SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice.


:Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differentiation of interleukin (IL)-17-producing CD8(+) T cells, and significantly suppressed the growth of EL4 tumor cells in vivo. Moreover, the tumor tissue from SUMO2-overexpressing mice had higher interferon (IFN)-γ and granzyme B mRNA levels. Although SUMO2 overexpression did not increase IFN-γ or granzyme B production in cytotoxic T lymphocytes, IL-12 treatment restored and increased IFN-γ secretion in IL-17-producing CD8(+) T cells. SUMO2 overexpression also increased gene expression of chemokines, CCL4, and CXCL10, which attract cytotoxic T lymphocytes to tumor tissues. Additionally, SUMO2-overexpressing T cells exhibited increased STAT3 phosphorylation, implying a SUMO2 target which up-regulates STAT3 activity governing IL-17A-producing CD8(+) T cell differentiation and antitumor immune responses.


Cell Signal


Cellular signalling


Won TJ,Lee YJ,Hyung KE,Yang E,Sohn UD,Min HY,Lee DI,Park SY,Hwang KW




Has Abstract


2015-06-01 00:00:00














  • ER stress signaling in ARPE-19 cells after inhibition of protein kinase CK2 by CX-4945.

    abstract::Protein kinase CK2 is a critical factor for the survival of cells. It is overexpressed in many cancer cells and provides protection against apoptosis in these cells. Inhibition of CK2 kinase activity in various cancer cells leads to apoptosis, which makes CK2 an attractive target for cancer therapy. Little is, however...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Intemann J,Saidu NE,Schwind L,Montenarh M

    更新日期:2014-07-01 00:00:00

  • c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

    abstract::Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been proposed that the RING fi...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Wiggins CM,Band H,Cook SJ

    更新日期:2007-12-01 00:00:00

  • Human omental adipose-derived mesenchymal stem cells enhance autophagy in ovarian carcinoma cells through the STAT3 signalling pathway.

    abstract:BACKGROUND:Our previous study showed that human omental adipose-derived stem cells (ADSCs) promote ovarian cancer growth and metastasis. In this study, the role of autophagy in the ovarian cancer-promoting effects of omental ADSCs was further determined. METHODS:The growth and invasion of ovarian cancer cells were det...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Chu Y,Wang Y,Li K,Liu M,Zhang Y,Li Y,Hu X,Liu C,Zhou H,Zuo J,Peng W

    更新日期:2020-05-01 00:00:00

  • Negative regulation of interferon-γ/STAT1 signaling through cell adhesion and cell density-dependent STAT1 dephosphorylation.

    abstract::Signal transducer and activator of transcription 1 (STAT1) is an important mediator for cytokine signal transduction, particularly IFN-γ. Following IFN-γ stimulation, STAT1 is activated through tyrosine phosphorylation. Little is known about the function and regulation of STAT1 dephosphorylation after activation. We s...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Chen Z,Ma X,Zhang H,Sun X,Shen S,Li Y,Gu Y,Wang Y,Yan S,Yu Q

    更新日期:2011-08-01 00:00:00

  • Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549.

    abstract::Stathmin is overexpressed in a variety of assessed human malignancies and is correlated with tumor progression and poor prognosis. Downregulation of its expression will contribute to optimize therapeutic outcomes in the treatment of various malignancies. However, the mechanisms of stathmin gene overexpression are not ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Fang L,Min L,Lin Y,Ping G,Rui W,Ying Z,Xi W,Ting H,Li L,Ke D,Jihong R,Huizhong Z

    更新日期:2010-01-01 00:00:00

  • Regulation of the CCN genes by vitamin D: A possible adjuvant therapy in the treatment of cancer and fibrosis.

    abstract::The CCN family is composed of six cysteine-rich, modular, and conserved proteins whose functions span a variety of tissues and include cell proliferation, adhesion, angiogenesis, and wound healing. Roles for the CCN proteins throughout the entire body including the skin, kidney, brain, blood vessels, hematopoietic com...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Piszczatowski RT,Lents NH

    更新日期:2016-10-01 00:00:00

  • The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.

    abstract::By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Hoa L,Kulaberoglu Y,Gundogdu R,Cook D,Mavis M,Gomez M,Gomez V,Hergovich A

    更新日期:2016-05-01 00:00:00

  • GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.

    abstract::GRB2 related adaptor protein downstream of Shc (GADS) is a member of the GRB2 family of adaptors and is critical for TCR-induced signaling. The current model is that GADS recruits SLP-76 to the LAT complex, which facilitates the phosphorylation of SLP-76, the activation of PLC-γ1, T cell adhesion and cytokine producti...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Bilal MY,Zhang EY,Dinkel B,Hardy D,Yankee TM,Houtman JC

    更新日期:2015-04-01 00:00:00

  • Lithium enhances CRTC oligomer formation and the interaction between the CREB coactivators CRTC and CBP--implications for CREB-dependent gene transcription.

