Regulation of alternative splicing of CD44 in cancer.

abstract：:In this study, we showed that nitric oxide (NO) donors induced the mesangial cell proliferation and cyclooxygenase-2 (COX-2) protein expression in murine mesangial cells. An inflammatory condition [lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma)] could also induce cell proliferation and significantly enhanc...

journal_title：Cellular signalling

authors： Sheu ML,Chao KF,Sung YJ,Lin WW,Lin-Shiau SY,Liu SH

更新日期：2005-08-01 00:00:00

abstract：:The role of microtubules (MTs) in steroid hormone-dependent human glucocorticoid receptor (hGR) activation/translocation is controversial. It was demonstrated recently that colchicine (COL) down-regulates hGR-driven genes in primary human hepatocytes by a mechanism involving inhibition of hGR translocation to the nucl...

journal_title：Cellular signalling

authors： Dvorák Z,Modrianský M,Ulrichová J,Maurel P,Vilarem MJ,Pascussi JM

更新日期：2005-02-01 00:00:00

abstract：:Janus kinase 2 (Jak2) has a pivotal role in erythropoietin (Epo) signaling pathway, including erythrocyte differentiation and Stat5 activation. In the course of screening for critical phosphorylation of tyrosine residues in Jak2, we identified tyrosine 913 (Y(913)) as a novel and functional phosphorylation site, which...

journal_title：Cellular signalling

authors： Funakoshi-Tago M,Tago K,Kasahara T,Parganas E,Ihle JN

更新日期：2008-11-01 00:00:00

abstract：:Inositol 1,4,5-trisphosphate 5-phosphatase catalyses the dephosphorylation of the phosphate in the 5-position from inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate. One particulate and two soluble enzymes were previously described in bovine brain. In this study, we have obtained a precipitating anti...

journal_title：Cellular signalling

authors： Verjans B,Hollande F,Moreau C,Lejeune C,Erneux C

更新日期：1990-01-01 00:00:00

abstract：:Homer1 protein is an important scaffold protein at postsynaptic density and has been demonstrated to play a central role in calcium signaling in the central nervous system. The aim of this study was to investigate the effects of Homer1 knockdown on MPP(+) induced neuronal injury in cultured dopamine (DA) neurons. We f...

journal_title：Cellular signalling

authors： Chen T,Yang YF,Luo P,Liu W,Dai SH,Zheng XR,Fei Z,Jiang XF

更新日期：2013-12-01 00:00:00

abstract：:Calcineurin (CnA) is an important signalling molecule in skeletal muscle, in the promotion of differentiation, slow-fibre phenotype and possibly fibre hypertrophy. We found that stable expression of constitutively active CnA in muscle C2C12 cells strongly activated NF-kappaB, a key mediator of muscle wasting. NF-kappa...

journal_title：Cellular signalling

authors： Alzuherri H,Chang KC

更新日期：2003-05-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) can engage multiple pathways to activate ERK1/2 via both G proteins and/or ßarrestin. Receptor recruitment of ßarrestin is also important for GPCR desensitization, internalization and resensitization. Modulation of the receptor/ßarrestin interaction through modification of either co...

journal_title：Cellular signalling

authors： Zimmerman B,Simaan M,Akoume MY,Houri N,Chevallier S,Séguéla P,Laporte SA

更新日期：2011-04-01 00:00:00

abstract：:Aggregation of the high-affinity receptor for IgE (Fc eta RI) on the surface of intact or permeabilized rodent mast cells results in tyrosine phosphorylation of phospholipase C-gamma 1 (PLC gamma 1) and PLC gamma 2, and translocation of both isozymes to the particulate fraction. We report here that activation of resid...

journal_title：Cellular signalling

authors： Atkinson TP,Yang Q

更新日期：1996-09-01 00:00:00

abstract：:In diverse neuronal processes ranging from neuronal survival to synaptic plasticity cyclic adenosine monophosphate (cAMP)-dependent signaling is tightly connected with the protein kinase B (PKB)/Akt pathway but the precise nature of this connection remains unknown. In the current study we investigated the effect of tw...

journal_title：Cellular signalling

authors： Nijholt IM,Dolga AM,Ostroveanu A,Luiten PG,Schmidt M,Eisel UL

更新日期：2008-10-01 00:00:00

abstract：:Circulating symmetric dimethylarginine (SDMA) is increased in patients with chronic kidney disease. SDMA is considered an inert metabolite, but because it can transported into cells, we studied the effect of SDMA on glomerular endothelial cells. SDMA suppressed VEGF-induced endothelial nitric oxide synthase (eNOS) pho...

