当前位置： SCI文献检索 > CELLULAR SIGNALLING期刊下所有文献 > RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling.

RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling.

Abstract：

:SLAP (Src like adaptor protein) contains adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains closely related in sequence to that of cytoplasmic Src family tyrosine kinases. Expressed most abundantly in the immune system, SLAP function has been predominantly studied in the context of lymphocyte signaling, where it functions in the Cbl dependent downregulation of antigen receptor signaling. However, accumulating evidence suggests that SLAP plays a role in the regulation of a broad range of membrane receptors including members of the receptor tyrosine kinase (RTK) family. In this review we highlight the role of SLAP in the ubiquitin dependent regulation of type III RTKs PDGFR, CSF-1R, KIT and Flt3, as well as Eph family RTKs. SLAP appears to bind activated type III and Eph RTKs via a conserved autophosphorylated juxtamembrane tyrosine motif in an SH2-dependent manner, suggesting that SLAP is important in regulating RTK signaling.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Wybenga-Groot LE,McGlade CJ

doi

10.1016/j.cellsig.2014.11.010

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

267-74

issue

2

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(14)00356-8

journal_volume

27

pub_type

杂志文章,评审

相关文献

CELLULAR SIGNALLING文献大全
  • Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling.

    abstract：:The ectodomain of TOLL-like receptors (TLR) is highly glycosylated with several N-linked gylcosylation sites located in the inner concave surface. The precise role of these sugar N-glycans in TLR receptor activation is unknown. Recently, we have shown that Neu1 sialidase and not Neu2, -3 and -4 forms a complex with TL...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.09.038

    authors： Amith SR,Jayanth P,Franchuk S,Finlay T,Seyrantepe V,Beyaert R,Pshezhetsky AV,Szewczuk MR

    更新日期：2010-02-01 00:00:00

  • Activated EGF receptor may balance ERK-inhibitory network signalling pathways.

    abstract：:In the COS-7 cell signalling network high levels of cAMP produced, for example, by co-stimulation of beta2-adrenergic receptor (beta2-AR) and bradykinin B2 receptor (BKR) may affect epidermal growth factor receptor (EGFR)-mediated activation of extracellular signal-stimulated kinase (ERK). In contrast, co-stimulation ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2005.08.019

    authors： Hanke S,Valkova C,Stirnweiss J,Drube S,Liebmann C

    更新日期：2006-07-01 00:00:00

  • RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI.

    abstract：:Transforming growth factor β (TGF-β), a cytokine, and its receptors play a vital role during normal embryogenesis, cell proliferation, differentiation, apoptosis and migration. Ran-binding protein in the microtubule-organizing center (RanBPM) serves as a scaffold protein that has been shown to interact with many other...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.09.019

    authors： Zhang J,Ma W,Tian S,Fan Z,Ma X,Yang X,Zhao Q,Tan K,Chen H,Chen D,Huang BR

    更新日期：2014-01-01 00:00:00

  • Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus.

    abstract：:Agonist stimulation of G-protein coupled receptors (GPCRs) results in the redistribution of the receptor from the cell surface into intracellular compartments through the process of endocytosis. Monitoring ligand-mediated internalization of GPCRs in living cells has become experimentally accessible by applying fluores...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.05.017

    authors： Böhme I,Stichel J,Walther C,Mörl K,Beck-Sickinger AG

    更新日期：2008-10-01 00:00:00

  • Effects of retinoic acid on signalling by prostaglandin E2 in osteoblast-like cells.

    abstract：:We investigated the effects of retinoic acid (RA) on the signalling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with RA significantly inhibited the formation of inositol phosphates induced by 10 microM PGE2 in a dose-dependent manner in the range between 0.1 nM and 0.1 micro...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(93)90080-6

    authors： Kotoyori J,Tokuda H,Oiso Y,Kozawa O

    更新日期：1993-07-01 00:00:00

  • Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR.

    abstract：:Lysophosphatidic acid (LPA) and its ether analog alkyl-glycerophosphate (AGP) elicit arterial wall remodeling when applied intralumenally into the uninjured carotid artery. LPA is the ligand of eight GPCRs and the peroxisome proliferator-activated receptor gamma (PPARgamma). We pursued a gene knockout strategy to iden...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.08.003

    authors： Cheng Y,Makarova N,Tsukahara R,Guo H,Shuyu E,Farrar P,Balazs L,Zhang C,Tigyi G

