Abstract:
:Postoperative liver failure remains a major cause of morbidity and mortality after extensive hepatectomies. This study aims to evaluate the effectiveness of a hepatocyte bioreactor in the treatment of experimental post-hepatectomy liver failure. Our experimental model included a combination of a side-to-side portacaval shunt, occlusion of the hepatoduodenal ligament for 150 min, 70% hepatectomy, and reperfusion. Following the development of liver failure, 12 pigs were randomized into a control group (n = 6) and a treatment group (n = 6). Both groups underwent extracorporeal perfusion through a plasma separation device, a membrane oxygenator, and two parallel bioreactors. In the latter group, the bioreactors were loaded with 10 billion fresh hepatocytes, isolated from a donor pig. Following hepatocyte treatment, all animals were maintained for 24 h under mechanical ventilation, with intravenous fluid and glucose supplementation. Hemodynamic parameters, intracranial pressure, and biochemical parameters were measured. Liver biopsies were obtained during the 24-h autopsy. The extracorporeal circuit was well-tolerated hemodynamically. Treated animals had lower intracranial pressure compared with controls (at 24 h, 15 ± 3.1 vs. 22 ± 3.5 mm Hg, P = 0.006). Plasma ammonia in treated animals was lower compared with controls at 12 h (100 ± 29 vs. 244 ± 131 µmol, P = 0.026). Liver histological study showed decreased necrosis and increased regeneration activity in treated animals compared with controls. Treatment through an extracorporeal hepatocyte bioreactor attenuates brain edema and improves histological and functional parameters of the liver remnant of pigs with posthepatectomy liver failure.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Arkadopoulos N,Kostopanagiotou G,Nastos C,Papalois A,Papoutsidakis N,Kalimeris K,Defterevos G,Kanna T,Polyzois K,Kampouroglou G,Kypriotis D,Costopanagiotou C,Pafiti A,Tzanatos H,Smyrniotis Vdoi
10.1111/j.1525-1594.2010.01016.xsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
29-36issue
1eissn
0160-564Xissn
1525-1594pii
AOR1016journal_volume
35pub_type
杂志文章abstract::The outcome predictors of intra-aortic balloon pump (IABP) in patients who undergo mitral valve surgery remain unknown. This study aimed to retrospectively review valvular surgery in patients who received an IABP to identify the predictors of failure of IABP support and anticipate the necessary therapy. This retrospec...
journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1979.tb01080.x
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abstract::In this study, a series of natural biodegradable materials in the form of chitosan (C)-alginate (A)-hyaluronate (H) complexes are evaluated as tissue-engineering scaffolds. The weight ratio of C/A is 1 : 1 or 1 : 2. Sodium hyaluronate is mixed in 2%. The complexes can be cast into films or fabricated as scaffolds. The...
journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
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journal_title:Artificial organs
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Artificial organs
pub_type: 临床试验,杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Artificial organs
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更新日期:2014-07-01 00:00:00
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