journal_title：Cellular signalling

authors： Feliers D,Lee DY,Gorin Y,Kasinath BS

更新日期：2015-01-01 00:00:00

abstract：:Strategies which can be used to elucidate the nature of a GTP-binding regulatory protein (G-protein) involved in an intracellular pathway of interest in the complex environment of the cell are described and evaluated. A desirable strategy is considered to be one in which the first stage indicates a requirement for one...

journal_title：Cellular signalling

authors： Barritt GJ,Gregory RB

更新日期：1997-05-01 00:00:00

abstract：:Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylat...

journal_title：Cellular signalling

authors： Velazquez FN,Hernandez-Corbacho M,Trayssac M,Stith JL,Bonica J,Jean B,Pulkoski-Gross MJ,Carroll BL,Salama MF,Hannun YA,Snider AJ

更新日期：2021-03-01 00:00:00

abstract：:The glucose-regulated protein grp78 gene is rapidly transactivated in 9L rat brain tumour (RBT) cells treated with okadaic acid (OA) followed by heat shock (HS) (termed OA-->HS treatment). By Northern blotting analyses and transient transfection assays, we herein show that transactivation of grp78 by OA-->HS is abolis...

journal_title：Cellular signalling

authors： Chang WM,Chen KD,Chen LY,Lai MT,Lai YK

更新日期：2003-01-01 00:00:00

abstract：:Src homology (SH) 3 domains are small modules found in a diverse array of proteins. The presence of an SH3 domain confers upon its resident protein the ability to interact with specific proline-rich sequences in protein binding partners. A major focus of research has highlighted a role for SH3 domain-mediated interact...

journal_title：Cellular signalling

authors： McPherson PS

更新日期：1999-04-01 00:00:00

abstract：:Immune responses to pathogens are regulated by immune receptors containing either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibitory motif (ITIM). The important diarrheal pathogen enteropathogenic Escherichia coli (EPEC) require delivery and insertion of the bacteri...

journal_title：Cellular signalling

authors： Yan D,Quan H,Wang L,Liu F,Liu H,Chen J,Cao X,Ge B

更新日期：2013-09-01 00:00:00

abstract：:We have isolated a cDNA from a human liver library which is 2349 base pairs in length and encodes a near-full length seven transmembrane receptor (432 amino acids), 85% homologous to the amino acid sequence for the rat vasoactive intestinal peptide (VIP) receptor. Northern blot analysis identifies a major species at 3...

journal_title：Cellular signalling

authors： Gagnon AW,Aiyar N,Elshourbagy NA

更新日期：1994-03-01 00:00:00

abstract：:Protein kinase C and the annexins appear to share some unusual and potentially important membrane- and calcium-binding properties. While these proteins are calcium response elements, they are not calcium-binding proteins in the formal sense; at intracellular calcium concentrations, they only bind significant amounts o...

journal_title：Cellular signalling

authors： Bazzi MD,Nelsestuen GL

更新日期：1993-07-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cell lines treated by genotoxic agents or by Tumor Necrosis Factor alpha (TNFalpha) acquire potent cytotoxicity towards myeloid cells through activation of granzyme B (GrB)/perforin (PFN) system. Here we first extend this observation to another death receptor activator, Fas Ligand (FasL). ...

journal_title：Cellular signalling

authors： Guilloton F,Jean C,de Thonel A,Laurent G,Quillet-Mary A

更新日期：2007-06-01 00:00:00

abstract：:Lithium salts are important drugs to treat bipolar disorder. Previous work showed that lithium by enforcing the interaction between the transcription factor CREB and its coactivator CRTC1 enhanced cAMP-stimulated CREB-dependent gene transcription. Both CREB and CRTC have been implicated in neuronal adaptation, which m...

journal_title：Cellular signalling

authors： Heinrich A,von der Heyde AS,Böer U,Phu do T,Tzvetkov M,Oetjen E

更新日期：2013-01-01 00:00:00

abstract：:The induction of cytolytic activity in PC60, a murine T-cell hybridoma, is paralleled by a rise in the level of BLT-esterase (N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl esterase), a serine esterase specific for activated T-cells. Both interleukin-1 (IL-1) and dibutyryl cAMP were albe to increase the esterase activi...