    abstract::Lithium salts are important drugs to treat bipolar disorder. Previous work showed that lithium by enforcing the interaction between the transcription factor CREB and its coactivator CRTC1 enhanced cAMP-stimulated CREB-dependent gene transcription. Both CREB and CRTC have been implicated in neuronal adaptation, which m...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Heinrich A,von der Heyde AS,Böer U,Phu do T,Tzvetkov M,Oetjen E

    更新日期:2013-01-01 00:00:00

  • p130Cas: a key signalling node in health and disease.

    abstract::p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function. The Cas family of ...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Barrett A,Pellet-Many C,Zachary IC,Evans IM,Frankel P

    更新日期:2013-04-01 00:00:00

  • Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT (SLC7A11).

    abstract::The cystine/glutamate antiporter xCT (SLC7A11) is frequently overexpressed in many cancers, including glioblastoma. Cystine taken up by the cells via xCT is reduced to cysteine, which is used to synthesize glutathione for antioxidant cellular defense. However, overexpression of xCT causes cell death under glucose-limi...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Yamamoto M,Teramoto K,Katoh H

    更新日期:2021-02-01 00:00:00

  • MAP kinases have different functions in Dictyostelium G protein-mediated signaling.

    abstract::Extracellular signal regulated kinases (ERKs) are a class of MAP kinases that function in many signaling pathways in eukaryotic cells and in some cases, a single stimulus can activate more than one ERK suggesting functional redundancy or divergence from a common pathway. Dictyostelium discoideum encodes only two MAP k...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Nguyen HN,Raisley B,Hadwiger JA

    更新日期:2010-05-01 00:00:00

  • Involvement of glycogen synthase kinase-3beta in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity.

    abstract::Hydrogen peroxide (H(2)O(2)) mediates induction of cytotoxicity in various cell types. GSK-3beta has been found to participate in a number of signaling pathways, including cell proliferation and cell death. In the present study, we show that GSK-3beta is rapidly dephosphorylated and activated in response to H(2)O(2) t...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Shin SY,Chin BR,Lee YH,Kim JH

    更新日期:2006-05-01 00:00:00

  • Protein kinase C and annexins: unusual calcium response elements in the cell.

    abstract::Protein kinase C and the annexins appear to share some unusual and potentially important membrane- and calcium-binding properties. While these proteins are calcium response elements, they are not calcium-binding proteins in the formal sense; at intracellular calcium concentrations, they only bind significant amounts o...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审


    authors: Bazzi MD,Nelsestuen GL

    更新日期:1993-07-01 00:00:00

  • Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase.

    abstract::Cellular hypoxia can lead to cell death or adaptation and has important effects on development, physiology, and pathology. Here, we investigated the role and regulation of ceramide in hypoxia-induced apoptosis of SH-SY5Y neuroblastoma cells. Hypoxia increased the ceramide concentration; subsequently, we observed bioch...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Kang MS,Ahn KH,Kim SK,Jeon HJ,Ji JE,Choi JM,Jung KM,Jung SY,Kim DK

    更新日期:2010-04-01 00:00:00

  • Differential mechanisms involved in RG-7388 and Nutlin-3 induced cell death in SJSA-1 osteosarcoma cells.

    abstract::Targeted therapy is becoming the mainstay of cancer treatment due to reduced side effects and enhanced tumor attack. In the last few decades, Murine Double Minute 2 (MDM2) protein has become one of the targets for developing cancer therapies. Blocking MDM2-p53 interaction has long been considered to offer a broad rang...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Natarajan U,Venkatesan T,Dhandayuthapani S,Dondapatti P,Rathinavelu A

    更新日期:2020-11-01 00:00:00

  • TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents.

    abstract::Eight paralogue members form the family of transmembrane channel-like (TMC) proteins that share considerable sequence homology to anoctamin 1 (Ano1, TMEM16A). Ano1 is a Ca(2+) activated Cl(-) channel that is related to head and neck cancer, often caused by human papilloma virus (HPV) infection. Mutations in TMC 6 and ...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Sirianant L,Ousingsawat J,Tian Y,Schreiber R,Kunzelmann K

    更新日期:2014-12-01 00:00:00

  • Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation.

    abstract::The interferon regulated transcription factor IRF-1 is a tumour suppressor protein that is activated in response to viral infection and cell signalling activated by double stranded DNA lesions. IRF-1 has a short half-life (t(0.5) 20-40 min) allowing rapid changes in steady state levels by modulating its rate of degrad...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Pion E,Narayan V,Eckert M,Ball KL

    更新日期:2009-10-01 00:00:00

  • CaMKIIδ interacts directly with IKKβ and modulates NF-κB signalling in adult cardiac fibroblasts.

    abstract::Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease. Activation of CaMKIIδ is also known to regulate cardiovascular inflammation and is reported to be required for pro-inflammatory NF-κB signalling. In this...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Martin TP,McCluskey C,Cunningham MR,Beattie J,Paul A,Currie S

    更新日期:2018-11-01 00:00:00

  • Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells.

    abstract::Growing evidence shows that chronic inflammation drives the progression of colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes involved in solid tumor metastasis. Epidermal growth factor receptor (EGFR) also plays a key role in cancer cell development. We compared the expr...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Wang JY,Chen BK,Wang YS,Tsai YT,Chen WC,Chang WC,Hou MF,Wu YC,Chang WC

