Genistein inhibits potentiation by wortmannin of protein kinase C-activated phospholipase D in osteoblast-like cells.

abstract：:JNK signaling functions to induce defense mechanisms that protect organisms against a variety of different situations. The sestrin 2 gene, a p53-regulated member of the sestrins family, which lead to AMPK-dependent inhibition of TOR signaling, emerges as a novel player in autophagy induction. However, the relationship...

journal_title：Cellular signalling

authors： Zhang XY,Wu XQ,Deng R,Sun T,Feng GK,Zhu XF

更新日期：2013-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family in the human genome with over 800 members identified to date. They play critical roles in numerous cellular and physiological processes, including cell proliferation, differentiation, neurotransmission, development and apoptosis...

journal_title：Cellular signalling

authors： Nieto Gutierrez A,McDonald PH

更新日期：2018-01-01 00:00:00

abstract：:In this work, we used colon carcinoma cell-line HCT116 to study the involvement of the 86-kDa subunit (Ku86) of DNA-protein kinase (DNA-PK) in human tumoural cell proliferation. We transfected these cells with a 639-bp cDNA encoding a Ku86 portion inserted into pcDNA3.1 vector in the antisense orientation. After selec...

journal_title：Cellular signalling

authors： Sadji Z,Le Romancer M,Lewin MJ,Reyl-Desmars F

更新日期：2000-12-01 00:00:00

abstract：:Single disseminated tumor cells (DTC) can be detected in the bone marrow (BM) from 20% to 60% of patients with various tumors including non-small cell lung cancer (NSCLC). Detection of DTC in the BM of NSCLC patients is associated with poor prognosis and may be responsible for metastatic relapse. However, the function...

journal_title：Cellular signalling

authors： Grabinski N,Bartkowiak K,Grupp K,Brandt B,Pantel K,Jücker M

更新日期：2011-12-01 00:00:00

abstract：:In extracts of human platelets, three isoenzymes of cyclic nucleotide phosphodiesterase (PDE), namely, PDE2, PDE3, and PDE5, were identified; activities of PDE1 and PDE4 were not detected. In human platelets, the cGMP-hydrolytic activity was about six times higher than the cAMP-hydrolytic activity, and PDE5 and PDE3 a...

journal_title：Cellular signalling

authors： Ito M,Nishikawa M,Fujioka M,Miyahara M,Isaka N,Shiku H,Nakano T

更新日期：1996-12-01 00:00:00

abstract：:In vitro, little specificity is seen for modulation of effectors by different combinations of Gbetagamma subunits from heterotrimeric G proteins. Here, we demonstrate that the coupling of specific combinations of Gbetagamma subunits to different receptors leads to a differential ability to modulate effectors in vivo. ...

journal_title：Cellular signalling

authors： Robillard L,Ethier N,Lachance M,Hébert TE

更新日期：2000-10-01 00:00:00

abstract：:Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the Transforming Growth Factor Beta superfamily. To date over 20 members have been identified in humans with varying functions during processes such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis. Though their functions hav...

journal_title：Cellular signalling

authors： Bragdon B,Moseychuk O,Saldanha S,King D,Julian J,Nohe A

更新日期：2011-04-01 00:00:00

abstract：:Whole-cell currents activated by bath applications of acetylcholine (ACh) (10-30 microM) were recorded from patch-clamped myotubes of the mouse C2 cell line. Increasing concentrations of forskolin caused a dose-dependent fast decay of ACh-activated currents as compared to the long-lasting ACh-currents in control cells...

journal_title：Cellular signalling

authors： Giovannelli A,Farini D,Gauzzi MC,Alema S,Eusebi F

更新日期：1990-01-01 00:00:00

abstract：:Protein Kinase B (PKB/Akt) is a key regulator of cell proliferation, motility and survival. The activation status of PKB is regulated by phosphatidylinositol 3-kinase (PI3K) via the synthesis of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3, PIP3). PTEN antagonises PI3K by degrading PIP3 to phosphatidylinosito...

journal_title：Cellular signalling

authors： Sharrard RM,Maitland NJ

更新日期：2007-01-01 00:00:00

abstract：:Cross-talk between nuclear receptors involved in the control of drug metabolism is being increasingly recognised as a source of drug side effects. Omeprazole is a well known activator of the aryl hydrocarbon receptor (AhR). We investigated the regulation of AhR by omeprazole-sulphide, a degradation metabolite of omepr...

