Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes.

abstract：:Octimibate and related nonprostanoid prostacyclin mimetics are partial agonists displaying highly tissue-specific responses. Octimibate demonstrated considerably greater efficacy for stimulation of adenylyl cyclase activity in Chinese hamster ovary cells transiently expressing mouse prostacyclin receptors (mIP-CHO cel...

journal_title：Cellular signalling

authors： Kam Y,Chow KB,Wise H

更新日期：2001-11-01 00:00:00

abstract：:Protease-activated receptor 1 (PAR1) is an unusual GPCR that interacts with multiple G protein subfamilies (G(q/11), G(i/o), and G(12/13)) and their linked signaling pathways to regulate a broad range of pathophysiological processes. However, the molecular mechanisms whereby PAR1 interacts with multiple G proteins are...

journal_title：Cellular signalling

authors： McCoy KL,Gyoneva S,Vellano CP,Smrcka AV,Traynelis SF,Hepler JR

更新日期：2012-06-01 00:00:00

abstract：:Hepatocyte membranes from both lean and obese Zucker rats exhibited adenylate cyclase activity that could be stimulated by glucagon, forskolin, NaF and elevated concentrations of p[NH]ppG. In membranes from lean animals, functional Gi was detected by the ability of low concentrations of p[NH]ppG to inhibit forskolin-a...

journal_title：Cellular signalling

authors： Houslay MD,Gawler DJ,Milligan G,Wilson A

更新日期：1989-01-01 00:00:00

abstract：:We previously showed that an increase of cellular Bcl-xL mediates acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and knockdown of Bcl-xL expression greatly sensitized TRAIL-induced cytotoxicity. Here, we show that Daxx downregulation increases the anti-tumorigenic activity throu...

journal_title：Cellular signalling

authors： Kang S,Kang D,Bakhtiar Ul Islam SM,Je S,Kim JH,Song JJ

更新日期：2015-06-01 00:00:00

abstract：:Nur77 (NR4A1) plays an important role in various inflammatory responses. Nur77 is rapidly degraded in cells and its protein level is critically controlled. Although few E3 ligases regulating the Nur77 protein have been defined, the deubiquitinase (DUB) responsible for Nur77 stability has not been reported to date. We ...

journal_title：Cellular signalling

authors： Pei HZ,Huang B,Chang HW,Baek SH

更新日期：2019-07-01 00:00:00

abstract：:The role of the ras oncogene in the signalling pathway triggered by platelet-derived growth factor BB (PDGF-BB) has been investigated in a cell line which normally differentiates into myotubes. Following the activation of the N-ras oncogene, however, the cells proliferate and form foci. PDGF-BB stimulated the phosphor...

journal_title：Cellular signalling

authors： Zeytinoğlu H,Griffiths SL,Dawson AP,Gibson I

更新日期：1995-03-01 00:00:00

abstract：:Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinic...

journal_title：Cellular signalling

authors： Fan GH,Zhu TY,Huang J

更新日期：2020-08-01 00:00:00

abstract：:CK1δ and CK1ε are unique in the casein kinase 1 family and play critical roles in a number of physiological intracellular pathways. In particular, these kinases are involved in composing the mammalian circadian clock by phosphorylating core clock proteins. Considering that CK1δ/ε phosphorylate other key biological mol...

journal_title：Cellular signalling

authors： Yang Y,Xu T,Zhang Y,Qin X

更新日期：2017-02-01 00:00:00

abstract：:Circular RNAs (circRNAs) belong to a diverse class of stable RNAs expressed in all cell types. Their proposed functions include sponging of microRNAs (miRNAs), sequestration and trafficking of proteins, assembly of multimeric complexes, production of peptides, and regulation of transcription. Backsplicing due to RNA s...

journal_title：Cellular signalling

authors： Ottesen EW,Singh RN

更新日期：2020-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is involved in cell survival and proliferation and has been found to be persistently activated in most human cancers mainly through its phosphorylation at Tyr-705. However, the role and regulation of Stat3 Ser-727 phosphorylation...

journal_title：Cellular signalling

authors： Mandal T,Bhowmik A,Chatterjee A,Chatterjee U,Chatterjee S,Ghosh MK

更新日期：2014-08-01 00:00:00

abstract：:Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin. Here, we have foc...

journal_title：Cellular signalling

authors： Karger A,Fitzner B,Brock P,Sparmann G,Emmrich J,Liebe S,Jaster R

更新日期：2008-10-01 00:00:00

abstract：:Our previous oligonucleotide array studies revealed that ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL) express high levels of the disheveled proteins (Dvls), a family of proteins that is integral to the Wnt signaling pathways. In this study, we assessed whether the Dvls are important in the pathogenesis of ...