    更新日期:2012-01-01 00:00:00

  • Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation.

    abstract::Heat shock protein 90 (Hsp90) serves to stabilise and correctly fold multiple significant client proteins associated with cell proliferation and cell survival. However, little is known about the Hsp90 client proteins that regulate cell metabolism. Here, we describe a unique ability of Hsp90 to regulate the stability a...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Zhang L,Yi Y,Guo Q,Sun Y,Ma S,Xiao S,Geng J,Zheng Z,Song S

    更新日期:2012-04-01 00:00:00

  • Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes.

    abstract::The functional role of peroxisome proliferator-activated receptor-beta(PPARbeta; also referred to as PPARdelta) in epidermal cell growth remains controversial. Recent evidence suggests that ligand activation of PPARbeta/delta increases cell growth and inhibits apoptosis in epidermal cells. In contrast, other reports s...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Burdick AD,Bility MT,Girroir EE,Billin AN,Willson TM,Gonzalez FJ,Peters JM

    更新日期:2007-06-01 00:00:00

  • FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1.

    abstract::JNK proteins are conserved stress-activated MAP kinases. In C. elegans, the JNK-homolog KGB-1 plays essential roles in protection from heavy metals and protein folding stress. However, the contributions of KGB-1 are age-dependent, providing protection in larvae, but reducing stress resistance and shortening lifespan i...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Zhang Z,Liu L,Twumasi-Boateng K,Block DH,Shapira M

    更新日期:2017-01-01 00:00:00

  • TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion.

    abstract::TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed in pancreatic, thyroid, colon, and other cancer tissues. Previously, we demonstrated that TMPRSS4 mediates tumor cell invasion, migration, and metastasis. However, the mechanisms by which TMPRSS4 contributes to invasion are not fully und...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Min HJ,Lee Y,Zhao XF,Park YK,Lee MK,Lee JW,Kim S

    更新日期:2014-02-01 00:00:00

  • Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: evidence for an involvement of phospholipase D-derived phosphatidic acid.

    abstract::Human neutrophils pre-incubated with granulocyte-macrophage-colony-stimulating factor (GM-CSF) exhibit an enhanced mobilization of calcium in response to secondary stimuli such as chemotactic factors. The mechanisms underlying this priming effect of GM-CSF were examined. It was first demonstrated that the additional c...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Naccache PH,Hamelin B,Gaudry M,Bourgoin S

    更新日期:1991-01-01 00:00:00

  • Phosphorylation of rap1B by protein kinase A is not involved in platelet inhibition by cyclic AMP.

    abstract::The functional consequence of cyclic AMP-dependent phosphorylation of rap1B for stimulus-induced platelet activation is not known. Platelets were pretreated with the stable prostacyclin-analogue iloprost and resuspended in plasma without iloprost. Western blot analysis showed that rap1B was completely converted into i...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Siess W,Grünberg B

    更新日期:1993-03-01 00:00:00

  • Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A₂ receptor.

    abstract::In humans, thromboxane (TX) A₂ signals through the TPα and TPβ isoforms of its G-protein coupled TXA₂ receptor (TP) to mediate a host of (patho)physiologic responses. Herein, angio-associated migratory cell protein (AAMP) was identified as a novel interacting partner of both TPα and TPβ through an interaction dependen...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Reid HM,Wikström K,Kavanagh DJ,Mulvaney EP,Kinsella BT

    更新日期:2011-04-01 00:00:00

  • CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.

    abstract::Tyrosine phosphorylation (Tyr-P) of focal adhesion kinase (FAK) regulates FAK activation. Phosphorylated FAK Tyr 397 binds Src family kinases (Src), which in turn directly phosphorylate FAK Tyr 576/577 to produce maximal FAK enzymatic activity. CB₁ cannabinoid receptors (CB₁) are abundantly expressed in the nervous sy...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Dalton GD,Peterson LJ,Howlett AC

    更新日期:2013-08-01 00:00:00

  • Alteration of membrane transductive mechanisms induced by ethanol in human lymphocyte cultures.

    abstract::Ethanol, in millimolar concentrations, significantly modifies different transductive systems in human lymphocyte cultures. In particular, the presence of alcohol in the medium more than doubles the [Ca2+]i (from 70-90 to 200-250 nM), increasing Ca2+ fluxes from outside, and inhibits the active transport carried out by...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Fanò G,Belia S,Mariggiò MA,Antonica A,Agea E,Spinozzi F

    更新日期:1993-03-01 00:00:00

  • Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK.

    abstract::Growing evidence suggests that alterations of the inflammatory/immune system contribute to the pathogenesis of major depression and that inflammatory processes may influence the antidepressant treatment response. Depressed patients exhibit increased levels of inflammatory markers in both the periphery and brain, and h...

    journal_title:Cellular signalling

    pub_type: 杂志文章


    authors: Daniele S,Da Pozzo E,Zappelli E,Martini C

    更新日期:2015-08-01 00:00:00