journal_title：Cellular signalling

authors： Gerbal-Chaloin S,Pichard-Garcia L,Fabre JM,Sa-Cunha A,Poellinger L,Maurel P,Daujat-Chavanieu M

更新日期：2006-05-01 00:00:00

abstract：:Extracellular signal regulated kinases (ERKs) are a class of MAP kinases that function in many signaling pathways in eukaryotic cells and in some cases, a single stimulus can activate more than one ERK suggesting functional redundancy or divergence from a common pathway. Dictyostelium discoideum encodes only two MAP k...

journal_title：Cellular signalling

authors： Nguyen HN,Raisley B,Hadwiger JA

更新日期：2010-05-01 00:00:00

abstract：:Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylat...

journal_title：Cellular signalling

authors： Velazquez FN,Hernandez-Corbacho M,Trayssac M,Stith JL,Bonica J,Jean B,Pulkoski-Gross MJ,Carroll BL,Salama MF,Hannun YA,Snider AJ

更新日期：2021-03-01 00:00:00

abstract：:Signal transducer and activator of transcription 1 (STAT1) is an important mediator for cytokine signal transduction, particularly IFN-γ. Following IFN-γ stimulation, STAT1 is activated through tyrosine phosphorylation. Little is known about the function and regulation of STAT1 dephosphorylation after activation. We s...

journal_title：Cellular signalling

authors： Chen Z,Ma X,Zhang H,Sun X,Shen S,Li Y,Gu Y,Wang Y,Yan S,Yu Q

更新日期：2011-08-01 00:00:00

abstract：:High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic cancer. Emerging evidence suggests that tumor-associated macrophages (TAMs) play an immunosuppressive role in the tumor microenvironment and promote tumor growth, angiogenesis, and metastasis in ovarian cancer. Therefore, targeting TAMs in pati...

journal_title：Cellular signalling

authors： El-Arabey AA,Denizli M,Kanlikilicer P,Bayraktar R,Ivan C,Rashed M,Kabil N,Ozpolat B,Calin GA,Salama SA,Abd-Allah AR,Sood AK,Lopez-Berestein G

更新日期：2020-04-01 00:00:00

abstract：:Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. However the relative role of each pathway and how they interact are not understood. Here we delineate how Akt and Rac1 pathways signal to increa...

journal_title：Cellular signalling

authors： Sylow L,Kleinert M,Pehmøller C,Prats C,Chiu TT,Klip A,Richter EA,Jensen TE

更新日期：2014-02-01 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14-15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional...

journal_title：Cellular signalling

authors： Birch JL,Coull BJ,Spender LC,Watt C,Willison A,Syed N,Chalmers AJ,Hossain-Ibrahim MK,Inman GJ

更新日期：2020-08-01 00:00:00

abstract：:CyrA is a novel cysteine-rich protein with four EGFL repeats that was isolated using the calmodulin (CaM) binding overlay technique (CaMBOT), suggesting it is a CaM-binding protein (CaMBP). The full-length 63kDa cyrA is cleaved into two major C-terminal fragments, cyrA-C45 and cyrA-C40. A putative CaM-binding domain w...

journal_title：Cellular signalling

authors： Suarez A,Huber RJ,Myre MA,O'Day DH

更新日期：2011-07-01 00:00:00

abstract：:Eight paralogue members form the family of transmembrane channel-like (TMC) proteins that share considerable sequence homology to anoctamin 1 (Ano1, TMEM16A). Ano1 is a Ca(2+) activated Cl(-) channel that is related to head and neck cancer, often caused by human papilloma virus (HPV) infection. Mutations in TMC 6 and ...

journal_title：Cellular signalling

authors： Sirianant L,Ousingsawat J,Tian Y,Schreiber R,Kunzelmann K

更新日期：2014-12-01 00:00:00

abstract：:The transforming growth factor beta (TGFbeta) family of growth regulatory peptides plays an important role in the regulation of gastrointestinal epithelial cell homeostasis. Loss of growth inhibitory signalling by TGFbeta is common in the context of Ras-transformation and it has been hypothesized that loss of TGFbeta ...

journal_title：Cellular signalling

authors： Jiang B,Zhang JS,Du J,Urrutia R,Barnard J

更新日期：2003-07-01 00:00:00

abstract：:Desensitization of the micro-opioid receptor (MOR) has been implicated as an important regulatory process in the development of tolerance to opiates. Monitoring the release of intracellular Ca(2+) ([Ca(2+)](i)), we reported that [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO)-induced receptor desensitization req...