journal_title：Cellular signalling

authors： Hegazy SA,Alshareef A,Gelebart P,Anand M,Armanious H,Ingham RJ,Lai R

更新日期：2013-01-01 00:00:00

abstract：:The CCN family is composed of six cysteine-rich, modular, and conserved proteins whose functions span a variety of tissues and include cell proliferation, adhesion, angiogenesis, and wound healing. Roles for the CCN proteins throughout the entire body including the skin, kidney, brain, blood vessels, hematopoietic com...

journal_title：Cellular signalling

authors： Piszczatowski RT,Lents NH

更新日期：2016-10-01 00:00:00

abstract：:As a member of the Rab small GTPase family, Rab11a has been shown to be involved in different vesicle trafficking processes. In earlier work we identified Rab11a to be present in GLUT4-containing vesicles after insulin stimulation and showed its involvement in insulin-dependent glucose uptake. However, it remained elu...

journal_title：Cellular signalling

authors： Schwenk RW,Eckel J

更新日期：2007-04-01 00:00:00

abstract：:Induction of nitrosative stress has been observed in various cancer types and in tumor environment. However, it is still unclear how cancer cells combat the effect of nitrosative stress. The main targets of nitrosative stress in cells are cellular lipids, proteins and DNA. Autophagy or self-cleaning generates energy f...

journal_title：Cellular signalling

authors： Chakraborty S,Datta S,Ghosh S

更新日期：2019-12-01 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK)-dependent phosphorylation is an important regulator for cytosolic phospholipase A(2) (cPLA(2)). In this study, we found that the protein synthesis inhibitor cycloheximide can potentiate thapsigargin-induced arachidonic acid (AA) release concomitant with ERK phosphorylation f...

journal_title：Cellular signalling

authors： Lin WW,Hsu YW

更新日期：2000-07-01 00:00:00

abstract：:In Galpha(z)-deficient mice, survival of sympathetic neurons is significantly attenuated in the presence of pertussis toxin (PTX). This suggests that G(i/o) proteins may have distinct roles in neuronal survival. Here, we investigated the possible involvement of G(i/o) proteins in nerve growth factor (NGF)-induced pro-...

journal_title：Cellular signalling

authors： Wu EH,Wong YH

更新日期：2005-07-01 00:00:00

abstract：:G protein-coupled receptor kinases (GRKs) are key modulators of G protein-coupled receptor signalling. Increasing evidence points to the occurrence of complex mechanisms able to modulate the subcellular localization, activity and expression levels of GRKs, revealing new functional interactions of these kinases with di...

journal_title：Cellular signalling

authors： Penela P,Ribas C,Mayor F Jr

更新日期：2003-11-01 00:00:00

abstract：:Members of the phosducin gene family were initially proposed to act as down-regulators of G protein signaling by binding G protein betagamma dimers (Gbetagamma) and inhibiting their ability to interact with G protein alpha subunits (Galpha) and effectors. However, recent findings have over-turned this hypothesis by sh...

journal_title：Cellular signalling

authors： Willardson BM,Howlett AC

更新日期：2007-12-01 00:00:00

abstract：:Ubiquitination controls multiple cellular processes relevant to cancer pathogenesis. Using Gene Set Enrichment Analysis of an mRNA transcriptome dataset, we have identified genes encoding components of the ubiquitin system that are differentially expressed in colorectal cancers as compared to normal colonic mucosa. Am...

journal_title：Cellular signalling

authors： Eide PW,Cekaite L,Danielsen SA,Eilertsen IA,Kjenseth A,Fykerud TA,Ågesen TH,Bruun J,Rivedal E,Lothe RA,Leithe E

更新日期：2013-01-01 00:00:00

abstract：:Glioblastoma, the most lethal form of brain cancer, is characterized by fast growth, migration and invasion of the surrounding parenchyma, with epithelial-to-mesenchymal transition (EMT)-like process being mostly responsible for tumour spreading and dissemination. A number of actors, including cadherins, vimentin, tra...

journal_title：Cellular signalling

authors： Cutone A,Colella B,Pagliaro A,Rosa L,Lepanto MS,Bonaccorsi di Patti MC,Valenti P,Di Bartolomeo S,Musci G

