SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice.

Abstract:

:Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differentiation of interleukin (IL)-17-producing CD8(+) T cells, and significantly suppressed the growth of EL4 tumor cells in vivo. Moreover, the tumor tissue from SUMO2-overexpressing mice had higher interferon (IFN)-γ and granzyme B mRNA levels. Although SUMO2 overexpression did not increase IFN-γ or granzyme B production in cytotoxic T lymphocytes, IL-12 treatment restored and increased IFN-γ secretion in IL-17-producing CD8(+) T cells. SUMO2 overexpression also increased gene expression of chemokines, CCL4, and CXCL10, which attract cytotoxic T lymphocytes to tumor tissues. Additionally, SUMO2-overexpressing T cells exhibited increased STAT3 phosphorylation, implying a SUMO2 target which up-regulates STAT3 activity governing IL-17A-producing CD8(+) T cell differentiation and antitumor immune responses.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Won TJ,Lee YJ,Hyung KE,Yang E,Sohn UD,Min HY,Lee DI,Park SY,Hwang KW

doi

10.1016/j.cellsig.2015.03.001

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

1246-52

issue

6

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(15)00077-7

journal_volume

27

pub_type

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