journal_title：Cellular signalling

authors： Chu J,Zheng H,Zhang Y,Loh HH,Law PY

更新日期：2010-04-01 00:00:00

abstract：:Renal fibrosis is characterized by chronic inflammation and excessive accumulation of extracellular matrix and progressively leads to functional insufficiency and even total loss of kidney function. In this study we investigated the anti-fibrotic potential of two highly selective and potent SK2 inhibitors, SLM6031434 ...

journal_title：Cellular signalling

authors： Schwalm S,Beyer S,Hafizi R,Trautmann S,Geisslinger G,Adams DR,Pyne S,Pyne N,Schaefer L,Huwiler A,Pfeilschifter J

更新日期：2021-03-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). This study aimed to investigate the roles of LPA2 and LPA3 in the modulation of chemoresistance to anticancer drug in lung cancer A549 cells. In cell survival assay...

journal_title：Cellular signalling

authors： Ueda N,Minami K,Ishimoto K,Tsujiuchi T

更新日期：2020-05-01 00:00:00

abstract：:Inflammation is characterized by early influx of polymorphonuclear neutrophils (PMNs), followed by a second wave of monocyte recruitment. PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes. However, the pathways for such sig...

journal_title：Cellular signalling

authors： Chang M,Guo F,Zhou Z,Huang X,Yi L,Dou Y,Huan J

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have shown that RGS4 associates with the C-termini of μ- and δ-opioid receptors in living cells and plays a key role in Gi/Go protein coupling selectivity and signalling of these receptors [12,20]. To deduce whether similar effects also occur for the κ-opioid receptor (κ-ΟR) and define the ability of ...

journal_title：Cellular signalling

authors： Papakonstantinou MP,Karoussiotis C,Georgoussi Z

更新日期：2015-01-01 00:00:00

abstract：:DMSO differentiated U937 cells responded to 10(-6) M LTD4, LTB4 and FMLP with an increase in both InsP formation and [Ca2+]i. FMLP caused a greater rise in InsPs than either LTD4 or LTB4, which were equivalent. LTD4, however, caused a greater increase in [Ca2+]i than LTB4 (4-fold) or FMLP. The FMLP [Ca2+]i and InsP re...

journal_title：Cellular signalling

authors： Pollock K,Creba J

更新日期：1990-01-01 00:00:00

abstract：:Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. In many tissues, orexins activate extracellular signal-regulated kinase (ERK(1/2)) and p38 mitogen-activated protein kinase (MAPK); however, the mechani...

journal_title：Cellular signalling

authors： Tang J,Chen J,Ramanjaneya M,Punn A,Conner AC,Randeva HS

更新日期：2008-09-01 00:00:00

abstract：:Slug, a Snail-related zinc-finger transcription factor implicated in the increased motility of mesenchymal cells during embryonic development and progression of cancer cells towards an invasive phenotype, plays a specific and critical role in the pathogenesis of Bcr-Abl-associated leukemias. Here we report that Slug o...

journal_title：Cellular signalling

authors： Mancini M,Petta S,Iacobucci I,Salvestrini V,Barbieri E,Santucci MA

更新日期：2010-08-01 00:00:00

abstract：:A tight control of the machineries regulating membrane bending and actin dynamics is very important for the generation of membrane protrusions, which are crucial for cell migration and invasion. Protein/protein and protein/phosphoinositides complexes assemble and disassemble to coordinate these mechanisms, the scaffol...

journal_title：Cellular signalling

authors： Antoine M,Vandenbroere I,Ghosh S,Erneux C,Pirson I

更新日期：2020-09-01 00:00:00

abstract：:JNK proteins are conserved stress-activated MAP kinases. In C. elegans, the JNK-homolog KGB-1 plays essential roles in protection from heavy metals and protein folding stress. However, the contributions of KGB-1 are age-dependent, providing protection in larvae, but reducing stress resistance and shortening lifespan i...

journal_title：Cellular signalling

authors： Zhang Z,Liu L,Twumasi-Boateng K,Block DH,Shapira M

更新日期：2017-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor type beta1 (TGF-beta1) exert opposite effects in most cells. A potential regulation between the two factors has been studied at a transcriptional level, but never at a protein level. MDA-MB-231 is a breast carcinoma cell line which possesses large quantities...

journal_title：Cellular signalling

authors： Martínez-Carpio PA,Mur C,Rosel P,Navarro MA

更新日期：1999-10-01 00:00:00