journal_title：Cellular signalling

authors： Schlegel-Haueter SE,Aebischer F

更新日期：1990-01-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) serves to stabilise and correctly fold multiple significant client proteins associated with cell proliferation and cell survival. However, little is known about the Hsp90 client proteins that regulate cell metabolism. Here, we describe a unique ability of Hsp90 to regulate the stability a...

journal_title：Cellular signalling

authors： Zhang L,Yi Y,Guo Q,Sun Y,Ma S,Xiao S,Geng J,Zheng Z,Song S

更新日期：2012-04-01 00:00:00

abstract：:The Rho family of GTPases consists of several small proteins that have been described as molecular switches, playing important roles in a wide variety of fundamental cellular processes and in human diseases such as cancer. These proteins, active in the GTP conformation and inactive in the GDP form, are in turn regulat...

journal_title：Cellular signalling

authors： Boissier P,Huynh-Do U

更新日期：2014-03-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) define a specific group of eukaryotic protein kinases which regulate a number of cellular functions by transducing extracellular signals to intracellular responses. Unlike other protein kinases, catalytic activation of MAPKs by MAPKKs depends on dual phosphorylation at two tyr...

journal_title：Cellular signalling

authors： Vázquez B,Soto T,del Dedo JE,Franco A,Vicente J,Hidalgo E,Gacto M,Cansado J,Madrid M

更新日期：2015-12-01 00:00:00

abstract：:Interferon-α (IFNα) has enormous potential for anti-proliferative and anti-viral treatments. However, clinical success is still hampered due to its limited bioavailability and thus, lack of sustained modulation of disease-relevant protective programs. Consequently, we here examined whether IFNα immobilized on nanoscal...

journal_title：Cellular signalling

authors： Pollok S,Ginter T,Günzel K,Pieper J,Henke A,Stauber RH,Reichardt W,Krämer OH

更新日期：2013-04-01 00:00:00

abstract：:Glioblastoma, the most lethal form of brain cancer, is characterized by fast growth, migration and invasion of the surrounding parenchyma, with epithelial-to-mesenchymal transition (EMT)-like process being mostly responsible for tumour spreading and dissemination. A number of actors, including cadherins, vimentin, tra...

journal_title：Cellular signalling

authors： Cutone A,Colella B,Pagliaro A,Rosa L,Lepanto MS,Bonaccorsi di Patti MC,Valenti P,Di Bartolomeo S,Musci G

更新日期：2020-01-01 00:00:00

abstract：:Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70), a member of Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T cells. Its role in T-cell development has been established by the severe combined immune deficiency syndrome in ZAP-70 deficient human...

journal_title：Cellular signalling

authors： Kaur M,Singh M,Silakari O

更新日期：2014-11-01 00:00:00

abstract：:Proliferation of mammalian cells both in vivo and in vitro is dependent upon physiological concentrations of extracellular Ca2+. Growth factor stimulation of quiescent cells at the G0/G1 border usually results in a rapid mobilization of Ca2+ from both intra- and extracellular pools. However, Ca2+ influx is also requir...

journal_title：Cellular signalling

authors： Takuwa N,Zhou W,Takuwa Y

更新日期：1995-02-01 00:00:00

abstract：:We have studied the effects of cholinergic agonists on the rates of insulin release and the concentrations of diacylglycerol (DAG) and intracellular free Ca2+ ([Ca2+]i) in the beta-cell line MIN6. Insulin secretion was stimulated by glucose, by glibenclamide and by bombesin. In the presence of glucose, both acetylchol...

journal_title：Cellular signalling

authors： Weng L,Davies M,Ashcroft SJ

更新日期：1993-11-01 00:00:00

abstract：:We demonstrate the difference between the follistatin isoforms (FS-288 and FS-315), two activin-binding proteins, in the neutralizing activity for activin signalling. Transcriptional reporter assay using 3TP-Lux, an activin-responsive reporter construct, showed that the inhibitory effect of FS-288 on activin-induced t...

journal_title：Cellular signalling

authors： Hashimoto O,Kawasaki N,Tsuchida K,Shimasaki S,Hayakawa T,Sugino H

更新日期：2000-08-01 00:00:00

abstract：:Desensitization of the micro-opioid receptor (MOR) has been implicated as an important regulatory process in the development of tolerance to opiates. Monitoring the release of intracellular Ca(2+) ([Ca(2+)](i)), we reported that [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO)-induced receptor desensitization req...

journal_title：Cellular signalling

authors： Chu J,Zheng H,Zhang Y,Loh HH,Law PY

更新日期：2010-04-01 00:00:00