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Steering signal transduction pathway towards cardiac lineage from human pluripotent stem cells: a review.

Abstract：

:In humans injured myocardium cannot avert the onset and progression of ventricular dysfunction because of limited regenerative ability of myocytes. Although limited renaissance of cardiomyocytes has been reported in human infarcted hearts, it is generally accredited that non-functional fibrous tissue replaces the dead myocardium. High cardiovascular morbidity and dearth of donor hearts warrant a constant hunt for radically different approach to treat heart failure. Pluripotent stem (PS) cells possess the ability to produce functional cardiomyocytes for clinical applications and drug development, which may provide the answer to this problem. Although progress has been made in differentiating human PS cells into cardiomyocytes, however, the in vitro differentiation of pluripotent cells into cardiomyocytes involves a poorly defined, inefficient and relatively non-selective process. A thorough understanding of signaling pathways would tender a roadmap for the streamlined development of in vitro cardiac differentiation strategies. The ability to obtain unlimited numbers of human cardiomyocytes would improve development of cell-based therapies for cardiovascular diseases, facilitate the study of cardiovascular biology and improve the early stages of drug discovery. Here in this review, we highlight the interacting endogenous cellular signals and their modulators involved in directing the human PSCs towards cardiac differentiation.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Verma V,Purnamawati K,Manasi,Shim W

doi

10.1016/j.cellsig.2013.01.027

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

1096-107

issue

5

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(13)00041-7

journal_volume

25

pub_type

杂志文章,评审

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