Emitted dose and lung deposition of inhaled terbutaline from Turbuhaler at different conditions.

abstract：OBJECTIVE:To assess whether tumor necrosis factor (TNF) antagonism can attenuate eosinophilic airway inflammation in patients with mild-to-moderate allergic asthma. DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:National Institutes of Health (NIH) Clinical Center. PATIENTS:Twenty-six patients wit...

journal_title：Respiratory medicine

authors： Rouhani FN,Meitin CA,Kaler M,Miskinis-Hilligoss D,Stylianou M,Levine SJ

更新日期：2005-09-01 00:00:00

abstract：:The sick building syndrome has been the subject of research for approximately 10 years. Although it is often suggested that symptoms in office workers are due to circulating micro-organisms or particles, epidemiological studies investigating the relationship between them have been lacking. This cross-sectional study h...

journal_title：Respiratory medicine

authors： Harrison J,Pickering CA,Faragher EB,Austwick PK,Little SA,Lawton L

更新日期：1992-05-01 00:00:00

abstract：INTRODUCTION:The release of tumor necrosis factor (TNF-alpha) is increased in sarcoidosis patients. TNF-alpha exerts its effect by binding to specific cell surface receptors. There are only fragmentary data concerning the expression of tumor necrosis factor receptors (TNFRs) on bronchoalveolar lavage fluid (BALF) and p...

journal_title：Respiratory medicine

authors： Kieszko R,Krawczyk P,Chocholska S,Bojarska-Junak A,Jankowska O,Król A,Roliński J,Milanowski J

更新日期：2007-03-01 00:00:00

abstract：:The 72 kDa matrix metalloproteinase (MMP-2) and the 92 kDa matrix metalloproteinase (MMP-9), are type IV collagenases that have been implicated as important factors in cancer invasion and metastasis formation. We have used quantitative zymography and computer-assisted image analysis to measure the levels of MMP-9 and ...

journal_title：Respiratory medicine

authors： Hrabec E,Strek M,Nowak D,Hrabec Z

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Lung fibrosis is attributed to derangements in extracellular matrix remodeling, a process driven by collagen turnover. We examined the association of two collagen biomarkers, carboxy-terminal telopeptide of collagen type I (ICTP) and amino-terminal propeptide of type III procollagen (PIIINP), with subclinica...

journal_title：Respiratory medicine

authors： Madahar P,Duprez DA,Podolanczuk AJ,Bernstein EJ,Kawut SM,Raghu G,Barr RG,Gross MD,Jacobs DR Jr,Lederer DJ

更新日期：2018-07-01 00:00:00

abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...

journal_title：Respiratory medicine

authors： Levine M,Taylor R,Ryan M,Sculpher M

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The inhaled corticosteroid fluticasone furoate (FF) is efficacious as a once-daily treatment for the management of asthma. Asthma is associated with circadian changes, with worsening lung function at night. We compared the efficacy of once-daily FF in the morning or evening for the treatment of asthma. METH...

journal_title：Respiratory medicine

authors： Kempsford RD,Bal J,Baines A,Renaux J,Ravindranath R,Thomas PS

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Although high-resolution computed tomography (HRCT) is useful for the characterization of minute morphological changes in the lungs, no study has investigated risk factors for lung involvement detected by HRCT in patients with Sjögren's syndrome with or without respiratory symptoms. The aim of the current stu...

journal_title：Respiratory medicine

authors： Kakugawa T,Sakamoto N,Ishimoto H,Shimizu T,Nakamura H,Nawata A,Ito C,Sato S,Hanaka T,Oda K,Kido T,Miyamura T,Nakashima S,Aoki T,Nakamichi S,Obase Y,Saito K,Yatera K,Ishimatsu Y,Nakayama T,Korogi Y,Kawakami A,T

更新日期：2018-04-01 00:00:00

abstract：INRODUCTION:The mechanistic target of rapamycin inhibitors (mTORi) sirolimus and everolimus stabilize lung function in patients with pulmonary lymphangioleiomyomatosis (LAM) but do not induce remission. Pre-clinical studies suggest that simvastatin in combination with sirolimus induces LAM cell death. The objective of ...