    更新日期：2009-12-01 00:00:00

  • Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation.

    abstract：:Previous studies from acutely transfected HeLa cells have identified an acidic alpha-helix in the Type IIbeta PtdIns5P 4-kinase (PIPkin IIbeta) as a putative novel nuclear localisation sequence (Ciruela et al. Biochem. J. 364, 587-591 2000). However, some heterogeneity in cellular localisation was always observed, and...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2007.01.010

    authors： Richardson JP,Wang M,Clarke JH,Patel KJ,Irvine RF

    更新日期：2007-06-01 00:00:00

  • Overexpression of p75(NTR) increases survival of breast cancer cells through p21(waf1).

    abstract：:The p75 neurotrophin receptor (p75(NTR)) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation and proliferation. To evaluate the influence of p75(NTR) in breast cancer development, we have established and characterized breast cancer cells which stably overe...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2010.07.014

    authors： Verbeke S,Meignan S,Lagadec C,Germain E,Hondermarck H,Adriaenssens E,Le Bourhis X

    更新日期：2010-12-01 00:00:00

  • Silencing Daxx increases the anti-tumor activity of a TRAIL/shRNA Bcl-xL-expressing oncolytic adenovirus through enhanced viral replication and cellular arrest.

    abstract：:We previously showed that an increase of cellular Bcl-xL mediates acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and knockdown of Bcl-xL expression greatly sensitized TRAIL-induced cytotoxicity. Here, we show that Daxx downregulation increases the anti-tumorigenic activity throu...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2015.02.028

    authors： Kang S,Kang D,Bakhtiar Ul Islam SM,Je S,Kim JH,Song JJ

    更新日期：2015-06-01 00:00:00

  • Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area.

    abstract：:Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins, and that the Ser 824 residue of TRPV4 is phosphorylated by SGK1. In this study, ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2011.11.002

    authors： Shin SH,Lee EJ,Hyun S,Chun J,Kim Y,Kang SS

    更新日期：2012-03-01 00:00:00

  • In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.

    abstract：:The long cyclic AMP (cAMP)-specific phosphodiesterase isoform, PDE4A5 (PDE4A subfamily isoform variant 5), when transiently expressed in COS-7 cells, was shown in subcellular fractionation studies to be associated with both membrane and cytosol fractions, with immunofluorescence analyses identifying PDE4A5 as associat...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(01)00264-9

    authors： Beard MB,Huston E,Campbell L,Gall I,McPhee I,Yarwood S,Scotland G,Houslay MD

    更新日期：2002-05-01 00:00:00

  • LncRNA HAND2-AS1 inhibits 5-fluorouracil resistance by modulating miR-20a/PDCD4 axis in colorectal cancer.

    abstract：BACKGROUND:Chemoresistance is one of the main obstacles in the therapy of human cancers, including colorectal cancer (CRC). Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (lncRNA HAND2-AS1) has been demonstrated to be associated with CRC. However, the function of HAND2-AS1 in 5-Fluor...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2019.109483

    authors： Jiang Z,Li L,Hou Z,Liu W,Wang H,Zhou T,Li Y,Chen S

    更新日期：2020-02-01 00:00:00

  • Inhibition of protein phosphatases by okadaic acid and calyculin-A differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT-20 corticotrophs: effect of pituitary adenylate activating polypeptide and corticotropin-releasin

    abstract：:The effect of phosphatase inhibitors okadaic acid and calyculin-A on cAMP formation and adrenocorticotropic hormone (ACTH) secretion in AtT-20 corticotrophs was investigated. Both okadaic acid and calyculin-A inhibited dose-dependently the accumulation of cAMP in cells stimulated with pituitary adenylate cyclase activ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(94)90094-9

    authors： Koch B,Lutz-Bucher B

    更新日期：1994-05-01 00:00:00

  • Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

    abstract：:Microglia play a prominent role in the brain's inflammatory response to injury or infection by migrating to affected locations, secreting inflammatory molecules, and phagocytosing damaged tissue. However, because severe or chronic neuroinflammation exacerbates many neurological conditions, controlling microglia action...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2008.10.014

    authors： Yuskaitis CJ,Jope RS

    更新日期：2009-02-01 00:00:00

  • Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.

