Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells.

abstract：:Regulator of G Protein Signalling (RGS) proteins impede heterotrimeric G protein signalling. RGS2 decreases cAMP production and appears to interact with both adenylyl cyclase (AC) and its stimulatory G protein Gs. We showed previously that Green Fluorescent Protein-tagged RGS2 (GFP-RGS2) localizes to the nucleus in HE...

journal_title：Cellular signalling

authors： Roy AA,Baragli A,Bernstein LS,Hepler JR,Hébert TE,Chidiac P

更新日期：2006-03-01 00:00:00

abstract：:High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic cancer. Emerging evidence suggests that tumor-associated macrophages (TAMs) play an immunosuppressive role in the tumor microenvironment and promote tumor growth, angiogenesis, and metastasis in ovarian cancer. Therefore, targeting TAMs in pati...

journal_title：Cellular signalling

authors： El-Arabey AA,Denizli M,Kanlikilicer P,Bayraktar R,Ivan C,Rashed M,Kabil N,Ozpolat B,Calin GA,Salama SA,Abd-Allah AR,Sood AK,Lopez-Berestein G

更新日期：2020-04-01 00:00:00

abstract：:Ephedrine (Eph) is one of alkaloids that has been isolated from the ancient herb ephedra (ma huang) and is used as the treatment of asthma, hypotension and fatigue. However, its molecular mechanism remains unknown. Thioredoxin-1 (Trx-1) is a redox regulating protein, which has various biological activities, including ...

journal_title：Cellular signalling

authors： Jia JJ,Zeng XS,Li Y,Ma S,Bai J

更新日期：2013-05-01 00:00:00

abstract：:Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important roles in adipogenesis and inflammation. The aim of this study is to investigate the impact of GATA-3 s...

journal_title：Cellular signalling

authors： Al-Mansoori L,Al-Jaber H,Madani AY,Mazloum NA,Agouni A,Ramanjaneya M,Abou-Samra AB,Elrayess MA

更新日期：2020-11-01 00:00:00

abstract：:The interactions between kidney and thyroid functions have been known for many years, but how the thyroid affects the kidney function is largely unknown. Here we analyzed the role of T3 on the tubular epithelial-to-mesenchymal transition (EMT), which is recognized to play pivotal roles in the process of renal fibrosis...

journal_title：Cellular signalling

authors： Lu X,Chen Z,Liang H,Li Z,Zou X,Luo H,Guo W,Xu L

更新日期：2013-10-01 00:00:00

abstract：:The orthologous proteins of the stress-activated protein kinase-interacting 1 (Sin1) family have been implicated in several different signal transduction pathways. In this study, we have investigated the function of the full-length human Sin1 protein and a C-terminally truncated isoform, Sin1alpha, which is produced b...

journal_title：Cellular signalling

authors： Schroder W,Bushell G,Sculley T

更新日期：2005-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral squamous cell carcinoma tumorigenesis and progression remain to be elucidated. Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and extracellular RNAs (exRNAs) are emerging group...

journal_title：Cellular signalling

authors： Momen-Heravi F,Bala S

更新日期：2018-01-01 00:00:00

abstract：:Although increasing evidence demonstrated that deregulation of mircoRNA-503 (miRNA-503) contributes to tumorigenesis, little is known about the biological role and intrinsic regulatory mechanisms of miR-503 in prostate cancer (PCa). In present study, we found that miR-503 was significantly downregulated in advanced PC...

journal_title：Cellular signalling

authors： Jiang X,Chen Y,Du E,Yang K,Zhang Z,Qi S,Xu Y

更新日期：2016-09-01 00:00:00

abstract：:In fura-2 loaded isolated mouse pancreatic acinar cells, xanthine oxidase (XOD)-catalyzed reactive oxygen species (ROS) generation caused an increase in the cytosolic Ca(2+) concentration ([Ca(2+)](i)) by release of Ca(2+) from intracellular stores. The ROS-induced Ca(2+) signals showed large variability in shape and ...

journal_title：Cellular signalling

authors： González A,Schmid A,Salido GM,Camello PJ,Pariente JA

更新日期：2002-02-01 00:00:00

abstract：:The nuclear factor kappa B (NF-κB) transcription factor-mediated transcription is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli. Both the proteolytic and non-proteolytic functions of ubiquitination are critically important for the regulation of NF-κB activation. L...