journal_title：Respiratory medicine

authors： Krymskaya VP,Courtwright AM,Fleck V,Dorgan D,Kotloff R,McCormack FX,Kreider M

更新日期：2020-03-01 00:00:00

abstract：:Both albuterol and nedocromil sodium have been recognized to possess certain anti-inflammatory properties. However, there are no data on the impact of these drugs on the pathophysiology of the bronchial extracellular matrix in asthma characterized by enhanced tenascin (Tn) expression, known to occur proportional to th...

journal_title：Respiratory medicine

authors： Altraja A,Laitinen A,Meriste S,Marran S,Märtson T,Sillastu H,Laitinen LA

更新日期：1999-07-01 00:00:00

abstract：:The objective of this study was to describe asthma exacerbation self-management in children and adolescents. We used a cross-sectional study population enrolled in the International Study of Asthma and Allergies in Childhood (ISAAC) in Bordeaux. Subjects answered an additional questionnaire on utilization of health se...

journal_title：Respiratory medicine

authors： Raherison C,Tunon-de-Lara JM,Vernejoux JM,Taytard A

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost-utility of the treatment with a long acting beta-agonist (LABA) and inhaled corticosteroid (ICS) combination inhaler [salmeterol xinafoate (SAL)/fluticasone propionate (FP) combination inhaler (SFC) (Advair(®))] to continuing on current ICS dose (no ICS dose change) or increased ICS dose ...

journal_title：Respiratory medicine

authors： Ismaila AS,Risebrough N,Li C,Corriveau D,Hawkins N,FitzGerald JM,Su Z

更新日期：2014-09-01 00:00:00

abstract：:Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

journal_title：Respiratory medicine

authors： Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. OBJECTIVE:To investigate the effect of long-term AD on cli...

journal_title：Respiratory medicine

authors： Tyrak KE,Kupryś-Lipińska I,Czarnobilska E,Jakieła B,Pajdzik K,Ćmiel A,Plutecka H,Koziej M,Gawrońska A,Konduracka E,Kuna P,Sanak M,Mastalerz L

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with poor prognosis despite the recent availability of two antifibrotic drugs. Patients are more susceptible to cardiovascular comorbidities. In this study, we aimed to determine the impact of concom...

journal_title：Respiratory medicine

authors： M Lambert E,A Wuyts W,Yserbyt J,De Sadeleer LJ

更新日期：2020-11-26 00:00:00

abstract：STUDY OBJECTIVES:Surgical lung biopsy (SLB) plays an important role in the diagnosis of interstitial pneumonia, however, the occurrence of acute respiratory failure following SLB remains largely unreported. We evaluated the incidence, clinical features, therapy and prognosis of acute exacerbation of interstitial pneumo...

journal_title：Respiratory medicine

authors： Kondoh Y,Taniguchi H,Kitaichi M,Yokoi T,Johkoh T,Oishi T,Kimura T,Nishiyama O,Kato K,du Bois RM

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to estimate the societal costs and the key cost drivers for patients with severe asthma in Sweden. In addition, health-related quality of life (HRQOL) and morbidity of patients with severe asthma is described. METHODS:The study population comprised adults with severe asthma ...

journal_title：Respiratory medicine

authors： Jansson SA,Backman H,Andersson M,Telg G,Lindberg A,Stridsman C,Lundbäck B,Rönmark E

更新日期：2020-02-01 00:00:00

abstract：:Primary ciliary dyskinesia (PCD) is a genetic condition resulting in bronchiectasis. Exhaled gas nitric oxide (FE(NO)) is reduced in PCD. A model of pulmonary NO exchange dynamics can be used to demonstrate relative contributions of bronchial (J'aw(NO)) and peripheral airway (Calv(NO)) NO to the final FE(NO) concentra...

journal_title：Respiratory medicine

authors： Shoemark A,Wilson R

更新日期：2009-05-01 00:00:00

abstract：:Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the tre...

journal_title：Respiratory medicine

authors： Alton EW,Johnson M,Turner-Warwick M

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Neuromuscular electrical stimulation (NMES) improves muscle performance and exercise tolerance in chronic obstructive pulmonary disease (COPD) patients. In contrast, no study has assessed the effect of NMES on dynamic hyperinflation (DH) in COPD. This study investigated the effect of short-term, high-frequen...