更新日期：2020-01-01 00:00:00

abstract：:Quantitative analysis of the proteins which compromise the stimulatory arm of the adenylyl cyclase cascade indicate that the adenylyl cyclase catalytic component is usually the least highly expressed. The effects on both potency of agonist ligands and maximal output resulting from targetted alterations in expression l...

journal_title：Cellular signalling

authors： Milligan G

更新日期：1996-02-01 00:00:00

abstract：:We have studied modulation of "store-operated calcium influx" by tyrosine phosphatases in the pancreatic acinar cell line AR42J and in HEK 293 cells. We show that inhibition of tyrosine phosphatases by bis-(N,N-dimethyl-hydroxamido) hydrooxovanadate (DMHV) leads to an increase in Ca(2+) release-activated Ca(2+) (CRAC)...

journal_title：Cellular signalling

authors： Hsu S,Schmid A,Sternfeld L,Anderie I,Solis G,Hofer HW,Schulz I

更新日期：2003-12-01 00:00:00

abstract：:The functions of nerve growth factor (NGF) in skeletal muscles physiology and pathology are not clear and call for an updated investigation. To achieve this goal we sought to investigate NGF-induced ERK1/2 phosphorylation and its role in the C2C12 skeletal muscle myoblasts and myotubes. RT-PCR and western blotting exp...

journal_title：Cellular signalling

authors： Ettinger K,Lecht S,Arien-Zakay H,Cohen G,Aga-Mizrachi S,Yanay N,Saragovi HU,Nedev H,Marcinkiewicz C,Nevo Y,Lazarovici P

更新日期：2012-12-01 00:00:00

abstract：:Induction of apoptosis in Hep3B hepatoma cells by transforming growth factor beta 1 (TGF-beta 1) was accompanied by the activation of interleukin-1-beta-converting-enzyme-like proteases, which have recently been renamed as caspases. The caspase inhibitor ZVAD-FMK, which has a broader specificity for caspase family pro...

journal_title：Cellular signalling

authors： Hung WC,Chang HC,Chuang LY

更新日期：1998-07-01 00:00:00

abstract：:Angiotensin I and II have been shown to directly induce protein degradation in skeletal muscle through an increased activity and expression of the ubiquitin-proteasome proteolytic pathway. This investigation determines the role of the nuclear transcription factor nuclear factor-kappaB (NF-kappaB) in this process. Usin...

journal_title：Cellular signalling

authors： Russell ST,Wyke SM,Tisdale MJ

更新日期：2006-07-01 00:00:00

abstract：:Arap3 is a phosphoinositide (PI) 3 kinase effector that serves as a GTPase activating protein (GAP) for both Arf and Rho G-proteins. The protein has multiple pleckstrin homology (PH) domains that bind preferentially phosphatidyl-inositol-3,4,5-trisphosphate (PI(3,4,5,)P3) to induce translocation of Arap3 to the plasma...

journal_title：Cellular signalling

authors： Raaijmakers JH,Deneubourg L,Rehmann H,de Koning J,Zhang Z,Krugmann S,Erneux C,Bos JL

更新日期：2007-06-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress activated by perturbations in ER homeostasis induces the unfolded protein response (UPR) with chaperon Grp78 as the key activator of UPR signalling. The aim of UPR is to restore normal ER function; however prolonged or severe ER stress triggers apoptosis of damaged cells to ensure pro...

journal_title：Cellular signalling

authors： Kyriakakis E,Philippova M,Joshi MB,Pfaff D,Bochkov V,Afonyushkin T,Erne P,Resink TJ

更新日期：2010-09-01 00:00:00

abstract：:JNK signaling functions to induce defense mechanisms that protect organisms against a variety of different situations. The sestrin 2 gene, a p53-regulated member of the sestrins family, which lead to AMPK-dependent inhibition of TOR signaling, emerges as a novel player in autophagy induction. However, the relationship...

journal_title：Cellular signalling

authors： Zhang XY,Wu XQ,Deng R,Sun T,Feng GK,Zhu XF

更新日期：2013-01-01 00:00:00

abstract：:The p53 tumor suppressor protein is a transcription factor activated by phosphorylation of its N-terminus. MDM2, encoded by a p53-activated gene, acts as a negative-feedback regulator of p53 by promoting p53 degradation. Moreover, MDM2 inhibits p53 by binding to and concealing its N-terminal transcription-activating d...

journal_title：Cellular signalling

authors： Zajkowicz A,Gdowicz-Kłosok A,Krześniak M,Ścieglińska D,Rusin M

更新日期：2015-09-01 00:00:00