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Testosterone- and phorbol ester-stimulated proliferation in human cultured prostatic stromal cells.

Abstract：

:Prostatic stromal proliferation may be commonly associated with the development of benign prostatic hyperplasia. In this study, we investigate the role of testosterone and protein kinase C in stimulating cultured stromal cell proliferation. Testosterone increased the uptake of [(3)H]-thymidine into the human cultured prostatic stromal cells, this was reduced by the protein kinase C inhibitors, bisindolylymaleimide (10 nM) and myristoylated protein kinase C inhibitor (mPKCi, 20 microM), but not by Gö 6983 (1 microM) or Gö 6976 (1 microM). Cells responded to the addition of the PKC activators phorbol 12,13 dibutyrate (PDB), phorbol 12,13 diacetate (PDA), 12-deoxyphorbol 13-acetate (DPA) and 12-deoxyphorbol 13-tetradecanoate (DPT) with proliferation (order of potency DPT> or =PDB>PDA=DPA). The DPT-stimulated proliferative response was inhibited after cells were electroporated with PKCalpha antisense, but not mismatch oligonucleotides (8 microM). These results indicate that PKCalpha is involved in the proliferative response of human cultured prostatic stromal cells.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Haynes JM,Frydenberg M,Majewski H

doi

10.1016/s0898-6568(01)00205-4

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

703-9

issue

10

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(01)00205-4

journal_volume

13

pub_type

杂志文章

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