journal_title：Respiratory medicine

authors： Vieira PJ,Chiappa AM,Cipriano G Jr,Umpierre D,Arena R,Chiappa GR

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:In vivo, the airway epithelium stretches and relaxes with each respiratory cycle, but little is known about the effect this pattern of elongation and relaxation has on bronchial epithelial cells. We have used a model of cell deformation to measure the effect of stretch on inflammatory cytokine release by t...

journal_title：Respiratory medicine

authors： Thomas RA,Norman JC,Huynh TT,Williams B,Bolton SJ,Wardlaw AJ

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the intra-alveolar accumulation of surfactant lipids and proteins. The aim of the study is to describe the epidemiologic, clinical, physiologic, and laboratory features of PAP in a large single-center cohort of patients with PAP. STUDY...

journal_title：Respiratory medicine

authors： Bonella F,Bauer PC,Griese M,Ohshimo S,Guzman J,Costabel U

更新日期：2011-12-01 00:00:00

abstract：:Gemcitabine is a newer pyrimidine analog used for the treatment of solid tumors. Though generally considered safe, it can cause pulmonary toxicity, which is generally mild and reversible. The purpose of this publication is to document a case of adult respiratory distress syndrome (ARDS) caused by Gemcitabine administr...

journal_title：Respiratory medicine

authors： Davidoff S,Shah RD,Arunabh T

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:An increasing number of studies confirm that pathogenesis and prevalence of bronchial asthma are age and sex dependent. Detailed physiological mechanisms of the changing sex ratios with age are not fully known, however, the gender (socio-cultural) factors are also imperative. Although multiple factors defini...

journal_title：Respiratory medicine

authors： Lux R,Awa W,Walter U

更新日期：2009-05-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a condition characterized by progressive airflow limitation, with symptoms of dyspnoea, cough, and sputum production. Aside from information on prevalence, mortality and hospital resource utilization arising from COPD in Canada, there is a lack of data on the impact of t...

journal_title：Respiratory medicine

authors： Chapman KR,Bourbeau J,Rance L

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Sarcoidosis (SA) is a multisystem granulomatous disorder of unknown etiology. It seems likely that in genetically different predisposed hosts, the same antigen(s) may cause the development of sarcoid Th1 response. The interaction of the T-cell receptor with the human leukocyte antigen-DQA1*03011 peptide-comp...

journal_title：Respiratory medicine

authors： Dubaniewicz A,Dubaniewicz A,Dubaniewicz A,Moszkowska G

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:GINA guideline recommends stepping down treatment of asthma patients where control is achieved. The aim of this analysis was to estimate the costs and health outcomes associated with step down of controlled patients on high dose fluticasone/salmeterol (FP/S 1000/100 μg daily) to either medium dose FP/S (500/...

journal_title：Respiratory medicine

authors： Paggiaro P,Patel S,Nicolini G,Pradelli L,Zaniolo O,Papi A

更新日期：2013-10-01 00:00:00

abstract：:To document the rate and cost of antibiotic prescribing for patients diagnosed only with influenza during US ambulatory care visits. Federal survey data for 1997-2001 were used to estimate outpatient trends for all patients and healthy people age 5-49 years. Cost estimates were based on Medicare payments and Red Book ...

journal_title：Respiratory medicine

authors： Ciesla G,Leader S,Stoddard J

更新日期：2004-11-01 00:00:00

abstract：:Lung cancer remains the most common cause of cancer-related mortality in Scotland, accounting for 28.9% of all cancer deaths in 2007. (1) Current guidelines recommend assessment of patient fitness and operability by a multi-disciplinary team when selecting management options. (2-6) Two of the most important prognostic...

journal_title：Respiratory medicine

authors： Tsim S,O'Dowd CA,Milroy R,Davidson S

更新日期：2010-12-01 00:00:00

abstract：:Lung function (FEV1 before and after bronchodilatation) was studied prospectively over five visits in 55 asthmatic children (28 boys) from childhood to adulthood (age 30). At the last follow-up recordings were made at rest, after cold air challenge (CACh), and after bronchodilatation. Results were related to clinical ...

journal_title：Respiratory medicine

authors： Gustafsson PM,Kjellman B

更新日期：2000-05-01 00:00:00