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Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.

Abstract：

:Sec8 is one of the subunits of the exocyst, which is an evolutionarily conserved complex of eight proteins, comprising Sec3 (EXOC1), Sec5 (EXOC2), Sec6 (EXOC3), Sec8 (EXOC4), Sec10 (EXOC5), Sec15 (EXOC6), Exo70 (EXOC7), and Exo84 (EXOC8) subunits. Sec8 knockout mice embryos initiate gastrulation but are unable to progress beyond the primitive streak stage and die shortly. During embryonic development, the first epithelial-mesenchymal transition (EMT) event occurs at gastrulation. Sec8 may be involved in the early embryonic development through EMT. However, the function of Sec8 in EMT remains unclear. In the present study, it was found that Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression at the basal transcriptional level, thereby modulating cell migration and adhesion. Furthermore, Sec8 knockdown decreased CREB binding protein (CBP) expression at mRNA and protein levels. However, CBP knockdown did not affect Sec8 expression. These results indicated that Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression through CBP, thereby mediating the EMT.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Tanaka T,Goto K,Iino M

doi

10.1016/j.cellsig.2016.10.007

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

115-126

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(16)30251-0

journal_volume

29

pub_type

杂志文章

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