    abstract：:Clinical studies have elucidated the negative correlation between microtubules-associated protein 1 light chain 3-B (LC3B) protein expression and overall survival of breast cancer patients. Our previous data demonstrated corticortropin-releasing hormone family (CRHs) suppressed migration of breast cancer cells via CRH...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2019.03.001

    authors： Jin L,Qian Y,Zhou J,Dai L,Cao C,Zhu C,Li S

    更新日期：2019-06-01 00:00:00

  • Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses.

    abstract：:Interferon-α (IFNα) has enormous potential for anti-proliferative and anti-viral treatments. However, clinical success is still hampered due to its limited bioavailability and thus, lack of sustained modulation of disease-relevant protective programs. Consequently, we here examined whether IFNα immobilized on nanoscal...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2013.01.012

    authors： Pollok S,Ginter T,Günzel K,Pieper J,Henke A,Stauber RH,Reichardt W,Krämer OH

    更新日期：2013-04-01 00:00:00

  • Recent advances in the molecular pharmacology of the alpha 1-adrenergic receptors.

    abstract：:This review is intended to discuss recent developments in the molecular pharmacology of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes. After a brief historical development, we will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regarding the cl...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/0898-6568(96)00066-6

    authors： Guarino RD,Perez DM,Piascik MT

    更新日期：1996-08-01 00:00:00

  • Mechanisms of ATP-induced Ca2+ signaling in osteoclasts.

    abstract：:We investigate the mechanisms underlying the intracellular calcium pulse that occurs in response to extracellular adenosine triphosphate (ATP) in osteoclasts. We find that pre-loading of GDP-beta-S abolishes the response in Ca(2+)-free medium, demonstrating an internal release of Ca2+ via a pathway that involves a G p...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(94)90023-x

    authors： Yu H,Ferrier J

    更新日期：1994-11-01 00:00:00

  • Is the glycogen synthase analogue C1-peptide a suitable fluorescent substrate for routine measurements of protein kinase C?

    abstract：:We have compared a new commercially available non-radioactive protein kinase C (PKC) activity assay based on the fluorescent [A9,10K11]glycogen synthase1-11 analogue C1-peptide with a classical radioactive assay based on myelin basic protein4-14 (MBP4-14) and other substrates. The C1-peptide had lower affinity for PKC...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(95)00029-o

    authors： Erdbrügger W,Strohm P,Michel MC

    更新日期：1995-08-01 00:00:00

  • Selective down-regulation of angiotensin II receptor type 1A signaling by protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells.

    abstract：:The heptahelical AT(1) G-protein-coupled receptor lacks inherent tyrosine kinase activity. Angiotensin II binding to AT(1) nevertheless activates several tyrosine kinases and stimulates both tyrosine phosphorylation and phosphatase activity of the SHP-2 tyrosine phosphatase in vascular smooth muscle cells. Since a bal...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2003.08.001

    authors： Doan T,Farmer P,Cooney T,Ali MS

    更新日期：2004-03-01 00:00:00

  • Odorant-sensitive phospholipase C in insect antennae.

    abstract：:Exogenous tritiated phosphatidylinositol bisphosphate added to antennal preparations from locust and cockroach was hydrolysed releasing inositol trisphosphate. High activity of phospholipase C was detected in the soluble as well as in the membrane fraction. At low free calcium concentrations hydrolysis of the labelled...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/0898-6568(90)90032-6

    authors： Boekhoff I,Strotmann J,Raming K,Tareilus E,Breer H

    更新日期：1990-01-01 00:00:00

  • Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

    abstract：:The induction of suppressor of cytokine signalling (SOCS)3 expression context dependently involves regulation of SOCS3 transcript stability as previously demonstrated for MAPK activated protein kinase (MK)2-dependent regulation of SOCS3 expression by TNFα (Ehlting et al., 2007). In how far the IL-6-type cytokine OSM, ...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.12.016

    authors： Ehlting C,Böhmer O,Hahnel MJ,Thomas M,Zanger UM,Gaestel M,Knoefel WT,Schulte Am Esch J,Häussinger D,Bode JG

