Abstract:
:Members of the phosducin gene family were initially proposed to act as down-regulators of G protein signaling by binding G protein betagamma dimers (Gbetagamma) and inhibiting their ability to interact with G protein alpha subunits (Galpha) and effectors. However, recent findings have over-turned this hypothesis by showing that most members of the phosducin family act as co-chaperones with the cytosolic chaperonin complex (CCT) to assist in the folding of a variety of proteins from their nascent polypeptides. In fact rather than inhibiting G protein pathways, phosducin-like protein 1 (PhLP1) has been shown to be essential for G protein signaling by catalyzing the folding and assembly of the Gbetagamma dimer. PhLP2 and PhLP3 have no role in G protein signaling, but they appear to assist in the folding of proteins essential in regulating cell cycle progression as well as actin and tubulin. Phosducin itself is the only family member that does not participate with CCT in protein folding, but it is believed to have a specific role in visual signal transduction to chaperone Gbetagamma subunits as they translocate to and from the outer and inner segments of photoreceptor cells during light-adaptation.
journal_name
Cell Signaljournal_title
Cellular signallingauthors
Willardson BM,Howlett ACdoi
10.1016/j.cellsig.2007.06.013subject
Has Abstractpub_date
2007-12-01 00:00:00pages
2417-27issue
12eissn
0898-6568issn
1873-3913pii
S0898-6568(07)00190-8journal_volume
19pub_type
杂志文章,评审abstract::The human NPY Y(1) receptor undergoes fast agonist-induced internalization via clathrin-coated pits then recycles back to the cell membrane. In an attempt to identify the molecular determinants involved in this process, we studied several C-terminal truncation mutants tagged with EFGP. In the absence of agonist, Y(1) ...
journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章,评审
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journal_title:Cellular signalling
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更新日期:2001-03-01 00:00:00
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journal_title:Cellular signalling
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更新日期:2004-12-01 00:00:00
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journal_title:Cellular signalling
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Cellular signalling
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journal_title:Cellular signalling
pub_type: 杂志文章
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journal_title:Cellular signalling
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更新日期:2008-07-01 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:Cellular signalling
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更新日期:2009-05-01 00:00:00
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journal_title:Cellular signalling
pub_type: 杂志文章
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