is frequently overexpressed in many cancers, including glioblastoma. Cystine taken up by the cells via xCT is reduced to cysteine, which is used to synthesize glutathione for antioxidant cellular defense. However, overexpression of xCT causes cell death under glucose-limi...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109874

    authors： Yamamoto M,Teramoto K,Katoh H

    更新日期：2021-02-01 00:00:00

  • Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.

    abstract：:The stimulatory effect of Mn2+ (1.5-fold), forskolin (1.6-fold) and low (1 microM) concentrations of GTP (1.9-fold) on the adenylyl cyclase of adipocyte membranes from obese, diabetic CBA/Ca mice was markedly enhanced compared to that seen using membranes prepared from their lean littermates. In contrast, receptor-med...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(92)90031-3

    authors： Palmer TM,Taberner PV,Houslay MD

    更新日期：1992-07-01 00:00:00

  • Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene.

    abstract：:Despite the essential role of the fibrinogen gamma-chain as a blood clotting factor, the fibrinogen gamma-chain contains a number of interaction sites to recruit other factors such as leukocytes important for prevention of pathogen entry and propagation of the repair process. Interleukin-6 (IL-6) is known as the major...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.04.007

    authors： Albrecht U,Yang X,Asselta R,Keitel V,Tenchini ML,Ludwig S,Heinrich PC,Häussinger D,Schaper F,Bode JG

    更新日期：2007-09-01 00:00:00

  • Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction.

    abstract：:Endothelin-1 (ET-1) is a vasoconstrictor peptide known to be a potent mitogen for glomerular mesangial cells. We have shown that ET-1 stimulates the adaptor protein p66Shc through Rac/Cdc42 guanine nucleotide exchange factor beta(1)Pix. In this study, we demonstrate that ET-1-induced serine phosphorylation of p66Shc i...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.09.039

    authors： Chahdi A,Sorokin A

    更新日期：2010-02-01 00:00:00

  • The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.

    abstract：:The Rho family of GTPases consists of several small proteins that have been described as molecular switches, playing important roles in a wide variety of fundamental cellular processes and in human diseases such as cancer. These proteins, active in the GTP conformation and inactive in the GDP form, are in turn regulat...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2013.11.034

    authors： Boissier P,Huynh-Do U

    更新日期：2014-03-01 00:00:00

  • A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.

    abstract：:Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of urokinase-and tissue-type plasminogen activators (uPA and tPA), is an injury-response gene implicated in the development of tissue fibrosis and cardiovascular disease. PAI-1 mRNA and protein levels were elevated in the balloon catheter-injured carotid...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2015.01.009

    authors： Simone TM,Higgins SP,Archambeault J,Higgins CE,Ginnan RG,Singer H,Higgins PJ

    更新日期：2015-05-01 00:00:00

  • TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD.

    abstract：:Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological ranges. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. The initia...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.12.009

    authors： Stokes A,Wakano C,Koblan-Huberson M,Adra CN,Fleig A,Turner H

    更新日期：2006-10-01 00:00:00

  • The focal adhesion targeting sequence is the major inhibitory moiety of Fak-related non-kinase.

    abstract：:Focal adhesion kinase (FAK) plays an important role in integrin-mediated signal transduction pathways and its C-terminal noncatalytic domain Fak-related non-kinase (FRNK), which is autonomously expressed, acts as an inhibitor of FAK. A model has been proposed where FAK and FRNK compete for an essential common binding ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(01)00226-1

    authors： Mortier E,Cornelissen F,van Hove C,Dillen L,Richardson A

    更新日期：2001-12-01 00:00:00

  • Negative regulation of interferon-γ/STAT1 signaling through cell adhesion and cell density-dependent STAT1 dephosphorylation.

    abstract：:Signal transducer and activator of transcription 1 (STAT1) is an important mediator for cytokine signal transduction, particularly IFN-γ. Following IFN-γ stimulation, STAT1 is activated through tyrosine phosphorylation. Little is known about the function and regulation of STAT1 dephosphorylation after activation. We s...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.04.003

    authors： Chen Z,Ma X,Zhang H,Sun X,Shen S,Li Y,Gu Y,Wang Y,Yan S,Yu Q

    更新日期：2011-08-01 00:00:00

  • Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor.

    abstract：:Ceramide 1-phosphate (C1P) is a bioactive sphingolipid that is implicated in the regulation of cell homeostasis and the control of inflammation. It is mitogenic for fibroblasts and macrophages, and has been described as potent inhibitor of apoptosis. Using RAW 264.7 macrophages we have now discovered a new biological ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.11.003

    authors： Granado MH,Gangoiti P,Ouro A,Arana L,González M,Trueba M,Gómez-Muñoz A

    更新日期：2009-03-01 00:00:00

  • Genistein inhibits potentiation by wortmannin of protein kinase C-activated phospholipase D in osteoblast-like cells.

    abstract：:We previously showed that protein kinase C (PKC) induces phosphatidylcholine-hydrolysing phospholipase D activation in osteoblast-like MC3T3-E1 cells and that tyrosine kinase is involved in this activation. Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, markedly enhanced the formation of choline indu...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(94)00080-u

    authors： Kozawa O,Suzuki A,Shinoda J,Oiso Y

    更新日期：1995-03-01 00:00:00

  • Functional interactions between calmodulin and estrogen receptor-alpha.

    abstract：:The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor alpha and estrogen receptor beta (ERalpha and ERbeta). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERalpha. Calmodulin contributes to the regulation of ...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2006.08.018

    authors： Li L,Sacks DB

    更新日期：2007-03-01 00:00:00

  • Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.

    abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinas...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2020.109842

    authors： Kaur H,Moreau R

    更新日期：2021-02-01 00:00:00

  • Molecular pathways in peritoneal fibrosis.

    abstract：:Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other outcome parameters, yet providing superior quality-of-life measures and cost savings. However, long-term usage of the patient's peritoneal ...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2020.109778

    authors： Balzer MS

    更新日期：2020-11-01 00:00:00

  • Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.

    abstract：:Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibrotic factor, the role ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.02.017

    authors： Overstreet JM,Samarakoon R,Meldrum KK,Higgins PJ

    更新日期：2014-07-01 00:00:00

  • Crosstalk and specificity in signalling. Are we crosstalking ourselves into general confusion?

    abstract：:The numerous examples of "crosstalk" between signal transduction pathways reported in the biochemical literature seem to imply a general common response of cells to different stimuli, even when these stimuli act initially on different cascades. This contradicts our knowledge of the specificity of action of extracellul...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/s0898-6568(01)00168-1

    authors： Dumont JE,Pécasse F,Maenhaut C

    更新日期：2001-07-01 00:00:00

  • The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer.

    abstract：:Quantitative analysis of the proteins which compromise the stimulatory arm of the adenylyl cyclase cascade indicate that the adenylyl cyclase catalytic component is usually the least highly expressed. The effects on both potency of agonist ligands and maximal output resulting from targetted alterations in expression l...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/0898-6568(95)02034-9

    authors： Milligan G

    更新日期：1996-02-01 00:00:00