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Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.

Abstract：

:Both type I interferons (IFNs) and interferon regulatory factors (IRFs) are well characterized in viral infections, whereas they are far less studied in bacterially activated toll-like receptor (TLR) pathways. Here, we studied the involvement of IRF1 and IRF2 in TLR2-mediated responses. In mouse macrophages, IRF2 was activated by lipoteichoic acid (LTA) of Staphylococcus aureus, resulting in up-regulation of IRF1 and rapid secretion of IFN-alpha. In addition, LTA-induced activation of Signal transducers and activators of transcription 1 (Stat1) and Stat3 via IRF2. The secretion of IFN-alpha was reduced in IRF2-silenced macrophages, resulting in a disappearance of tyrosine-phosphorylated Stat3 and a reduction of pro-inflammatory responses, despite induction of Mal adapter protein. These results provide a mechanistic insight into the pro-inflammatory responses against S. aureus LTA in mouse macrophages. IRFs can be intersecting factors of viral and bacterial responses in activated TLR signalling pathways.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Liljeroos M,Vuolteenaho R,Rounioja S,Henriques-Normark B,Hallman M,Ojaniemi M

doi

10.1016/j.cellsig.2008.06.017

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1873-81

issue

10

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(08)00191-5

journal_volume

20

pub_type

杂志文章

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