    更新日期：2015-03-01 00:00:00

  • CDK9 inhibitors reactivate p53 by downregulating iASPP.

    abstract：:Loss of p53's tumor-suppressive function, either via TP53 mutation or hyperactive p53 inhibitory proteins, is one of the most frequent events in the development of human cancer. Here, we describe a strategy of pharmacologically inhibiting iASPP, a negative regulator of p53, to restore wild-type p53's tumor-suppressive...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2019.109508

    authors： Wu J,Liang Y,Tan Y,Tang Y,Song H,Wang Z,Li Y,Lu M

    更新日期：2020-03-01 00:00:00

  • Total inhibition of phospholipase C and phosphatidylinositol 3-kinase by okadaic acid in thrombin-stimulated platelets.

    abstract：:The strong inhibition of thrombin-induced platelet functions induced by okadaic acid is not correlated with the partial modification of pleckstrin phosphorylation, which remains still phosphorylated two min after stimulation, indicating that protein kinase C is not affected by okadaic acid. We then investigated the ef...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/s0898-6568(96)00119-2

    authors： Mauco G,Artçanuthurry V,Pidard D,Grelac F,Maclouf J,Lévy-Tolédano S

    更新日期：1997-01-01 00:00:00

  • Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.

    abstract：:Sec8 is one of the subunits of the exocyst, which is an evolutionarily conserved complex of eight proteins, comprising Sec3 (EXOC1), Sec5 (EXOC2), Sec6 (EXOC3), Sec8 (EXOC4), Sec10 (EXOC5), Sec15 (EXOC6), Exo70 (EXOC7), and Exo84 (EXOC8) subunits. Sec8 knockout mice embryos initiate gastrulation but are unable to prog...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2016.10.007

    authors： Tanaka T,Goto K,Iino M

    更新日期：2017-01-01 00:00:00

  • Structure and function of phosphatidylinositol-3,4 kinase.

    abstract：:Activation of phosphatidylinositol (PI)-kinase is involved in the regulation of a wide array of cellular activities. The enzyme exists as a dimer, consisting of a catalytic and a regulatory subunit. Five isoforms of the regulatory subunit have been identified and classified into three groups comprising respectively 85...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/s0898-6568(99)00086-8

    authors： Funaki M,Katagiri H,Inukai K,Kikuchi M,Asano T

    更新日期：2000-03-01 00:00:00

  • Cellular signaling in normal and cancerous stem cells.

    abstract：:Self-renewing divisions of normal and cancerous stem cells are responsible for the initiation and maintenance of normal and certain cancerous tissues, respectively. Recent findings suggest that tumor surveillance mechanisms can reduce regenerative capacity and frequency of normal stem cells, thereby contributing to ti...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2007.06.021

    authors： Grinstein E,Wernet P

    更新日期：2007-12-01 00:00:00

  • Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.

    abstract：:C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. However, relatively little is known about the regulation of C1-Ten, such as changes in its protein leve...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2014.07.033

    authors： Koh A,Park D,Jeong H,Lee J,Lee MN,Suh PG,Ryu SH

    更新日期：2014-11-01 00:00:00

  • Signal transduction of constitutively active protein kinase C epsilon.

    abstract：:The protein kinase C (PKC) family is the most prominent target of tumor-promoting phorbol esters. For the PKCepsilon isozyme, different intracellular localizations and oncogenic potential in several but not all experimental systems have been reported. To obtain information about PKCepsilon-signaling, we investigated t...

    journal_title：Cellular signalling

    pub_type： 杂志文章

    doi：10.1016/j.cellsig.2009.01.017

    authors： Garczarczyk D,Toton E,Biedermann V,Rosivatz E,Rechfeld F,Rybczynska M,Hofmann J

    更新日期：2009-05-01 00:00:00

  • Cell survival and metastasis regulation by Akt signaling in colorectal cancer.

    abstract：:Dissemination of cancer cells to distant organ sites is the leading cause of death due to treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the importance of the development of inappropriate cell survival signaling for various steps in the metastatic process and have noted the particula...

    journal_title：Cellular signalling

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellsig.2013.03.025

    authors： Agarwal E,Brattain MG,Chowdhury S

    更新日期：2013-08-01 00:00:00