journal_title：Cellular signalling

authors： Fan Y,Yu Y,Mao R,Zhang H,Yang J

更新日期：2011-04-01 00:00:00

abstract：:Recent global incidences and mortality rates have placed colorectal cancer (CRC) at third and second positions, respectively, among both sexes of all ages. Resistance during chemotherapy is a big problem in the treatment and disease-free survival of CRC patients. Discovery of new anticancer drug(s) is a time taking pr...

journal_title：Cellular signalling

authors： Dhiman DK,Sanyal SN,Vaish V

更新日期：2020-12-01 00:00:00

abstract：:Receptor for Activated C-Kinase 1 (RACK1) belongs to the WD40 family of proteins, known to act as scaffolding proteins in interaction networks. Accordingly, RACK1 is found to have numerous interacting partners ranging from kinases and signaling proteins to membrane bound receptors and ion channels. Interestingly, RACK...

journal_title：Cellular signalling

authors： Nielsen MH,Flygaard RK,Jenner LB

更新日期：2017-07-01 00:00:00

abstract：:Unc119 is an adapter signaling molecule, which regulates activation of tyrosine kinases in T cells, eosinophils and fibroblasts. It plays an important role in the photoreceptor synapses of the retina. Recently, we have shown that it inhibits bacterial uptake through macropinocytosis. In this paper we demonstrate a rol...

journal_title：Cellular signalling

authors： Karim Z,Vepachedu R,Gorska M,Alam R

更新日期：2010-01-01 00:00:00

abstract：:We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. While NPRL2 interacts with Rag GTPases, RagD in particular, to interfere with mTORC1 activity in amino acid sc...

journal_title：Cellular signalling

authors： Kwak SS,Kang KH,Kim S,Lee S,Lee JH,Kim JW,Byun B,Meadows GG,Joe CO

更新日期：2016-02-01 00:00:00

abstract：:Endothelial cell apoptosis induced by hypoxia is implicated in the pathogenesis of vascular diseases. However, the underlying mechanism is not clearly elucidated. In this study, we found that hypoxia increased Mxi1-0 expression, and the Mxi1-0 siRNA could inhibit caspase-8 activation and apoptosis in HUVECs induced by...

journal_title：Cellular signalling

authors： Hu Z,Wang F,Wu Z,Gu H,Dong N,Jiang X,Xu J,Wu Z,Wechsler DS,Zheng D

更新日期：2018-11-01 00:00:00

abstract：:When oxygen sensing cells are excited by hypoxia, background K+ currents are inhibited. TASK-1, which is commonly expressed in oxygen sensing cells and makes a background K+ current, is inactivated by hypoxia. Thus TASK-1 is a candidate molecule responsible for hypoxic excitation. However, TASK-1 per se cannot sense o...

journal_title：Cellular signalling

authors： Lee YM,Kim BJ,Chun YS,So I,Choi H,Kim MS,Park JW

更新日期：2006-04-01 00:00:00

abstract：:PGE2 and prostacyclin each enhance cAMP synthesis in the osteoblast-like cell line UMR-106. The amount of cAMP induced by PGE2 was 5-7-fold greater than the amount induced by cicaprost or iloprost, stable prostacyclin analogues. Both PGE2 and the two prostacyclin analogues enhanced cAMP synthesis with similar time dep...

journal_title：Cellular signalling

authors： Khanin M,Liel Y,Rimon G

更新日期：1999-03-01 00:00:00

abstract：:Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS) domain of p115 RhoGEF), we investigated the contributions of G(q/11), Gi and G(12/13) proteins to G protein-coupled receptor (GPCR)-mediated activation of the extracellular signal-regulated kinase (ERK) pathway in adult rat ventric...

journal_title：Cellular signalling

authors： Snabaitis AK,Muntendorf A,Wieland T,Avkiran M

更新日期：2005-05-01 00:00:00

abstract：:Our previous oligonucleotide array studies revealed that ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL) express high levels of the disheveled proteins (Dvls), a family of proteins that is integral to the Wnt signaling pathways. In this study, we assessed whether the Dvls are important in the pathogenesis of ...

journal_title：Cellular signalling

authors： Hegazy SA,Alshareef A,Gelebart P,Anand M,Armanious H,Ingham RJ,Lai R

更新日期：2013-01-01 00:00:00

abstract：:Macrophages are projected as one of the key players responsible for the progression of cancer. Classically activated (M1) macrophages are pro-inflammatory and have a central role in host defense, while alternatively activated (M2) macrophages are associated with immunosuppression. Macrophages residing at the site of n...

journal_title：Cellular signalling

authors： Ghosh S,Mukherjee S,Choudhury S,Gupta P,Adhikary A,Baral R,Chattopadhyay S

更新日期：2015-07-01 00:00:00

abstract：:Cellular signal transmission requires the dynamic formation of spatiotemporally controlled molecular interactions. At the cell surface information is received by receptor complexes and relayed through intracellular signaling platforms which organize the actions of functionally interacting signaling enzymes and substra...

journal_title：Cellular signalling

authors： Torres-Quesada O,Mayrhofer JE,Stefan E

更新日期：2017-09-01 00:00:00

abstract：:Wnt proteins are secreted glycoproteins that bind to the N-terminal extra-cellular cysteine-rich domain of the Frizzled (Fzd) receptor family. The Fzd receptors can respond to Wnt proteins in the presence of Wnt co-receptors to activate the canonical and non-canonical Wnt pathways. Recent studies indicated that, among...

journal_title：Cellular signalling

authors： King TD,Zhang W,Suto MJ,Li Y

更新日期：2012-04-01 00:00:00

abstract：:The induction of suppressor of cytokine signalling (SOCS)3 expression context dependently involves regulation of SOCS3 transcript stability as previously demonstrated for MAPK activated protein kinase (MK)2-dependent regulation of SOCS3 expression by TNFα (Ehlting et al., 2007). In how far the IL-6-type cytokine OSM, ...

journal_title：Cellular signalling

authors： Ehlting C,Böhmer O,Hahnel MJ,Thomas M,Zanger UM,Gaestel M,Knoefel WT,Schulte Am Esch J,Häussinger D,Bode JG

更新日期：2015-03-01 00:00:00

abstract：:C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. However, relatively little is known about the regulation of C1-Ten, such as changes in its protein leve...

journal_title：Cellular signalling

authors： Koh A,Park D,Jeong H,Lee J,Lee MN,Suh PG,Ryu SH

更新日期：2014-11-01 00:00:00

abstract：:Understanding how cells integrate signals from a variety of chemically diverse information-containing molecules into complex, orchestrated responses such as cell proliferation, differentiation and apoptosis is an overarching goal of cell biology. The ligand molecules that act upon cell surface receptors include those ...

journal_title：Cellular signalling

authors： Malbon CC,Karoor V

更新日期：1998-09-01 00:00:00

abstract：:Recent studies have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in cancer development and progression. However, the mechanism by which lncRNAs contribute to colorectal cancer remains unclear. In this study, we identified the lncRNA, DANCR, which was upregulated in colorectal cancer. The upregu...

journal_title：Cellular signalling

authors： Lian J,Zhang H,Wei F,Li Q,Lu Y,Yu B,Yu L,Liang X,Wen Y,Jin K,Tang J,Xie W

更新日期：2020-03-01 00:00:00

abstract：:Nore1A was originally identified as a potential Ras effector, and Nore1B is an alternatively spliced isoform. Both share a Ras/Rap association domain (RA domain) but only Nore1A contains sequence motifs that predict SH3 domain binding and diacylglycerol/phorbol ester binding in the amino-terminal region. Here we repor...

journal_title：Cellular signalling

authors： Ishiguro K,Avruch J,Landry A,Qin S,Ando T,Goto H,Xavier R

更新日期：2006-10-01 00:00:00

abstract：:The inwardly rectifying K+ channels of the GIRK (Kir3) family, members of the superfamily of inwardly rectifying K+ channels (Kir), are important physiological tools to regulate excitability in heart and brain by neurotransmitters, and the only ion channels conclusively shown to be activated by a direct interaction wi...

journal_title：Cellular signalling

authors： Dascal N

更新日期：1997-12-01 00:00:00

abstract：:Activation of β2-adrenergic receptor (β2AR) and deorphanized GPR55 has been shown to modulate cancer growth in diverse tumor types in vitro and in xenograft models in vivo. (R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a bivalent compound that agonizes β2AR but inhibits GPR55-mediated pro-oncogenic responses. ...

journal_title：Cellular signalling

authors： Wnorowski A,Such J,Paul RK,Wersto RP,Indig FE,Jozwiak K,Bernier M,Wainer IW

更新日期：2017-08-01 00:00:00

abstract：:The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anapha...

journal_title：Cellular signalling

authors： Hatano Y,Naoki K,Suzuki A,Ushimaru T

更新日期：2016-10-01 00:00:00